Q9H1D9 (RPC6_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 96.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA-directed RNA polymerase III subunit RPC6 Short name=RNA polymerase III subunit C6 Alternative name(s): DNA-directed RNA polymerase III subunit F RNA polymerase III 39 kDa subunit Short name=RPC39 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 316 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Ref.10 Ref.11 |
| Subunit structure | Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex By similarity. Interacts with TBP and TFIIIB90 and GTF3C4. Ref.6 |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| PNRC1 | Q12796 | 3 | EBI-710067,EBI-2827376 | |
| PRPF4B | Q13523 | 2 | EBI-710067,EBI-395940 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||
Molecule processing | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 316 | 316 | DNA-directed RNA polymerase III subunit RPC6 | PRO_0000073972 | |||||||||||||||||
Experimental info | |||||||||||||||||||||
| Sequence conflict | 2 | 1 | A → G in AAB63677. Ref.1 | ||||||||||||||||||
| Sequence conflict | 44 – 53 | 10 | HIEAQQRAVA → QYRSPAAGSS in AAB63677. Ref.1 | ||||||||||||||||||
| Sequence conflict | 255 – 290 | 36 | AKEGT…PCGLC → CKRRHSWQCRWTHETVQGSQ SNHPSHRFGPGHPVDSA Ref.1 | ||||||||||||||||||
Secondary structure | |||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||
| Beta strand | 73 – 76 | 4 | |||||||||||||||||||
| Helix | 92 – 102 | 11 | |||||||||||||||||||
| Helix | 109 – 115 | 7 | |||||||||||||||||||
| Helix | 120 – 132 | 13 | |||||||||||||||||||
| Beta strand | 135 – 139 | 5 | |||||||||||||||||||
| Beta strand | 149 – 155 | 7 | |||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation." Wang Z., Roeder R.G. Genes Dev. 11:1315-1326(1997) [PubMed: 9171375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity." Hsieh Y.-J., Kundu T.K., Wang Z., Kovelman R., Roeder R.G. Mol. Cell. Biol. 19:7697-7704(1999) [PubMed: 10523658] [Abstract] Cited for: INTERACTION WITH GTF3C4. |
| [7] | "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits." Hu P., Wu S., Sun Y., Yuan C.-C., Kobayashi R., Myers M.P., Hernandez N. Mol. Cell. Biol. 22:8044-8055(2002) [PubMed: 12391170] [Abstract] Cited for: IDENTIFICATION IN THE RNA POL III COMPLEX, MASS SPECTROMETRY. |
| [8] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [9] | "Solution structure of winged-helix domain in RNA polymerase III 39kDa polypeptide." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 60-155. |
| [10] | "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway." Chiu Y.-H., Macmillan J.B., Chen Z.J. Cell 138:576-591(2009) [PubMed: 19631370] [Abstract] Cited for: FUNCTION. |
| [11] | "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate." Ablasser A., Bauernfeind F., Hartmann G., Latz E., Fitzgerald K.A., Hornung V. Nat. Immunol. 10:1065-1072(2009) [PubMed: 19609254] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U93869 mRNA. Translation: AAB63677.1. AK290892 mRNA. Translation: BAF83581.1. AL121893 Genomic DNA. Translation: CAC11110.1. CH471133 Genomic DNA. Translation: EAX10240.1. BC012588 mRNA. Translation: AAH12588.1. | ||||||||||||||||||
| IPI | IPI00100245. | ||||||||||||||||||
| RefSeq | NP_006457.2. NM_006466.2. | ||||||||||||||||||
| UniGene | Hs.472227. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | Q9H1D9. | ||||||||||||||||||
| SMR | Q9H1D9. Positions 11-155. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP-34646N. | ||||||||||||||||||
| IntAct | Q9H1D9. 8 interactions. | ||||||||||||||||||
| MINT | MINT-1377146. | ||||||||||||||||||
| STRING | Q9H1D9. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q9H1D9. | ||||||||||||||||||
Polymorphism databases | |||||||||||||||||||
| DMDM | 20139728. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q9H1D9. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000377603; ENSP00000366828; ENSG00000132664. | ||||||||||||||||||
| GeneID | 10621. | ||||||||||||||||||
| KEGG | hsa:10621. | ||||||||||||||||||
| UCSC | uc002wqv.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 10621. | ||||||||||||||||||
| GeneCards | GC20P018455. | ||||||||||||||||||
| H-InvDB | HIX0015667. | ||||||||||||||||||
| HGNC | HGNC:15763. POLR3F. | ||||||||||||||||||
| neXtProt | NX_Q9H1D9. | ||||||||||||||||||
| PharmGKB | PA33520. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| GeneTree | ENSGT00390000009679. | ||||||||||||||||||
| HOGENOM | HBG562065. | ||||||||||||||||||
| HOVERGEN | HBG006817. | ||||||||||||||||||
| InParanoid | Q9H1D9. | ||||||||||||||||||
| OMA | TPCGLCP. | ||||||||||||||||||
| OrthoDB | EOG4VQ9PP. | ||||||||||||||||||
| PhylomeDB | Q9H1D9. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| Reactome | REACT_1788. Transcription. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q9H1D9. | ||||||||||||||||||
| Bgee | Q9H1D9. | ||||||||||||||||||
| CleanEx | HS_POLR3F. | ||||||||||||||||||
| Genevestigator | Q9H1D9. | ||||||||||||||||||
| GermOnline | ENSG00000132664. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR007832. RNA_pol_Rpc34. IPR016049. RNA_pol_Rpc34-like. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. | ||||||||||||||||||
| KO | K03025. | ||||||||||||||||||
| PANTHER | PTHR12780. RNA_pol_Rpc34. 1 hit. | ||||||||||||||||||
| Pfam | PF05158. RNA_pol_Rpc34. 1 hit. [Graphical view] | ||||||||||||||||||
| PIRSF | PIRSF028763. RNA_pol_Rpc34. 1 hit. | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other | |||||||||||||||||||
| NextBio | 40356. | ||||||||||||||||||
Entry information
| Entry name | RPC6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9H1D9 Secondary accession number(s): A8K4C7, O15319 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with