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Q9H1C3

- GL8D2_HUMAN

UniProt

Q9H1C3 - GL8D2_HUMAN

Protein

Glycosyltransferase 8 domain-containing protein 2

Gene

GLT8D2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT8. Glycosyltransferase Family 8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycosyltransferase 8 domain-containing protein 2 (EC:2.4.1.-)
    Gene namesi
    Name:GLT8D2
    Synonyms:GALA4A
    ORF Names:UNQ1901/PRO4347
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24890. GLT8D2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Glycosyltransferase 8 domain-containing protein 2PRO_0000271382Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9H1C3.
    PaxDbiQ9H1C3.
    PRIDEiQ9H1C3.

    PTM databases

    PhosphoSiteiQ9H1C3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H1C3.
    BgeeiQ9H1C3.
    CleanExiHS_GLT8D2.
    GenevestigatoriQ9H1C3.

    Organism-specific databases

    HPAiHPA026904.

    Interactioni

    Protein-protein interaction databases

    BioGridi123660. 1 interaction.
    STRINGi9606.ENSP00000354053.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1C3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini25 – 349325LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2418Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 8 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74598.
    HOGENOMiHOG000112730.
    HOVERGENiHBG055240.
    InParanoidiQ9H1C3.
    OMAiYSAINPL.
    OrthoDBiEOG7RBZ8R.
    PhylomeDBiQ9H1C3.
    TreeFamiTF332433.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR002495. Glyco_trans_8.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01501. Glyco_transf_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9H1C3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLRKINQV LLFLLIVTLC VILYKKVHKG TVPKNDADDE SETPEELEEE    50
    IPVVICAAAG RMGATMAAIN SIYSNTDANI LFYVVGLRNT LTRIRKWIEH 100
    SKLREINFKI VEFNPMVLKG KIRPDSSRPE LLQPLNFVRF YLPLLIHQHE 150
    KVIYLDDDVI VQGDIQELYD TTLALGHAAA FSDDCDLPSA QDINRLVGLQ 200
    NTYMGYLDYR KKAIKDLGIS PSTCSFNPGV IVANMTEWKH QRITKQLEKW 250
    MQKNVEENLY SSSLGGGVAT SPMLIVFHGK YSTINPLWHI RHLGWNPDAR 300
    YSEHFLQEAK LLHWNGRHKP WDFPSVHNDL WESWFVPDPA GIFKLNHHS 349
    Length:349
    Mass (Da):40,026
    Last modified:March 1, 2001 - v1
    Checksum:i19FBF16C5AB1D647
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti72 – 721I → F in BAB55033. (PubMed:14702039)Curated
    Sequence conflicti227 – 2271N → D in BAB55033. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371A → T.1 Publication
    Corresponds to variant rs17035120 [ dbSNP | Ensembl ].
    VAR_049247

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271711 mRNA. Translation: CAC19667.1.
    AY358763 mRNA. Translation: AAQ89123.1.
    AK027310 mRNA. Translation: BAB55033.1.
    AK056056 mRNA. Translation: BAB71085.1.
    BC022343 mRNA. Translation: AAH22343.1.
    CCDSiCCDS9096.1.
    RefSeqiNP_112592.1. NM_031302.3.
    XP_005269228.1. XM_005269171.1.
    UniGeneiHs.631650.

    Genome annotation databases

    EnsembliENST00000360814; ENSP00000354053; ENSG00000120820.
    ENST00000546436; ENSP00000449750; ENSG00000120820.
    ENST00000548660; ENSP00000447450; ENSG00000120820.
    GeneIDi83468.
    KEGGihsa:83468.
    UCSCiuc001tkh.1. human.

    Polymorphism databases

    DMDMi74733535.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271711 mRNA. Translation: CAC19667.1 .
    AY358763 mRNA. Translation: AAQ89123.1 .
    AK027310 mRNA. Translation: BAB55033.1 .
    AK056056 mRNA. Translation: BAB71085.1 .
    BC022343 mRNA. Translation: AAH22343.1 .
    CCDSi CCDS9096.1.
    RefSeqi NP_112592.1. NM_031302.3.
    XP_005269228.1. XM_005269171.1.
    UniGenei Hs.631650.

    3D structure databases

    ProteinModelPortali Q9H1C3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123660. 1 interaction.
    STRINGi 9606.ENSP00000354053.

    Protein family/group databases

    CAZyi GT8. Glycosyltransferase Family 8.

    PTM databases

    PhosphoSitei Q9H1C3.

    Polymorphism databases

    DMDMi 74733535.

    Proteomic databases

    MaxQBi Q9H1C3.
    PaxDbi Q9H1C3.
    PRIDEi Q9H1C3.

    Protocols and materials databases

    DNASUi 83468.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360814 ; ENSP00000354053 ; ENSG00000120820 .
    ENST00000546436 ; ENSP00000449750 ; ENSG00000120820 .
    ENST00000548660 ; ENSP00000447450 ; ENSG00000120820 .
    GeneIDi 83468.
    KEGGi hsa:83468.
    UCSCi uc001tkh.1. human.

    Organism-specific databases

    CTDi 83468.
    GeneCardsi GC12M104382.
    HGNCi HGNC:24890. GLT8D2.
    HPAi HPA026904.
    neXtProti NX_Q9H1C3.
    PharmGKBi PA134939919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74598.
    HOGENOMi HOG000112730.
    HOVERGENi HBG055240.
    InParanoidi Q9H1C3.
    OMAi YSAINPL.
    OrthoDBi EOG7RBZ8R.
    PhylomeDBi Q9H1C3.
    TreeFami TF332433.

    Miscellaneous databases

    GenomeRNAii 83468.
    NextBioi 72397.
    PROi Q9H1C3.

    Gene expression databases

    ArrayExpressi Q9H1C3.
    Bgeei Q9H1C3.
    CleanExi HS_GLT8D2.
    Genevestigatori Q9H1C3.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR002495. Glyco_trans_8.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01501. Glyco_transf_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Gala4a, glycosyltransferase."
      Steffensen R., Bennett E.P.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-37.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiGL8D2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1C3
    Secondary accession number(s): Q96KA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3