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UniProtKB - Q9H190 (SDCB2_HUMAN)

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Protein

Syntenin-2

Gene

SDCBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).1 Publication

Caution

The nuclear speckles location of SDCBP2 is under debate. One study shows that in paraformaldehyde fixed cells, SDCBP2 is highly enriched in nuclear speckles (PubMed:15961997). The same authors investigate subcellular location in living cells and fail to detect SDCBP2 in nuclear speckles, and propose that enrichment in nuclear speckles is fixation-dependent (PubMed:23300061).2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • intracellular transport Source: UniProtKB
  • nervous system development Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-2
Alternative name(s):
Similar to TACIP181 Publication
Short name:
SITAC1 Publication
Syndecan-binding protein 2
Gene namesi
Name:SDCBP2Imported
Synonyms:SITAC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125775.14
HGNCiHGNC:15756 SDCBP2
MIMi617358 gene
neXtProtiNX_Q9H190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi113K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-167; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-167. 1 Publication1
Mutagenesisi167K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-113. 1 Publication1
Mutagenesisi197K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-244. 1 Publication1
Mutagenesisi244K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-197. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-197. 1 Publication1

Organism-specific databases

DisGeNETi27111
OpenTargetsiENSG00000125775
PharmGKBiPA38033

Polymorphism and mutation databases

BioMutaiSDCBP2
DMDMi20455288

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840041 – 292Syntenin-2Add BLAST292

Proteomic databases

EPDiQ9H190
MaxQBiQ9H190
PaxDbiQ9H190
PeptideAtlasiQ9H190
PRIDEiQ9H190

PTM databases

iPTMnetiQ9H190
PhosphoSitePlusiQ9H190
SwissPalmiQ9H190

Expressioni

Tissue specificityi

Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796).2 Publications

Inductioni

Down-regulated by HPV8 E6 papillomavirus (HPV) oncoprotein (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000125775
CleanExiHS_SDCBP2
GenevisibleiQ9H190 HS

Organism-specific databases

HPAiHPA054554

Interactioni

Subunit structurei

Monomer and homodimer (PubMed:11152476, PubMed:23300061). Interacts with SDCBP (PubMed:11152476). Interacts with TM4SF1 (PubMed:11102519).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein C-terminus binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi118007, 39 interactors
IntActiQ9H190, 69 interactors
MINTiQ9H190

Structurei

3D structure databases

ProteinModelPortaliQ9H190
SMRiQ9H190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 187PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini192 – 267PDZ 2PROSITE-ProRule annotationAdd BLAST76

Domaini

Binds phosphatidylinositol 4,5-bisphosphate (PIP2) via its two PDZ domains. These domains target SDCBP2 to the plasma membranes and nucleoli, two PIP2-rich regions.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IK98 Eukaryota
ENOG410YNPQ LUCA
GeneTreeiENSGT00390000014465
HOGENOMiHOG000231604
HOVERGENiHBG053211
InParanoidiQ9H190
OMAiEIHLCKD
OrthoDBiEOG091G0HJI
PhylomeDBiQ9H190
TreeFamiTF327131

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H190-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL 
        60         70         80         90        100
ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA 
       110        120        130        140        150
EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD 
       160        170        180        190        200
QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM 
       210        220        230        240        250
GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME 
       260        270        280        290 
ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA
Length:292
Mass (Da):31,594
Last modified:May 2, 2002 - v2
Checksum:iE12536839E1CD91C
GO
Isoform 3 (identifier: Q9H190-3) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:207
Mass (Da):22,664
Checksum:i16913A0148BF691A
GO

Sequence cautioni

The sequence AAH02727 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69Q → H in CAC21716 (PubMed:11152476).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053700182V → M2 PublicationsCorresponds to variant dbSNP:rs2273959Ensembl.1
Natural variantiVAR_036544191R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs35367003Ensembl.1
Natural variantiVAR_053701223R → C. Corresponds to variant dbSNP:rs1048621Ensembl.1
Natural variantiVAR_053702242G → R. Corresponds to variant dbSNP:rs4814111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0063521 – 85Missing in isoform 3. 2 PublicationsAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159228 mRNA Translation: AAF80369.1
AJ292245 mRNA Translation: CAC21573.1
AJ292244 mRNA Translation: CAC21716.1
AF131809 mRNA Translation: AAD20049.1
AL136531 Genomic DNA No translation available.
BC002727 mRNA Translation: AAH02727.2 Different initiation.
CCDSiCCDS13013.1 [Q9H190-3]
CCDS42848.1 [Q9H190-1]
RefSeqiNP_001186713.1, NM_001199784.1 [Q9H190-1]
NP_056500.2, NM_015685.5 [Q9H190-3]
NP_536737.3, NM_080489.4 [Q9H190-1]
UniGeneiHs.657015

Genome annotation databases

EnsembliENST00000339987; ENSP00000342935; ENSG00000125775 [Q9H190-1]
ENST00000360779; ENSP00000354013; ENSG00000125775 [Q9H190-1]
ENST00000381808; ENSP00000371229; ENSG00000125775 [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775 [Q9H190-1]
GeneIDi27111
KEGGihsa:27111
UCSCiuc002weu.5 human [Q9H190-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSDCB2_HUMAN
AccessioniPrimary (citable) accession number: Q9H190
Secondary accession number(s): O95892
, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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