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Q9H1A3

- METL9_HUMAN

UniProt

Q9H1A3 - METL9_HUMAN

Protein

Methyltransferase-like protein 9

Gene

METTL9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyltransferase-like protein 9
    Alternative name(s):
    DORA reverse strand protein
    Short name:
    DREV
    DREV1
    Gene namesi
    Name:METTL9
    Synonyms:DREV
    ORF Names:CGI-81
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:24586. METTL9.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148428.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 318300Methyltransferase-like protein 9PRO_0000317490Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9H1A3.
    PaxDbiQ9H1A3.
    PRIDEiQ9H1A3.

    PTM databases

    PhosphoSiteiQ9H1A3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H1A3.
    BgeeiQ9H1A3.
    CleanExiHS_METTL9.
    GenevestigatoriQ9H1A3.

    Organism-specific databases

    HPAiHPA053588.
    HPA056347.

    Interactioni

    Protein-protein interaction databases

    BioGridi119297. 2 interactions.
    IntActiQ9H1A3. 2 interactions.
    STRINGi9606.ENSP00000350874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1A3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 474Poly-Ala

    Sequence similaritiesi

    Belongs to the DREV family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG255968.
    HOGENOMiHOG000258992.
    HOVERGENiHBG060014.
    InParanoidiQ9H1A3.
    OMAiKVMSPHF.
    PhylomeDBiQ9H1A3.
    TreeFamiTF314187.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR007884. DREV_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR12890. PTHR12890. 1 hit.
    PfamiPF05219. DREV. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H1A3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLLAGWLCL SLASVWLARR MWTLRSPLTR SLYVNMTSGP GGPAAAAGGR    50
    KENHQWYVCN REKLCESLQA VFVQSYLDQG TQIFLNNSIE KSGWLFIQLY 100
    HSFVSSVFSL FMSRTSINGL LGRGSMFVFS PDQFQRLLKI NPDWKTHRLL 150
    DLGAGDGEVT KIMSPHFEEI YATELSETMI WQLQKKKYRV LGINEWQNTG 200
    FQYDVISCLN LLDRCDQPLT LLKDIRSVLE PTRGRVILAL VLPFHPYVEN 250
    VGGKWEKPSE ILEIKGQNWE EQVNSLPEVF RKAGFVIEAF TRLPYLCEGD 300
    MYNDYYVLDD AVFVLKPV 318
    Length:318
    Mass (Da):36,536
    Last modified:March 1, 2001 - v1
    Checksum:i81DEF9CC78342229
    GO
    Isoform 2 (identifier: Q9H1A3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         251-251: Missing.

    Show »
    Length:317
    Mass (Da):36,437
    Checksum:i45232A032F2FC6BD
    GO

    Sequence cautioni

    The sequence AAD34076.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 442PA → RS in AAD34076. (PubMed:10810093)Curated
    Sequence conflicti57 – 571Y → C in BAC11490. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei251 – 2511Missing in isoform 2. 3 PublicationsVSP_030997

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278578 mRNA. Translation: CAC20438.1.
    AJ278577 mRNA. Translation: CAC20437.1.
    AJ278581 Genomic DNA. Translation: CAC20439.1.
    AK075237 mRNA. Translation: BAC11490.1.
    AK074529 mRNA. Translation: BAC11042.1.
    AK075022 mRNA. Translation: BAC11356.1.
    CH878403 Genomic DNA. Translation: EAW50517.1.
    CH878403 Genomic DNA. Translation: EAW50518.1.
    BC000195 mRNA. Translation: AAH00195.2.
    AF151839 mRNA. Translation: AAD34076.1. Different initiation.
    CCDSiCCDS10598.2. [Q9H1A3-1]
    CCDS45440.1. [Q9H1A3-2]
    RefSeqiNP_001070648.1. NM_001077180.2. [Q9H1A3-2]
    NP_001275588.1. NM_001288659.1.
    NP_001275589.1. NM_001288660.1.
    NP_057109.3. NM_016025.4. [Q9H1A3-1]
    UniGeneiHs.279583.

    Genome annotation databases

    EnsembliENST00000358154; ENSP00000350874; ENSG00000197006. [Q9H1A3-1]
    ENST00000396014; ENSP00000379335; ENSG00000197006. [Q9H1A3-2]
    GeneIDi51108.
    KEGGihsa:51108.
    UCSCiuc002dje.3. human. [Q9H1A3-1]
    uc002djf.3. human. [Q9H1A3-2]

    Polymorphism databases

    DMDMi74718034.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278578 mRNA. Translation: CAC20438.1 .
    AJ278577 mRNA. Translation: CAC20437.1 .
    AJ278581 Genomic DNA. Translation: CAC20439.1 .
    AK075237 mRNA. Translation: BAC11490.1 .
    AK074529 mRNA. Translation: BAC11042.1 .
    AK075022 mRNA. Translation: BAC11356.1 .
    CH878403 Genomic DNA. Translation: EAW50517.1 .
    CH878403 Genomic DNA. Translation: EAW50518.1 .
    BC000195 mRNA. Translation: AAH00195.2 .
    AF151839 mRNA. Translation: AAD34076.1 . Different initiation.
    CCDSi CCDS10598.2. [Q9H1A3-1 ]
    CCDS45440.1. [Q9H1A3-2 ]
    RefSeqi NP_001070648.1. NM_001077180.2. [Q9H1A3-2 ]
    NP_001275588.1. NM_001288659.1.
    NP_001275589.1. NM_001288660.1.
    NP_057109.3. NM_016025.4. [Q9H1A3-1 ]
    UniGenei Hs.279583.

    3D structure databases

    ProteinModelPortali Q9H1A3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119297. 2 interactions.
    IntActi Q9H1A3. 2 interactions.
    STRINGi 9606.ENSP00000350874.

    PTM databases

    PhosphoSitei Q9H1A3.

    Polymorphism databases

    DMDMi 74718034.

    Proteomic databases

    MaxQBi Q9H1A3.
    PaxDbi Q9H1A3.
    PRIDEi Q9H1A3.

    Protocols and materials databases

    DNASUi 51108.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358154 ; ENSP00000350874 ; ENSG00000197006 . [Q9H1A3-1 ]
    ENST00000396014 ; ENSP00000379335 ; ENSG00000197006 . [Q9H1A3-2 ]
    GeneIDi 51108.
    KEGGi hsa:51108.
    UCSCi uc002dje.3. human. [Q9H1A3-1 ]
    uc002djf.3. human. [Q9H1A3-2 ]

    Organism-specific databases

    CTDi 51108.
    GeneCardsi GC16P021610.
    HGNCi HGNC:24586. METTL9.
    HPAi HPA053588.
    HPA056347.
    MIMi 609388. gene.
    neXtProti NX_Q9H1A3.
    PharmGKBi PA145148428.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255968.
    HOGENOMi HOG000258992.
    HOVERGENi HBG060014.
    InParanoidi Q9H1A3.
    OMAi KVMSPHF.
    PhylomeDBi Q9H1A3.
    TreeFami TF314187.

    Miscellaneous databases

    GenomeRNAii 51108.
    NextBioi 53851.
    PROi Q9H1A3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H1A3.
    Bgeei Q9H1A3.
    CleanExi HS_METTL9.
    Genevestigatori Q9H1A3.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR007884. DREV_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR12890. PTHR12890. 1 hit.
    Pfami PF05219. DREV. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function."
      Bates E.E.M., Kissenpfennig A., Peronne C., Mattei M.-G., Fossiez F., Malissen B., Lebecque S.
      Immunogenetics 52:112-120(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    5. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-318 (ISOFORM 2).
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMETL9_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1A3
    Secondary accession number(s): Q8NBT8
    , Q9BWJ7, Q9H1A2, Q9Y390
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3