Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9H1D9 (RPC6_HUMAN)

Last modified July 7, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA-directed RNA polymerase III subunit RPC6
      Short name=RNA polymerase III subunit C6
Alternative name(s):
    DNA-directed RNA polymerase III subunit F
    DNA-directed RNA polymerase III 39 kDa polypeptide
    RPC39
Gene names
Name: POLR3F
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex.

Subunit structure

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex By similarity. Interacts with TBP and TFIIIB90 and GTF3C4.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PRPF4BQ135231EBI-710067,EBI-395940

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316DNA-directed RNA polymerase III subunit RPC6
PRO_0000073972

Experimental info

Sequence conflict21A → G in AAB63677. Ref.1
Sequence conflict44 – 5310HIEAQQRAVA → QYRSPAAGSS in AAB63677. Ref.1
Sequence conflict255 – 29036AKEGT…PCGLC → CKRRHSWQCRWTHETVQGSQ SNHPSHRFGPGHPVDSA Ref.1

Secondary structure

............. 316
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9H1D9-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 49B1360AF8B365ED

FASTA31635,684
        10         20         30         40         50         60 
MAEVKVKVQP PDADPVEIEN RIIELCHQFP HGITDQVIQN EMPHIEAQQR AVAINRLLSM 

        70         80         90        100        110        120 
GQLDLLRSNT GLLYRIKDSQ NAGKMKGSDN QEKLVYQIIE DAGNKGIWSR DIRYKSNLPL 

       130        140        150        160        170        180 
TEINKILKNL ESKKLIKAVK SVAASKKKVY MLYNLQPDRS VTGGAWYSDQ DFESEFVEVL 

       190        200        210        220        230        240 
NQQCFKFLQS KAETARESKQ NPMIQRNSSF ASSHEVWKYI CELGISKVEL SMEDIETILN 

       250        260        270        280        290        300 
TLIYDGKVEM TIIAAKEGTV GSVDGHMKLY RAVNPIIPPT GLVRAPCGLC PVFDDCHEGG 

       310 
EISPSNCIYM TEWLEF 

« Hide

References

« Hide 'large scale' references
[1]"Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation."
Wang Z., Roeder R.G.
Genes Dev. 11:1315-1326(1997) [PubMed: 9171375] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity."
Hsieh Y.-J., Kundu T.K., Wang Z., Kovelman R., Roeder R.G.
Mol. Cell. Biol. 19:7697-7704(1999) [PubMed: 10523658] [Abstract]
Cited for: INTERACTION WITH GTF3C4.
[5]"Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits."
Hu P., Wu S., Sun Y., Yuan C.-C., Kobayashi R., Myers M.P., Hernandez N.
Mol. Cell. Biol. 22:8044-8055(2002) [PubMed: 12391170] [Abstract]
Cited for: IDENTIFICATION IN THE RNA POL III COMPLEX, MASS SPECTROMETRY.
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]"Solution structure of winged-helix domain in RNA polymerase III 39kDa polypeptide."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 78-155.

Cross-references

Sequence databases

U93869 mRNA. Translation: AAB63677.1.
AL121893 Genomic DNA. Translation: CAC11110.1.
BC012588 mRNA. Translation: AAH12588.1.
IPIIPI00100245.
RefSeqNP_006457.2.
UniGeneHs.472227

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2DK5NMR-A78-155[»]
2YU3NMR-A59-143[»]
SMRQ9H1D9. Positions 11-79.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9H1D9. 6 interactions.

PTM databases

PhosphoSiteQ9H1D9.

Proteomic databases

PRIDEQ9H1D9.

Genome annotation databases

EnsemblENSG00000132664. Homo sapiens. [Contig view]
GeneID10621.
KEGGhsa:10621.
UCSCuc002wqv.1. human.

Organism-specific databases

GeneCardsGC20P018395.
H-InvDBHIX0015667.
HGNCHGNC:15763. POLR3F.
PharmGKBPA33520.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9H1D9.
HOVERGENQ9H1D9.
OMAQ9H1D9. TPCGLCP.

Enzyme and pathway databases

ReactomeREACT_1788. Transcription.

Gene expression databases

ArrayExpressQ9H1D9.
BgeeQ9H1D9.
CleanExHS_POLR3F.
GermOnlineENSG00000132664. Homo sapiens.

Family and domain databases

InterProIPR007832. RNA_pol_Rpc34.
IPR016049. RNA_pol_Rpc34-like.
[Graphical view]
PANTHERPTHR12780. RNA_pol_Rpc34. 1 hit.
PfamPF05158. RNA_pol_Rpc34. 1 hit.
[Graphical view]
PIRSFPIRSF028763. RNA_pol_Rpc34. 1 hit.
ProtoNetSearch...

Other Resources

NextBio40356.

Entry information

Entry nameRPC6_HUMAN
AccessionPrimary (citable) accession number: Q9H1D9
Secondary accession number(s): O15319
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: July 7, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents