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Protein

Lysophosphatidic acid receptor 5

Gene

LPAR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18365. Lysosphingolipid and LPA receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 5
Short name:
LPA receptor 5
Short name:
LPA-5
Alternative name(s):
G-protein coupled receptor 92
G-protein coupled receptor 93
Gene namesi
Name:LPAR5
Synonyms:GPR92, GPR93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:13307. LPAR5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 9620ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini118 – 13619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 18730ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 23931CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini298 – 37275CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28935.

Polymorphism and mutation databases

BioMutaiLPAR5.
DMDMi48474954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Lysophosphatidic acid receptor 5PRO_0000069600Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H1C0.
PRIDEiQ9H1C0.

PTM databases

PhosphoSiteiQ9H1C0.

Expressioni

Tissue specificityi

Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.

Gene expression databases

BgeeiQ9H1C0.
CleanExiHS_LPAR5.
ExpressionAtlasiQ9H1C0. baseline and differential.
GenevisibleiQ9H1C0. HS.

Organism-specific databases

HPAiHPA013170.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327875.

Structurei

3D structure databases

ProteinModelPortaliQ9H1C0.
SMRiQ9H1C0. Positions 26-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146804.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG103813.
InParanoidiQ9H1C0.
KOiK08390.
OMAiMLINVDR.
OrthoDBiEOG75J0NM.
PhylomeDBiQ9H1C0.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H1C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA
60 70 80 90 100
LRVHSVVSVY MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI
110 120 130 140 150
FQMNMYGSCI FLMLINVDRY AAIVHPLRLR HLRRPRVARL LCLGVWALIL
160 170 180 190 200
VFAVPAARVH RPSRCRYRDL EVRLCFESFS DELWKGRLLP LVLLAEALGF
210 220 230 240 250
LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL VIFLLCFVPY
260 270 280 290 300
NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS
310 320 330 340 350
AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG
360 370
LLRPSDSHSL SSFTQCPQDS AL
Length:372
Mass (Da):41,347
Last modified:March 1, 2001 - v1
Checksum:iBA35709084BB6D84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272207 mRNA. Translation: CAC03715.1.
AF411112 Genomic DNA. Translation: AAL26483.1.
AB083600 Genomic DNA. Translation: BAB89313.1.
BC033571 mRNA. Translation: AAH33571.1.
BC072394 mRNA. Translation: AAH72394.1.
CCDSiCCDS8553.1.
RefSeqiNP_001136433.1. NM_001142961.1.
NP_065133.1. NM_020400.5.
UniGeneiHs.155538.

Genome annotation databases

EnsembliENST00000329858; ENSP00000327875; ENSG00000184574.
ENST00000431922; ENSP00000393098; ENSG00000184574.
GeneIDi57121.
KEGGihsa:57121.
UCSCiuc001qps.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272207 mRNA. Translation: CAC03715.1.
AF411112 Genomic DNA. Translation: AAL26483.1.
AB083600 Genomic DNA. Translation: BAB89313.1.
BC033571 mRNA. Translation: AAH33571.1.
BC072394 mRNA. Translation: AAH72394.1.
CCDSiCCDS8553.1.
RefSeqiNP_001136433.1. NM_001142961.1.
NP_065133.1. NM_020400.5.
UniGeneiHs.155538.

3D structure databases

ProteinModelPortaliQ9H1C0.
SMRiQ9H1C0. Positions 26-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327875.

Chemistry

BindingDBiQ9H1C0.
ChEMBLiCHEMBL5700.
GuidetoPHARMACOLOGYi124.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9H1C0.

Polymorphism and mutation databases

BioMutaiLPAR5.
DMDMi48474954.

Proteomic databases

PaxDbiQ9H1C0.
PRIDEiQ9H1C0.

Protocols and materials databases

DNASUi57121.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329858; ENSP00000327875; ENSG00000184574.
ENST00000431922; ENSP00000393098; ENSG00000184574.
GeneIDi57121.
KEGGihsa:57121.
UCSCiuc001qps.2. human.

Organism-specific databases

CTDi57121.
GeneCardsiGC12M006728.
HGNCiHGNC:13307. LPAR5.
HPAiHPA013170.
MIMi606926. gene.
neXtProtiNX_Q9H1C0.
PharmGKBiPA28935.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146804.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG103813.
InParanoidiQ9H1C0.
KOiK08390.
OMAiMLINVDR.
OrthoDBiEOG75J0NM.
PhylomeDBiQ9H1C0.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18365. Lysosphingolipid and LPA receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiLPAR5. human.
GeneWikiiLPAR5.
GenomeRNAii57121.
NextBioi63005.
PROiQ9H1C0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H1C0.
CleanExiHS_LPAR5.
ExpressionAtlasiQ9H1C0. baseline and differential.
GenevisibleiQ9H1C0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
    White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.
    Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell and Brain.

Entry informationi

Entry nameiLPAR5_HUMAN
AccessioniPrimary (citable) accession number: Q9H1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.