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Q9H190 (SDCB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntenin-2
Alternative name(s):
Syndecan-binding protein 2
Gene names
Name:SDCBP2
Synonyms:SITAC18
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Monomer and homodimer. Interacts with SDCBP By similarity.

Sequence similarities

Contains 2 PDZ (DHR) domains.

Sequence caution

The sequence AAH02727.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H190-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 3 (identifier: Q9H190-3)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Syntenin-2
PRO_0000184004

Regions

Domain108 – 18780PDZ 1
Domain192 – 26776PDZ 2

Natural variations

Alternative sequence1 – 8585Missing in isoform 3.
VSP_006352
Natural variant1821V → M. Ref.2 Ref.3
Corresponds to variant rs2273959 [ dbSNP | Ensembl ].
VAR_053700
Natural variant1911R → Q in a colorectal cancer sample; somatic mutation. Ref.6
Corresponds to variant rs35367003 [ dbSNP | Ensembl ].
VAR_036544
Natural variant2231R → C.
Corresponds to variant rs1048621 [ dbSNP | Ensembl ].
VAR_053701
Natural variant2421G → R.
Corresponds to variant rs4814111 [ dbSNP | Ensembl ].
VAR_053702

Experimental info

Sequence conflict691Q → H in CAC21716. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Alpha) [UniParc].

Last modified May 2, 2002. Version 2.
Checksum: E12536839E1CD91C

FASTA29231,594
        10         20         30         40         50         60 
MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL ENYMGLSLSS 

        70         80         90        100        110        120 
QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA EIKPGVREIH LCKDERGKTG 

       130        140        150        160        170        180 
LRLRKVDQGL FVQLVQANTP ASLVGLRFGD QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI 

       190        200        210        220        230        240 
VVVVRDRPFQ RTVTMHKDSM GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV 

       250        260        270        280        290 
IGLKDKKIME ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA 

« Hide

Isoform 3 (Beta) [UniParc].

Checksum: 16913A0148BF691A
Show »

FASTA20722,664

References

« Hide 'large scale' references
[1]"SITAC18, a PDZ protein similar to TACIP18/syntenin/mda9 with restricted specificity and expression pattern."
Fernandez-Larrea J., Borrell-Pages M., Urena J.M., Rojo F., Merlos-Suarez A., Baselga J., Arribas J.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity."
Koroll M., Rathjen F.G., Volkmer H.
J. Biol. Chem. 276:10646-10654(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), VARIANT MET-182.
Tissue: Fetal brain.
[3]Mei G., Yu W., Gibbs R.A.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-182.
Tissue: Brain.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Uterus.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-191.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF159228 mRNA. Translation: AAF80369.1.
AJ292245 mRNA. Translation: CAC21573.1.
AJ292244 mRNA. Translation: CAC21716.1.
AF131809 mRNA. Translation: AAD20049.1.
AL136531 Genomic DNA. Translation: CAC16178.1.
AL136531 Genomic DNA. Translation: CAH72383.1.
BC002727 mRNA. Translation: AAH02727.2. Different initiation.
CCDSCCDS13013.1. [Q9H190-3]
CCDS42848.1. [Q9H190-1]
RefSeqNP_001186713.1. NM_001199784.1. [Q9H190-1]
NP_056500.2. NM_015685.5. [Q9H190-3]
NP_536737.3. NM_080489.4. [Q9H190-1]
UniGeneHs.657015.

3D structure databases

ProteinModelPortalQ9H190.
SMRQ9H190. Positions 107-266.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118007. 13 interactions.
IntActQ9H190. 19 interactions.
MINTMINT-1438328.
STRING9606.ENSP00000342935.

PTM databases

PhosphoSiteQ9H190.

Polymorphism databases

DMDM20455288.

Proteomic databases

MaxQBQ9H190.
PaxDbQ9H190.
PRIDEQ9H190.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339987; ENSP00000342935; ENSG00000125775. [Q9H190-1]
ENST00000360779; ENSP00000354013; ENSG00000125775. [Q9H190-1]
ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775. [Q9H190-1]
GeneID27111.
KEGGhsa:27111.
UCSCuc002weu.4. human. [Q9H190-1]

Organism-specific databases

CTD27111.
GeneCardsGC20M001238.
H-InvDBHIX0158663.
HGNCHGNC:15756. SDCBP2.
HPAHPA054554.
neXtProtNX_Q9H190.
PharmGKBPA38033.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG140434.
HOGENOMHOG000231604.
HOVERGENHBG053211.
InParanoidQ9H190.
OMAHTMDHSI.
OrthoDBEOG75MVWZ.
PhylomeDBQ9H190.
TreeFamTF327131.

Gene expression databases

BgeeQ9H190.
CleanExHS_SDCBP2.
GenevestigatorQ9H190.

Family and domain databases

Gene3D2.30.42.10. 2 hits.
InterProIPR001478. PDZ.
[Graphical view]
PfamPF00595. PDZ. 2 hits.
[Graphical view]
SMARTSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMSSF50156. SSF50156. 2 hits.
PROSITEPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSDCBP2. human.
GeneWikiSDCBP2.
GenomeRNAi27111.
NextBio49786.
PROQ9H190.

Entry information

Entry nameSDCB2_HUMAN
AccessionPrimary (citable) accession number: Q9H190
Secondary accession number(s): O95892 expand/collapse secondary AC list , Q5W0X1, Q9BZ42, Q9H567, Q9NRY8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM