Q9H1A3 (METL9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methyltransferase-like protein 9

Alternative name(s):
DORA reverse strand protein
Short name=DREV
DREV1

Gene names

Name:	METTL9
Synonyms:	DREV
ORF Names:	CGI-81

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the DREV family.
Sequence caution	The sequence AAD34076.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H1A3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H1A3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 318	300	Methyltransferase-like protein 9		PRO_0000317490
Regions
	Compositional bias	44 – 47	4	Poly-Ala
Amino acid modifications
	Glycosylation	35	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	251	1	Missing in isoform 2.		VSP_030997
Experimental info
	Sequence conflict	43 – 44	2	PA → RS in AAD34076. Ref.5
	Sequence conflict	57	1	Y → C in BAC11490. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 81DEF9CC78342229	FASTA	318	36,536
	10 20 30 40 50 60 MRLLAGWLCL SLASVWLARR MWTLRSPLTR SLYVNMTSGP GGPAAAAGGR KENHQWYVCN 70 80 90 100 110 120 REKLCESLQA VFVQSYLDQG TQIFLNNSIE KSGWLFIQLY HSFVSSVFSL FMSRTSINGL 130 140 150 160 170 180 LGRGSMFVFS PDQFQRLLKI NPDWKTHRLL DLGAGDGEVT KIMSPHFEEI YATELSETMI 190 200 210 220 230 240 WQLQKKKYRV LGINEWQNTG FQYDVISCLN LLDRCDQPLT LLKDIRSVLE PTRGRVILAL 250 260 270 280 290 300 VLPFHPYVEN VGGKWEKPSE ILEIKGQNWE EQVNSLPEVF RKAGFVIEAF TRLPYLCEGD 310 MYNDYYVLDD AVFVLKPV
	Isoform 2 [UniParc]. Checksum: 45232A032F2FC6BD	FASTA	317	36,437
	10 20 30 40 50 60 MRLLAGWLCL SLASVWLARR MWTLRSPLTR SLYVNMTSGP GGPAAAAGGR KENHQWYVCN 70 80 90 100 110 120 REKLCESLQA VFVQSYLDQG TQIFLNNSIE KSGWLFIQLY HSFVSSVFSL FMSRTSINGL 130 140 150 160 170 180 LGRGSMFVFS PDQFQRLLKI NPDWKTHRLL DLGAGDGEVT KIMSPHFEEI YATELSETMI 190 200 210 220 230 240 WQLQKKKYRV LGINEWQNTG FQYDVISCLN LLDRCDQPLT LLKDIRSVLE PTRGRVILAL 250 260 270 280 290 300 VLPFHPYVEN GGKWEKPSEI LEIKGQNWEE QVNSLPEVFR KAGFVIEAFT RLPYLCEGDM 310 YNDYYVLDDA VFVLKPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function." Bates E.E.M., Kissenpfennig A., Peronne C., Mattei M.-G., Fossiez F., Malissen B., Lebecque S. Immunogenetics 52:112-120(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye.
[5]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-318 (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ278578 mRNA. Translation: CAC20438.1. AJ278577 mRNA. Translation: CAC20437.1. AJ278581 Genomic DNA. Translation: CAC20439.1. AK075237 mRNA. Translation: BAC11490.1. AK074529 mRNA. Translation: BAC11042.1. AK075022 mRNA. Translation: BAC11356.1. CH878403 Genomic DNA. Translation: EAW50517.1. CH878403 Genomic DNA. Translation: EAW50518.1. BC000195 mRNA. Translation: AAH00195.2. AF151839 mRNA. Translation: AAD34076.1. Different initiation.
IPI	IPI00100239. IPI00396595.
RefSeq	NP_001070648.1. NM_001077180.1. NP_057109.3. NM_016025.3.
UniGene	Hs.279583.
3D structure databases
ProteinModelPortal	Q9H1A3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H1A3. 2 interactions.
STRING	9606.ENSP00000350874.
PTM databases
PhosphoSite	Q9H1A3.
Polymorphism databases
DMDM	74718034.
Proteomic databases
PaxDb	Q9H1A3.
PRIDE	Q9H1A3.
Protocols and materials databases
DNASU	51108.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358154; ENSP00000350874; ENSG00000197006. ENST00000396014; ENSP00000379335; ENSG00000197006.
GeneID	51108.
KEGG	hsa:51108.
UCSC	uc002dje.3. human. uc002djf.3. human.
Organism-specific databases
CTD	51108.
GeneCards	GC16P021610.
HGNC	HGNC:24586. METTL9.
MIM	609388. gene.
neXtProt	NX_Q9H1A3.
PharmGKB	PA145148428.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG255968.
HOGENOM	HOG000258992.
HOVERGEN	HBG060014.
InParanoid	Q9H1A3.
OMA	FAIEAFT.
OrthoDB	EOG4RXZ0Z.
PhylomeDB	Q9H1A3.
Gene expression databases
ArrayExpress	Q9H1A3.
Bgee	Q9H1A3.
CleanEx	HS_METTL9.
Genevestigator	Q9H1A3.
Family and domain databases
InterPro	IPR007884. DREV_MeTrfase. [Graphical view]
PANTHER	PTHR12890. PTHR12890. 1 hit.
Pfam	PF05219. DREV. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51108.
NextBio	53851.
SOURCE	Search...

Entry information

Entry name

METL9_HUMAN

Accession

Primary (citable) accession number: Q9H1A3
Secondary accession number(s): Q8NBT8 , Q9BWJ7, Q9H1A2, Q9Y390

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.