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Protein

Methyltransferase-like protein 9

Gene

METTL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 9
Alternative name(s):
DORA reverse strand protein
Short name:
DREV
DREV1
Gene namesi
Name:METTL9
Synonyms:DREV
ORF Names:CGI-81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:24586. METTL9.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 318300Methyltransferase-like protein 9PRO_0000317490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9H1A3.
PaxDbiQ9H1A3.
PRIDEiQ9H1A3.

PTM databases

PhosphoSiteiQ9H1A3.

Expressioni

Gene expression databases

BgeeiQ9H1A3.
CleanExiHS_METTL9.
ExpressionAtlasiQ9H1A3. baseline and differential.
GenevestigatoriQ9H1A3.

Organism-specific databases

HPAiHPA053588.
HPA056347.

Interactioni

Protein-protein interaction databases

BioGridi119297. 10 interactions.
IntActiQ9H1A3. 2 interactions.
STRINGi9606.ENSP00000350874.

Structurei

3D structure databases

ProteinModelPortaliQ9H1A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 474Poly-Ala

Sequence similaritiesi

Belongs to the DREV family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG255968.
GeneTreeiENSGT00390000013648.
HOGENOMiHOG000258992.
HOVERGENiHBG060014.
InParanoidiQ9H1A3.
OMAiLKRGSMF.
PhylomeDBiQ9H1A3.
TreeFamiTF314187.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR007884. DREV_MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12890. PTHR12890. 1 hit.
PfamiPF05219. DREV. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H1A3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLAGWLCL SLASVWLARR MWTLRSPLTR SLYVNMTSGP GGPAAAAGGR
60 70 80 90 100
KENHQWYVCN REKLCESLQA VFVQSYLDQG TQIFLNNSIE KSGWLFIQLY
110 120 130 140 150
HSFVSSVFSL FMSRTSINGL LGRGSMFVFS PDQFQRLLKI NPDWKTHRLL
160 170 180 190 200
DLGAGDGEVT KIMSPHFEEI YATELSETMI WQLQKKKYRV LGINEWQNTG
210 220 230 240 250
FQYDVISCLN LLDRCDQPLT LLKDIRSVLE PTRGRVILAL VLPFHPYVEN
260 270 280 290 300
VGGKWEKPSE ILEIKGQNWE EQVNSLPEVF RKAGFVIEAF TRLPYLCEGD
310
MYNDYYVLDD AVFVLKPV
Length:318
Mass (Da):36,536
Last modified:March 1, 2001 - v1
Checksum:i81DEF9CC78342229
GO
Isoform 2 (identifier: Q9H1A3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: Missing.

Show »
Length:317
Mass (Da):36,437
Checksum:i45232A032F2FC6BD
GO

Sequence cautioni

The sequence AAD34076.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 442PA → RS in AAD34076. (PubMed:10810093)Curated
Sequence conflicti57 – 571Y → C in BAC11490. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei251 – 2511Missing in isoform 2. 3 PublicationsVSP_030997

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278578 mRNA. Translation: CAC20438.1.
AJ278577 mRNA. Translation: CAC20437.1.
AJ278581 Genomic DNA. Translation: CAC20439.1.
AK075237 mRNA. Translation: BAC11490.1.
AK074529 mRNA. Translation: BAC11042.1.
AK075022 mRNA. Translation: BAC11356.1.
CH878403 Genomic DNA. Translation: EAW50517.1.
CH878403 Genomic DNA. Translation: EAW50518.1.
BC000195 mRNA. Translation: AAH00195.2.
AF151839 mRNA. Translation: AAD34076.1. Different initiation.
CCDSiCCDS10598.2. [Q9H1A3-1]
CCDS45440.1. [Q9H1A3-2]
RefSeqiNP_001070648.1. NM_001077180.2. [Q9H1A3-2]
NP_001275588.1. NM_001288659.1.
NP_001275589.1. NM_001288660.1.
NP_057109.3. NM_016025.4. [Q9H1A3-1]
UniGeneiHs.279583.

Genome annotation databases

EnsembliENST00000358154; ENSP00000350874; ENSG00000197006. [Q9H1A3-1]
ENST00000396014; ENSP00000379335; ENSG00000197006. [Q9H1A3-2]
GeneIDi51108.
KEGGihsa:51108.
UCSCiuc002dje.3. human. [Q9H1A3-1]
uc002djf.3. human. [Q9H1A3-2]

Polymorphism databases

DMDMi74718034.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278578 mRNA. Translation: CAC20438.1.
AJ278577 mRNA. Translation: CAC20437.1.
AJ278581 Genomic DNA. Translation: CAC20439.1.
AK075237 mRNA. Translation: BAC11490.1.
AK074529 mRNA. Translation: BAC11042.1.
AK075022 mRNA. Translation: BAC11356.1.
CH878403 Genomic DNA. Translation: EAW50517.1.
CH878403 Genomic DNA. Translation: EAW50518.1.
BC000195 mRNA. Translation: AAH00195.2.
AF151839 mRNA. Translation: AAD34076.1. Different initiation.
CCDSiCCDS10598.2. [Q9H1A3-1]
CCDS45440.1. [Q9H1A3-2]
RefSeqiNP_001070648.1. NM_001077180.2. [Q9H1A3-2]
NP_001275588.1. NM_001288659.1.
NP_001275589.1. NM_001288660.1.
NP_057109.3. NM_016025.4. [Q9H1A3-1]
UniGeneiHs.279583.

3D structure databases

ProteinModelPortaliQ9H1A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119297. 10 interactions.
IntActiQ9H1A3. 2 interactions.
STRINGi9606.ENSP00000350874.

PTM databases

PhosphoSiteiQ9H1A3.

Polymorphism databases

DMDMi74718034.

Proteomic databases

MaxQBiQ9H1A3.
PaxDbiQ9H1A3.
PRIDEiQ9H1A3.

Protocols and materials databases

DNASUi51108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358154; ENSP00000350874; ENSG00000197006. [Q9H1A3-1]
ENST00000396014; ENSP00000379335; ENSG00000197006. [Q9H1A3-2]
GeneIDi51108.
KEGGihsa:51108.
UCSCiuc002dje.3. human. [Q9H1A3-1]
uc002djf.3. human. [Q9H1A3-2]

Organism-specific databases

CTDi51108.
GeneCardsiGC16P021610.
HGNCiHGNC:24586. METTL9.
HPAiHPA053588.
HPA056347.
MIMi609388. gene.
neXtProtiNX_Q9H1A3.
PharmGKBiPA145148428.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG255968.
GeneTreeiENSGT00390000013648.
HOGENOMiHOG000258992.
HOVERGENiHBG060014.
InParanoidiQ9H1A3.
OMAiLKRGSMF.
PhylomeDBiQ9H1A3.
TreeFamiTF314187.

Miscellaneous databases

GenomeRNAii51108.
NextBioi53851.
PROiQ9H1A3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H1A3.
CleanExiHS_METTL9.
ExpressionAtlasiQ9H1A3. baseline and differential.
GenevestigatoriQ9H1A3.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR007884. DREV_MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12890. PTHR12890. 1 hit.
PfamiPF05219. DREV. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function."
    Bates E.E.M., Kissenpfennig A., Peronne C., Mattei M.-G., Fossiez F., Malissen B., Lebecque S.
    Immunogenetics 52:112-120(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  5. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-318 (ISOFORM 2).
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMETL9_HUMAN
AccessioniPrimary (citable) accession number: Q9H1A3
Secondary accession number(s): Q8NBT8
, Q9BWJ7, Q9H1A2, Q9Y390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.