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Protein

Thioredoxin-related transmembrane protein 4

Gene

TMX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125827-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-related transmembrane protein 4
Alternative name(s):
Thioredoxin domain-containing protein 13
Gene namesi
Name:TMX4
Synonyms:KIAA1162, TXNDC13
ORF Names:PSEC0095, UNQ475/PRO938
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:25237. TMX4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125827.
PharmGKBiPA164726669.

Polymorphism and mutation databases

BioMutaiTMX4.
DMDMi30173124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003419124 – 349Thioredoxin-related transmembrane protein 4Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 67Redox-activePROSITE-ProRule annotation
Modified residuei251PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9H1E5.
MaxQBiQ9H1E5.
PaxDbiQ9H1E5.
PeptideAtlasiQ9H1E5.
PRIDEiQ9H1E5.

PTM databases

iPTMnetiQ9H1E5.
PhosphoSitePlusiQ9H1E5.
SwissPalmiQ9H1E5.

Expressioni

Gene expression databases

BgeeiENSG00000125827.
CleanExiHS_TXNDC13.
ExpressionAtlasiQ9H1E5. baseline and differential.
GenevisibleiQ9H1E5. HS.

Organism-specific databases

HPAiHPA000399.
HPA015752.

Interactioni

Protein-protein interaction databases

BioGridi121120. 21 interactors.
IntActiQ9H1E5. 3 interactors.
MINTiMINT-6944233.
STRINGi9606.ENSP00000246024.

Structurei

3D structure databases

ProteinModelPortaliQ9H1E5.
SMRiQ9H1E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 137ThioredoxinPROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 334Glu-richAdd BLAST111

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0913. Eukaryota.
ENOG4111H66. LUCA.
GeneTreeiENSGT00390000011580.
HOGENOMiHOG000045750.
InParanoidiQ9H1E5.
OMAiQHADKGP.
OrthoDBiEOG091G0MRE.
PhylomeDBiQ9H1E5.
TreeFamiTF106376.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGRCGPQL TALLAAWIAA VAATAGPEEA ALPPEQSRVQ PMTASNWTLV
60 70 80 90 100
MEGEWMLKFY APWCPSCQQT DSEWEAFAKN GEILQISVGK VDVIQEPGLS
110 120 130 140 150
GRFFVTTLPA FFHAKDGIFR RYRGPGIFED LQNYILEKKW QSVEPLTGWK
160 170 180 190 200
SPASLTMSGM AGLFSISGKI WHLHNYFTVT LGIPAWCSYV FFVIATLVFG
210 220 230 240 250
LFMGLVLVVI SECFYVPLPR HLSERSEQNR RSEEAHRAEQ LQDAEEEKDD
260 270 280 290 300
SNEEENKDSL VDDEEEKEDL GDEDEAEEEE EEDNLAAGVD EERSEANDQG
310 320 330 340
PPGEDGVTRE EVEPEEAEEG ISEQPCPADT EVVEDSLRQR KSQHADKGL
Length:349
Mass (Da):38,952
Last modified:March 1, 2001 - v1
Checksum:iFE944AA2F44131F1
GO

Sequence cautioni

The sequence CAB56344 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289V → E in BAC11237 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052578215Y → C.Corresponds to variant rs1135711dbSNPEnsembl.1
Natural variantiVAR_052579303G → R.1 PublicationCorresponds to variant rs2076015dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359004 mRNA. Translation: AAQ89363.1.
AK074838 mRNA. Translation: BAC11237.1.
AK075404 mRNA. Translation: BAC11599.1.
AL021396 Genomic DNA. Translation: CAC17521.1.
BC033787 mRNA. Translation: AAH33787.1.
AL118494 mRNA. Translation: CAB56344.1. Different initiation.
AB032988 mRNA. Translation: BAA86476.1.
CCDSiCCDS13101.1.
RefSeqiNP_066979.2. NM_021156.3.
UniGeneiHs.169358.

Genome annotation databases

EnsembliENST00000246024; ENSP00000246024; ENSG00000125827.
GeneIDi56255.
KEGGihsa:56255.
UCSCiuc002wmx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359004 mRNA. Translation: AAQ89363.1.
AK074838 mRNA. Translation: BAC11237.1.
AK075404 mRNA. Translation: BAC11599.1.
AL021396 Genomic DNA. Translation: CAC17521.1.
BC033787 mRNA. Translation: AAH33787.1.
AL118494 mRNA. Translation: CAB56344.1. Different initiation.
AB032988 mRNA. Translation: BAA86476.1.
CCDSiCCDS13101.1.
RefSeqiNP_066979.2. NM_021156.3.
UniGeneiHs.169358.

3D structure databases

ProteinModelPortaliQ9H1E5.
SMRiQ9H1E5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121120. 21 interactors.
IntActiQ9H1E5. 3 interactors.
MINTiMINT-6944233.
STRINGi9606.ENSP00000246024.

PTM databases

iPTMnetiQ9H1E5.
PhosphoSitePlusiQ9H1E5.
SwissPalmiQ9H1E5.

Polymorphism and mutation databases

BioMutaiTMX4.
DMDMi30173124.

Proteomic databases

EPDiQ9H1E5.
MaxQBiQ9H1E5.
PaxDbiQ9H1E5.
PeptideAtlasiQ9H1E5.
PRIDEiQ9H1E5.

Protocols and materials databases

DNASUi56255.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246024; ENSP00000246024; ENSG00000125827.
GeneIDi56255.
KEGGihsa:56255.
UCSCiuc002wmx.2. human.

Organism-specific databases

CTDi56255.
GeneCardsiTMX4.
H-InvDBHIX0174699.
HGNCiHGNC:25237. TMX4.
HPAiHPA000399.
HPA015752.
neXtProtiNX_Q9H1E5.
OpenTargetsiENSG00000125827.
PharmGKBiPA164726669.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0913. Eukaryota.
ENOG4111H66. LUCA.
GeneTreeiENSGT00390000011580.
HOGENOMiHOG000045750.
InParanoidiQ9H1E5.
OMAiQHADKGP.
OrthoDBiEOG091G0MRE.
PhylomeDBiQ9H1E5.
TreeFamiTF106376.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125827-MONOMER.

Miscellaneous databases

GeneWikiiTMX4.
GenomeRNAii56255.
PROiQ9H1E5.

Gene expression databases

BgeeiENSG00000125827.
CleanExiHS_TXNDC13.
ExpressionAtlasiQ9H1E5. baseline and differential.
GenevisibleiQ9H1E5. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMX4_HUMAN
AccessioniPrimary (citable) accession number: Q9H1E5
Secondary accession number(s): Q8N4P7
, Q8NCC1, Q9UJA1, Q9ULQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.