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Q9H171

- ZBP1_HUMAN

UniProt

Q9H171 - ZBP1_HUMAN

Protein

Z-DNA-binding protein 1

Gene

ZBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • Format
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. double-stranded RNA adenosine deaminase activity Source: InterPro
    3. left-handed Z-DNA binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. RNA binding Source: InterPro

    GO - Biological processi

    1. innate immune response Source: Reactome
    2. positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
    3. positive regulation of type I interferon production Source: Reactome

    Keywords - Biological processi

    Immunity, Innate immunity

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_118563. RIP-mediated NFkB activation via ZBP1.
    REACT_118764. ZBP1(DAI) mediated induction of type I IFNs.
    REACT_118811. IRF3 mediated activation of type 1 IFN.
    REACT_163977. Regulation of innate immune responses to cytosolic DNA.
    REACT_163993. IRF3-mediated induction of type I IFN.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Z-DNA-binding protein 1
    Alternative name(s):
    Tumor stroma and activated macrophage protein DLM-1
    Gene namesi
    Name:ZBP1
    Synonyms:C20orf183, DLM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16176. ZBP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. nucleus Source: MGI

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38094.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Z-DNA-binding protein 1PRO_0000066564Add
    BLAST

    Proteomic databases

    PaxDbiQ9H171.
    PRIDEiQ9H171.

    PTM databases

    PhosphoSiteiQ9H171.

    Expressioni

    Tissue specificityi

    Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.

    Gene expression databases

    BgeeiQ9H171.
    CleanExiHS_ZBP1.
    GenevestigatoriQ9H171.

    Organism-specific databases

    HPAiHPA041256.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KRR1Q136013EBI-6264672,EBI-744525
    RIPK3Q9Y5724EBI-6264672,EBI-298250

    Protein-protein interaction databases

    BioGridi123349. 10 interactions.
    DIPiDIP-44121N.
    IntActiQ9H171. 6 interactions.
    MINTiMINT-6167522.
    STRINGi9606.ENSP00000360215.

    Structurei

    Secondary structure

    1
    429
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 2516
    Helixi31 – 388
    Helixi42 – 5413
    Beta strandi57 – 626
    Beta strandi65 – 728
    Helixi108 – 12013
    Beta strandi122 – 1243
    Helixi125 – 1317
    Helixi137 – 1393
    Helixi141 – 1499
    Beta strandi152 – 1554
    Turni157 – 1593
    Beta strandi161 – 1644

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L4MNMR-A103-166[»]
    2LNBNMR-A6-74[»]
    3EYIX-ray1.45A/B103-166[»]
    4KA4X-ray2.60A/B/D/E96-165[»]
    ProteinModelPortaliQ9H171.
    SMRiQ9H171. Positions 6-74, 103-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H171.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati6 – 7267DRADA 1Add
    BLAST
    Repeati103 – 16866DRADA 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi195 – 21925RIP homotypic interaction motif (RHIM) 1Add
    BLAST
    Motifi253 – 27725RIP homotypic interaction motif (RHIM) 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 DRADA repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG38978.
    HOGENOMiHOG000230878.
    HOVERGENiHBG036279.
    KOiK12965.
    OMAiRLEYAYH.
    OrthoDBiEOG70S75W.
    PhylomeDBiQ9H171.
    TreeFamiTF337658.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR000607. dsRNA_A_deaminase.
    IPR025735. RHIM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF12721. RHIM. 2 hits.
    PF02295. z-alpha. 2 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9H171-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQAPADPGR EGHLEQRILQ VLTEAGSPVK LAQLVKECQA PKRELNQVLY    50
    RMKKELKVSL TSPATWCLGG TDPEGEGPAE LALSSPAERP QQHAATIPET 100
    PGPQFSQQRE EDIYRFLKDN GPQRALVIAQ ALGMRTAKDV NRDLYRMKSR 150
    HLLDMDEQSK AWTIYRPEDS GRRAKSASII YQHNPINMIC QNGPNSWISI 200
    ANSEAIQIGH GNIITRQTVS REDGSAGPRH LPSMAPGDSS TWGTLVDPWG 250
    PQDIHMEQSI LRRVQLGHSN EMRLHGVPSE GPAHIPPGSP PVSATAAGPE 300
    ASFEARIPSP GTHPEGEAAQ RIHMKSCFLE DATIGNSNKM SISPGVAGPG 350
    GVAGSGEGEP GEDAGRRPAD TQSRSHFPRD IGQPITPSHS KLTPKLETMT 400
    LGNRSHKAAE GSHYVDEASH EGSWWGGGI 429
    Length:429
    Mass (Da):46,343
    Last modified:July 19, 2005 - v2
    Checksum:i2C9B195112822991
    GO
    Isoform 2 (identifier: Q9H171-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         365-429: GRRPADTQSR...HEGSWWGGGI → VAAFTEVLNP...HKIYLLKNKK

    Show »
    Length:446
    Mass (Da):48,754
    Checksum:iAB6807A7F1397076
    GO
    Isoform 3 (identifier: Q9H171-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         365-429: GRRPADTQSR...HEGSWWGGGI → GRRPADTQSRSFDGQE

    Show »
    Length:380
    Mass (Da):41,028
    Checksum:i247472C6F85CEB36
    GO
    Isoform 4 (identifier: Q9H171-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         87-109: Missing.

    Show »
    Length:406
    Mass (Da):43,786
    Checksum:i709506D06777E8F2
    GO
    Isoform 5 (identifier: Q9H171-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         87-149: AERPQQHAAT...VNRDLYRMKS → GNCHPGEAGL...LTAGLLGRGC
         150-429: Missing.

    Show »
    Length:149
    Mass (Da):15,985
    Checksum:i1D948BB00599314B
    GO
    Isoform 6 (identifier: Q9H171-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         225-248: SAGPRHLPSMAPGDSSTWGTLVDP → KSPKRAQGGDLGGEPPDPLGGGKG
         249-429: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:248
    Mass (Da):27,218
    Checksum:iE79D75F5D4FE665C
    GO
    Isoform 7 (identifier: Q9H171-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-86: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:354
    Mass (Da):38,220
    Checksum:i162A79FBD15B1B0F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171R → I.
    Corresponds to variant rs35813125 [ dbSNP | Ensembl ].
    VAR_057030
    Natural varianti53 – 531K → R.
    Corresponds to variant rs35895307 [ dbSNP | Ensembl ].
    VAR_061728
    Natural varianti70 – 701G → R.
    Corresponds to variant rs34964609 [ dbSNP | Ensembl ].
    VAR_057031
    Natural varianti88 – 881E → K.2 Publications
    Corresponds to variant rs2073145 [ dbSNP | Ensembl ].
    VAR_014316
    Natural varianti154 – 1541D → H.
    Corresponds to variant rs16981187 [ dbSNP | Ensembl ].
    VAR_057032
    Natural varianti166 – 1661R → H.
    Corresponds to variant rs34478944 [ dbSNP | Ensembl ].
    VAR_057033
    Natural varianti258 – 2581Q → R.3 Publications
    Corresponds to variant rs2865394 [ dbSNP | Ensembl ].
    VAR_069138
    Natural varianti332 – 3321A → V.
    Corresponds to variant rs41275648 [ dbSNP | Ensembl ].
    VAR_061729

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei12 – 8675Missing in isoform 7. 1 PublicationVSP_046081Add
    BLAST
    Alternative sequencei87 – 14963AERPQ…YRMKS → GNCHPGEAGLTLQGASWQWT STDLSLGSNLNSATWELTGF LSLCLGFFFWLMELTAGLLG RGC in isoform 5. 1 PublicationVSP_004079Add
    BLAST
    Alternative sequencei87 – 10923Missing in isoform 4. CuratedVSP_004078Add
    BLAST
    Alternative sequencei150 – 429280Missing in isoform 5. 1 PublicationVSP_004080Add
    BLAST
    Alternative sequencei225 – 24824SAGPR…TLVDP → KSPKRAQGGDLGGEPPDPLG GGKG in isoform 6. 1 PublicationVSP_045405Add
    BLAST
    Alternative sequencei249 – 429181Missing in isoform 6. 1 PublicationVSP_045406Add
    BLAST
    Alternative sequencei365 – 42965GRRPA…WGGGI → VAAFTEVLNPSKSFMKFGIN FFQTPVNVDSLTSSHESQMF LTACRLVIFSRRFSTYFAQI HLRNHSVLHLCPHKIYLLKN KK in isoform 2. CuratedVSP_004081Add
    BLAST
    Alternative sequencei365 – 42965GRRPA…WGGGI → GRRPADTQSRSFDGQE in isoform 3. CuratedVSP_004082Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ300575 mRNA. Translation: CAC18810.1.
    CT002036 mRNA. No translation available.
    AK122761 mRNA. Translation: BAG53713.1.
    AL035541 Genomic DNA. Translation: CAI23107.1.
    AL035541 Genomic DNA. Translation: CAM28299.1.
    CH471077 Genomic DNA. Translation: EAW75511.1.
    BC028218 mRNA. Translation: AAH28218.1.
    CCDSiCCDS13461.1. [Q9H171-1]
    CCDS54477.1. [Q9H171-7]
    CCDS54478.1. [Q9H171-6]
    RefSeqiNP_001153889.1. NM_001160417.1.
    NP_001153890.1. NM_001160418.1. [Q9H171-7]
    NP_001153891.1. NM_001160419.2. [Q9H171-6]
    NP_110403.2. NM_030776.2. [Q9H171-1]
    UniGeneiHs.302123.

    Genome annotation databases

    EnsembliENST00000371173; ENSP00000360215; ENSG00000124256. [Q9H171-1]
    ENST00000395822; ENSP00000379167; ENSG00000124256. [Q9H171-7]
    ENST00000541799; ENSP00000440552; ENSG00000124256. [Q9H171-6]
    GeneIDi81030.
    KEGGihsa:81030.
    UCSCiuc002xyo.3. human. [Q9H171-1]

    Polymorphism databases

    DMDMi71153189.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ300575 mRNA. Translation: CAC18810.1 .
    CT002036 mRNA. No translation available.
    AK122761 mRNA. Translation: BAG53713.1 .
    AL035541 Genomic DNA. Translation: CAI23107.1 .
    AL035541 Genomic DNA. Translation: CAM28299.1 .
    CH471077 Genomic DNA. Translation: EAW75511.1 .
    BC028218 mRNA. Translation: AAH28218.1 .
    CCDSi CCDS13461.1. [Q9H171-1 ]
    CCDS54477.1. [Q9H171-7 ]
    CCDS54478.1. [Q9H171-6 ]
    RefSeqi NP_001153889.1. NM_001160417.1.
    NP_001153890.1. NM_001160418.1. [Q9H171-7 ]
    NP_001153891.1. NM_001160419.2. [Q9H171-6 ]
    NP_110403.2. NM_030776.2. [Q9H171-1 ]
    UniGenei Hs.302123.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L4M NMR - A 103-166 [» ]
    2LNB NMR - A 6-74 [» ]
    3EYI X-ray 1.45 A/B 103-166 [» ]
    4KA4 X-ray 2.60 A/B/D/E 96-165 [» ]
    ProteinModelPortali Q9H171.
    SMRi Q9H171. Positions 6-74, 103-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123349. 10 interactions.
    DIPi DIP-44121N.
    IntActi Q9H171. 6 interactions.
    MINTi MINT-6167522.
    STRINGi 9606.ENSP00000360215.

    PTM databases

    PhosphoSitei Q9H171.

    Polymorphism databases

    DMDMi 71153189.

    Proteomic databases

    PaxDbi Q9H171.
    PRIDEi Q9H171.

    Protocols and materials databases

    DNASUi 81030.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371173 ; ENSP00000360215 ; ENSG00000124256 . [Q9H171-1 ]
    ENST00000395822 ; ENSP00000379167 ; ENSG00000124256 . [Q9H171-7 ]
    ENST00000541799 ; ENSP00000440552 ; ENSG00000124256 . [Q9H171-6 ]
    GeneIDi 81030.
    KEGGi hsa:81030.
    UCSCi uc002xyo.3. human. [Q9H171-1 ]

    Organism-specific databases

    CTDi 81030.
    GeneCardsi GC20M056178.
    H-InvDB HIX0203057.
    HGNCi HGNC:16176. ZBP1.
    HPAi HPA041256.
    MIMi 606750. gene.
    neXtProti NX_Q9H171.
    PharmGKBi PA38094.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38978.
    HOGENOMi HOG000230878.
    HOVERGENi HBG036279.
    KOi K12965.
    OMAi RLEYAYH.
    OrthoDBi EOG70S75W.
    PhylomeDBi Q9H171.
    TreeFami TF337658.

    Enzyme and pathway databases

    Reactomei REACT_118563. RIP-mediated NFkB activation via ZBP1.
    REACT_118764. ZBP1(DAI) mediated induction of type I IFNs.
    REACT_118811. IRF3 mediated activation of type 1 IFN.
    REACT_163977. Regulation of innate immune responses to cytosolic DNA.
    REACT_163993. IRF3-mediated induction of type I IFN.

    Miscellaneous databases

    EvolutionaryTracei Q9H171.
    GeneWikii ZBP1.
    GenomeRNAii 81030.
    NextBioi 71358.
    PROi Q9H171.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H171.
    CleanExi HS_ZBP1.
    Genevestigatori Q9H171.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR000607. dsRNA_A_deaminase.
    IPR025735. RHIM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF12721. RHIM. 2 hits.
    PF02295. z-alpha. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complex regulation of the human gene for the Z-DNA binding protein DLM-1."
      Rothenburg S., Schwartz T., Koch-Nolte F., Haag F.
      Nucleic Acids Res. 30:993-1000(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANTS LYS-88 AND ARG-258.
      Tissue: Spleen.
    2. Heil O., Ebert L., Hennig S., Henze S., Radelof U., Schneider D., Korn B.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT LYS-88.
      Tissue: T-cell.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANT ARG-258.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-258.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Blood.
    7. "The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA."
      Ha S.C., Kim D., Hwang H.Y., Rich A., Kim Y.G., Kim K.K.
      Proc. Natl. Acad. Sci. U.S.A. 105:20671-20676(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 103-166, DNA-BINDING.

    Entry informationi

    Entry nameiZBP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H171
    Secondary accession number(s): A2A2F7
    , B3KVA1, F5GYT1, Q5JY39, Q9BYW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3