Reviewed, UniProtKB/Swiss-Prot Q9H159 (CAD19_HUMAN)

Names and origin

Protein names

Recommended name:
    Cadherin-19

Gene names

Name:	CDH19
Synonyms:	CDH7L2
ORF Names:	UNQ478/PRO941

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	772 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in many tissues, with the exception of uterus.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	homophilic cell adhesion Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 43	22	Potential		PRO_0000003817
	Chain	44 – 772	729	Cadherin-19		PRO_0000003818
Regions
	Topological domain	44 – 596	553	Extracellular Potential
	Transmembrane	597 – 617	21	Potential
	Topological domain	618 – 772	155	Cytoplasmic Potential
	Domain	44 – 148	105	Cadherin 1
	Domain	149 – 256	108	Cadherin 2
	Domain	257 – 370	114	Cadherin 3
	Domain	371 – 470	100	Cadherin 4
	Domain	470 – 581	112	Cadherin 5
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
	Glycosylation	74	1	N-linked (GlcNAc...) Potential
	Glycosylation	419	1	N-linked (GlcNAc...) Potential
	Glycosylation	437	1	N-linked (GlcNAc...) Potential
	Glycosylation	508	1	N-linked (GlcNAc...) Potential
	Glycosylation	515	1	N-linked (GlcNAc...) Potential
	Glycosylation	516	1	N-linked (GlcNAc...) Potential
	Glycosylation	534	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9H159-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 650AD27480343C39	FASTA	772	87,002
	10 20 30 40 50 60 MNCYLLLRFM LGIPLLWPCL GATENSQTKK VKQPVRSHLR VKRGWVWNQF FVPEEMNTTS 70 80 90 100 110 120 HHIGQLRSDL DNGNNSFQYK LLGAGAGSTF IIDERTGDIY AIQKLDREER SLYILRAQVI 130 140 150 160 170 180 DIATGRAVEP ESEFVIKVSD INDNEPKFLD EPYEAIVPEM SPEGTLVIQV TASDADDPSS 190 200 210 220 230 240 GNNARLLYSL LQGQPYFSVE PTTGVIRISS KMDRELQDEY WVIIQAKDMI GQPGALSGTT 250 260 270 280 290 300 SVLIKLSDVN DNKPIFKESL YRLTVSESAP TGTSIGTIMA YDNDIGENAE MDYSIEEDDS 310 320 330 340 350 360 QTFDIITNHE TQEGIVILKK KVDFEHQNHY GIRAKVKNHH VPEQLMKYHT EASTTFIKIQ 370 380 390 400 410 420 VEDVDEPPLF LLPYYVFEVF EETPQGSFVG VVSATDPDNR KSPIRYSITR SKVFNINDNG 430 440 450 460 470 480 TITTSNSLDR EISAWYNLSI TATEKYNIEQ ISSIPLYVQV LNINDHAPEF SQYYETYVCE 490 500 510 520 530 540 NAGSGQVIQT ISAVDRDESI EEHHFYFNLS VEDTNNSSFT IIDNQDNTAV ILTNRTGFNL 550 560 570 580 590 600 QEEPVFYISI LIADNGIPSL TSTNTLTIHV CDCGDSGSTQ TCQYQELVLS MGFKTEVIIA 610 620 630 640 650 660 ILICIMIIFG FIFLTLGLKQ RRKQILFPEK SEDFRENIFQ YDDEGGGEED TEAFDIAELR 670 680 690 700 710 720 SSTIMRERKT RKTTSAEIRS LYRQSLQVGP DSAIFRKFIL EKLEEANTDP CAPPFDSLQT 730 740 750 760 770 YAFEGTGSLA GSLSSLESAV SDQDESYDYL NELGPRFKRL ACMFGSAVQS NN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7." Kools P., Van Imschoot G., van Roy F. Genomics 68:283-295(2000) [PubMed: 10995570] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ007607 mRNA. Translation: CAC13126.1. AY358654 mRNA. Translation: AAQ89017.1.
IPI	IPI00028135.
RefSeq	NP_066976.1.
UniGene	Hs.42771
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H159.
PTM databases
PhosphoSite	Q9H159.
Proteomic databases
PRIDE	Q9H159.
Genome annotation databases
Ensembl	ENST00000262150; ENSP00000262150; ENSG00000071991; Homo sapiens. [Genome view]
GeneID	28513.
KEGG	hsa:28513.
UCSC	uc002lkc.1. human.
Organism-specific databases
CTD	28513.
GeneCards	GC18M062322.
H-InvDB	HIX0014506.
HGNC	HGNC:1758. CDH19.
MIM	603016. gene.
PharmGKB	PA26292.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9H159.
HOVERGEN	Q9H159.
OMA	GPDSAIF
OrthoDB	EOG98GZNF
Gene expression databases
ArrayExpress	Q9H159.
Bgee	Q9H159.
CleanEx	HS_CDH19.
Genevestigator	Q9H159.
GermOnline	ENSG00000071991. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR000233. Cadherin_C_term. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 5 hits.
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 2 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	50980.
SOURCE	Search...

Entry information

Entry name

CAD19_HUMAN

Accession

Primary (citable) accession number: Q9H159

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2001
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.