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Q9H169

- STMN4_HUMAN

UniProt

Q9H169 - STMN4_HUMAN

Protein

Stathmin-4

Gene

STMN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Exhibits microtubule-destabilizing activity.By similarity

    GO - Biological processi

    1. regulation of microtubule polymerization or depolymerization Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stathmin-4
    Alternative name(s):
    Stathmin-like protein B3
    Short name:
    RB3
    Gene namesi
    Name:STMN4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:16078. STMN4.

    Subcellular locationi

    Golgi apparatus By similarity. Cell projectiongrowth cone By similarity. Cell projectionaxon By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. growth cone Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38089.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Stathmin-4PRO_0000182406Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi20 – 201S-palmitoyl cysteineCurated
    Lipidationi22 – 221S-palmitoyl cysteineCurated

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ9H169.
    PaxDbiQ9H169.
    PRIDEiQ9H169.

    PTM databases

    PhosphoSiteiQ9H169.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H169.
    BgeeiQ9H169.
    CleanExiHS_STMN4.
    GenevestigatoriQ9H169.

    Organism-specific databases

    HPAiHPA027765.

    Interactioni

    Protein-protein interaction databases

    BioGridi123515. 3 interactions.
    IntActiQ9H169. 2 interactions.
    MINTiMINT-1402998.
    STRINGi9606.ENSP00000342538.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H169.
    SMRiQ9H169. Positions 50-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 189142SLDPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili90 – 18899Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the stathmin family.Curated
    Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG70176.
    HOGENOMiHOG000013197.
    HOVERGENiHBG054037.
    OMAiTVDLTWC.
    OrthoDBiEOG744TBN.
    PhylomeDBiQ9H169.
    TreeFamiTF326935.

    Family and domain databases

    InterProiIPR028834. Stathmin-4.
    IPR000956. Stathmin_fam.
    [Graphical view]
    PANTHERiPTHR10104. PTHR10104. 1 hit.
    PTHR10104:SF6. PTHR10104:SF6. 1 hit.
    PfamiPF00836. Stathmin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002285. Stathmin. 1 hit.
    PRINTSiPR00345. STATHMIN.
    SUPFAMiSSF101494. SSF101494. 1 hit.
    PROSITEiPS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H169-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEADTV DLNWCVISDM    50
    EVIELNKCTS GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA 100
    AEERRKYQEA ELLKHLAEKR EHEREVIQKA IEENNNFIKM AKEKLAQKME 150
    SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR 189
    Length:189
    Mass (Da):22,071
    Last modified:March 1, 2001 - v1
    Checksum:i861BBD533D3849AC
    GO
    Isoform 2 (identifier: Q9H169-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-36: E → EGWCGRQCRRKDESQRKDSADWRERRAQ

    Show »
    Length:216
    Mass (Da):25,418
    Checksum:i9B9FCE70A39F20B0
    GO
    Isoform 3 (identifier: Q9H169-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.
         171-188: DKHAEEVRKNKELKEEAS → EPPAA

    Note: No experimental confirmation available.

    Show »
    Length:167
    Mass (Da):19,378
    Checksum:i3EE89D84248BC91A
    GO
    Isoform 4 (identifier: Q9H169-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-36: E → EGWCGRQCRRKDESQRKDSADWRERRAQ
         171-188: DKHAEEVRKNKELKEEAS → EPPAA

    Note: No experimental confirmation available.

    Show »
    Length:203
    Mass (Da):23,761
    Checksum:i237ED0D212AE12F4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111K → M in BAH12575. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99Missing in isoform 3. 1 PublicationVSP_055279
    Alternative sequencei36 – 361E → EGWCGRQCRRKDESQRKDSA DWRERRAQ in isoform 2 and isoform 4. 2 PublicationsVSP_006279
    Alternative sequencei171 – 18818DKHAE…KEEAS → EPPAA in isoform 3 and isoform 4. 1 PublicationVSP_055280Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ303455 mRNA. Translation: CAC22254.1.
    AL136568 mRNA. Translation: CAB66503.1.
    AK295329 mRNA. Translation: BAH12033.1.
    AK297415 mRNA. Translation: BAH12575.1.
    AC090150 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63562.1.
    CH471080 Genomic DNA. Translation: EAW63563.1.
    CH471080 Genomic DNA. Translation: EAW63565.1.
    CH471080 Genomic DNA. Translation: EAW63567.1.
    BC011520 mRNA. Translation: AAH11520.1.
    BC111001 mRNA. Translation: AAI11002.1.
    CCDSiCCDS6055.1. [Q9H169-2]
    CCDS64851.1. [Q9H169-3]
    CCDS64852.1. [Q9H169-1]
    RefSeqiNP_001269983.1. NM_001283054.1. [Q9H169-1]
    NP_001269984.1. NM_001283055.1.
    NP_110422.2. NM_030795.3. [Q9H169-2]
    UniGeneiHs.201058.
    Hs.734948.

    Genome annotation databases

    EnsembliENST00000265770; ENSP00000265770; ENSG00000015592. [Q9H169-1]
    ENST00000350889; ENSP00000342538; ENSG00000015592. [Q9H169-2]
    ENST00000519997; ENSP00000428474; ENSG00000015592. [Q9H169-3]
    ENST00000523048; ENSP00000428428; ENSG00000015592. [Q9H169-4]
    GeneIDi81551.
    KEGGihsa:81551.
    UCSCiuc003xfj.3. human. [Q9H169-2]
    uc003xfk.3. human. [Q9H169-1]

    Polymorphism databases

    DMDMi17368936.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ303455 mRNA. Translation: CAC22254.1 .
    AL136568 mRNA. Translation: CAB66503.1 .
    AK295329 mRNA. Translation: BAH12033.1 .
    AK297415 mRNA. Translation: BAH12575.1 .
    AC090150 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63562.1 .
    CH471080 Genomic DNA. Translation: EAW63563.1 .
    CH471080 Genomic DNA. Translation: EAW63565.1 .
    CH471080 Genomic DNA. Translation: EAW63567.1 .
    BC011520 mRNA. Translation: AAH11520.1 .
    BC111001 mRNA. Translation: AAI11002.1 .
    CCDSi CCDS6055.1. [Q9H169-2 ]
    CCDS64851.1. [Q9H169-3 ]
    CCDS64852.1. [Q9H169-1 ]
    RefSeqi NP_001269983.1. NM_001283054.1. [Q9H169-1 ]
    NP_001269984.1. NM_001283055.1.
    NP_110422.2. NM_030795.3. [Q9H169-2 ]
    UniGenei Hs.201058.
    Hs.734948.

    3D structure databases

    ProteinModelPortali Q9H169.
    SMRi Q9H169. Positions 50-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123515. 3 interactions.
    IntActi Q9H169. 2 interactions.
    MINTi MINT-1402998.
    STRINGi 9606.ENSP00000342538.

    PTM databases

    PhosphoSitei Q9H169.

    Polymorphism databases

    DMDMi 17368936.

    Proteomic databases

    MaxQBi Q9H169.
    PaxDbi Q9H169.
    PRIDEi Q9H169.

    Protocols and materials databases

    DNASUi 81551.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265770 ; ENSP00000265770 ; ENSG00000015592 . [Q9H169-1 ]
    ENST00000350889 ; ENSP00000342538 ; ENSG00000015592 . [Q9H169-2 ]
    ENST00000519997 ; ENSP00000428474 ; ENSG00000015592 . [Q9H169-3 ]
    ENST00000523048 ; ENSP00000428428 ; ENSG00000015592 . [Q9H169-4 ]
    GeneIDi 81551.
    KEGGi hsa:81551.
    UCSCi uc003xfj.3. human. [Q9H169-2 ]
    uc003xfk.3. human. [Q9H169-1 ]

    Organism-specific databases

    CTDi 81551.
    GeneCardsi GC08M027092.
    HGNCi HGNC:16078. STMN4.
    HPAi HPA027765.
    neXtProti NX_Q9H169.
    PharmGKBi PA38089.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70176.
    HOGENOMi HOG000013197.
    HOVERGENi HBG054037.
    OMAi TVDLTWC.
    OrthoDBi EOG744TBN.
    PhylomeDBi Q9H169.
    TreeFami TF326935.

    Miscellaneous databases

    GenomeRNAii 81551.
    NextBioi 35479115.
    PROi Q9H169.

    Gene expression databases

    ArrayExpressi Q9H169.
    Bgeei Q9H169.
    CleanExi HS_STMN4.
    Genevestigatori Q9H169.

    Family and domain databases

    InterProi IPR028834. Stathmin-4.
    IPR000956. Stathmin_fam.
    [Graphical view ]
    PANTHERi PTHR10104. PTHR10104. 1 hit.
    PTHR10104:SF6. PTHR10104:SF6. 1 hit.
    Pfami PF00836. Stathmin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002285. Stathmin. 1 hit.
    PRINTSi PR00345. STATHMIN.
    SUPFAMi SSF101494. SSF101494. 1 hit.
    PROSITEi PS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of the human RB3 gene."
      Coadwell W.J., Mimmack M.L.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Brain and Caudate nucleus.
    4. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiSTMN4_HUMAN
    AccessioniPrimary (citable) accession number: Q9H169
    Secondary accession number(s): B7Z2Z7
    , B7Z4I9, D3DSS8, D3DSS9, G5EA16, Q2TAB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3