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Q9H1A3 (METL9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyltransferase-like protein 9
Alternative name(s):
DORA reverse strand protein
Short name=DREV
DREV1
Gene names
Name:METTL9
Synonyms:DREV
ORF Names:CGI-81
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the DREV family.

Sequence caution

The sequence AAD34076.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H1A3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H1A3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 318300Methyltransferase-like protein 9
PRO_0000317490

Regions

Compositional bias44 – 474Poly-Ala

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence2511Missing in isoform 2.
VSP_030997

Experimental info

Sequence conflict43 – 442PA → RS in AAD34076. Ref.5
Sequence conflict571Y → C in BAC11490. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 81DEF9CC78342229

FASTA31836,536
        10         20         30         40         50         60 
MRLLAGWLCL SLASVWLARR MWTLRSPLTR SLYVNMTSGP GGPAAAAGGR KENHQWYVCN 

        70         80         90        100        110        120 
REKLCESLQA VFVQSYLDQG TQIFLNNSIE KSGWLFIQLY HSFVSSVFSL FMSRTSINGL 

       130        140        150        160        170        180 
LGRGSMFVFS PDQFQRLLKI NPDWKTHRLL DLGAGDGEVT KIMSPHFEEI YATELSETMI 

       190        200        210        220        230        240 
WQLQKKKYRV LGINEWQNTG FQYDVISCLN LLDRCDQPLT LLKDIRSVLE PTRGRVILAL 

       250        260        270        280        290        300 
VLPFHPYVEN VGGKWEKPSE ILEIKGQNWE EQVNSLPEVF RKAGFVIEAF TRLPYLCEGD 

       310 
MYNDYYVLDD AVFVLKPV 

« Hide

Isoform 2 [UniParc].

Checksum: 45232A032F2FC6BD
Show »

FASTA31736,437

References

« Hide 'large scale' references
[1]"The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function."
Bates E.E.M., Kissenpfennig A., Peronne C., Mattei M.-G., Fossiez F., Malissen B., Lebecque S.
Immunogenetics 52:112-120(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryo.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[5]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-318 (ISOFORM 2).
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ278578 mRNA. Translation: CAC20438.1.
AJ278577 mRNA. Translation: CAC20437.1.
AJ278581 Genomic DNA. Translation: CAC20439.1.
AK075237 mRNA. Translation: BAC11490.1.
AK074529 mRNA. Translation: BAC11042.1.
AK075022 mRNA. Translation: BAC11356.1.
CH878403 Genomic DNA. Translation: EAW50517.1.
CH878403 Genomic DNA. Translation: EAW50518.1.
BC000195 mRNA. Translation: AAH00195.2.
AF151839 mRNA. Translation: AAD34076.1. Different initiation.
RefSeqNP_001070648.1. NM_001077180.2.
NP_001275588.1. NM_001288659.1.
NP_001275589.1. NM_001288660.1.
NP_057109.3. NM_016025.4.
UniGeneHs.279583.

3D structure databases

ProteinModelPortalQ9H1A3.
SMRQ9H1A3. Positions 140-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119297. 2 interactions.
IntActQ9H1A3. 2 interactions.
STRING9606.ENSP00000350874.

PTM databases

PhosphoSiteQ9H1A3.

Polymorphism databases

DMDM74718034.

Proteomic databases

PaxDbQ9H1A3.
PRIDEQ9H1A3.

Protocols and materials databases

DNASU51108.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358154; ENSP00000350874; ENSG00000197006. [Q9H1A3-1]
ENST00000396014; ENSP00000379335; ENSG00000197006. [Q9H1A3-2]
GeneID51108.
KEGGhsa:51108.
UCSCuc002dje.3. human. [Q9H1A3-1]
uc002djf.3. human. [Q9H1A3-2]

Organism-specific databases

CTD51108.
GeneCardsGC16P021610.
HGNCHGNC:24586. METTL9.
HPAHPA053588.
HPA056347.
MIM609388. gene.
neXtProtNX_Q9H1A3.
PharmGKBPA145148428.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG255968.
HOGENOMHOG000258992.
HOVERGENHBG060014.
InParanoidQ9H1A3.
OMALKRGSMF.
PhylomeDBQ9H1A3.
TreeFamTF314187.

Gene expression databases

ArrayExpressQ9H1A3.
BgeeQ9H1A3.
CleanExHS_METTL9.
GenevestigatorQ9H1A3.

Family and domain databases

InterProIPR007884. DREV_MeTrfase.
[Graphical view]
PANTHERPTHR12890. PTHR12890. 1 hit.
PfamPF05219. DREV. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi51108.
NextBio53851.
PROQ9H1A3.
SOURCESearch...

Entry information

Entry nameMETL9_HUMAN
AccessionPrimary (citable) accession number: Q9H1A3
Secondary accession number(s): Q8NBT8 expand/collapse secondary AC list , Q9BWJ7, Q9H1A2, Q9Y390
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM