Q9H1C0 (LPAR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysophosphatidic acid receptor 5
Short name=LPA receptor 5
Short name=LPA-5

Alternative name(s):
G-protein coupled receptor 92
G-protein coupled receptor 93

Gene names

Name:	LPAR5
Synonyms:	GPR92, GPR93

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Lysophosphatidic acid receptor 5		PRO_0000069600
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 47	21	Helical; Name=1; Potential
	Topological domain	48 – 55	8	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 96	20	Extracellular Potential
	Transmembrane	97 – 117	21	Helical; Name=3; Potential
	Topological domain	118 – 136	19	Cytoplasmic Potential
	Transmembrane	137 – 157	21	Helical; Name=4; Potential
	Topological domain	158 – 187	30	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 239	31	Cytoplasmic Potential
	Transmembrane	240 – 260	21	Helical; Name=6; Potential
	Topological domain	261 – 276	16	Extracellular Potential
	Transmembrane	277 – 297	21	Helical; Name=7; Potential
	Topological domain	298 – 372	75	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Disulfide bond	94 ↔ 175		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9H1C0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: BA35709084BB6D84	FASTA	372	41,347
	10 20 30 40 50 60 MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA LRVHSVVSVY 70 80 90 100 110 120 MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI FQMNMYGSCI FLMLINVDRY 130 140 150 160 170 180 AAIVHPLRLR HLRRPRVARL LCLGVWALIL VFAVPAARVH RPSRCRYRDL EVRLCFESFS 190 200 210 220 230 240 DELWKGRLLP LVLLAEALGF LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL 250 260 270 280 290 300 VIFLLCFVPY NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS 310 320 330 340 350 360 AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG LLRPSDSHSL 370 SSFTQCPQDS AL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23." White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M. Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Discovery and mapping of ten novel G protein-coupled receptor genes." Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F. Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell and Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ272207 mRNA. Translation: CAC03715.1. AF411112 Genomic DNA. Translation: AAL26483.1. AB083600 Genomic DNA. Translation: BAB89313.1. BC033571 mRNA. Translation: AAH33571.1. BC072394 mRNA. Translation: AAH72394.1.
IPI	IPI00942484.
RefSeq	NP_001136433.1. NM_001142961.1. NP_065133.1. NM_020400.5.
UniGene	Hs.155538.
3D structure databases
ProteinModelPortal	Q9H1C0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000327875.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9H1C0.
Polymorphism databases
DMDM	48474954.
Proteomic databases
PaxDb	Q9H1C0.
PRIDE	Q9H1C0.
Protocols and materials databases
DNASU	57121.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329858; ENSP00000327875; ENSG00000184574. ENST00000431922; ENSP00000393098; ENSG00000184574.
GeneID	57121.
KEGG	hsa:57121.
UCSC	uc001qps.2. human.
Organism-specific databases
CTD	57121.
GeneCards	GC12M006728.
HGNC	HGNC:13307. LPAR5.
HPA	HPA013170.
MIM	606926. gene.
neXtProt	NX_Q9H1C0.
PharmGKB	PA28935.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146804.
HOGENOM	HOG000231307.
HOVERGEN	HBG103813.
InParanoid	Q9H1C0.
KO	K08390.
PhylomeDB	Q9H1C0.
Gene expression databases
ArrayExpress	Q9H1C0.
Bgee	Q9H1C0.
CleanEx	HS_LPAR5.
Genevestigator	Q9H1C0.
GermOnline	ENSG00000184574. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002286. P2_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9H1C0.
ChEMBL	CHEMBL5700.
ChiTaRS	LPAR5. human.
GenomeRNAi	57121.
NextBio	63005.
SOURCE	Search...

Entry information

Entry name

LPAR5_HUMAN

Accession

Primary (citable) accession number: Q9H1C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.