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Protein

Stathmin-4

Gene

STMN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits microtubule-destabilizing activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-4
Alternative name(s):
Stathmin-like protein B3
Short name:
RB3
Gene namesi
Name:STMN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000015592.16
HGNCiHGNC:16078 STMN4
neXtProtiNX_Q9H169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi81551
OpenTargetsiENSG00000015592
PharmGKBiPA38089

Chemistry databases

DrugBankiDB01206 Lomustine

Polymorphism and mutation databases

DMDMi17368936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824061 – 189Stathmin-4Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20S-palmitoyl cysteineBy similarity1
Lipidationi22S-palmitoyl cysteineBy similarity1
Modified residuei90PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9H169
PeptideAtlasiQ9H169
PRIDEiQ9H169

PTM databases

iPTMnetiQ9H169
PhosphoSitePlusiQ9H169

Expressioni

Gene expression databases

BgeeiENSG00000015592
CleanExiHS_STMN4
ExpressionAtlasiQ9H169 baseline and differential
GenevisibleiQ9H169 HS

Organism-specific databases

HPAiHPA027765

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123515, 17 interactors
IntActiQ9H169, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9H169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 189SLDPROSITE-ProRule annotationAdd BLAST142

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 188Sequence analysisAdd BLAST99

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiQ9H169
OMAiTVDLTWC
PhylomeDBiQ9H169
TreeFamiTF326935

Family and domain databases

InterProiView protein in InterPro
IPR028834 Stathmin-4
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 2 hits
PTHR10104:SF6 PTHR10104:SF6, 2 hits
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H169-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEADTV DLNWCVISDM
60 70 80 90 100
EVIELNKCTS GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA
110 120 130 140 150
AEERRKYQEA ELLKHLAEKR EHEREVIQKA IEENNNFIKM AKEKLAQKME
160 170 180
SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR
Length:189
Mass (Da):22,071
Last modified:March 1, 2001 - v1
Checksum:i861BBD533D3849AC
GO
Isoform 2 (identifier: Q9H169-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: E → EGWCGRQCRRKDESQRKDSADWRERRAQ

Show »
Length:216
Mass (Da):25,418
Checksum:i9B9FCE70A39F20B0
GO
Isoform 3 (identifier: Q9H169-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     171-188: DKHAEEVRKNKELKEEAS → EPPAA

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):19,378
Checksum:i3EE89D84248BC91A
GO
Isoform 4 (identifier: Q9H169-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: E → EGWCGRQCRRKDESQRKDSADWRERRAQ
     171-188: DKHAEEVRKNKELKEEAS → EPPAA

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):23,761
Checksum:i237ED0D212AE12F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11K → M in BAH12575 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552791 – 9Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_00627936E → EGWCGRQCRRKDESQRKDSA DWRERRAQ in isoform 2 and isoform 4. 2 Publications1
Alternative sequenceiVSP_055280171 – 188DKHAE…KEEAS → EPPAA in isoform 3 and isoform 4. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303455 mRNA Translation: CAC22254.1
AL136568 mRNA Translation: CAB66503.1
AK295329 mRNA Translation: BAH12033.1
AK297415 mRNA Translation: BAH12575.1
AC090150 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63562.1
CH471080 Genomic DNA Translation: EAW63563.1
CH471080 Genomic DNA Translation: EAW63565.1
CH471080 Genomic DNA Translation: EAW63567.1
BC011520 mRNA Translation: AAH11520.1
BC111001 mRNA Translation: AAI11002.1
CCDSiCCDS6055.1 [Q9H169-2]
CCDS64851.1 [Q9H169-3]
CCDS64852.1 [Q9H169-1]
CCDS64854.1 [Q9H169-4]
RefSeqiNP_001269982.1, NM_001283053.1 [Q9H169-4]
NP_001269983.1, NM_001283054.1 [Q9H169-1]
NP_001269984.1, NM_001283055.1 [Q9H169-3]
NP_110422.2, NM_030795.3 [Q9H169-2]
UniGeneiHs.201058
Hs.734948

Genome annotation databases

EnsembliENST00000265770; ENSP00000265770; ENSG00000015592 [Q9H169-1]
ENST00000350889; ENSP00000342538; ENSG00000015592 [Q9H169-2]
ENST00000519997; ENSP00000428474; ENSG00000015592 [Q9H169-3]
ENST00000523048; ENSP00000428428; ENSG00000015592 [Q9H169-4]
GeneIDi81551
KEGGihsa:81551
UCSCiuc003xfj.5 human [Q9H169-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTMN4_HUMAN
AccessioniPrimary (citable) accession number: Q9H169
Secondary accession number(s): B7Z2Z7
, B7Z4I9, D3DSS8, D3DSS9, G5EA16, Q2TAB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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