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Protein

DNA-directed RNA polymerase II subunit RPB11-b2

Gene

POLR2J3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB11-b2
Short name:
RNA polymerase II subunit B11-b2
Short name:
RPB11b2
Alternative name(s):
DNA-directed RNA polymerase II subunit J3
Gene namesi
Name:POLR2J3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:33853. POLR2J3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724678.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115DNA-directed RNA polymerase II subunit RPB11-b2PRO_0000316947Add
BLAST

Proteomic databases

EPDiQ9H1A7.
PaxDbiQ9H1A7.
PeptideAtlasiQ9H1A7.
PRIDEiQ9H1A7.

PTM databases

iPTMnetiQ9H1A7.
PhosphoSiteiQ9H1A7.

Expressioni

Gene expression databases

BgeeiQ9H1A7.
ExpressionAtlasiQ9H1A7. baseline and differential.
GenevisibleiQ9H1A7. HS.

Organism-specific databases

HPAiHPA044010.
HPA046970.

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

Protein-protein interaction databases

STRINGi9606.ENSP00000368645.

Structurei

3D structure databases

ProteinModelPortaliQ9H1A7.
SMRiQ9H1A7. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4392. Eukaryota.
COG1761. LUCA.
HOVERGENiHBG073419.
InParanoidiQ9H1A7.

Family and domain databases

InterProiIPR009025. RBP11-like_dimer.
IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
[Graphical view]
SUPFAMiSSF55257. SSF55257. 1 hit.
PROSITEiPS01154. RNA_POL_L_13KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H1A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPPAFESF LLFEGEKITI NKDTKVPNAC LFTMNKEDHT LGNIIKSQLL
60 70 80 90 100
KDPQVLFAGY KVPHPLEHKI IIRVQTTPDY SPQEAFTNAI TDLISELSLL
110
EERFRTCLLP LRLLP
Length:115
Mass (Da):13,092
Last modified:March 1, 2001 - v1
Checksum:iF03331C8024E00D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277741 mRNA. Translation: CAC18331.1.
AC004084 Genomic DNA. Translation: AAP22342.1.
CCDSiCCDS47673.1.
UniGeneiHs.610255.
Hs.656696.
Hs.700609.
Hs.732239.

Genome annotation databases

EnsembliENST00000379340; ENSP00000368645; ENSG00000168255.
UCSCiuc011kkw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277741 mRNA. Translation: CAC18331.1.
AC004084 Genomic DNA. Translation: AAP22342.1.
CCDSiCCDS47673.1.
UniGeneiHs.610255.
Hs.656696.
Hs.700609.
Hs.732239.

3D structure databases

ProteinModelPortaliQ9H1A7.
SMRiQ9H1A7. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368645.

PTM databases

iPTMnetiQ9H1A7.
PhosphoSiteiQ9H1A7.

Proteomic databases

EPDiQ9H1A7.
PaxDbiQ9H1A7.
PeptideAtlasiQ9H1A7.
PRIDEiQ9H1A7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379340; ENSP00000368645; ENSG00000168255.
UCSCiuc011kkw.2. human.

Organism-specific databases

GeneCardsiPOLR2J3.
HGNCiHGNC:33853. POLR2J3.
HPAiHPA044010.
HPA046970.
neXtProtiNX_Q9H1A7.
PharmGKBiPA164724678.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4392. Eukaryota.
COG1761. LUCA.
HOVERGENiHBG073419.
InParanoidiQ9H1A7.

Miscellaneous databases

PROiQ9H1A7.

Gene expression databases

BgeeiQ9H1A7.
ExpressionAtlasiQ9H1A7. baseline and differential.
GenevisibleiQ9H1A7. HS.

Family and domain databases

InterProiIPR009025. RBP11-like_dimer.
IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
[Graphical view]
SUPFAMiSSF55257. SSF55257. 1 hit.
PROSITEiPS01154. RNA_POL_L_13KD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A human RNA polymerase II subunit is encoded by a recently generated multigene family."
    Grandemange S., Schaller S., Yamano S., Du Manoir S., Shpakovski G.V., Mattei M.-G., Kedinger C., Vigneron M.
    BMC Mol. Biol. 2:14-14(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cervix carcinoma.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRPB1C_HUMAN
AccessioniPrimary (citable) accession number: Q9H1A7
Secondary accession number(s): A6NKA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.