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Q9H171

- ZBP1_HUMAN

UniProt

Q9H171 - ZBP1_HUMAN

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Protein

Z-DNA-binding protein 1

Gene
ZBP1, C20orf183, DLM1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 By similarity.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. double-stranded RNA adenosine deaminase activity Source: InterPro
  3. left-handed Z-DNA binding Source: UniProtKB
  4. protein binding Source: IntAct
  5. RNA binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: Reactome
  2. positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
  3. positive regulation of type I interferon production Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_118563. RIP-mediated NFkB activation via ZBP1.
REACT_118764. ZBP1(DAI) mediated induction of type I IFNs.
REACT_118811. IRF3 mediated activation of type 1 IFN.
REACT_163977. Regulation of innate immune responses to cytosolic DNA.
REACT_163993. IRF3-mediated induction of type I IFN.

Names & Taxonomyi

Protein namesi
Recommended name:
Z-DNA-binding protein 1
Alternative name(s):
Tumor stroma and activated macrophage protein DLM-1
Gene namesi
Name:ZBP1
Synonyms:C20orf183, DLM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16176. ZBP1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38094.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Z-DNA-binding protein 1PRO_0000066564Add
BLAST

Proteomic databases

PaxDbiQ9H171.
PRIDEiQ9H171.

PTM databases

PhosphoSiteiQ9H171.

Expressioni

Tissue specificityi

Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.

Gene expression databases

BgeeiQ9H171.
CleanExiHS_ZBP1.
GenevestigatoriQ9H171.

Organism-specific databases

HPAiHPA041256.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRR1Q136013EBI-6264672,EBI-744525
RIPK3Q9Y5724EBI-6264672,EBI-298250

Protein-protein interaction databases

BioGridi123349. 10 interactions.
DIPiDIP-44121N.
IntActiQ9H171. 6 interactions.
MINTiMINT-6167522.
STRINGi9606.ENSP00000360215.

Structurei

Secondary structure

1
429
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2516
Helixi31 – 388
Helixi42 – 5413
Beta strandi57 – 626
Beta strandi65 – 728
Helixi108 – 12013
Beta strandi122 – 1243
Helixi125 – 1317
Helixi137 – 1393
Helixi141 – 1499
Beta strandi152 – 1554
Turni157 – 1593
Beta strandi161 – 1644

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L4MNMR-A103-166[»]
2LNBNMR-A6-74[»]
3EYIX-ray1.45A/B103-166[»]
4KA4X-ray2.60A/B/D/E96-165[»]
ProteinModelPortaliQ9H171.
SMRiQ9H171. Positions 6-74, 103-165.

Miscellaneous databases

EvolutionaryTraceiQ9H171.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 7267DRADA 1Add
BLAST
Repeati103 – 16866DRADA 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi195 – 21925RIP homotypic interaction motif (RHIM) 1Add
BLAST
Motifi253 – 27725RIP homotypic interaction motif (RHIM) 2Add
BLAST

Sequence similaritiesi

Contains 2 DRADA repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG38978.
HOGENOMiHOG000230878.
HOVERGENiHBG036279.
KOiK12965.
OMAiRLEYAYH.
OrthoDBiEOG70S75W.
PhylomeDBiQ9H171.
TreeFamiTF337658.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR000607. dsRNA_A_deaminase.
IPR025735. RHIM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12721. RHIM. 2 hits.
PF02295. z-alpha. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9H171-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQAPADPGR EGHLEQRILQ VLTEAGSPVK LAQLVKECQA PKRELNQVLY    50
RMKKELKVSL TSPATWCLGG TDPEGEGPAE LALSSPAERP QQHAATIPET 100
PGPQFSQQRE EDIYRFLKDN GPQRALVIAQ ALGMRTAKDV NRDLYRMKSR 150
HLLDMDEQSK AWTIYRPEDS GRRAKSASII YQHNPINMIC QNGPNSWISI 200
ANSEAIQIGH GNIITRQTVS REDGSAGPRH LPSMAPGDSS TWGTLVDPWG 250
PQDIHMEQSI LRRVQLGHSN EMRLHGVPSE GPAHIPPGSP PVSATAAGPE 300
ASFEARIPSP GTHPEGEAAQ RIHMKSCFLE DATIGNSNKM SISPGVAGPG 350
GVAGSGEGEP GEDAGRRPAD TQSRSHFPRD IGQPITPSHS KLTPKLETMT 400
LGNRSHKAAE GSHYVDEASH EGSWWGGGI 429
Length:429
Mass (Da):46,343
Last modified:July 19, 2005 - v2
Checksum:i2C9B195112822991
GO
Isoform 2 (identifier: Q9H171-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-429: GRRPADTQSR...HEGSWWGGGI → VAAFTEVLNP...HKIYLLKNKK

Show »
Length:446
Mass (Da):48,754
Checksum:iAB6807A7F1397076
GO
Isoform 3 (identifier: Q9H171-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-429: GRRPADTQSR...HEGSWWGGGI → GRRPADTQSRSFDGQE

Show »
Length:380
Mass (Da):41,028
Checksum:i247472C6F85CEB36
GO
Isoform 4 (identifier: Q9H171-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-109: Missing.

Show »
Length:406
Mass (Da):43,786
Checksum:i709506D06777E8F2
GO
Isoform 5 (identifier: Q9H171-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-149: AERPQQHAAT...VNRDLYRMKS → GNCHPGEAGL...LTAGLLGRGC
     150-429: Missing.

Show »
Length:149
Mass (Da):15,985
Checksum:i1D948BB00599314B
GO
Isoform 6 (identifier: Q9H171-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-248: SAGPRHLPSMAPGDSSTWGTLVDP → KSPKRAQGGDLGGEPPDPLGGGKG
     249-429: Missing.

Note: No experimental confirmation available.

Show »
Length:248
Mass (Da):27,218
Checksum:iE79D75F5D4FE665C
GO
Isoform 7 (identifier: Q9H171-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-86: Missing.

Note: No experimental confirmation available.

Show »
Length:354
Mass (Da):38,220
Checksum:i162A79FBD15B1B0F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171R → I.
Corresponds to variant rs35813125 [ dbSNP | Ensembl ].
VAR_057030
Natural varianti53 – 531K → R.
Corresponds to variant rs35895307 [ dbSNP | Ensembl ].
VAR_061728
Natural varianti70 – 701G → R.
Corresponds to variant rs34964609 [ dbSNP | Ensembl ].
VAR_057031
Natural varianti88 – 881E → K.2 Publications
Corresponds to variant rs2073145 [ dbSNP | Ensembl ].
VAR_014316
Natural varianti154 – 1541D → H.
Corresponds to variant rs16981187 [ dbSNP | Ensembl ].
VAR_057032
Natural varianti166 – 1661R → H.
Corresponds to variant rs34478944 [ dbSNP | Ensembl ].
VAR_057033
Natural varianti258 – 2581Q → R.3 Publications
Corresponds to variant rs2865394 [ dbSNP | Ensembl ].
VAR_069138
Natural varianti332 – 3321A → V.
Corresponds to variant rs41275648 [ dbSNP | Ensembl ].
VAR_061729

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 8675Missing in isoform 7. VSP_046081Add
BLAST
Alternative sequencei87 – 14963AERPQ…YRMKS → GNCHPGEAGLTLQGASWQWT STDLSLGSNLNSATWELTGF LSLCLGFFFWLMELTAGLLG RGC in isoform 5. VSP_004079Add
BLAST
Alternative sequencei87 – 10923Missing in isoform 4. VSP_004078Add
BLAST
Alternative sequencei150 – 429280Missing in isoform 5. VSP_004080Add
BLAST
Alternative sequencei225 – 24824SAGPR…TLVDP → KSPKRAQGGDLGGEPPDPLG GGKG in isoform 6. VSP_045405Add
BLAST
Alternative sequencei249 – 429181Missing in isoform 6. VSP_045406Add
BLAST
Alternative sequencei365 – 42965GRRPA…WGGGI → VAAFTEVLNPSKSFMKFGIN FFQTPVNVDSLTSSHESQMF LTACRLVIFSRRFSTYFAQI HLRNHSVLHLCPHKIYLLKN KK in isoform 2. VSP_004081Add
BLAST
Alternative sequencei365 – 42965GRRPA…WGGGI → GRRPADTQSRSFDGQE in isoform 3. VSP_004082Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ300575 mRNA. Translation: CAC18810.1.
CT002036 mRNA. No translation available.
AK122761 mRNA. Translation: BAG53713.1.
AL035541 Genomic DNA. Translation: CAI23107.1.
AL035541 Genomic DNA. Translation: CAM28299.1.
CH471077 Genomic DNA. Translation: EAW75511.1.
BC028218 mRNA. Translation: AAH28218.1.
CCDSiCCDS13461.1. [Q9H171-1]
CCDS54477.1. [Q9H171-7]
CCDS54478.1. [Q9H171-6]
RefSeqiNP_001153889.1. NM_001160417.1.
NP_001153890.1. NM_001160418.1. [Q9H171-7]
NP_001153891.1. NM_001160419.2. [Q9H171-6]
NP_110403.2. NM_030776.2. [Q9H171-1]
UniGeneiHs.302123.

Genome annotation databases

EnsembliENST00000340462; ENSP00000344954; ENSG00000124256. [Q9H171-4]
ENST00000343535; ENSP00000340584; ENSG00000124256. [Q9H171-2]
ENST00000371173; ENSP00000360215; ENSG00000124256. [Q9H171-1]
ENST00000395822; ENSP00000379167; ENSG00000124256. [Q9H171-7]
ENST00000541799; ENSP00000440552; ENSG00000124256. [Q9H171-6]
GeneIDi81030.
KEGGihsa:81030.
UCSCiuc002xyo.3. human. [Q9H171-1]

Polymorphism databases

DMDMi71153189.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ300575 mRNA. Translation: CAC18810.1 .
CT002036 mRNA. No translation available.
AK122761 mRNA. Translation: BAG53713.1 .
AL035541 Genomic DNA. Translation: CAI23107.1 .
AL035541 Genomic DNA. Translation: CAM28299.1 .
CH471077 Genomic DNA. Translation: EAW75511.1 .
BC028218 mRNA. Translation: AAH28218.1 .
CCDSi CCDS13461.1. [Q9H171-1 ]
CCDS54477.1. [Q9H171-7 ]
CCDS54478.1. [Q9H171-6 ]
RefSeqi NP_001153889.1. NM_001160417.1.
NP_001153890.1. NM_001160418.1. [Q9H171-7 ]
NP_001153891.1. NM_001160419.2. [Q9H171-6 ]
NP_110403.2. NM_030776.2. [Q9H171-1 ]
UniGenei Hs.302123.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L4M NMR - A 103-166 [» ]
2LNB NMR - A 6-74 [» ]
3EYI X-ray 1.45 A/B 103-166 [» ]
4KA4 X-ray 2.60 A/B/D/E 96-165 [» ]
ProteinModelPortali Q9H171.
SMRi Q9H171. Positions 6-74, 103-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123349. 10 interactions.
DIPi DIP-44121N.
IntActi Q9H171. 6 interactions.
MINTi MINT-6167522.
STRINGi 9606.ENSP00000360215.

PTM databases

PhosphoSitei Q9H171.

Polymorphism databases

DMDMi 71153189.

Proteomic databases

PaxDbi Q9H171.
PRIDEi Q9H171.

Protocols and materials databases

DNASUi 81030.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340462 ; ENSP00000344954 ; ENSG00000124256 . [Q9H171-4 ]
ENST00000343535 ; ENSP00000340584 ; ENSG00000124256 . [Q9H171-2 ]
ENST00000371173 ; ENSP00000360215 ; ENSG00000124256 . [Q9H171-1 ]
ENST00000395822 ; ENSP00000379167 ; ENSG00000124256 . [Q9H171-7 ]
ENST00000541799 ; ENSP00000440552 ; ENSG00000124256 . [Q9H171-6 ]
GeneIDi 81030.
KEGGi hsa:81030.
UCSCi uc002xyo.3. human. [Q9H171-1 ]

Organism-specific databases

CTDi 81030.
GeneCardsi GC20M056178.
H-InvDB HIX0203057.
HGNCi HGNC:16176. ZBP1.
HPAi HPA041256.
MIMi 606750. gene.
neXtProti NX_Q9H171.
PharmGKBi PA38094.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG38978.
HOGENOMi HOG000230878.
HOVERGENi HBG036279.
KOi K12965.
OMAi RLEYAYH.
OrthoDBi EOG70S75W.
PhylomeDBi Q9H171.
TreeFami TF337658.

Enzyme and pathway databases

Reactomei REACT_118563. RIP-mediated NFkB activation via ZBP1.
REACT_118764. ZBP1(DAI) mediated induction of type I IFNs.
REACT_118811. IRF3 mediated activation of type 1 IFN.
REACT_163977. Regulation of innate immune responses to cytosolic DNA.
REACT_163993. IRF3-mediated induction of type I IFN.

Miscellaneous databases

EvolutionaryTracei Q9H171.
GeneWikii ZBP1.
GenomeRNAii 81030.
NextBioi 71358.
PROi Q9H171.
SOURCEi Search...

Gene expression databases

Bgeei Q9H171.
CleanExi HS_ZBP1.
Genevestigatori Q9H171.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
InterProi IPR000607. dsRNA_A_deaminase.
IPR025735. RHIM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF12721. RHIM. 2 hits.
PF02295. z-alpha. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complex regulation of the human gene for the Z-DNA binding protein DLM-1."
    Rothenburg S., Schwartz T., Koch-Nolte F., Haag F.
    Nucleic Acids Res. 30:993-1000(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANTS LYS-88 AND ARG-258.
    Tissue: Spleen.
  2. Heil O., Ebert L., Hennig S., Henze S., Radelof U., Schneider D., Korn B.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT LYS-88.
    Tissue: T-cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANT ARG-258.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-258.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Blood.
  7. "The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA."
    Ha S.C., Kim D., Hwang H.Y., Rich A., Kim Y.G., Kim K.K.
    Proc. Natl. Acad. Sci. U.S.A. 105:20671-20676(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 103-166, DNA-BINDING.

Entry informationi

Entry nameiZBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H171
Secondary accession number(s): A2A2F7
, B3KVA1, F5GYT1, Q5JY39, Q9BYW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 19, 2005
Last modified: September 3, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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