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Protein

Syntenin-2

Gene

SDCBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB
  • intracellular transport Source: UniProtKB
  • nervous system development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-2
Alternative name(s):
Syndecan-binding protein 2
Gene namesi
Name:SDCBP2
Synonyms:SITAC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15756. SDCBP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38033.

Polymorphism and mutation databases

BioMutaiSDCBP2.
DMDMi20455288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Syntenin-2PRO_0000184004Add
BLAST

Proteomic databases

MaxQBiQ9H190.
PaxDbiQ9H190.
PRIDEiQ9H190.

PTM databases

PhosphoSiteiQ9H190.

Expressioni

Gene expression databases

BgeeiQ9H190.
CleanExiHS_SDCBP2.
GenevisibleiQ9H190. HS.

Organism-specific databases

HPAiHPA054554.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with SDCBP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAP1O756893EBI-742426,EBI-714732
ARF4P180853EBI-742426,EBI-1237085
C11orf57Q6ZUT13EBI-742426,EBI-3920396
C11orf57Q6ZUT1-23EBI-742426,EBI-10180231
CT45A3Q8NHU04EBI-742426,EBI-8643558
CT45A5Q6NSH34EBI-742426,EBI-8635816
EIF1ADQ8N9N84EBI-742426,EBI-750700
FAM133AQ8N9E03EBI-742426,EBI-10268158
FAM13CQ8NE313EBI-742426,EBI-751248
FAM9BQ8IZU03EBI-742426,EBI-10175124
FBXO28Q9NVF73EBI-742426,EBI-740282
LGALS14Q8TCE93EBI-742426,EBI-10274069
LGALS2P051623EBI-742426,EBI-7181544
LYARQ9NX583EBI-742426,EBI-713507
NPM2Q86SE83EBI-742426,EBI-6658150
PRPF38AQ8NAV13EBI-742426,EBI-715374
PRPF40AO75400-23EBI-742426,EBI-5280197
PRR13Q9NZ814EBI-742426,EBI-740924
RNPS1D3DU923EBI-742426,EBI-10176640
SREK1IP1Q8N9Q23EBI-742426,EBI-10268630
TDO2P487753EBI-742426,EBI-743494
TIFAQ96CG34EBI-742426,EBI-740711
TNP1P094303EBI-742426,EBI-10196343
YTHDC1Q96MU73EBI-742426,EBI-2849854
ZCCHC10Q8TBK63EBI-742426,EBI-597063
ZCCHC17Q9NP645EBI-742426,EBI-746345
ZNF581Q9P0T43EBI-742426,EBI-745520
ZRSR2Q156963EBI-742426,EBI-6657923

Protein-protein interaction databases

BioGridi118007. 39 interactions.
IntActiQ9H190. 39 interactions.
MINTiMINT-1438328.
STRINGi9606.ENSP00000342935.

Structurei

3D structure databases

ProteinModelPortaliQ9H190.
SMRiQ9H190. Positions 107-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 18780PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini192 – 26776PDZ 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG140434.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiQ9H190.
OMAiHTMDHSI.
OrthoDBiEOG75MVWZ.
PhylomeDBiQ9H190.
TreeFamiTF327131.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H190-1) [UniParc]FASTAAdd to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL
60 70 80 90 100
ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA
110 120 130 140 150
EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD
160 170 180 190 200
QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM
210 220 230 240 250
GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME
260 270 280 290
ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA
Length:292
Mass (Da):31,594
Last modified:May 2, 2002 - v2
Checksum:iE12536839E1CD91C
GO
Isoform 3 (identifier: Q9H190-3) [UniParc]FASTAAdd to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:207
Mass (Da):22,664
Checksum:i16913A0148BF691A
GO

Sequence cautioni

The sequence AAH02727.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691Q → H in CAC21716 (PubMed:11152476).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821V → M.2 Publications
Corresponds to variant rs2273959 [ dbSNP | Ensembl ].
VAR_053700
Natural varianti191 – 1911R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs35367003 [ dbSNP | Ensembl ].
VAR_036544
Natural varianti223 – 2231R → C.
Corresponds to variant rs1048621 [ dbSNP | Ensembl ].
VAR_053701
Natural varianti242 – 2421G → R.
Corresponds to variant rs4814111 [ dbSNP | Ensembl ].
VAR_053702

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 3. 2 PublicationsVSP_006352Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159228 mRNA. Translation: AAF80369.1.
AJ292245 mRNA. Translation: CAC21573.1.
AJ292244 mRNA. Translation: CAC21716.1.
AF131809 mRNA. Translation: AAD20049.1.
AL136531 Genomic DNA. Translation: CAC16178.1.
AL136531 Genomic DNA. Translation: CAH72383.1.
BC002727 mRNA. Translation: AAH02727.2. Different initiation.
CCDSiCCDS13013.1. [Q9H190-3]
CCDS42848.1. [Q9H190-1]
RefSeqiNP_001186713.1. NM_001199784.1. [Q9H190-1]
NP_056500.2. NM_015685.5. [Q9H190-3]
NP_536737.3. NM_080489.4. [Q9H190-1]
UniGeneiHs.657015.

Genome annotation databases

EnsembliENST00000339987; ENSP00000342935; ENSG00000125775.
ENST00000360779; ENSP00000354013; ENSG00000125775.
ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775.
GeneIDi27111.
KEGGihsa:27111.
UCSCiuc002weu.4. human. [Q9H190-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159228 mRNA. Translation: AAF80369.1.
AJ292245 mRNA. Translation: CAC21573.1.
AJ292244 mRNA. Translation: CAC21716.1.
AF131809 mRNA. Translation: AAD20049.1.
AL136531 Genomic DNA. Translation: CAC16178.1.
AL136531 Genomic DNA. Translation: CAH72383.1.
BC002727 mRNA. Translation: AAH02727.2. Different initiation.
CCDSiCCDS13013.1. [Q9H190-3]
CCDS42848.1. [Q9H190-1]
RefSeqiNP_001186713.1. NM_001199784.1. [Q9H190-1]
NP_056500.2. NM_015685.5. [Q9H190-3]
NP_536737.3. NM_080489.4. [Q9H190-1]
UniGeneiHs.657015.

3D structure databases

ProteinModelPortaliQ9H190.
SMRiQ9H190. Positions 107-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118007. 39 interactions.
IntActiQ9H190. 39 interactions.
MINTiMINT-1438328.
STRINGi9606.ENSP00000342935.

PTM databases

PhosphoSiteiQ9H190.

Polymorphism and mutation databases

BioMutaiSDCBP2.
DMDMi20455288.

Proteomic databases

MaxQBiQ9H190.
PaxDbiQ9H190.
PRIDEiQ9H190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339987; ENSP00000342935; ENSG00000125775.
ENST00000360779; ENSP00000354013; ENSG00000125775.
ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775.
GeneIDi27111.
KEGGihsa:27111.
UCSCiuc002weu.4. human. [Q9H190-1]

Organism-specific databases

CTDi27111.
GeneCardsiGC20M001238.
H-InvDBHIX0158663.
HGNCiHGNC:15756. SDCBP2.
HPAiHPA054554.
neXtProtiNX_Q9H190.
PharmGKBiPA38033.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG140434.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiQ9H190.
OMAiHTMDHSI.
OrthoDBiEOG75MVWZ.
PhylomeDBiQ9H190.
TreeFamiTF327131.

Miscellaneous databases

ChiTaRSiSDCBP2. human.
GeneWikiiSDCBP2.
GenomeRNAii27111.
NextBioi49786.
PROiQ9H190.

Gene expression databases

BgeeiQ9H190.
CleanExiHS_SDCBP2.
GenevisibleiQ9H190. HS.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SITAC18, a PDZ protein similar to TACIP18/syntenin/mda9 with restricted specificity and expression pattern."
    Fernandez-Larrea J., Borrell-Pages M., Urena J.M., Rojo F., Merlos-Suarez A., Baselga J., Arribas J.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity."
    Koroll M., Rathjen F.G., Volkmer H.
    J. Biol. Chem. 276:10646-10654(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), VARIANT MET-182.
    Tissue: Fetal brain.
  3. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-182.
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-191.

Entry informationi

Entry nameiSDCB2_HUMAN
AccessioniPrimary (citable) accession number: Q9H190
Secondary accession number(s): O95892
, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: July 22, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.