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Protein

Anaphase-promoting complex subunit 1

Gene

ANAPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-HSA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-HSA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-HSA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-HSA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-HSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-HSA-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-HSA-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-HSA-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-HSA-176412. Phosphorylation of the APC/C.
R-HSA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SIGNORiQ9H1A4.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 1
Short name:
APC1
Alternative name(s):
Cyclosome subunit 1
Mitotic checkpoint regulator
Testis-specific gene 24 protein
Gene namesi
Name:ANAPC1
Synonyms:TSG24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000153107.11.
HGNCiHGNC:19988. ANAPC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi64682.
OpenTargetsiENSG00000153107.
PharmGKBiPA134907013.

Polymorphism and mutation databases

BioMutaiANAPC1.
DMDMi37537845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158711 – 1944Anaphase-promoting complex subunit 1Add BLAST1944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei202Phosphoserine1 Publication1
Modified residuei286Phosphoserine1 Publication1
Modified residuei291PhosphothreonineCombined sources1 Publication1
Modified residuei313PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1 Publication1
Modified residuei362PhosphoserineCombined sources1
Modified residuei373Phosphoserine1 Publication1
Modified residuei377PhosphoserineCombined sources1 Publication1
Modified residuei537Phosphothreonine1 Publication1
Modified residuei547PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei571Phosphotyrosine1 Publication1
Modified residuei686PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1 Publication1
Modified residuei916PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H1A4.
MaxQBiQ9H1A4.
PaxDbiQ9H1A4.
PeptideAtlasiQ9H1A4.
PRIDEiQ9H1A4.

PTM databases

iPTMnetiQ9H1A4.
PhosphoSitePlusiQ9H1A4.

Expressioni

Gene expression databases

BgeeiENSG00000153107.
CleanExiHS_ANAPC1.
ExpressionAtlasiQ9H1A4. baseline and differential.
GenevisibleiQ9H1A4. HS.

Organism-specific databases

HPAiHPA036329.
HPA036330.
HPA042998.

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.1 Publication

Protein-protein interaction databases

BioGridi122229. 82 interactors.
CORUMiQ9H1A4.
DIPiDIP-32940N.
IntActiQ9H1A4. 46 interactors.
MINTiMINT-2817292.
STRINGi9606.ENSP00000339109.

Structurei

Secondary structure

11944
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 13Combined sources3
Beta strandi15 – 19Combined sources5
Helixi23 – 27Combined sources5
Beta strandi72 – 78Combined sources7
Beta strandi89 – 96Combined sources8
Beta strandi99 – 108Combined sources10
Beta strandi113 – 118Combined sources6
Beta strandi125 – 134Combined sources10
Beta strandi146 – 154Combined sources9
Beta strandi159 – 163Combined sources5
Beta strandi168 – 171Combined sources4
Beta strandi177 – 183Combined sources7
Beta strandi186 – 191Combined sources6
Beta strandi209 – 215Combined sources7
Beta strandi224 – 226Combined sources3
Beta strandi244 – 250Combined sources7
Turni251 – 254Combined sources4
Beta strandi255 – 260Combined sources6
Turni261 – 264Combined sources4
Beta strandi265 – 273Combined sources9
Beta strandi406 – 414Combined sources9
Beta strandi430 – 434Combined sources5
Beta strandi436 – 438Combined sources3
Beta strandi440 – 446Combined sources7
Helixi447 – 449Combined sources3
Beta strandi451 – 459Combined sources9
Beta strandi463 – 475Combined sources13
Beta strandi477 – 482Combined sources6
Helixi483 – 485Combined sources3
Beta strandi487 – 491Combined sources5
Beta strandi493 – 495Combined sources3
Beta strandi497 – 501Combined sources5
Beta strandi504 – 510Combined sources7
Helixi517 – 519Combined sources3
Turni580 – 582Combined sources3
Beta strandi584 – 591Combined sources8
Beta strandi594 – 599Combined sources6
Beta strandi604 – 608Combined sources5
Helixi616 – 628Combined sources13
Helixi631 – 646Combined sources16
Helixi656 – 667Combined sources12
Helixi674 – 676Combined sources3
Helixi705 – 712Combined sources8
Helixi714 – 721Combined sources8
Turni753 – 756Combined sources4
Helixi759 – 776Combined sources18
Helixi782 – 794Combined sources13
Turni795 – 798Combined sources4
Helixi801 – 809Combined sources9
Helixi811 – 814Combined sources4
Turni823 – 826Combined sources4
Helixi844 – 853Combined sources10
Beta strandi864 – 866Combined sources3
Helixi868 – 880Combined sources13
Helixi927 – 936Combined sources10
Helixi941 – 944Combined sources4
Helixi949 – 964Combined sources16
Helixi972 – 977Combined sources6
Helixi981 – 991Combined sources11
Helixi1021 – 1027Combined sources7
Helixi1033 – 1041Combined sources9
Beta strandi1055 – 1057Combined sources3
Helixi1059 – 1087Combined sources29
Beta strandi1096 – 1098Combined sources3
Beta strandi1108 – 1111Combined sources4
Turni1112 – 1115Combined sources4
Beta strandi1116 – 1119Combined sources4
Beta strandi1122 – 1125Combined sources4
Turni1129 – 1132Combined sources4
Helixi1133 – 1145Combined sources13
Helixi1150 – 1153Combined sources4
Beta strandi1155 – 1157Combined sources3
Beta strandi1164 – 1168Combined sources5
Helixi1169 – 1182Combined sources14
Helixi1184 – 1187Combined sources4
Helixi1195 – 1199Combined sources5
Helixi1202 – 1216Combined sources15
Helixi1222 – 1231Combined sources10
Turni1233 – 1235Combined sources3
Helixi1247 – 1260Combined sources14
Turni1261 – 1264Combined sources4
Helixi1267 – 1277Combined sources11
Turni1284 – 1287Combined sources4
Helixi1291 – 1306Combined sources16
Beta strandi1317 – 1319Combined sources3
Helixi1321 – 1330Combined sources10
Helixi1360 – 1374Combined sources15
Helixi1381 – 1386Combined sources6
Helixi1393 – 1398Combined sources6
Helixi1401 – 1414Combined sources14
Turni1416 – 1418Combined sources3
Helixi1423 – 1429Combined sources7
Helixi1432 – 1436Combined sources5
Turni1454 – 1456Combined sources3
Helixi1457 – 1475Combined sources19
Turni1477 – 1479Combined sources3
Helixi1482 – 1500Combined sources19
Helixi1504 – 1507Combined sources4
Helixi1509 – 1526Combined sources18
Helixi1533 – 1545Combined sources13
Beta strandi1547 – 1549Combined sources3
Helixi1552 – 1565Combined sources14
Helixi1567 – 1570Combined sources4
Beta strandi1572 – 1574Combined sources3
Helixi1579 – 1587Combined sources9
Beta strandi1600 – 1602Combined sources3
Helixi1604 – 1609Combined sources6
Helixi1610 – 1613Combined sources4
Beta strandi1614 – 1616Combined sources3
Beta strandi1620 – 1622Combined sources3
Beta strandi1624 – 1626Combined sources3
Beta strandi1633 – 1639Combined sources7
Turni1642 – 1644Combined sources3
Beta strandi1646 – 1656Combined sources11
Turni1660 – 1662Combined sources3
Beta strandi1663 – 1668Combined sources6
Turni1670 – 1672Combined sources3
Beta strandi1675 – 1678Combined sources4
Helixi1685 – 1692Combined sources8
Turni1693 – 1695Combined sources3
Beta strandi1696 – 1698Combined sources3
Turni1708 – 1710Combined sources3
Turni1722 – 1728Combined sources7
Beta strandi1729 – 1732Combined sources4
Helixi1738 – 1741Combined sources4
Helixi1745 – 1753Combined sources9
Helixi1765 – 1780Combined sources16
Helixi1786 – 1802Combined sources17
Helixi1809 – 1820Combined sources12
Beta strandi1821 – 1824Combined sources4
Helixi1825 – 1827Combined sources3
Turni1828 – 1831Combined sources4
Beta strandi1832 – 1834Combined sources3
Beta strandi1836 – 1840Combined sources5
Helixi1845 – 1862Combined sources18
Helixi1865 – 1872Combined sources8
Helixi1881 – 1892Combined sources12
Turni1897 – 1899Combined sources3
Helixi1912 – 1920Combined sources9
Helixi1925 – 1934Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UI9electron microscopy3.60A1-1944[»]
5A31electron microscopy4.30A11-1897[»]
5G04electron microscopy4.00A1-1943[»]
5G05electron microscopy3.40A1-1944[»]
5KHRelectron microscopy6.10A1-1944[»]
5KHUelectron microscopy4.80A1-1944[»]
5L9Telectron microscopy6.40A1-1944[»]
5L9Uelectron microscopy6.40A1-1944[»]
5LCWelectron microscopy4.00A1-1944[»]
5LGGX-ray2.15A1-33[»]
A70-306[»]
A403-613[»]
ProteinModelPortaliQ9H1A4.
SMRiQ9H1A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1297 – 1325PC 1Add BLAST29
Repeati1366 – 1404PC 2Add BLAST39
Repeati1467 – 1501PC 3Add BLAST35
Repeati1520 – 1552PC 4Add BLAST33

Sequence similaritiesi

Belongs to the APC1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1858. Eukaryota.
ENOG410XQ83. LUCA.
GeneTreeiENSGT00390000016757.
HOGENOMiHOG000231934.
HOVERGENiHBG045326.
InParanoidiQ9H1A4.
KOiK03348.
OMAiAIAEWMQ.
OrthoDBiEOG091G00RP.
PhylomeDBiQ9H1A4.
TreeFamiTF105441.

Family and domain databases

InterProiView protein in InterPro
IPR024990. Apc1.
PANTHERiPTHR12827. PTHR12827. 1 hit.
PfamiView protein in Pfam
PF12859. ANAPC1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H1A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNFYEERTT MIAARDLQEF VPFGRDHCKH HPNALNLQLR QLQPASELWS
60 70 80 90 100
SDGAAGLVGS LQEVTIHEKQ KESWQLRKGV SEIGEDVDYD EELYVAGNMV
110 120 130 140 150
IWSKGSKSQA LAVYKAFTVD SPVQQALWCD FIISQDKSEK AYSSNEVEKC
160 170 180 190 200
ICILQSSCIN MHSIEGKDYI ASLPFQVANV WPTKYGLLFE RSASSHEVPP
210 220 230 240 250
GSPREPLPTM FSMLHPLDEI TPLVCKSGSL FGSSRVQYVV DHAMKIVFLN
260 270 280 290 300
TDPSIVMTYD AVQNVHSVWT LRRVKSEEEN VVLKFSEQGG TPQNVATSSS
310 320 330 340 350
LTAHLRSLSK GDSPVTSPFQ NYSSIHSQSR STSSPSLHSR SPSISNMAAL
360 370 380 390 400
SRAHSPALGV HSFSGVQRFN ISSHNQSPKR HSISHSPNSN SNGSFLAPET
410 420 430 440 450
EPIVPELCID HLWTETITNI REKNSQASKV FITSDLCGQK FLCFLVESQL
460 470 480 490 500
QLRCVKFQES NDKTQLIFGS VTNIPAKDAA PVEKIDTMLV LEGSGNLVLY
510 520 530 540 550
TGVVRVGKVF IPGLPAPSLT MSNTMPRPST PLDGVSTPKP LSKLLGSLDE
560 570 580 590 600
VVLLSPVPEL RDSSKLHDSL YNEDCTFQQL GTYIHSIRDP VHNRVTLELS
610 620 630 640 650
NGSMVRITIP EIATSELVQT CLQAIKFILP KEIAVQMLVK WYNVHSAPGG
660 670 680 690 700
PSYHSEWNLF VTCLMNMMGY NTDRLAWTRN FDFEGSLSPV IAPKKARPSE
710 720 730 740 750
TGSDDDWEYL LNSDYHQNVE SHLLNRSLCL SPSEASQMKD EDFSQNLSLD
760 770 780 790 800
SSTLLFTHIP AIFFVLHLVY EELKLNTLMG EGICSLVELL VQLARDLKLG
810 820 830 840 850
PYVDHYYRDY PTLVRTTGQV CTIDPGQTGF MHHPSFFTSE PPSIYQWVSS
860 870 880 890 900
CLKGEGMPPY PYLPGICERS RLVVLSIALY ILGDESLVSD ESSQYLTRIT
910 920 930 940 950
IAPQKLQVEQ EENRFSFRHS TSVSSLAERL VVWMTNVGFT LRDLETLPFG
960 970 980 990 1000
IALPIRDAIY HCREQPASDW PEAVCLLIGR QDLSKQACEG NLPKGKSVLS
1010 1020 1030 1040 1050
SDVPSGTETE EEDDGMNDMN HEVMSLIWSE DLRVQDVRRL LQSAHPVRVN
1060 1070 1080 1090 1100
VVQYPELSDH EFIEEKENRL LQLCQRTMAL PVGRGMFTLF SYHPVPTEPL
1110 1120 1130 1140 1150
PIPKLNLTGR APPRNTTVDL NSGNIDVPPN MTSWASFHNG VAAGLKIAPA
1160 1170 1180 1190 1200
SQIDSAWIVY NKPKHAELAN EYAGFLMALG LNGHLTKLAT LNIHDYLTKG
1210 1220 1230 1240 1250
HEMTSIGLLL GVSAAKLGTM DMSITRLLSI HIPALLPPTS TELDVPHNVQ
1260 1270 1280 1290 1300
VAAVVGIGLV YQGTAHRHTA EVLLAEIGRP PGPEMEYCTD RESYSLAAGL
1310 1320 1330 1340 1350
ALGMVCLGHG SNLIGMSDLN VPEQLYQYMV GGHRRFQTGM HREKHKSPSY
1360 1370 1380 1390 1400
QIKEGDTINV DVTCPGATLA LAMIYLKTNN RSIADWLRAP DTMYLLDFVK
1410 1420 1430 1440 1450
PEFLLLRTLA RCLILWDDIL PNSKWVDSNV PQIIRENSIS LSEIELPCSE
1460 1470 1480 1490 1500
DLNLETLSQA HVYIIAGACL SLGFRFAGSE NLSAFNCLHK FAKDFMTYLS
1510 1520 1530 1540 1550
APNASVTGPH NLETCLSVVL LSLAMVMAGS GNLKVLQLCR FLHMKTGGEM
1560 1570 1580 1590 1600
NYGFHLAHHM ALGLLFLGGG RYSLSTSNSS IAALLCALYP HFPAHSTDNR
1610 1620 1630 1640 1650
YHLQALRHLY VLAAEPRLLV PVDVDTNTPC YALLEVTYKG TQWYEQTKEE
1660 1670 1680 1690 1700
LMAPTLLPEL HLLKQIKVKG PRYWELLIDL SKGTQHLKSI LSKDGVLYVK
1710 1720 1730 1740 1750
LRAGQLSYKE DPMGWQSLLA QTVANRNSEA RAFKPETISA FTSDPALLSF
1760 1770 1780 1790 1800
AEYFCKPTVN MGQKQEILDL FSSVLYECVT QETPEMLPAY IAMDQAIRRL
1810 1820 1830 1840 1850
GRREMSETSE LWQIKLVLEF FSSRSHQERL QNHPKRGLFM NSEFLPVVKC
1860 1870 1880 1890 1900
TIDNTLDQWL QVGGDMCVHA YLSGQPLEES QLSMLACFLV YHSVPAPQHL
1910 1920 1930 1940
PPIGLEGSTS FAELLFKFKQ LKMPVRALLR LAPLLLGNPQ PMVM
Length:1,944
Mass (Da):216,500
Last modified:March 1, 2001 - v1
Checksum:iE08B1FE3FC28917E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti604M → V in BAB14687 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278357 mRNA. Translation: CAC19484.1.
BC005089 mRNA. Translation: AAH05089.1.
BC104902 mRNA. Translation: AAI04903.1.
BC104904 mRNA. Translation: AAI04905.1.
AK023807 mRNA. Translation: BAB14687.1.
CCDSiCCDS2093.1.
RefSeqiNP_073153.1. NM_022662.3.
UniGeneiHs.436527.

Genome annotation databases

EnsembliENST00000341068; ENSP00000339109; ENSG00000153107.
GeneIDi64682.
KEGGihsa:64682.
UCSCiuc002thi.4. human.

Similar proteinsi

Entry informationi

Entry nameiAPC1_HUMAN
AccessioniPrimary (citable) accession number: Q9H1A4
Secondary accession number(s): Q2M3H8, Q9BSE6, Q9H8D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families