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Protein

DNA-directed RNA polymerase II subunit RPB11-b2

Gene

POLR2J3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB11-b2
Short name:
RNA polymerase II subunit B11-b2
Short name:
RPB11b2
Alternative name(s):
DNA-directed RNA polymerase II subunit J3
Gene namesi
Name:POLR2J3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000168255.19
HGNCiHGNC:33853 POLR2J3
neXtProtiNX_Q9H1A7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724678

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169471 – 115DNA-directed RNA polymerase II subunit RPB11-b2Add BLAST115

Proteomic databases

MaxQBiQ9H1A7
PaxDbiQ9H1A7
PeptideAtlasiQ9H1A7
PRIDEiQ9H1A7

PTM databases

iPTMnetiQ9H1A7
PhosphoSitePlusiQ9H1A7

Expressioni

Gene expression databases

BgeeiENSG00000168255
ExpressionAtlasiQ9H1A7 baseline and differential
GenevisibleiQ9H1A7 HS

Organism-specific databases

HPAiHPA044010
HPA046970

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9H1A7, 6 interactors
STRINGi9606.ENSP00000368645

Structurei

3D structure databases

ProteinModelPortaliQ9H1A7
SMRiQ9H1A7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4392 Eukaryota
COG1761 LUCA
HOVERGENiHBG073419
InParanoidiQ9H1A7

Family and domain databases

CDDicd06926 RNAP_II_RPB11, 1 hit
Gene3Di3.30.1360.10, 1 hit
InterProiView protein in InterPro
IPR037685 RBP11
IPR036603 RBP11-like
IPR009025 RBP11-like_dimer
IPR008193 RNA_pol_Rpb11_13-16kDa_CS
PfamiView protein in Pfam
PF13656 RNA_pol_L_2, 1 hit
SUPFAMiSSF55257 SSF55257, 1 hit
PROSITEiView protein in PROSITE
PS01154 RNA_POL_L_13KD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H1A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPPAFESF LLFEGEKITI NKDTKVPNAC LFTMNKEDHT LGNIIKSQLL
60 70 80 90 100
KDPQVLFAGY KVPHPLEHKI IIRVQTTPDY SPQEAFTNAI TDLISELSLL
110
EERFRTCLLP LRLLP
Length:115
Mass (Da):13,092
Last modified:March 1, 2001 - v1
Checksum:iF03331C8024E00D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277741 mRNA Translation: CAC18331.1
AC004084 Genomic DNA Translation: AAP22342.1
CCDSiCCDS47673.1
UniGeneiHs.610255
Hs.656696
Hs.700609
Hs.732239

Genome annotation databases

EnsembliENST00000379340; ENSP00000368645; ENSG00000168255
UCSCiuc011kkw.2 human

Similar proteinsi

Entry informationi

Entry nameiRPB1C_HUMAN
AccessioniPrimary (citable) accession number: Q9H1A7
Secondary accession number(s): A6NKA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health