Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine/serine-rich nuclear protein 2

Gene

CSRNP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis.By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of phosphatase activity Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 2
Short name:
CSRNP-2
Alternative name(s):
Protein FAM130A1
TGF-beta-induced apoptosis protein 12
Short name:
TAIP-12
Gene namesi
Name:CSRNP2
Synonyms:C12orf22, FAM130A1, TAIP12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000110925.6
HGNCiHGNC:16006 CSRNP2
neXtProtiNX_Q9H175

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110925
PharmGKBiPA25503

Polymorphism and mutation databases

BioMutaiCSRNP2
DMDMi71153583

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147901 – 543Cysteine/serine-rich nuclear protein 2Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H175
PaxDbiQ9H175
PeptideAtlasiQ9H175
PRIDEiQ9H175
ProteomicsDBi80377

PTM databases

iPTMnetiQ9H175
PhosphoSitePlusiQ9H175

Expressioni

Gene expression databases

BgeeiENSG00000110925
ExpressionAtlasiQ9H175 baseline and differential
GenevisibleiQ9H175 HS

Organism-specific databases

HPAiHPA018503
HPA019914

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123528, 4 interactors
ELMiQ9H175
IntActiQ9H175, 3 interactors
MINTiQ9H175
STRINGi9606.ENSP00000228515

Structurei

3D structure databases

ProteinModelPortaliQ9H175
SMRiQ9H175
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi213 – 251Cys-richAdd BLAST39

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813 Eukaryota
ENOG410XREB LUCA
GeneTreeiENSGT00390000015510
HOGENOMiHOG000039987
HOVERGENiHBG067792
InParanoidiQ9H175
KOiK17494
OMAiNETAVMH
OrthoDBiEOG091G04PA
PhylomeDBiQ9H175
TreeFamiTF323969

Family and domain databases

InterProiView protein in InterPro
IPR031972 CSRNP_N
IPR023260 Cys/Ser-rich_nuc_prot
PANTHERiPTHR13580 PTHR13580, 1 hit
PfamiView protein in Pfam
PF16019 CSRNP_N, 1 hit
PRINTSiPR02031 CYSSERRICHNP

Sequencei

Sequence statusi: Complete.

Q9H175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAFTGSGLK RKFDDVDVGS SVSNSDDEIS SSDSADSCDS LNPPTTASFT
60 70 80 90 100
PTSILKRQKQ LRRKNVRFDQ VTVYYFARRQ GFTSVPSQGG SSLGMAQRHN
110 120 130 140 150
SVRSYTLCEF AQEQEVNHRE ILREHLKEEK LHAKKMKLTK NGTVESVEAD
160 170 180 190 200
GLTLDDVSDE DIDVENVEVD DYFFLQPLPT KRRRALLRAS GVHRIDAEEK
210 220 230 240 250
QELRAIRLSR EECGCDCRLY CDPEACACSQ AGIKCQVDRM SFPCGCSRDG
260 270 280 290 300
CGNMAGRIEF NPIRVRTHYL HTIMKLELES KRQVSRPAAP DEEPSPTASC
310 320 330 340 350
SLTGAQGSET QDFQEFIAEN ETAVMHLQSA EELERLKAEE DSSGSSASLD
360 370 380 390 400
SSIESLGVCI LEEPLAVPEE LCPGLTAPIL IQAQLPPGSS VLCFTENSDH
410 420 430 440 450
PTASTVNSPS YLNSGPLVYY QVEQRPVLGV KGEPGTEEGS ASFPKEKDLN
460 470 480 490 500
VFSLPVTSLV ACSSTDPAAL CKSEVGKTPT LEALLPEDCN PEEPENEDFH
510 520 530 540
PSWSPSSLPF RTDNEEGCGM VKTSQQNEDR PPEDSSLELP LAV
Length:543
Mass (Da):59,591
Last modified:March 1, 2001 - v1
Checksum:i54C147A9F18C6038
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053016436T → M. Corresponds to variant dbSNP:rs11542510Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298133 mRNA Translation: CAC22252.1
AB063302 mRNA Translation: BAB79451.2
BC017221 mRNA Translation: AAH17221.1
CCDSiCCDS8807.1
RefSeqiNP_110436.1, NM_030809.2
XP_006719684.1, XM_006719621.2
UniGeneiHs.524425

Genome annotation databases

EnsembliENST00000228515; ENSP00000228515; ENSG00000110925
GeneIDi81566
KEGGihsa:81566
UCSCiuc001rxu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCSRN2_HUMAN
AccessioniPrimary (citable) accession number: Q9H175
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health