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Protein

Interferon regulatory factor 2-binding protein-like

Gene

IRF2BPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to the control of female reproductive function (By similarity). May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri715 – 762RING-type; degenerateAdd BLAST48

GO - Molecular functioni

GO - Biological processi

  • development of secondary female sexual characteristics Source: ParkinsonsUK-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119669-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein-like
Alternative name(s):
Enhanced at puberty protein 1
Gene namesi
Name:IRF2BPL
Synonyms:C14orf4, EAP1, KIAA1865
ORF Names:My039
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:14282. IRF2BPL.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi715C → A: Loss of transcription activity. 1 Publication1

Organism-specific databases

DisGeNETi64207.
OpenTargetsiENSG00000119669.
PharmGKBiPA25516.

Polymorphism and mutation databases

BioMutaiIRF2BPL.
DMDMi34395562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564111 – 796Interferon regulatory factor 2-binding protein-likeAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei519PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei658PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei662PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H1B7.
MaxQBiQ9H1B7.
PaxDbiQ9H1B7.
PeptideAtlasiQ9H1B7.
PRIDEiQ9H1B7.

PTM databases

iPTMnetiQ9H1B7.
PhosphoSitePlusiQ9H1B7.

Miscellaneous databases

PMAP-CutDBQ9H1B7.

Expressioni

Tissue specificityi

Highly expressed in the heart, moderately in skeletal muscle and pancreas, and weakly in brain, kidney, liver, testis, thyroid gland and lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000119669.
CleanExiHS_C14orf4.
GenevisibleiQ9H1B7. HS.

Organism-specific databases

HPAiHPA050862.
HPA061333.

Interactioni

Protein-protein interaction databases

BioGridi122101. 16 interactors.
IntActiQ9H1B7. 3 interactors.
STRINGi9606.ENSP00000238647.

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi716 – 718Combined sources3
Beta strandi727 – 729Combined sources3
Helixi740 – 751Combined sources12
Beta strandi752 – 754Combined sources3
Beta strandi767 – 772Combined sources6
Helixi777 – 784Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B9Gmodel-A708-771[»]
2CS3NMR-A705-784[»]
ProteinModelPortaliQ9H1B7.
SMRiQ9H1B7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H1B7.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 132Sequence analysisAdd BLAST48
Coiled coili335 – 371Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 102Poly-AlaAdd BLAST15
Compositional biasi103 – 127Poly-GlnAdd BLAST25
Compositional biasi153 – 164Poly-AlaAdd BLAST12
Compositional biasi174 – 296Gly/Pro-richAdd BLAST123
Compositional biasi596 – 623Pro-richAdd BLAST28

Sequence similaritiesi

Belongs to the IRF2BP family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri715 – 762RING-type; degenerateAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3579. Eukaryota.
ENOG410Z1AW. LUCA.
GeneTreeiENSGT00390000005089.
HOVERGENiHBG108364.
InParanoidiQ9H1B7.
OMAiQNGPSPM.
OrthoDBiEOG091G040R.
PhylomeDBiQ9H1B7.
TreeFamiTF317075.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H1B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAQVSSSR RQSCYLCDLP RMPWAMIWDF SEPVCRGCVN YEGADRIEFV
60 70 80 90 100
IETARQLKRA HGCFQDGRSP GPPPPVGVKT VALSAKEAAA AAAAAAAAAA
110 120 130 140 150
AAQQQQQQQQ QQQQQQQQQQ QQQQQQQLNH VDGSSKPAVL AAPSGLERYG
160 170 180 190 200
LSAAAAAAAA AAAAVEQRSR FEYPPPPVSL GSSSHTARLP NGLGGPNGFP
210 220 230 240 250
KPTPEEGPPE LNRQSPNSSS AAASVASRRG THGGLVTGLP NPGGGGGPQL
260 270 280 290 300
TVPPNLLPQT LLNGPASAAV LPPPPPHALG SRGPPTPAPP GAPGGPACLG
310 320 330 340 350
GTPGVSATSS SASSSTSSSV AEVGVGAGGK RPGSVSSTDQ ERELKEKQRN
360 370 380 390 400
AEALAELSES LRNRAEEWAS KPKMVRDTLL TLAGCTPYEV RFKKDHSLLG
410 420 430 440 450
RVFAFDAVSK PGMDYELKLF IEYPTGSGNV YSSASGVAKQ MYQDCMKDFG
460 470 480 490 500
RGLSSGFKYL EYEKKHGSGD WRLLGDLLPE AVRFFKEGVP GADMLPQPYL
510 520 530 540 550
DASCPMLPTA LVSLSRAPSA PPGTGALPPA APSGRGAAAS LRKRKASPEP
560 570 580 590 600
PDSAEGALKL GEEQQRQQWM ANQSEALKLT MSAGGFAAPG HAAGGPPPPP
610 620 630 640 650
PPLGPHSNRT TPPESAPQNG PSPMAALMSV ADTLGTAHSP KDGSSVHSTT
660 670 680 690 700
ASARRNSSSP VSPASVPGQR RLASRNGDLN LQVAPPPPSA HPGMDQVHPQ
710 720 730 740 750
NIPDSPMANS GPLCCTICHE RLEDTHFVQC PSVPSHKFCF PCSRESIKAQ
760 770 780 790
GATGEVYCPS GEKCPLVGSN VPWAFMQGEI ATILAGDVKV KKERDP
Length:796
Mass (Da):82,659
Last modified:March 1, 2001 - v1
Checksum:iDCF7898F15AD6A37
GO

Sequence cautioni

The sequence BAB47494 differs from that shown. Aberrant splicing.Curated

Polymorphismi

The poly-Gln region is polymorphic; the most frequent allele contained 24 Gln. Stretches of 20-31 Gln are observed in healthy individuals.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277365 Genomic DNA. Translation: CAC10539.1.
AC007686 Genomic DNA. No translation available.
AB058768 mRNA. Translation: BAB47494.1. Sequence problems.
AL832320 mRNA. Translation: CAD38615.1.
AF063597 mRNA. Translation: AAG43156.1.
CCDSiCCDS9854.1.
PIRiJC7555.
RefSeqiNP_078772.1. NM_024496.3.
UniGeneiHs.179260.
Hs.745194.

Genome annotation databases

EnsembliENST00000238647; ENSP00000238647; ENSG00000119669.
GeneIDi64207.
KEGGihsa:64207.
UCSCiuc001xsy.4. human.

Keywords - Coding sequence diversityi

Polymorphism, Triplet repeat expansion

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277365 Genomic DNA. Translation: CAC10539.1.
AC007686 Genomic DNA. No translation available.
AB058768 mRNA. Translation: BAB47494.1. Sequence problems.
AL832320 mRNA. Translation: CAD38615.1.
AF063597 mRNA. Translation: AAG43156.1.
CCDSiCCDS9854.1.
PIRiJC7555.
RefSeqiNP_078772.1. NM_024496.3.
UniGeneiHs.179260.
Hs.745194.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B9Gmodel-A708-771[»]
2CS3NMR-A705-784[»]
ProteinModelPortaliQ9H1B7.
SMRiQ9H1B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122101. 16 interactors.
IntActiQ9H1B7. 3 interactors.
STRINGi9606.ENSP00000238647.

PTM databases

iPTMnetiQ9H1B7.
PhosphoSitePlusiQ9H1B7.

Polymorphism and mutation databases

BioMutaiIRF2BPL.
DMDMi34395562.

Proteomic databases

EPDiQ9H1B7.
MaxQBiQ9H1B7.
PaxDbiQ9H1B7.
PeptideAtlasiQ9H1B7.
PRIDEiQ9H1B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238647; ENSP00000238647; ENSG00000119669.
GeneIDi64207.
KEGGihsa:64207.
UCSCiuc001xsy.4. human.

Organism-specific databases

CTDi64207.
DisGeNETi64207.
GeneCardsiIRF2BPL.
H-InvDBHIX0011839.
HGNCiHGNC:14282. IRF2BPL.
HPAiHPA050862.
HPA061333.
MIMi611720. gene.
neXtProtiNX_Q9H1B7.
OpenTargetsiENSG00000119669.
PharmGKBiPA25516.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3579. Eukaryota.
ENOG410Z1AW. LUCA.
GeneTreeiENSGT00390000005089.
HOVERGENiHBG108364.
InParanoidiQ9H1B7.
OMAiQNGPSPM.
OrthoDBiEOG091G040R.
PhylomeDBiQ9H1B7.
TreeFamiTF317075.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119669-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9H1B7.
GeneWikiiC14orf4.
GenomeRNAii64207.
PMAP-CutDBQ9H1B7.
PROiQ9H1B7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119669.
CleanExiHS_C14orf4.
GenevisibleiQ9H1B7. HS.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI2BPL_HUMAN
AccessioniPrimary (citable) accession number: Q9H1B7
Secondary accession number(s): Q8NDQ2, Q96JG2, Q9H3I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.