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Protein

Syntenin-2

Gene

SDCBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein C-terminus binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB
  • intracellular transport Source: UniProtKB
  • nervous system development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125775-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-2
Alternative name(s):
Syndecan-binding protein 2
Gene namesi
Name:SDCBP2
Synonyms:SITAC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15756. SDCBP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB

Pathology & Biotechi

Organism-specific databases

DisGeNETi27111.
OpenTargetsiENSG00000125775.
PharmGKBiPA38033.

Polymorphism and mutation databases

BioMutaiSDCBP2.
DMDMi20455288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840041 – 292Syntenin-2Add BLAST292

Proteomic databases

EPDiQ9H190.
MaxQBiQ9H190.
PaxDbiQ9H190.
PeptideAtlasiQ9H190.
PRIDEiQ9H190.

PTM databases

iPTMnetiQ9H190.
PhosphoSitePlusiQ9H190.
SwissPalmiQ9H190.

Expressioni

Gene expression databases

BgeeiENSG00000125775.
CleanExiHS_SDCBP2.
GenevisibleiQ9H190. HS.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with SDCBP (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein C-terminus binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi118007. 38 interactors.
IntActiQ9H190. 62 interactors.
MINTiMINT-1438328.
STRINGi9606.ENSP00000342935.

Structurei

3D structure databases

ProteinModelPortaliQ9H190.
SMRiQ9H190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 187PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini192 – 267PDZ 2PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IK98. Eukaryota.
ENOG410YNPQ. LUCA.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiQ9H190.
OMAiHTMDHSI.
OrthoDBiEOG091G0HJI.
PhylomeDBiQ9H190.
TreeFamiTF327131.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H190-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL
60 70 80 90 100
ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA
110 120 130 140 150
EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD
160 170 180 190 200
QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM
210 220 230 240 250
GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME
260 270 280 290
ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA
Length:292
Mass (Da):31,594
Last modified:May 2, 2002 - v2
Checksum:iE12536839E1CD91C
GO
Isoform 3 (identifier: Q9H190-3) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:207
Mass (Da):22,664
Checksum:i16913A0148BF691A
GO

Sequence cautioni

The sequence AAH02727 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69Q → H in CAC21716 (PubMed:11152476).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053700182V → M. Corresponds to variant dbSNP:rs22739592 PublicationsEnsembl.1
Natural variantiVAR_036544191R → Q in a colorectal cancer sample; somatic mutation. Corresponds to variant dbSNP:rs353670031 PublicationEnsembl.1
Natural variantiVAR_053701223R → C. Corresponds to variant dbSNP:rs1048621Ensembl.1
Natural variantiVAR_053702242G → R. Corresponds to variant dbSNP:rs4814111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0063521 – 85Missing in isoform 3. 2 PublicationsAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159228 mRNA. Translation: AAF80369.1.
AJ292245 mRNA. Translation: CAC21573.1.
AJ292244 mRNA. Translation: CAC21716.1.
AF131809 mRNA. Translation: AAD20049.1.
AL136531 Genomic DNA. Translation: CAC16178.1.
AL136531 Genomic DNA. Translation: CAH72383.1.
BC002727 mRNA. Translation: AAH02727.2. Different initiation.
CCDSiCCDS13013.1. [Q9H190-3]
CCDS42848.1. [Q9H190-1]
RefSeqiNP_001186713.1. NM_001199784.1. [Q9H190-1]
NP_056500.2. NM_015685.5. [Q9H190-3]
NP_536737.3. NM_080489.4. [Q9H190-1]
UniGeneiHs.657015.

Genome annotation databases

EnsembliENST00000339987; ENSP00000342935; ENSG00000125775. [Q9H190-1]
ENST00000360779; ENSP00000354013; ENSG00000125775. [Q9H190-1]
ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775. [Q9H190-1]
GeneIDi27111.
KEGGihsa:27111.
UCSCiuc002weu.5. human. [Q9H190-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159228 mRNA. Translation: AAF80369.1.
AJ292245 mRNA. Translation: CAC21573.1.
AJ292244 mRNA. Translation: CAC21716.1.
AF131809 mRNA. Translation: AAD20049.1.
AL136531 Genomic DNA. Translation: CAC16178.1.
AL136531 Genomic DNA. Translation: CAH72383.1.
BC002727 mRNA. Translation: AAH02727.2. Different initiation.
CCDSiCCDS13013.1. [Q9H190-3]
CCDS42848.1. [Q9H190-1]
RefSeqiNP_001186713.1. NM_001199784.1. [Q9H190-1]
NP_056500.2. NM_015685.5. [Q9H190-3]
NP_536737.3. NM_080489.4. [Q9H190-1]
UniGeneiHs.657015.

3D structure databases

ProteinModelPortaliQ9H190.
SMRiQ9H190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118007. 38 interactors.
IntActiQ9H190. 62 interactors.
MINTiMINT-1438328.
STRINGi9606.ENSP00000342935.

PTM databases

iPTMnetiQ9H190.
PhosphoSitePlusiQ9H190.
SwissPalmiQ9H190.

Polymorphism and mutation databases

BioMutaiSDCBP2.
DMDMi20455288.

Proteomic databases

EPDiQ9H190.
MaxQBiQ9H190.
PaxDbiQ9H190.
PeptideAtlasiQ9H190.
PRIDEiQ9H190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339987; ENSP00000342935; ENSG00000125775. [Q9H190-1]
ENST00000360779; ENSP00000354013; ENSG00000125775. [Q9H190-1]
ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775. [Q9H190-1]
GeneIDi27111.
KEGGihsa:27111.
UCSCiuc002weu.5. human. [Q9H190-1]

Organism-specific databases

CTDi27111.
DisGeNETi27111.
GeneCardsiSDCBP2.
H-InvDBHIX0158663.
HGNCiHGNC:15756. SDCBP2.
neXtProtiNX_Q9H190.
OpenTargetsiENSG00000125775.
PharmGKBiPA38033.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK98. Eukaryota.
ENOG410YNPQ. LUCA.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiQ9H190.
OMAiHTMDHSI.
OrthoDBiEOG091G0HJI.
PhylomeDBiQ9H190.
TreeFamiTF327131.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125775-MONOMER.

Miscellaneous databases

ChiTaRSiSDCBP2. human.
GeneWikiiSDCBP2.
GenomeRNAii27111.
PROiQ9H190.

Gene expression databases

BgeeiENSG00000125775.
CleanExiHS_SDCBP2.
GenevisibleiQ9H190. HS.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDCB2_HUMAN
AccessioniPrimary (citable) accession number: Q9H190
Secondary accession number(s): O95892
, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: January 18, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.