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Q9H1C0

- LPAR5_HUMAN

UniProt

Q9H1C0 - LPAR5_HUMAN

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Protein
Lysophosphatidic acid receptor 5
Gene
LPAR5, GPR92, GPR93
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18365. Lysosphingolipid and LPA receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophosphatidic acid receptor 5
    Short name:
    LPA receptor 5
    Short name:
    LPA-5
    Alternative name(s):
    G-protein coupled receptor 92
    G-protein coupled receptor 93
    Gene namesi
    Name:LPAR5
    Synonyms:GPR92, GPR93
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13307. LPAR5.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei27 – 4721Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini48 – 558Cytoplasmic Reviewed prediction
    Transmembranei56 – 7621Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini77 – 9620Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei97 – 11721Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini118 – 13619Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei137 – 15721Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini158 – 18730Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei188 – 20821Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini209 – 23931Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei240 – 26021Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini261 – 27616Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei277 – 29721Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini298 – 37275Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28935.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Lysophosphatidic acid receptor 5
    PRO_0000069600Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi94 ↔ 175 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H1C0.
    PRIDEiQ9H1C0.

    PTM databases

    PhosphoSiteiQ9H1C0.

    Expressioni

    Tissue specificityi

    Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.

    Gene expression databases

    ArrayExpressiQ9H1C0.
    BgeeiQ9H1C0.
    CleanExiHS_LPAR5.
    GenevestigatoriQ9H1C0.

    Organism-specific databases

    HPAiHPA013170.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000327875.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1C0.
    SMRiQ9H1C0. Positions 26-306.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146804.
    HOGENOMiHOG000231307.
    HOVERGENiHBG103813.
    InParanoidiQ9H1C0.
    KOiK08390.
    OMAiSGRVFWT.
    OrthoDBiEOG75J0NM.
    PhylomeDBiQ9H1C0.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H1C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA    50
    LRVHSVVSVY MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI 100
    FQMNMYGSCI FLMLINVDRY AAIVHPLRLR HLRRPRVARL LCLGVWALIL 150
    VFAVPAARVH RPSRCRYRDL EVRLCFESFS DELWKGRLLP LVLLAEALGF 200
    LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL VIFLLCFVPY 250
    NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS 300
    AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG 350
    LLRPSDSHSL SSFTQCPQDS AL 372
    Length:372
    Mass (Da):41,347
    Last modified:March 1, 2001 - v1
    Checksum:iBA35709084BB6D84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272207 mRNA. Translation: CAC03715.1.
    AF411112 Genomic DNA. Translation: AAL26483.1.
    AB083600 Genomic DNA. Translation: BAB89313.1.
    BC033571 mRNA. Translation: AAH33571.1.
    BC072394 mRNA. Translation: AAH72394.1.
    CCDSiCCDS8553.1.
    RefSeqiNP_001136433.1. NM_001142961.1.
    NP_065133.1. NM_020400.5.
    UniGeneiHs.155538.

    Genome annotation databases

    EnsembliENST00000329858; ENSP00000327875; ENSG00000184574.
    ENST00000431922; ENSP00000393098; ENSG00000184574.
    GeneIDi57121.
    KEGGihsa:57121.
    UCSCiuc001qps.2. human.

    Polymorphism databases

    DMDMi48474954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272207 mRNA. Translation: CAC03715.1 .
    AF411112 Genomic DNA. Translation: AAL26483.1 .
    AB083600 Genomic DNA. Translation: BAB89313.1 .
    BC033571 mRNA. Translation: AAH33571.1 .
    BC072394 mRNA. Translation: AAH72394.1 .
    CCDSi CCDS8553.1.
    RefSeqi NP_001136433.1. NM_001142961.1.
    NP_065133.1. NM_020400.5.
    UniGenei Hs.155538.

    3D structure databases

    ProteinModelPortali Q9H1C0.
    SMRi Q9H1C0. Positions 26-306.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000327875.

    Chemistry

    BindingDBi Q9H1C0.
    ChEMBLi CHEMBL5700.
    GuidetoPHARMACOLOGYi 124.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9H1C0.

    Polymorphism databases

    DMDMi 48474954.

    Proteomic databases

    PaxDbi Q9H1C0.
    PRIDEi Q9H1C0.

    Protocols and materials databases

    DNASUi 57121.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329858 ; ENSP00000327875 ; ENSG00000184574 .
    ENST00000431922 ; ENSP00000393098 ; ENSG00000184574 .
    GeneIDi 57121.
    KEGGi hsa:57121.
    UCSCi uc001qps.2. human.

    Organism-specific databases

    CTDi 57121.
    GeneCardsi GC12M006728.
    HGNCi HGNC:13307. LPAR5.
    HPAi HPA013170.
    MIMi 606926. gene.
    neXtProti NX_Q9H1C0.
    PharmGKBi PA28935.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146804.
    HOGENOMi HOG000231307.
    HOVERGENi HBG103813.
    InParanoidi Q9H1C0.
    KOi K08390.
    OMAi SGRVFWT.
    OrthoDBi EOG75J0NM.
    PhylomeDBi Q9H1C0.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18365. Lysosphingolipid and LPA receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi LPAR5. human.
    GeneWikii LPAR5.
    GenomeRNAii 57121.
    NextBioi 63005.
    PROi Q9H1C0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H1C0.
    Bgeei Q9H1C0.
    CleanExi HS_LPAR5.
    Genevestigatori Q9H1C0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
      White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.
      Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Discovery and mapping of ten novel G protein-coupled receptor genes."
      Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
      Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell and Brain.

    Entry informationi

    Entry nameiLPAR5_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: March 1, 2001
    Last modified: September 3, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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