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Q9H1C0

- LPAR5_HUMAN

UniProt

Q9H1C0 - LPAR5_HUMAN

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Protein

Lysophosphatidic acid receptor 5

Gene

LPAR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18365. Lysosphingolipid and LPA receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 5
Short name:
LPA receptor 5
Short name:
LPA-5
Alternative name(s):
G-protein coupled receptor 92
G-protein coupled receptor 93
Gene namesi
Name:LPAR5
Synonyms:GPR92, GPR93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13307. LPAR5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28935.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Lysophosphatidic acid receptor 5PRO_0000069600Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H1C0.
PRIDEiQ9H1C0.

PTM databases

PhosphoSiteiQ9H1C0.

Expressioni

Tissue specificityi

Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.

Gene expression databases

BgeeiQ9H1C0.
CleanExiHS_LPAR5.
ExpressionAtlasiQ9H1C0. baseline and differential.
GenevestigatoriQ9H1C0.

Organism-specific databases

HPAiHPA013170.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327875.

Structurei

3D structure databases

ProteinModelPortaliQ9H1C0.
SMRiQ9H1C0. Positions 26-306.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Topological domaini77 – 9620ExtracellularSequence AnalysisAdd
BLAST
Topological domaini118 – 13619CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini158 – 18730ExtracellularSequence AnalysisAdd
BLAST
Topological domaini209 – 23931CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini261 – 27616ExtracellularSequence AnalysisAdd
BLAST
Topological domaini298 – 37275CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146804.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG103813.
InParanoidiQ9H1C0.
KOiK08390.
OMAiSGRVFWT.
OrthoDBiEOG75J0NM.
PhylomeDBiQ9H1C0.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H1C0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA
60 70 80 90 100
LRVHSVVSVY MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI
110 120 130 140 150
FQMNMYGSCI FLMLINVDRY AAIVHPLRLR HLRRPRVARL LCLGVWALIL
160 170 180 190 200
VFAVPAARVH RPSRCRYRDL EVRLCFESFS DELWKGRLLP LVLLAEALGF
210 220 230 240 250
LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL VIFLLCFVPY
260 270 280 290 300
NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS
310 320 330 340 350
AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG
360 370
LLRPSDSHSL SSFTQCPQDS AL
Length:372
Mass (Da):41,347
Last modified:March 1, 2001 - v1
Checksum:iBA35709084BB6D84
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272207 mRNA. Translation: CAC03715.1.
AF411112 Genomic DNA. Translation: AAL26483.1.
AB083600 Genomic DNA. Translation: BAB89313.1.
BC033571 mRNA. Translation: AAH33571.1.
BC072394 mRNA. Translation: AAH72394.1.
CCDSiCCDS8553.1.
RefSeqiNP_001136433.1. NM_001142961.1.
NP_065133.1. NM_020400.5.
UniGeneiHs.155538.

Genome annotation databases

EnsembliENST00000329858; ENSP00000327875; ENSG00000184574.
ENST00000431922; ENSP00000393098; ENSG00000184574.
GeneIDi57121.
KEGGihsa:57121.
UCSCiuc001qps.2. human.

Polymorphism databases

DMDMi48474954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272207 mRNA. Translation: CAC03715.1 .
AF411112 Genomic DNA. Translation: AAL26483.1 .
AB083600 Genomic DNA. Translation: BAB89313.1 .
BC033571 mRNA. Translation: AAH33571.1 .
BC072394 mRNA. Translation: AAH72394.1 .
CCDSi CCDS8553.1.
RefSeqi NP_001136433.1. NM_001142961.1.
NP_065133.1. NM_020400.5.
UniGenei Hs.155538.

3D structure databases

ProteinModelPortali Q9H1C0.
SMRi Q9H1C0. Positions 26-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000327875.

Chemistry

BindingDBi Q9H1C0.
ChEMBLi CHEMBL5700.
GuidetoPHARMACOLOGYi 124.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9H1C0.

Polymorphism databases

DMDMi 48474954.

Proteomic databases

PaxDbi Q9H1C0.
PRIDEi Q9H1C0.

Protocols and materials databases

DNASUi 57121.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329858 ; ENSP00000327875 ; ENSG00000184574 .
ENST00000431922 ; ENSP00000393098 ; ENSG00000184574 .
GeneIDi 57121.
KEGGi hsa:57121.
UCSCi uc001qps.2. human.

Organism-specific databases

CTDi 57121.
GeneCardsi GC12M006728.
HGNCi HGNC:13307. LPAR5.
HPAi HPA013170.
MIMi 606926. gene.
neXtProti NX_Q9H1C0.
PharmGKBi PA28935.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146804.
GeneTreei ENSGT00760000118784.
HOGENOMi HOG000231307.
HOVERGENi HBG103813.
InParanoidi Q9H1C0.
KOi K08390.
OMAi SGRVFWT.
OrthoDBi EOG75J0NM.
PhylomeDBi Q9H1C0.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18365. Lysosphingolipid and LPA receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi LPAR5. human.
GeneWikii LPAR5.
GenomeRNAii 57121.
NextBioi 63005.
PROi Q9H1C0.
SOURCEi Search...

Gene expression databases

Bgeei Q9H1C0.
CleanExi HS_LPAR5.
ExpressionAtlasi Q9H1C0. baseline and differential.
Genevestigatori Q9H1C0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
    White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.
    Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell and Brain.

Entry informationi

Entry nameiLPAR5_HUMAN
AccessioniPrimary (citable) accession number: Q9H1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3