Q9H190 (SDCB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntenin-2

Alternative name(s):
Syndecan-binding protein 2

Gene names

Name:	SDCBP2
Synonyms:	SITAC18

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Monomer and homodimer. Interacts with SDCBP By similarity.
Sequence similarities	Contains 2 PDZ (DHR) domains.
Sequence caution	The sequence AAH02727.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Non-traceable author statement Ref.2. Source: UniProtKB intracellular transport Non-traceable author statement Ref.2. Source: UniProtKB nervous system development Non-traceable author statement Ref.2. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.2. Source: UniProtKB extracellular vesicular exosome Inferred from direct assay PubMed 19056867PubMed 23376485. Source: UniProt plasma membrane Inferred by curator Ref.2. Source: UniProtKB
Molecular_function	protein C-terminus binding Inferred from physical interaction Ref.2. Source: UniProtKB protein heterodimerization activity Inferred from physical interaction Ref.2. Source: UniProtKB protein homodimerization activity Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H190-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q9H190-3)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Syntenin-2		PRO_0000184004
Regions
	Domain	108 – 187	80	PDZ 1
	Domain	192 – 267	76	PDZ 2
Natural variations
	Alternative sequence	1 – 85	85	Missing in isoform 3.		VSP_006352
	Natural variant	182	1	V → M. Ref.2 Ref.3 Corresponds to variant rs2273959 [ dbSNP | Ensembl ].		VAR_053700
	Natural variant	191	1	R → Q in a colorectal cancer sample; somatic mutation. Ref.6 Corresponds to variant rs35367003 [ dbSNP | Ensembl ].		VAR_036544
	Natural variant	223	1	R → C. Corresponds to variant rs1048621 [ dbSNP | Ensembl ].		VAR_053701
	Natural variant	242	1	G → R. Corresponds to variant rs4814111 [ dbSNP | Ensembl ].		VAR_053702
Experimental info
	Sequence conflict	69	1	Q → H in CAC21716. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha) [UniParc]. Last modified May 2, 2002. Version 2. Checksum: E12536839E1CD91C	FASTA	292	31,594
	10 20 30 40 50 60 MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL ENYMGLSLSS 70 80 90 100 110 120 QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA EIKPGVREIH LCKDERGKTG 130 140 150 160 170 180 LRLRKVDQGL FVQLVQANTP ASLVGLRFGD QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI 190 200 210 220 230 240 VVVVRDRPFQ RTVTMHKDSM GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV 250 260 270 280 290 IGLKDKKIME ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA
	Isoform 3 (Beta) [UniParc]. Checksum: 16913A0148BF691A	FASTA	207	22,664
	10 20 30 40 50 60 MVAPVTGYSL GVRRAEIKPG VREIHLCKDE RGKTGLRLRK VDQGLFVQLV QANTPASLVG 70 80 90 100 110 120 LRFGDQLLQI DGRDCAGWSS HKAHQVVKKA SGDKIVVVVR DRPFQRTVTM HKDSMGHVGF 130 140 150 160 170 180 VIKKGKIVSL VKGSSAARNG LLTNHYVCEV DGQNVIGLKD KKIMEILATA GNVVTLTIIP 190 200 SVIYEHMVKK LPPVLLHHTM DHSIPDA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SITAC18, a PDZ protein similar to TACIP18/syntenin/mda9 with restricted specificity and expression pattern." Fernandez-Larrea J., Borrell-Pages M., Urena J.M., Rojo F., Merlos-Suarez A., Baselga J., Arribas J. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain.
[2]	"The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity." Koroll M., Rathjen F.G., Volkmer H. J. Biol. Chem. 276:10646-10654(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), VARIANT MET-182. Tissue: Fetal brain.
[3]	Mei G., Yu W., Gibbs R.A. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-182. Tissue: Brain.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-191.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF159228 mRNA. Translation: AAF80369.1. AJ292245 mRNA. Translation: CAC21573.1. AJ292244 mRNA. Translation: CAC21716.1. AF131809 mRNA. Translation: AAD20049.1. AL136531 Genomic DNA. Translation: CAC16178.1. AL136531 Genomic DNA. Translation: CAH72383.1. BC002727 mRNA. Translation: AAH02727.2. Different initiation.
CCDS	CCDS13013.1. [Q9H190-3] CCDS42848.1. [Q9H190-1]
RefSeq	NP_001186713.1. NM_001199784.1. [Q9H190-1] NP_056500.2. NM_015685.5. [Q9H190-3] NP_536737.3. NM_080489.4. [Q9H190-1]
UniGene	Hs.657015.
3D structure databases
ProteinModelPortal	Q9H190.
SMR	Q9H190. Positions 107-266.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	118007. 13 interactions.
IntAct	Q9H190. 19 interactions.
MINT	MINT-1438328.
STRING	9606.ENSP00000342935.
PTM databases
PhosphoSite	Q9H190.
Polymorphism databases
DMDM	20455288.
Proteomic databases
MaxQB	Q9H190.
PaxDb	Q9H190.
PRIDE	Q9H190.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339987; ENSP00000342935; ENSG00000125775. [Q9H190-1] ENST00000360779; ENSP00000354013; ENSG00000125775. [Q9H190-1] ENST00000381808; ENSP00000371229; ENSG00000125775. [Q9H190-3] ENST00000381812; ENSP00000371233; ENSG00000125775. [Q9H190-1]
GeneID	27111.
KEGG	hsa:27111.
UCSC	uc002weu.4. human. [Q9H190-1]
Organism-specific databases
CTD	27111.
GeneCards	GC20M001238.
H-InvDB	HIX0158663.
HGNC	HGNC:15756. SDCBP2.
HPA	HPA054554.
neXtProt	NX_Q9H190.
PharmGKB	PA38033.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG140434.
HOGENOM	HOG000231604.
HOVERGEN	HBG053211.
InParanoid	Q9H190.
OMA	HTMDHSI.
OrthoDB	EOG75MVWZ.
PhylomeDB	Q9H190.
TreeFam	TF327131.
Gene expression databases
Bgee	Q9H190.
CleanEx	HS_SDCBP2.
Genevestigator	Q9H190.
Family and domain databases
Gene3D	2.30.42.10. 2 hits.
InterPro	IPR001478. PDZ. [Graphical view]
Pfam	PF00595. PDZ. 2 hits. [Graphical view]
SMART	SM00228. PDZ. 2 hits. [Graphical view]
SUPFAM	SSF50156. SSF50156. 2 hits.
PROSITE	PS50106. PDZ. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SDCBP2. human.
GeneWiki	SDCBP2.
GenomeRNAi	27111.
NextBio	49786.
PRO	Q9H190.

Entry information

Entry name

SDCB2_HUMAN

Accession

Primary (citable) accession number: Q9H190
Secondary accession number(s): O95892 , Q5W0X1, Q9BZ42, Q9H567, Q9NRY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 2, 2002
Last modified:	July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.