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Q9H169 (STMN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stathmin-4
Alternative name(s):
Stathmin-like protein B3
Short name=RB3
Gene names
Name:STMN4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Exhibits microtubule-destabilizing activity By similarity.

Subcellular location

Golgi apparatus By similarity. Cell projectiongrowth cone By similarity. Cell projectionaxon By similarity.

Sequence similarities

Belongs to the stathmin family.

Contains 1 SLD (stathmin-like) domain.

Ontologies

Keywords
   Cellular componentCell projection
Golgi apparatus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of microtubule polymerization or depolymerization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

axon

Inferred from electronic annotation. Source: UniProtKB-SubCell

growth cone

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H169-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H169-2)

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: E → EGWCGRQCRRKDESQRKDSADWRERRAQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Stathmin-4
PRO_0000182406

Regions

Domain48 – 189142SLD
Coiled coil90 – 18899 Potential

Amino acid modifications

Lipidation201S-palmitoyl cysteine Probable
Lipidation221S-palmitoyl cysteine Probable

Natural variations

Alternative sequence361E → EGWCGRQCRRKDESQRKDSA DWRERRAQ in isoform 2.
VSP_006279

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 861BBD533D3849AC

FASTA18922,071
        10         20         30         40         50         60 
MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEADTV DLNWCVISDM EVIELNKCTS 

        70         80         90        100        110        120 
GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA AEERRKYQEA ELLKHLAEKR 

       130        140        150        160        170        180 
EHEREVIQKA IEENNNFIKM AKEKLAQKME SNKENREAHL AAMLERLQEK DKHAEEVRKN 


KELKEEASR 

« Hide

Isoform 2 [UniParc].

Checksum: 9B9FCE70A39F20B0
Show »

FASTA21625,418

References

« Hide 'large scale' references
[1]"The nucleotide sequence of the human RB3 gene."
Coadwell W.J., Mimmack M.L.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ303455 mRNA. Translation: CAC22254.1.
AL136568 mRNA. Translation: CAB66503.1.
CH471080 Genomic DNA. Translation: EAW63563.1.
CH471080 Genomic DNA. Translation: EAW63565.1.
CH471080 Genomic DNA. Translation: EAW63567.1.
BC011520 mRNA. Translation: AAH11520.1.
BC111001 mRNA. Translation: AAI11002.1.
RefSeqNP_001269983.1. NM_001283054.1.
NP_110422.2. NM_030795.3.
UniGeneHs.201058.
Hs.734948.

3D structure databases

ProteinModelPortalQ9H169.
SMRQ9H169. Positions 50-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123515. 3 interactions.
IntActQ9H169. 2 interactions.
MINTMINT-1402998.
STRING9606.ENSP00000342538.

PTM databases

PhosphoSiteQ9H169.

Polymorphism databases

DMDM17368936.

Proteomic databases

PaxDbQ9H169.
PRIDEQ9H169.

Protocols and materials databases

DNASU81551.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265770; ENSP00000265770; ENSG00000015592. [Q9H169-1]
ENST00000350889; ENSP00000342538; ENSG00000015592. [Q9H169-2]
GeneID81551.
KEGGhsa:81551.
UCSCuc003xfj.3. human. [Q9H169-2]
uc003xfk.3. human. [Q9H169-1]

Organism-specific databases

CTD81551.
GeneCardsGC08M027092.
HGNCHGNC:16078. STMN4.
HPAHPA027765.
neXtProtNX_Q9H169.
PharmGKBPA38089.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG70176.
HOGENOMHOG000013197.
HOVERGENHBG054037.
OMAKAFEENN.
OrthoDBEOG744TBN.
PhylomeDBQ9H169.
TreeFamTF326935.

Gene expression databases

ArrayExpressQ9H169.
BgeeQ9H169.
CleanExHS_STMN4.
GenevestigatorQ9H169.

Family and domain databases

InterProIPR028834. Stathmin-4.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF6. PTHR10104:SF6. 1 hit.
PfamPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFPIRSF002285. Stathmin. 1 hit.
PRINTSPR00345. STATHMIN.
SUPFAMSSF101494. SSF101494. 1 hit.
PROSITEPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi81551.
NextBio71795.
PROQ9H169.

Entry information

Entry nameSTMN4_HUMAN
AccessionPrimary (citable) accession number: Q9H169
Secondary accession number(s): D3DSS8, D3DSS9, Q2TAB9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM