Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H190

- SDCB2_HUMAN

UniProt

Q9H190 - SDCB2_HUMAN

Protein

Syntenin-2

Gene

SDCBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (02 May 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. protein C-terminus binding Source: UniProtKB
    2. protein heterodimerization activity Source: UniProtKB
    3. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. intracellular signal transduction Source: UniProtKB
    2. intracellular transport Source: UniProtKB
    3. nervous system development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntenin-2
    Alternative name(s):
    Syndecan-binding protein 2
    Gene namesi
    Name:SDCBP2
    Synonyms:SITAC18
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15756. SDCBP2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. plasma membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38033.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Syntenin-2PRO_0000184004Add
    BLAST

    Proteomic databases

    MaxQBiQ9H190.
    PaxDbiQ9H190.
    PRIDEiQ9H190.

    PTM databases

    PhosphoSiteiQ9H190.

    Expressioni

    Gene expression databases

    BgeeiQ9H190.
    CleanExiHS_SDCBP2.
    GenevestigatoriQ9H190.

    Organism-specific databases

    HPAiHPA054554.

    Interactioni

    Subunit structurei

    Monomer and homodimer. Interacts with SDCBP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi118007. 13 interactions.
    IntActiQ9H190. 19 interactions.
    MINTiMINT-1438328.
    STRINGi9606.ENSP00000342935.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H190.
    SMRiQ9H190. Positions 107-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini108 – 18780PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini192 – 26776PDZ 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG140434.
    HOGENOMiHOG000231604.
    HOVERGENiHBG053211.
    InParanoidiQ9H190.
    OMAiHTMDHSI.
    OrthoDBiEOG75MVWZ.
    PhylomeDBiQ9H190.
    TreeFamiTF327131.

    Family and domain databases

    Gene3Di2.30.42.10. 2 hits.
    InterProiIPR001478. PDZ.
    [Graphical view]
    PfamiPF00595. PDZ. 2 hits.
    [Graphical view]
    SMARTiSM00228. PDZ. 2 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 2 hits.
    PROSITEiPS50106. PDZ. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H190-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL    50
    ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA 100
    EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD 150
    QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM 200
    GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME 250
    ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA 292
    Length:292
    Mass (Da):31,594
    Last modified:May 2, 2002 - v2
    Checksum:iE12536839E1CD91C
    GO
    Isoform 3 (identifier: Q9H190-3) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: Missing.

    Show »
    Length:207
    Mass (Da):22,664
    Checksum:i16913A0148BF691A
    GO

    Sequence cautioni

    The sequence AAH02727.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691Q → H in CAC21716. (PubMed:11152476)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti182 – 1821V → M.2 Publications
    Corresponds to variant rs2273959 [ dbSNP | Ensembl ].
    VAR_053700
    Natural varianti191 – 1911R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
    Corresponds to variant rs35367003 [ dbSNP | Ensembl ].
    VAR_036544
    Natural varianti223 – 2231R → C.
    Corresponds to variant rs1048621 [ dbSNP | Ensembl ].
    VAR_053701
    Natural varianti242 – 2421G → R.
    Corresponds to variant rs4814111 [ dbSNP | Ensembl ].
    VAR_053702

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585Missing in isoform 3. 2 PublicationsVSP_006352Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159228 mRNA. Translation: AAF80369.1.
    AJ292245 mRNA. Translation: CAC21573.1.
    AJ292244 mRNA. Translation: CAC21716.1.
    AF131809 mRNA. Translation: AAD20049.1.
    AL136531 Genomic DNA. Translation: CAC16178.1.
    AL136531 Genomic DNA. Translation: CAH72383.1.
    BC002727 mRNA. Translation: AAH02727.2. Different initiation.
    CCDSiCCDS13013.1. [Q9H190-3]
    CCDS42848.1. [Q9H190-1]
    RefSeqiNP_001186713.1. NM_001199784.1. [Q9H190-1]
    NP_056500.2. NM_015685.5. [Q9H190-3]
    NP_536737.3. NM_080489.4. [Q9H190-1]
    UniGeneiHs.657015.

    Genome annotation databases

    EnsembliENST00000339987; ENSP00000342935; ENSG00000125775. [Q9H190-1]
    ENST00000360779; ENSP00000354013; ENSG00000125775. [Q9H190-1]
    ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3]
    ENST00000381812; ENSP00000371233; ENSG00000125775. [Q9H190-1]
    GeneIDi27111.
    KEGGihsa:27111.
    UCSCiuc002weu.4. human. [Q9H190-1]

    Polymorphism databases

    DMDMi20455288.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159228 mRNA. Translation: AAF80369.1 .
    AJ292245 mRNA. Translation: CAC21573.1 .
    AJ292244 mRNA. Translation: CAC21716.1 .
    AF131809 mRNA. Translation: AAD20049.1 .
    AL136531 Genomic DNA. Translation: CAC16178.1 .
    AL136531 Genomic DNA. Translation: CAH72383.1 .
    BC002727 mRNA. Translation: AAH02727.2 . Different initiation.
    CCDSi CCDS13013.1. [Q9H190-3 ]
    CCDS42848.1. [Q9H190-1 ]
    RefSeqi NP_001186713.1. NM_001199784.1. [Q9H190-1 ]
    NP_056500.2. NM_015685.5. [Q9H190-3 ]
    NP_536737.3. NM_080489.4. [Q9H190-1 ]
    UniGenei Hs.657015.

    3D structure databases

    ProteinModelPortali Q9H190.
    SMRi Q9H190. Positions 107-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118007. 13 interactions.
    IntActi Q9H190. 19 interactions.
    MINTi MINT-1438328.
    STRINGi 9606.ENSP00000342935.

    PTM databases

    PhosphoSitei Q9H190.

    Polymorphism databases

    DMDMi 20455288.

    Proteomic databases

    MaxQBi Q9H190.
    PaxDbi Q9H190.
    PRIDEi Q9H190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339987 ; ENSP00000342935 ; ENSG00000125775 . [Q9H190-1 ]
    ENST00000360779 ; ENSP00000354013 ; ENSG00000125775 . [Q9H190-1 ]
    ENST00000381808 ; ENSP00000371229 ; ENSG00000125775 . [Q9H190-3 ]
    ENST00000381812 ; ENSP00000371233 ; ENSG00000125775 . [Q9H190-1 ]
    GeneIDi 27111.
    KEGGi hsa:27111.
    UCSCi uc002weu.4. human. [Q9H190-1 ]

    Organism-specific databases

    CTDi 27111.
    GeneCardsi GC20M001238.
    H-InvDB HIX0158663.
    HGNCi HGNC:15756. SDCBP2.
    HPAi HPA054554.
    neXtProti NX_Q9H190.
    PharmGKBi PA38033.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG140434.
    HOGENOMi HOG000231604.
    HOVERGENi HBG053211.
    InParanoidi Q9H190.
    OMAi HTMDHSI.
    OrthoDBi EOG75MVWZ.
    PhylomeDBi Q9H190.
    TreeFami TF327131.

    Miscellaneous databases

    ChiTaRSi SDCBP2. human.
    GeneWikii SDCBP2.
    GenomeRNAii 27111.
    NextBioi 49786.
    PROi Q9H190.

    Gene expression databases

    Bgeei Q9H190.
    CleanExi HS_SDCBP2.
    Genevestigatori Q9H190.

    Family and domain databases

    Gene3Di 2.30.42.10. 2 hits.
    InterProi IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00595. PDZ. 2 hits.
    [Graphical view ]
    SMARTi SM00228. PDZ. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 2 hits.
    PROSITEi PS50106. PDZ. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SITAC18, a PDZ protein similar to TACIP18/syntenin/mda9 with restricted specificity and expression pattern."
      Fernandez-Larrea J., Borrell-Pages M., Urena J.M., Rojo F., Merlos-Suarez A., Baselga J., Arribas J.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity."
      Koroll M., Rathjen F.G., Volkmer H.
      J. Biol. Chem. 276:10646-10654(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), VARIANT MET-182.
      Tissue: Fetal brain.
    3. Mei G., Yu W., Gibbs R.A.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-182.
      Tissue: Brain.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-191.

    Entry informationi

    Entry nameiSDCB2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H190
    Secondary accession number(s): O95892
    , Q5W0X1, Q9BZ42, Q9H567, Q9NRY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3