Q9H169 (STMN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Stathmin-4

Alternative name(s):
Stathmin-like protein B3
Short name=RB3

Gene names

Name:

STMN4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Exhibits microtubule-destabilizing activity By similarity.
Subcellular location	Golgi apparatus By similarity. Cell projection › growth cone By similarity. Cell projection › axon By similarity.
Sequence similarities	Belongs to the stathmin family. Contains 1 SLD (stathmin-like) domain.

Ontologies

Keywords
Cellular component	Cell projection Golgi apparatus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of microtubule polymerization or depolymerization Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell axon Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H169-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H169-2)

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: E → EGWCGRQCRRKDESQRKDSADWRERRAQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Stathmin-4		PRO_0000182406
Regions
	Domain	48 – 189	142	SLD
	Coiled coil	90 – 188	99	Potential
Amino acid modifications
	Lipidation	20	1	S-palmitoyl cysteine Probable
	Lipidation	22	1	S-palmitoyl cysteine Probable
Natural variations
	Alternative sequence	36	1	E → EGWCGRQCRRKDESQRKDSA DWRERRAQ in isoform 2.		VSP_006279

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 861BBD533D3849AC	FASTA	189	22,071
	10 20 30 40 50 60 MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEADTV DLNWCVISDM EVIELNKCTS 70 80 90 100 110 120 GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA AEERRKYQEA ELLKHLAEKR 130 140 150 160 170 180 EHEREVIQKA IEENNNFIKM AKEKLAQKME SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR
	Isoform 2 [UniParc]. Checksum: 9B9FCE70A39F20B0	FASTA	216	25,418
	10 20 30 40 50 60 MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEGWCG RQCRRKDESQ RKDSADWRER 70 80 90 100 110 120 RAQADTVDLN WCVISDMEVI ELNKCTSGQS FEVILKPPSF DGVPEFNASL PRRRDPSLEE 130 140 150 160 170 180 IQKKLEAAEE RRKYQEAELL KHLAEKREHE REVIQKAIEE NNNFIKMAKE KLAQKMESNK 190 200 210 ENREAHLAAM LERLQEKDKH AEEVRKNKEL KEEASR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of the human RB3 gene." Coadwell W.J., Mimmack M.L. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ303455 mRNA. Translation: CAC22254.1. AL136568 mRNA. Translation: CAB66503.1. CH471080 Genomic DNA. Translation: EAW63563.1. CH471080 Genomic DNA. Translation: EAW63565.1. CH471080 Genomic DNA. Translation: EAW63567.1. BC011520 mRNA. Translation: AAH11520.1. BC111001 mRNA. Translation: AAI11002.1.
IPI	IPI00006572. IPI00216921.
RefSeq	NP_110422.2. NM_030795.2.
UniGene	Hs.201058.
3D structure databases
ProteinModelPortal	Q9H169.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H169. 2 interactions.
MINT	MINT-1402998.
STRING	9606.ENSP00000342538.
PTM databases
PhosphoSite	Q9H169.
Polymorphism databases
DMDM	17368936.
Proteomic databases
PaxDb	Q9H169.
PRIDE	Q9H169.
Protocols and materials databases
DNASU	81551.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265770; ENSP00000265770; ENSG00000015592. ENST00000350889; ENSP00000342538; ENSG00000015592.
GeneID	81551.
KEGG	hsa:81551.
UCSC	uc003xfj.3. human. uc003xfk.3. human.
Organism-specific databases
CTD	81551.
GeneCards	GC08M027092.
HGNC	HGNC:16078. STMN4.
HPA	HPA027765.
neXtProt	NX_Q9H169.
PharmGKB	PA38089.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG70176.
HOGENOM	HOG000013197.
HOVERGEN	HBG054037.
OMA	KAFEENN.
OrthoDB	EOG46MBKT.
Gene expression databases
ArrayExpress	Q9H169.
Bgee	Q9H169.
CleanEx	HS_STMN4.
Genevestigator	Q9H169.
GermOnline	ENSG00000015592. Homo sapiens.
Family and domain databases
InterPro	IPR000956. Stathmin_fam. [Graphical view]
PANTHER	PTHR10104. PTHR10104. 1 hit.
Pfam	PF00836. Stathmin. 1 hit. [Graphical view]
PIRSF	PIRSF002285. Stathmin. 1 hit.
PRINTS	PR00345. STATHMIN.
SUPFAM	SSF101494. Stathmin. 1 hit.
PROSITE	PS00563. STATHMIN_1. 1 hit. PS01041. STATHMIN_2. 1 hit. PS51663. STATHMIN_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81551.
NextBio	71795.

Entry information

Entry name

STMN4_HUMAN

Accession

Primary (citable) accession number: Q9H169
Secondary accession number(s): D3DSS8, D3DSS9, Q2TAB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.