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Protein

Stathmin-4

Gene

STMN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits microtubule-destabilizing activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-4
Alternative name(s):
Stathmin-like protein B3
Short name:
RB3
Gene namesi
Name:STMN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:16078. STMN4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38089.

Chemistry

DrugBankiDB01206. Lomustine.

Polymorphism and mutation databases

DMDMi17368936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Stathmin-4PRO_0000182406Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201S-palmitoyl cysteineCurated
Lipidationi22 – 221S-palmitoyl cysteineCurated

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9H169.
PaxDbiQ9H169.
PRIDEiQ9H169.

PTM databases

PhosphoSiteiQ9H169.

Expressioni

Gene expression databases

BgeeiQ9H169.
CleanExiHS_STMN4.
ExpressionAtlasiQ9H169. baseline and differential.
GenevisibleiQ9H169. HS.

Organism-specific databases

HPAiHPA027765.

Interactioni

Protein-protein interaction databases

BioGridi123515. 3 interactions.
IntActiQ9H169. 2 interactions.
MINTiMINT-1402998.

Structurei

3D structure databases

ProteinModelPortaliQ9H169.
SMRiQ9H169. Positions 50-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 189142SLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili90 – 18899Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG70176.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ9H169.
OMAiTVDLTWC.
OrthoDBiEOG744TBN.
PhylomeDBiQ9H169.
TreeFamiTF326935.

Family and domain databases

InterProiIPR028834. Stathmin-4.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF6. PTHR10104:SF6. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H169-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEADTV DLNWCVISDM
60 70 80 90 100
EVIELNKCTS GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA
110 120 130 140 150
AEERRKYQEA ELLKHLAEKR EHEREVIQKA IEENNNFIKM AKEKLAQKME
160 170 180
SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR
Length:189
Mass (Da):22,071
Last modified:March 1, 2001 - v1
Checksum:i861BBD533D3849AC
GO
Isoform 2 (identifier: Q9H169-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: E → EGWCGRQCRRKDESQRKDSADWRERRAQ

Show »
Length:216
Mass (Da):25,418
Checksum:i9B9FCE70A39F20B0
GO
Isoform 3 (identifier: Q9H169-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     171-188: DKHAEEVRKNKELKEEAS → EPPAA

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):19,378
Checksum:i3EE89D84248BC91A
GO
Isoform 4 (identifier: Q9H169-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: E → EGWCGRQCRRKDESQRKDSADWRERRAQ
     171-188: DKHAEEVRKNKELKEEAS → EPPAA

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):23,761
Checksum:i237ED0D212AE12F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111K → M in BAH12575 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99Missing in isoform 3. 1 PublicationVSP_055279
Alternative sequencei36 – 361E → EGWCGRQCRRKDESQRKDSA DWRERRAQ in isoform 2 and isoform 4. 2 PublicationsVSP_006279
Alternative sequencei171 – 18818DKHAE…KEEAS → EPPAA in isoform 3 and isoform 4. 1 PublicationVSP_055280Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303455 mRNA. Translation: CAC22254.1.
AL136568 mRNA. Translation: CAB66503.1.
AK295329 mRNA. Translation: BAH12033.1.
AK297415 mRNA. Translation: BAH12575.1.
AC090150 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63562.1.
CH471080 Genomic DNA. Translation: EAW63563.1.
CH471080 Genomic DNA. Translation: EAW63565.1.
CH471080 Genomic DNA. Translation: EAW63567.1.
BC011520 mRNA. Translation: AAH11520.1.
BC111001 mRNA. Translation: AAI11002.1.
CCDSiCCDS6055.1. [Q9H169-2]
CCDS64851.1. [Q9H169-3]
CCDS64852.1. [Q9H169-1]
CCDS64854.1. [Q9H169-4]
RefSeqiNP_001269982.1. NM_001283053.1. [Q9H169-4]
NP_001269983.1. NM_001283054.1. [Q9H169-1]
NP_001269984.1. NM_001283055.1. [Q9H169-3]
NP_110422.2. NM_030795.3. [Q9H169-2]
UniGeneiHs.201058.
Hs.734948.

Genome annotation databases

EnsembliENST00000265770; ENSP00000265770; ENSG00000015592.
ENST00000350889; ENSP00000342538; ENSG00000015592. [Q9H169-2]
ENST00000519997; ENSP00000428474; ENSG00000015592. [Q9H169-3]
ENST00000523048; ENSP00000428428; ENSG00000015592. [Q9H169-4]
GeneIDi81551.
KEGGihsa:81551.
UCSCiuc003xfj.3. human. [Q9H169-2]
uc003xfk.3. human. [Q9H169-1]
uc011laj.2. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303455 mRNA. Translation: CAC22254.1.
AL136568 mRNA. Translation: CAB66503.1.
AK295329 mRNA. Translation: BAH12033.1.
AK297415 mRNA. Translation: BAH12575.1.
AC090150 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63562.1.
CH471080 Genomic DNA. Translation: EAW63563.1.
CH471080 Genomic DNA. Translation: EAW63565.1.
CH471080 Genomic DNA. Translation: EAW63567.1.
BC011520 mRNA. Translation: AAH11520.1.
BC111001 mRNA. Translation: AAI11002.1.
CCDSiCCDS6055.1. [Q9H169-2]
CCDS64851.1. [Q9H169-3]
CCDS64852.1. [Q9H169-1]
CCDS64854.1. [Q9H169-4]
RefSeqiNP_001269982.1. NM_001283053.1. [Q9H169-4]
NP_001269983.1. NM_001283054.1. [Q9H169-1]
NP_001269984.1. NM_001283055.1. [Q9H169-3]
NP_110422.2. NM_030795.3. [Q9H169-2]
UniGeneiHs.201058.
Hs.734948.

3D structure databases

ProteinModelPortaliQ9H169.
SMRiQ9H169. Positions 50-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123515. 3 interactions.
IntActiQ9H169. 2 interactions.
MINTiMINT-1402998.

Chemistry

DrugBankiDB01206. Lomustine.

PTM databases

PhosphoSiteiQ9H169.

Polymorphism and mutation databases

DMDMi17368936.

Proteomic databases

MaxQBiQ9H169.
PaxDbiQ9H169.
PRIDEiQ9H169.

Protocols and materials databases

DNASUi81551.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265770; ENSP00000265770; ENSG00000015592.
ENST00000350889; ENSP00000342538; ENSG00000015592. [Q9H169-2]
ENST00000519997; ENSP00000428474; ENSG00000015592. [Q9H169-3]
ENST00000523048; ENSP00000428428; ENSG00000015592. [Q9H169-4]
GeneIDi81551.
KEGGihsa:81551.
UCSCiuc003xfj.3. human. [Q9H169-2]
uc003xfk.3. human. [Q9H169-1]
uc011laj.2. human.

Organism-specific databases

CTDi81551.
GeneCardsiGC08M027092.
HGNCiHGNC:16078. STMN4.
HPAiHPA027765.
neXtProtiNX_Q9H169.
PharmGKBiPA38089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70176.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ9H169.
OMAiTVDLTWC.
OrthoDBiEOG744TBN.
PhylomeDBiQ9H169.
TreeFamiTF326935.

Miscellaneous databases

GenomeRNAii81551.
NextBioi35479115.
PROiQ9H169.

Gene expression databases

BgeeiQ9H169.
CleanExiHS_STMN4.
ExpressionAtlasiQ9H169. baseline and differential.
GenevisibleiQ9H169. HS.

Family and domain databases

InterProiIPR028834. Stathmin-4.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF6. PTHR10104:SF6. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of the human RB3 gene."
    Coadwell W.J., Mimmack M.L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Brain and Caudate nucleus.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiSTMN4_HUMAN
AccessioniPrimary (citable) accession number: Q9H169
Secondary accession number(s): B7Z2Z7
, B7Z4I9, D3DSS8, D3DSS9, G5EA16, Q2TAB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.