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Protein

Cadherin-19

Gene

CDH19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-19
Gene namesi
Name:CDH19
Synonyms:CDH7L2
ORF Names:UNQ478/PRO941
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:1758. CDH19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini44 – 596553ExtracellularSequence analysisAdd
BLAST
Transmembranei597 – 61721HelicalSequence analysisAdd
BLAST
Topological domaini618 – 772155CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiCDH19.
PharmGKBiPA26292.

Polymorphism and mutation databases

DMDMi17366818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 4322Sequence analysisPRO_0000003817Add
BLAST
Chaini44 – 772729Cadherin-19PRO_0000003818Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence analysis
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiQ9H159.
PaxDbiQ9H159.
PRIDEiQ9H159.

PTM databases

iPTMnetiQ9H159.
PhosphoSiteiQ9H159.

Expressioni

Tissue specificityi

Expressed in many tissues, with the exception of uterus.

Gene expression databases

BgeeiQ9H159.
CleanExiHS_CDH19.
ExpressionAtlasiQ9H159. baseline and differential.
GenevisibleiQ9H159. HS.

Organism-specific databases

HPAiHPA056332.

Interactioni

Protein-protein interaction databases

BioGridi118390. 23 interactions.
STRINGi9606.ENSP00000262150.

Structurei

3D structure databases

ProteinModelPortaliQ9H159.
SMRiQ9H159. Positions 44-571, 698-763.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 148105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 256108Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini257 – 370114Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini371 – 470100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini470 – 581112Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9H159.
KOiK06806.
OMAiSAIFRKF.
OrthoDBiEOG79CXXW.
PhylomeDBiQ9H159.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H159-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNCYLLLRFM LGIPLLWPCL GATENSQTKK VKQPVRSHLR VKRGWVWNQF
60 70 80 90 100
FVPEEMNTTS HHIGQLRSDL DNGNNSFQYK LLGAGAGSTF IIDERTGDIY
110 120 130 140 150
AIQKLDREER SLYILRAQVI DIATGRAVEP ESEFVIKVSD INDNEPKFLD
160 170 180 190 200
EPYEAIVPEM SPEGTLVIQV TASDADDPSS GNNARLLYSL LQGQPYFSVE
210 220 230 240 250
PTTGVIRISS KMDRELQDEY WVIIQAKDMI GQPGALSGTT SVLIKLSDVN
260 270 280 290 300
DNKPIFKESL YRLTVSESAP TGTSIGTIMA YDNDIGENAE MDYSIEEDDS
310 320 330 340 350
QTFDIITNHE TQEGIVILKK KVDFEHQNHY GIRAKVKNHH VPEQLMKYHT
360 370 380 390 400
EASTTFIKIQ VEDVDEPPLF LLPYYVFEVF EETPQGSFVG VVSATDPDNR
410 420 430 440 450
KSPIRYSITR SKVFNINDNG TITTSNSLDR EISAWYNLSI TATEKYNIEQ
460 470 480 490 500
ISSIPLYVQV LNINDHAPEF SQYYETYVCE NAGSGQVIQT ISAVDRDESI
510 520 530 540 550
EEHHFYFNLS VEDTNNSSFT IIDNQDNTAV ILTNRTGFNL QEEPVFYISI
560 570 580 590 600
LIADNGIPSL TSTNTLTIHV CDCGDSGSTQ TCQYQELVLS MGFKTEVIIA
610 620 630 640 650
ILICIMIIFG FIFLTLGLKQ RRKQILFPEK SEDFRENIFQ YDDEGGGEED
660 670 680 690 700
TEAFDIAELR SSTIMRERKT RKTTSAEIRS LYRQSLQVGP DSAIFRKFIL
710 720 730 740 750
EKLEEANTDP CAPPFDSLQT YAFEGTGSLA GSLSSLESAV SDQDESYDYL
760 770
NELGPRFKRL ACMFGSAVQS NN
Length:772
Mass (Da):87,002
Last modified:March 1, 2001 - v1
Checksum:i650AD27480343C39
GO
Isoform 2 (identifier: Q9H159-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     487-490: VIQT → GLFF
     491-772: Missing.

Show »
Length:490
Mass (Da):55,384
Checksum:i508E3826311AD4BA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411I → V in BAG64917 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei487 – 4904VIQT → GLFF in isoform 2. 1 PublicationVSP_047020
Alternative sequencei491 – 772282Missing in isoform 2. 1 PublicationVSP_047021Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007607 mRNA. Translation: CAC13126.1.
AY358654 mRNA. Translation: AAQ89017.1.
AK304000 mRNA. Translation: BAG64917.1.
AC090393 Genomic DNA. No translation available.
AC091643 Genomic DNA. No translation available.
CCDSiCCDS11994.1. [Q9H159-1]
CCDS59325.1. [Q9H159-2]
RefSeqiNP_001257957.1. NM_001271028.1. [Q9H159-2]
NP_066976.1. NM_021153.3. [Q9H159-1]
UniGeneiHs.42771.

Genome annotation databases

EnsembliENST00000262150; ENSP00000262150; ENSG00000071991. [Q9H159-1]
ENST00000540086; ENSP00000439593; ENSG00000071991. [Q9H159-2]
GeneIDi28513.
KEGGihsa:28513.
UCSCiuc002lkc.3. human. [Q9H159-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007607 mRNA. Translation: CAC13126.1.
AY358654 mRNA. Translation: AAQ89017.1.
AK304000 mRNA. Translation: BAG64917.1.
AC090393 Genomic DNA. No translation available.
AC091643 Genomic DNA. No translation available.
CCDSiCCDS11994.1. [Q9H159-1]
CCDS59325.1. [Q9H159-2]
RefSeqiNP_001257957.1. NM_001271028.1. [Q9H159-2]
NP_066976.1. NM_021153.3. [Q9H159-1]
UniGeneiHs.42771.

3D structure databases

ProteinModelPortaliQ9H159.
SMRiQ9H159. Positions 44-571, 698-763.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118390. 23 interactions.
STRINGi9606.ENSP00000262150.

PTM databases

iPTMnetiQ9H159.
PhosphoSiteiQ9H159.

Polymorphism and mutation databases

DMDMi17366818.

Proteomic databases

MaxQBiQ9H159.
PaxDbiQ9H159.
PRIDEiQ9H159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262150; ENSP00000262150; ENSG00000071991. [Q9H159-1]
ENST00000540086; ENSP00000439593; ENSG00000071991. [Q9H159-2]
GeneIDi28513.
KEGGihsa:28513.
UCSCiuc002lkc.3. human. [Q9H159-1]

Organism-specific databases

CTDi28513.
GeneCardsiCDH19.
HGNCiHGNC:1758. CDH19.
HPAiHPA056332.
MalaCardsiCDH19.
MIMi603016. gene.
neXtProtiNX_Q9H159.
PharmGKBiPA26292.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9H159.
KOiK06806.
OMAiSAIFRKF.
OrthoDBiEOG79CXXW.
PhylomeDBiQ9H159.
TreeFamiTF329887.

Miscellaneous databases

GenomeRNAii28513.
PROiQ9H159.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H159.
CleanExiHS_CDH19.
ExpressionAtlasiQ9H159. baseline and differential.
GenevisibleiQ9H159. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7."
    Kools P., Van Imschoot G., van Roy F.
    Genomics 68:283-295(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCAD19_HUMAN
AccessioniPrimary (citable) accession number: Q9H159
Secondary accession number(s): B4E1V5, F5H1K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.