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Protein

Mucin-3B

Gene

MUC3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-3BCurated
Short name:
MUC-3BCurated
Alternative name(s):
Intestinal mucin-3B1 Publication
Gene namesi
Name:MUC3BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13384. MUC3B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1141 – 1161HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57876.

Polymorphism and mutation databases

DMDMi510120772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000026255122 – 1237Mucin-3BAdd BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi894 ↔ 900PROSITE-ProRule annotation
Disulfide bondi913 ↔ 922PROSITE-ProRule annotation

Post-translational modificationi

Highly O-glycosylated and probably also N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9H195.

PTM databases

iPTMnetiQ9H195.
PhosphoSitePlusiQ9H195.

Expressioni

Tissue specificityi

Fetal and adult small intestine and fetal and adult colon.2 Publications

Organism-specific databases

HPAiHPA010871.

Structurei

3D structure databases

ProteinModelPortaliQ9H195.
SMRiQ9H195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini890 – 923EGF-likePROSITE-ProRule annotationAdd BLAST34
Domaini932 – 1057SEAPROSITE-ProRule annotationAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 336Thr-richAdd BLAST260
Compositional biasi338 – 661Ser-richAdd BLAST324
Compositional biasi345 – 871Thr-richAdd BLAST527
Compositional biasi1151 – 1159Poly-Leu9

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9H195.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLGLLSIL WMLKSSPGAT GTLSTATSTS HVTFPRAEAT RTALSNSPHS
60 70 80 90 100
RYLAEWPQGV PQLASPAPGH RENAPMTLTT SPHDTLISET LLSSLVSSNT
110 120 130 140 150
STTPTSKFAF KVETTPPTVL VYSATTECVY PTSFIITISH STSICVTTTQ
160 170 180 190 200
VTFTSSYTPT PVTQKPVTTV TRTYPMTTTE KGTSAMISSP STTTARETPI
210 220 230 240 250
VTVTPSSSVS ATDTTFHTTI SSTTRTTERT PLPTGSIHTT MSPTPVFTTL
260 270 280 290 300
KTAVTSTSPI TSTITSTNTV TSMTTTTSRP TATNTLSSLT SSILSSTPAP
310 320 330 340 350
NTEVITSHTT TTTPPSTLVT TLPTAIARST PTSETTPSFM SSIITTETTS
360 370 380 390 400
HSTPSFSSST IHSTVSSSTT AITSPFTTAE TGVTSTPSSP SSLSTDIPTT
410 420 430 440 450
SLRTLTPLSL STSTSLTTTT DLPSIPTDIS SLPTPIHIIS SSPSIQSTET
460 470 480 490 500
SSLVGTTSPT MSTVRATLRS TENTPISSFS TSIVVTPETP TTQAPPVLMS
510 520 530 540 550
ATGTQTSPVP TTVTFGSMDS STSTLHTLTP STALSKIMST SQFPIPSTHS
560 570 580 590 600
STLQTTPSIP SLQTSLTSTS EFTTESFTRG STSTNAILTS FSTIIWSSTP
610 620 630 640 650
TIIMSSSPSS ASITPVFATT IHSVPSSPYI FSTENVGSAS ITAFPSLSSS
660 670 680 690 700
STTSTSPTSS SLTTALTEIT PFSYISLPST TPCPGTITIT IVPASPTDPC
710 720 730 740 750
VEMDPSTEAT SPPTTPLTVF PFTTEMVTCP SSISMQTTLA THMDTSSMTP
760 770 780 790 800
ESESSIIPNA SSSTGTGTVP TNTVFTSTRL PTSETWLSNN SVIPTPLPGV
810 820 830 840 850
STIPLTMKPS SSLPTILRTS SKSTHPSPPT ARTSQTSVAT TQTPTTLTTC
860 870 880 890 900
RTTPITSWMT TQSTLTTTAG TCDNGGTWEQ GQCACLPGFS GDRCQLQTRC
910 920 930 940 950
QNGGQWDGLK CQCPSTFYGS SCEFAVEQVD LDVVETEVGM EVSVDQQFSP
960 970 980 990 1000
DLNDNTSQAY RDFNKTFWNQ MQKIFADMQG FTFKGVEILS LRNGSIVVDY
1010 1020 1030 1040 1050
LVLLEMPFSP QLESEYEQVK TTLKEGLQNA SQDANSCQDS QALCFKPDSI
1060 1070 1080 1090 1100
KVNNNSKTEL TPEAICRRAA PTGYEEFYFP LVEATRLRCV TKCTSGLDNA
1110 1120 1130 1140 1150
IDCHQGQCVL ETSGPACRCY STDTHWFSGP RCEVTVHWRA LVGGLTAGAA
1160 1170 1180 1190 1200
LLVLLLLALG VRAVRSEWWG RQRRGRSWDQ DRKWFETWDE EVVGTFSNWG
1210 1220 1230
FEDDGTDKDT NFHVALENVD TTMKVHIKRP EMTSSSV
Length:1,237
Mass (Da):131,402
Last modified:May 29, 2013 - v2
Checksum:i964AEE628DDCE01D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-adjacent residuesi336 – 337Curated2
Sequence conflicti362H → Y in BAB12115 (PubMed:11289722).Curated1
Sequence conflicti362H → Y in BAB12117 (PubMed:11289722).Curated1
Sequence conflicti835Q → E in BAB12115 (PubMed:11289722).Curated1
Sequence conflicti835Q → E in BAB12117 (PubMed:11289722).Curated1
Sequence conflicti850C → R in BAB12115 (PubMed:11289722).Curated1
Sequence conflicti850C → R in BAB12117 (PubMed:11289722).Curated1
Sequence conflicti1042A → T in BAB12115 (PubMed:11289722).Curated1
Sequence conflicti1042A → T in BAB12117 (PubMed:11289722).Curated1
Sequence conflicti1042A → T in AAD45882 (PubMed:10405327).Curated1
Sequence conflicti1063E → A in AAD45882 (PubMed:10405327).Curated1
Sequence conflicti1097L → V in BAB12115 (PubMed:11289722).Curated1
Sequence conflicti1097L → V in BAB12117 (PubMed:11289722).Curated1
Sequence conflicti1097L → V in AAD45882 (PubMed:10405327).Curated1
Sequence conflicti1116A → T in AAD45882 (PubMed:10405327).Curated1
Sequence conflicti1135T → A in BAB12115 (PubMed:11289722).Curated1
Sequence conflicti1135T → A in BAB12117 (PubMed:11289722).Curated1
Sequence conflicti1135T → A in AAD45882 (PubMed:10405327).Curated1
Sequence conflicti1167E → G in BAB12115 (PubMed:11289722).Curated1
Sequence conflicti1167E → G in BAB12117 (PubMed:11289722).Curated1
Sequence conflicti1167E → G in AAD45882 (PubMed:10405327).Curated1
Sequence conflicti1171R → G in BAB12115 (PubMed:11289722).Curated1
Sequence conflicti1171R → G in BAB12117 (PubMed:11289722).Curated1
Sequence conflicti1171R → G in AAD45882 (PubMed:10405327).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0295071034A → V.1 Publication1
Natural variantiVAR_0295081213H → Y.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY307931 mRNA. Translation: AAQ73825.1.
AJ291390 Genomic DNA. Translation: CAC19572.1.
AB038781 Genomic DNA. Translation: BAB12115.1.
AB038783 mRNA. Translation: BAB12117.1.
AF007195 Genomic DNA. Translation: AAB84382.1.
AF143371 mRNA. Translation: AAD45882.1.
UniGeneiHs.703577.
Hs.723567.
Hs.744422.
Hs.744530.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY307931 mRNA. Translation: AAQ73825.1.
AJ291390 Genomic DNA. Translation: CAC19572.1.
AB038781 Genomic DNA. Translation: BAB12115.1.
AB038783 mRNA. Translation: BAB12117.1.
AF007195 Genomic DNA. Translation: AAB84382.1.
AF143371 mRNA. Translation: AAD45882.1.
UniGeneiHs.703577.
Hs.723567.
Hs.744422.
Hs.744530.

3D structure databases

ProteinModelPortaliQ9H195.
SMRiQ9H195.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9H195.
PhosphoSitePlusiQ9H195.

Polymorphism and mutation databases

DMDMi510120772.

Proteomic databases

PRIDEiQ9H195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi57876.
GeneCardsiMUC3B.
HGNCiHGNC:13384. MUC3B.
HPAiHPA010871.
MIMi605633. gene.
neXtProtiNX_Q9H195.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiQ9H195.

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUC3B_HUMAN
AccessioniPrimary (citable) accession number: Q9H195
Secondary accession number(s): Q6W762
, Q7LDU5, Q9GZZ2, Q9UN95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 29, 2013
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This gene is not currently present in the reference genome assembly (GRCh38/hg38) and is probably the result of a gene duplication of MUC3A.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.