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Protein

Cysteine/serine-rich nuclear protein 2

Gene

CSRNP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis.By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of phosphatase activity Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 2
Short name:
CSRNP-2
Alternative name(s):
Protein FAM130A1
TGF-beta-induced apoptosis protein 12
Short name:
TAIP-12
Gene namesi
Name:CSRNP2
Synonyms:C12orf22, FAM130A1, TAIP12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16006. CSRNP2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25503.

Polymorphism and mutation databases

BioMutaiCSRNP2.
DMDMi71153583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Cysteine/serine-rich nuclear protein 2PRO_0000114790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9H175.
PRIDEiQ9H175.

PTM databases

iPTMnetiQ9H175.
PhosphoSiteiQ9H175.

Expressioni

Gene expression databases

BgeeiQ9H175.
ExpressionAtlasiQ9H175. baseline and differential.
GenevisibleiQ9H175. HS.

Organism-specific databases

HPAiHPA018503.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621366EBI-5235958,EBI-357253
PPP1CBP621403EBI-5235958,EBI-352350
PPP1CCP368733EBI-5235958,EBI-356283

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123528. 4 interactions.
IntActiQ9H175. 3 interactions.
MINTiMINT-1183308.
STRINGi9606.ENSP00000228515.

Structurei

3D structure databases

ProteinModelPortaliQ9H175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi213 – 25139Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
HOVERGENiHBG067792.
InParanoidiQ9H175.
KOiK17494.
OMAiSVLCFAE.
OrthoDBiEOG7W6WM4.
PhylomeDBiQ9H175.
TreeFamiTF323969.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.

Sequencei

Sequence statusi: Complete.

Q9H175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAFTGSGLK RKFDDVDVGS SVSNSDDEIS SSDSADSCDS LNPPTTASFT
60 70 80 90 100
PTSILKRQKQ LRRKNVRFDQ VTVYYFARRQ GFTSVPSQGG SSLGMAQRHN
110 120 130 140 150
SVRSYTLCEF AQEQEVNHRE ILREHLKEEK LHAKKMKLTK NGTVESVEAD
160 170 180 190 200
GLTLDDVSDE DIDVENVEVD DYFFLQPLPT KRRRALLRAS GVHRIDAEEK
210 220 230 240 250
QELRAIRLSR EECGCDCRLY CDPEACACSQ AGIKCQVDRM SFPCGCSRDG
260 270 280 290 300
CGNMAGRIEF NPIRVRTHYL HTIMKLELES KRQVSRPAAP DEEPSPTASC
310 320 330 340 350
SLTGAQGSET QDFQEFIAEN ETAVMHLQSA EELERLKAEE DSSGSSASLD
360 370 380 390 400
SSIESLGVCI LEEPLAVPEE LCPGLTAPIL IQAQLPPGSS VLCFTENSDH
410 420 430 440 450
PTASTVNSPS YLNSGPLVYY QVEQRPVLGV KGEPGTEEGS ASFPKEKDLN
460 470 480 490 500
VFSLPVTSLV ACSSTDPAAL CKSEVGKTPT LEALLPEDCN PEEPENEDFH
510 520 530 540
PSWSPSSLPF RTDNEEGCGM VKTSQQNEDR PPEDSSLELP LAV
Length:543
Mass (Da):59,591
Last modified:March 1, 2001 - v1
Checksum:i54C147A9F18C6038
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti436 – 4361T → M.
Corresponds to variant rs11542510 [ dbSNP | Ensembl ].
VAR_053016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298133 mRNA. Translation: CAC22252.1.
AB063302 mRNA. Translation: BAB79451.2.
BC017221 mRNA. Translation: AAH17221.1.
CCDSiCCDS8807.1.
RefSeqiNP_110436.1. NM_030809.2.
XP_006719684.1. XM_006719621.2.
UniGeneiHs.524425.

Genome annotation databases

EnsembliENST00000228515; ENSP00000228515; ENSG00000110925.
GeneIDi81566.
KEGGihsa:81566.
UCSCiuc001rxu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298133 mRNA. Translation: CAC22252.1.
AB063302 mRNA. Translation: BAB79451.2.
BC017221 mRNA. Translation: AAH17221.1.
CCDSiCCDS8807.1.
RefSeqiNP_110436.1. NM_030809.2.
XP_006719684.1. XM_006719621.2.
UniGeneiHs.524425.

3D structure databases

ProteinModelPortaliQ9H175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123528. 4 interactions.
IntActiQ9H175. 3 interactions.
MINTiMINT-1183308.
STRINGi9606.ENSP00000228515.

PTM databases

iPTMnetiQ9H175.
PhosphoSiteiQ9H175.

Polymorphism and mutation databases

BioMutaiCSRNP2.
DMDMi71153583.

Proteomic databases

PaxDbiQ9H175.
PRIDEiQ9H175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228515; ENSP00000228515; ENSG00000110925.
GeneIDi81566.
KEGGihsa:81566.
UCSCiuc001rxu.3. human.

Organism-specific databases

CTDi81566.
GeneCardsiCSRNP2.
HGNCiHGNC:16006. CSRNP2.
HPAiHPA018503.
neXtProtiNX_Q9H175.
PharmGKBiPA25503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
HOVERGENiHBG067792.
InParanoidiQ9H175.
KOiK17494.
OMAiSVLCFAE.
OrthoDBiEOG7W6WM4.
PhylomeDBiQ9H175.
TreeFamiTF323969.

Miscellaneous databases

ChiTaRSiCSRNP2. human.
GenomeRNAii81566.
PROiQ9H175.

Gene expression databases

BgeeiQ9H175.
ExpressionAtlasiQ9H175. baseline and differential.
GenevisibleiQ9H175. HS.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hene L.
    Thesis (2001), University of Oxford, United Kingdom
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "TGF-beta induced apoptosis protein."
    Akiyama N., Kondoh S.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCSRN2_HUMAN
AccessioniPrimary (citable) accession number: Q9H175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.