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Q9H1C0 (LPAR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophosphatidic acid receptor 5

Short name=LPA receptor 5
Short name=LPA-5
Alternative name(s):
G-protein coupled receptor 92
G-protein coupled receptor 93
Gene names
Name:LPAR5
Synonyms:GPR92, GPR93
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Lysophosphatidic acid receptor 5
PRO_0000069600

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 9620Extracellular Potential
Transmembrane97 – 11721Helical; Name=3; Potential
Topological domain118 – 13619Cytoplasmic Potential
Transmembrane137 – 15721Helical; Name=4; Potential
Topological domain158 – 18730Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 23931Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 27616Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 37275Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation91N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 175 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9H1C0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: BA35709084BB6D84

FASTA37241,347
        10         20         30         40         50         60 
MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA LRVHSVVSVY 

        70         80         90        100        110        120 
MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI FQMNMYGSCI FLMLINVDRY 

       130        140        150        160        170        180 
AAIVHPLRLR HLRRPRVARL LCLGVWALIL VFAVPAARVH RPSRCRYRDL EVRLCFESFS 

       190        200        210        220        230        240 
DELWKGRLLP LVLLAEALGF LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL 

       250        260        270        280        290        300 
VIFLLCFVPY NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS 

       310        320        330        340        350        360 
AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG LLRPSDSHSL 

       370 
SSFTQCPQDS AL 

« Hide

References

« Hide 'large scale' references
[1]"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.
Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Discovery and mapping of ten novel G protein-coupled receptor genes."
Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell and Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ272207 mRNA. Translation: CAC03715.1.
AF411112 Genomic DNA. Translation: AAL26483.1.
AB083600 Genomic DNA. Translation: BAB89313.1.
BC033571 mRNA. Translation: AAH33571.1.
BC072394 mRNA. Translation: AAH72394.1.
RefSeqNP_001136433.1. NM_001142961.1.
NP_065133.1. NM_020400.5.
UniGeneHs.155538.

3D structure databases

ProteinModelPortalQ9H1C0.
SMRQ9H1C0. Positions 26-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000327875.

Chemistry

BindingDBQ9H1C0.
ChEMBLCHEMBL5700.
GuidetoPHARMACOLOGY124.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9H1C0.

Polymorphism databases

DMDM48474954.

Proteomic databases

PaxDbQ9H1C0.
PRIDEQ9H1C0.

Protocols and materials databases

DNASU57121.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329858; ENSP00000327875; ENSG00000184574.
ENST00000431922; ENSP00000393098; ENSG00000184574.
GeneID57121.
KEGGhsa:57121.
UCSCuc001qps.2. human.

Organism-specific databases

CTD57121.
GeneCardsGC12M006728.
HGNCHGNC:13307. LPAR5.
HPAHPA013170.
MIM606926. gene.
neXtProtNX_Q9H1C0.
PharmGKBPA28935.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146804.
HOGENOMHOG000231307.
HOVERGENHBG103813.
InParanoidQ9H1C0.
KOK08390.
OMAAIFQMNM.
OrthoDBEOG75J0NM.
PhylomeDBQ9H1C0.
TreeFamTF350009.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9H1C0.
BgeeQ9H1C0.
CleanExHS_LPAR5.
GenevestigatorQ9H1C0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLPAR5. human.
GeneWikiLPAR5.
GenomeRNAi57121.
NextBio63005.
PROQ9H1C0.
SOURCESearch...

Entry information

Entry nameLPAR5_HUMAN
AccessionPrimary (citable) accession number: Q9H1C0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries