UniProtKB - Q9H190 (SDCB2_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Syntenin-2
Gene
SDCBP2
Organism
Homo sapiens (Human)
Status
Functioni
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).1 Publication
GO - Molecular functioni
- identical protein binding Source: IntAct
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- cell proliferation Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- intracellular transport Source: UniProtKB
- nervous system development Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Syntenin-2Alternative name(s): Similar to TACIP181 Publication Short name: SITAC1 Publication Syndecan-binding protein 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000125775.14. |
HGNCi | HGNC:15756. SDCBP2. |
MIMi | 617358. gene. |
neXtProti | NX_Q9H190. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 113 | K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-167; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-167. 1 Publication | 1 | |
Mutagenesisi | 167 | K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-113. 1 Publication | 1 | |
Mutagenesisi | 197 | K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-244. 1 Publication | 1 | |
Mutagenesisi | 244 | K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-197. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-197. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 27111. |
OpenTargetsi | ENSG00000125775. |
PharmGKBi | PA38033. |
Polymorphism and mutation databases
BioMutai | SDCBP2. |
DMDMi | 20455288. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184004 | 1 – 292 | Syntenin-2Add BLAST | 292 |
Proteomic databases
EPDi | Q9H190. |
MaxQBi | Q9H190. |
PaxDbi | Q9H190. |
PeptideAtlasi | Q9H190. |
PRIDEi | Q9H190. |
PTM databases
iPTMneti | Q9H190. |
PhosphoSitePlusi | Q9H190. |
SwissPalmi | Q9H190. |
Expressioni
Tissue specificityi
Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796).2 Publications
Inductioni
Down-regulated by HPV8 E6 papillomavirus (HPV) oncoprotein (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000125775. |
CleanExi | HS_SDCBP2. |
Genevisiblei | Q9H190. HS. |
Organism-specific databases
HPAi | HPA054554. |
Interactioni
Subunit structurei
Monomer and homodimer (PubMed:11152476, PubMed:23300061). Interacts with SDCBP (PubMed:11152476). Interacts with TM4SF1 (PubMed:11102519).3 Publications
Binary interactionsi
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 118007. 39 interactors. |
IntActi | Q9H190. 77 interactors. |
MINTi | Q9H190. |
Structurei
3D structure databases
ProteinModelPortali | Q9H190. |
SMRi | Q9H190. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 108 – 187 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 192 – 267 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 76 |
Domaini
Binds phosphatidylinositol 4,5-bisphosphate (PIP2) via its two PDZ domains. These domains target SDCBP2 to the plasma membranes and nucleoli, two PIP2-rich regions.1 Publication
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG410IK98. Eukaryota. ENOG410YNPQ. LUCA. |
GeneTreei | ENSGT00390000014465. |
HOGENOMi | HOG000231604. |
HOVERGENi | HBG053211. |
InParanoidi | Q9H190. |
OMAi | EIHLCKD. |
OrthoDBi | EOG091G0HJI. |
PhylomeDBi | Q9H190. |
TreeFami | TF327131. |
Family and domain databases
InterProi | View protein in InterPro IPR001478. PDZ. IPR036034. PDZ_sf. |
Pfami | View protein in Pfam PF00595. PDZ. 1 hit. |
SMARTi | View protein in SMART SM00228. PDZ. 2 hits. |
SUPFAMi | SSF50156. SSF50156. 2 hits. |
PROSITEi | View protein in PROSITE PS50106. PDZ. 2 hits. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H190-1) [UniParc]FASTAAdd to basket
Also known as: Alpha
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL
60 70 80 90 100
ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA
110 120 130 140 150
EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD
160 170 180 190 200
QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM
210 220 230 240 250
GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME
260 270 280 290
ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA
Sequence cautioni
The sequence AAH02727 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 | Q → H in CAC21716 (PubMed:11152476).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053700 | 182 | V → M2 PublicationsCorresponds to variant dbSNP:rs2273959Ensembl. | 1 | |
Natural variantiVAR_036544 | 191 | R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs35367003Ensembl. | 1 | |
Natural variantiVAR_053701 | 223 | R → C. Corresponds to variant dbSNP:rs1048621Ensembl. | 1 | |
Natural variantiVAR_053702 | 242 | G → R. Corresponds to variant dbSNP:rs4814111Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006352 | 1 – 85 | Missing in isoform 3. 2 PublicationsAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159228 mRNA. Translation: AAF80369.1. AJ292245 mRNA. Translation: CAC21573.1. AJ292244 mRNA. Translation: CAC21716.1. AF131809 mRNA. Translation: AAD20049.1. AL136531 Genomic DNA. No translation available. BC002727 mRNA. Translation: AAH02727.2. Different initiation. |
CCDSi | CCDS13013.1. [Q9H190-3] CCDS42848.1. [Q9H190-1] |
RefSeqi | NP_001186713.1. NM_001199784.1. [Q9H190-1] NP_056500.2. NM_015685.5. [Q9H190-3] NP_536737.3. NM_080489.4. [Q9H190-1] |
UniGenei | Hs.657015. |
Genome annotation databases
Ensembli | ENST00000339987; ENSP00000342935; ENSG00000125775. [Q9H190-1] ENST00000360779; ENSP00000354013; ENSG00000125775. [Q9H190-1] ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3] ENST00000381812; ENSP00000371233; ENSG00000125775. [Q9H190-1] |
GeneIDi | 27111. |
KEGGi | hsa:27111. |
UCSCi | uc002weu.5. human. [Q9H190-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | SDCB2_HUMAN | |
Accessioni | Q9H190Primary (citable) accession number: Q9H190 Secondary accession number(s): O95892 Q9NRY8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | May 2, 2002 | |
Last modified: | March 28, 2018 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
The nuclear speckles location of SDCBP2 is under debate. One study shows that in paraformaldehyde fixed cells, SDCBP2 is highly enriched in nuclear speckles (PubMed:15961997). The same authors investigate subcellular location in living cells and fail to detect SDCBP2 in nuclear speckles, and propose that enrichment in nuclear speckles is fixation-dependent (PubMed:23300061).2 Publications