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Q9H190

- SDCB2_HUMAN

UniProt

Q9H190 - SDCB2_HUMAN

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Protein
Syntenin-2
Gene
SDCBP2, SITAC18
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein C-terminus binding Source: UniProtKB
  2. protein heterodimerization activity Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: UniProtKB
  2. intracellular transport Source: UniProtKB
  3. nervous system development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-2
Alternative name(s):
Syndecan-binding protein 2
Gene namesi
Name:SDCBP2
Synonyms:SITAC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15756. SDCBP2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Syntenin-2
PRO_0000184004Add
BLAST

Proteomic databases

MaxQBiQ9H190.
PaxDbiQ9H190.
PRIDEiQ9H190.

PTM databases

PhosphoSiteiQ9H190.

Expressioni

Gene expression databases

BgeeiQ9H190.
CleanExiHS_SDCBP2.
GenevestigatoriQ9H190.

Organism-specific databases

HPAiHPA054554.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with SDCBP By similarity.

Protein-protein interaction databases

BioGridi118007. 13 interactions.
IntActiQ9H190. 19 interactions.
MINTiMINT-1438328.
STRINGi9606.ENSP00000342935.

Structurei

3D structure databases

ProteinModelPortaliQ9H190.
SMRiQ9H190. Positions 107-266.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 18780PDZ 1
Add
BLAST
Domaini192 – 26776PDZ 2
Add
BLAST

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG140434.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiQ9H190.
OMAiHTMDHSI.
OrthoDBiEOG75MVWZ.
PhylomeDBiQ9H190.
TreeFamiTF327131.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H190-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL    50
ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA 100
EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD 150
QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM 200
GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME 250
ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA 292
Length:292
Mass (Da):31,594
Last modified:May 2, 2002 - v2
Checksum:iE12536839E1CD91C
GO
Isoform 3 (identifier: Q9H190-3) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:207
Mass (Da):22,664
Checksum:i16913A0148BF691A
GO

Sequence cautioni

The sequence AAH02727.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821V → M.2 Publications
Corresponds to variant rs2273959 [ dbSNP | Ensembl ].
VAR_053700
Natural varianti191 – 1911R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs35367003 [ dbSNP | Ensembl ].
VAR_036544
Natural varianti223 – 2231R → C.
Corresponds to variant rs1048621 [ dbSNP | Ensembl ].
VAR_053701
Natural varianti242 – 2421G → R.
Corresponds to variant rs4814111 [ dbSNP | Ensembl ].
VAR_053702

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 3.
VSP_006352Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691Q → H in CAC21716. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159228 mRNA. Translation: AAF80369.1.
AJ292245 mRNA. Translation: CAC21573.1.
AJ292244 mRNA. Translation: CAC21716.1.
AF131809 mRNA. Translation: AAD20049.1.
AL136531 Genomic DNA. Translation: CAC16178.1.
AL136531 Genomic DNA. Translation: CAH72383.1.
BC002727 mRNA. Translation: AAH02727.2. Different initiation.
CCDSiCCDS13013.1. [Q9H190-3]
CCDS42848.1. [Q9H190-1]
RefSeqiNP_001186713.1. NM_001199784.1. [Q9H190-1]
NP_056500.2. NM_015685.5. [Q9H190-3]
NP_536737.3. NM_080489.4. [Q9H190-1]
UniGeneiHs.657015.

Genome annotation databases

EnsembliENST00000339987; ENSP00000342935; ENSG00000125775. [Q9H190-1]
ENST00000360779; ENSP00000354013; ENSG00000125775. [Q9H190-1]
ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775. [Q9H190-1]
GeneIDi27111.
KEGGihsa:27111.
UCSCiuc002weu.4. human. [Q9H190-1]

Polymorphism databases

DMDMi20455288.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159228 mRNA. Translation: AAF80369.1 .
AJ292245 mRNA. Translation: CAC21573.1 .
AJ292244 mRNA. Translation: CAC21716.1 .
AF131809 mRNA. Translation: AAD20049.1 .
AL136531 Genomic DNA. Translation: CAC16178.1 .
AL136531 Genomic DNA. Translation: CAH72383.1 .
BC002727 mRNA. Translation: AAH02727.2 . Different initiation.
CCDSi CCDS13013.1. [Q9H190-3 ]
CCDS42848.1. [Q9H190-1 ]
RefSeqi NP_001186713.1. NM_001199784.1. [Q9H190-1 ]
NP_056500.2. NM_015685.5. [Q9H190-3 ]
NP_536737.3. NM_080489.4. [Q9H190-1 ]
UniGenei Hs.657015.

3D structure databases

ProteinModelPortali Q9H190.
SMRi Q9H190. Positions 107-266.
ModBasei Search...

Protein-protein interaction databases

BioGridi 118007. 13 interactions.
IntActi Q9H190. 19 interactions.
MINTi MINT-1438328.
STRINGi 9606.ENSP00000342935.

PTM databases

PhosphoSitei Q9H190.

Polymorphism databases

DMDMi 20455288.

Proteomic databases

MaxQBi Q9H190.
PaxDbi Q9H190.
PRIDEi Q9H190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339987 ; ENSP00000342935 ; ENSG00000125775 . [Q9H190-1 ]
ENST00000360779 ; ENSP00000354013 ; ENSG00000125775 . [Q9H190-1 ]
ENST00000381808 ; ENSP00000371229 ; ENSG00000125775 . [Q9H190-3 ]
ENST00000381812 ; ENSP00000371233 ; ENSG00000125775 . [Q9H190-1 ]
GeneIDi 27111.
KEGGi hsa:27111.
UCSCi uc002weu.4. human. [Q9H190-1 ]

Organism-specific databases

CTDi 27111.
GeneCardsi GC20M001238.
H-InvDB HIX0158663.
HGNCi HGNC:15756. SDCBP2.
HPAi HPA054554.
neXtProti NX_Q9H190.
PharmGKBi PA38033.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG140434.
HOGENOMi HOG000231604.
HOVERGENi HBG053211.
InParanoidi Q9H190.
OMAi HTMDHSI.
OrthoDBi EOG75MVWZ.
PhylomeDBi Q9H190.
TreeFami TF327131.

Miscellaneous databases

ChiTaRSi SDCBP2. human.
GeneWikii SDCBP2.
GenomeRNAii 27111.
NextBioi 49786.
PROi Q9H190.

Gene expression databases

Bgeei Q9H190.
CleanExi HS_SDCBP2.
Genevestigatori Q9H190.

Family and domain databases

Gene3Di 2.30.42.10. 2 hits.
InterProi IPR001478. PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 2 hits.
[Graphical view ]
SMARTi SM00228. PDZ. 2 hits.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 2 hits.
PROSITEi PS50106. PDZ. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SITAC18, a PDZ protein similar to TACIP18/syntenin/mda9 with restricted specificity and expression pattern."
    Fernandez-Larrea J., Borrell-Pages M., Urena J.M., Rojo F., Merlos-Suarez A., Baselga J., Arribas J.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity."
    Koroll M., Rathjen F.G., Volkmer H.
    J. Biol. Chem. 276:10646-10654(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), VARIANT MET-182.
    Tissue: Fetal brain.
  3. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-182.
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-191.

Entry informationi

Entry nameiSDCB2_HUMAN
AccessioniPrimary (citable) accession number: Q9H190
Secondary accession number(s): O95892
, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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