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Protein

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Gene

NUCKS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chromatin binding Source: ParkinsonsUK-UCL
  • double-stranded DNA binding Source: ParkinsonsUK-UCL
  • poly(A) RNA binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl
  • transcription factor binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • cellular glucose homeostasis Source: ParkinsonsUK-UCL
  • cellular response to X-ray Source: ParkinsonsUK-UCL
  • chromatin organization Source: ParkinsonsUK-UCL
  • double-strand break repair via homologous recombination Source: ParkinsonsUK-UCL
  • gene conversion Source: ParkinsonsUK-UCL
  • interstrand cross-link repair Source: ParkinsonsUK-UCL
  • modulation by host of RNA binding by virus Source: ParkinsonsUK-UCL
  • modulation by host of viral RNA-binding transcription factor activity Source: ParkinsonsUK-UCL
  • positive regulation by host of viral genome replication Source: ParkinsonsUK-UCL
  • positive regulation by host of viral transcription Source: ParkinsonsUK-UCL
  • positive regulation of insulin receptor signaling pathway Source: Ensembl
  • regulation of DNA replication Source: ParkinsonsUK-UCL
  • regulation of DNA strand elongation Source: ParkinsonsUK-UCL
  • regulation of insulin receptor signaling pathway Source: ParkinsonsUK-UCL
  • regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
  • release from viral latency Source: ParkinsonsUK-UCL
  • replication fork processing Source: ParkinsonsUK-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069275-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Alternative name(s):
P1
Gene namesi
Name:NUCKS1
Synonyms:NUCKS
ORF Names:JC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29923. NUCKS1.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: ParkinsonsUK-UCL
  • cytoplasm Source: BHF-UCL
  • nuclear chromatin Source: ParkinsonsUK-UCL
  • nucleus Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64710.
OpenTargetsiENSG00000069275.
PharmGKBiPA142671244.

Polymorphism and mutation databases

BioMutaiNUCKS1.
DMDMi13631947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579781 – 243Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1Add BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphotyrosineBy similarity1
Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei26PhosphotyrosineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei179PhosphothreonineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei202PhosphothreonineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDK1 and casein kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H1E3.
MaxQBiQ9H1E3.
PaxDbiQ9H1E3.
PeptideAtlasiQ9H1E3.
PRIDEiQ9H1E3.
TopDownProteomicsiQ9H1E3-1. [Q9H1E3-1]
Q9H1E3-2. [Q9H1E3-2]

PTM databases

iPTMnetiQ9H1E3.
PhosphoSitePlusiQ9H1E3.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.1 Publication

Gene expression databases

BgeeiENSG00000069275.
CleanExiHS_NUCKS1.
GenevisibleiQ9H1E3. HS.

Organism-specific databases

HPAiHPA062351.
HPA063843.

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi122238. 15 interactors.
IntActiQ9H1E3. 4 interactors.
MINTiMINT-1419873.
STRINGi9606.ENSP00000356110.

Structurei

3D structure databases

ProteinModelPortaliQ9H1E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 145Poly-Asp6
Compositional biasi150 – 206Lys-richAdd BLAST57

Phylogenomic databases

eggNOGiENOG410IH23. Eukaryota.
ENOG410XQNM. LUCA.
GeneTreeiENSGT00730000111108.
HOGENOMiHOG000113884.
HOVERGENiHBG052687.
InParanoidiQ9H1E3.
OMAiEDGGSDY.
OrthoDBiEOG091G13RX.
PhylomeDBiQ9H1E3.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H1E3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPTKKIRSS PREAKNKRRS
60 70 80 90 100
GKNSQEDSED SEDKDVKTKK DDSHSAEDSE DEKEDHKNVR QQRQAASKAA
110 120 130 140 150
SKQREMLMED VGSEEEQEEE DEAPFQEKDS GSDEDFLMED DDDSDYGSSK
160 170 180 190 200
KKNKKMVKKS KPERKEKKMP KPRLKATVTP SPVKGKGKVG RPTASKASKE
210 220 230 240
KTPSPKEEDE EPESPPEKKT STSPPPEKSG DEGSEDEAPS GED
Length:243
Mass (Da):27,296
Last modified:March 1, 2001 - v1
Checksum:i136BA1885F893950
GO
Isoform 2 (identifier: Q9H1E3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-53: Missing.

Show »
Length:203
Mass (Da):22,776
Checksum:i094C2FBDC4F2B694
GO

Sequence cautioni

The sequence BAB15076 differs from that shown. Reason: Erroneous termination at position 164. Translated as Arg.Curated
The sequence CAC20412 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112G → D in AAV83925 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051246119E → G.Corresponds to variant rs3207505dbSNPEnsembl.1
Natural variantiVAR_051247137L → P.Corresponds to variant rs17355035dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02177014 – 53Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012584 mRNA. Translation: CAC20408.1.
AB049824 mRNA. Translation: BAC06820.1.
AY823399 mRNA. Translation: AAV83925.1.
AJ237668 Genomic DNA. Translation: CAC20412.1. Sequence problems.
AK025133 mRNA. Translation: BAB15076.1. Sequence problems.
CH471067 Genomic DNA. Translation: EAW91578.1.
BC000805 mRNA. Translation: AAH00805.1.
CCDSiCCDS30987.1. [Q9H1E3-1]
RefSeqiNP_073568.2. NM_022731.4. [Q9H1E3-1]
UniGeneiHs.213061.
Hs.744865.

Genome annotation databases

EnsembliENST00000367142; ENSP00000356110; ENSG00000069275. [Q9H1E3-1]
GeneIDi64710.
KEGGihsa:64710.
UCSCiuc001hdb.4. human. [Q9H1E3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012584 mRNA. Translation: CAC20408.1.
AB049824 mRNA. Translation: BAC06820.1.
AY823399 mRNA. Translation: AAV83925.1.
AJ237668 Genomic DNA. Translation: CAC20412.1. Sequence problems.
AK025133 mRNA. Translation: BAB15076.1. Sequence problems.
CH471067 Genomic DNA. Translation: EAW91578.1.
BC000805 mRNA. Translation: AAH00805.1.
CCDSiCCDS30987.1. [Q9H1E3-1]
RefSeqiNP_073568.2. NM_022731.4. [Q9H1E3-1]
UniGeneiHs.213061.
Hs.744865.

3D structure databases

ProteinModelPortaliQ9H1E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122238. 15 interactors.
IntActiQ9H1E3. 4 interactors.
MINTiMINT-1419873.
STRINGi9606.ENSP00000356110.

PTM databases

iPTMnetiQ9H1E3.
PhosphoSitePlusiQ9H1E3.

Polymorphism and mutation databases

BioMutaiNUCKS1.
DMDMi13631947.

Proteomic databases

EPDiQ9H1E3.
MaxQBiQ9H1E3.
PaxDbiQ9H1E3.
PeptideAtlasiQ9H1E3.
PRIDEiQ9H1E3.
TopDownProteomicsiQ9H1E3-1. [Q9H1E3-1]
Q9H1E3-2. [Q9H1E3-2]

Protocols and materials databases

DNASUi64710.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367142; ENSP00000356110; ENSG00000069275. [Q9H1E3-1]
GeneIDi64710.
KEGGihsa:64710.
UCSCiuc001hdb.4. human. [Q9H1E3-1]

Organism-specific databases

CTDi64710.
DisGeNETi64710.
GeneCardsiNUCKS1.
HGNCiHGNC:29923. NUCKS1.
HPAiHPA062351.
HPA063843.
MIMi611912. gene.
neXtProtiNX_Q9H1E3.
OpenTargetsiENSG00000069275.
PharmGKBiPA142671244.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH23. Eukaryota.
ENOG410XQNM. LUCA.
GeneTreeiENSGT00730000111108.
HOGENOMiHOG000113884.
HOVERGENiHBG052687.
InParanoidiQ9H1E3.
OMAiEDGGSDY.
OrthoDBiEOG091G13RX.
PhylomeDBiQ9H1E3.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069275-MONOMER.

Miscellaneous databases

ChiTaRSiNUCKS1. human.
GeneWikiiNUCKS1.
GenomeRNAii64710.
PROiQ9H1E3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069275.
CleanExiHS_NUCKS1.
GenevisibleiQ9H1E3. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiNUCKS_HUMAN
AccessioniPrimary (citable) accession number: Q9H1E3
Secondary accession number(s): Q54AC0
, Q5PXE7, Q9H1D6, Q9H723
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.