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Protein

SLIT and NTRK-like protein 2

Gene

SLITRK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity).By similarity2 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-388844. Receptor protein tyrosine phosphatases interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 2
Gene namesi
Name:SLITRK2
Synonyms:CXorf2, KIAA1854, SLITL1
ORF Names:UNQ9197/PRO34756
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13449. SLITRK2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 621ExtracellularSequence analysisAdd BLAST600
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 845CytoplasmicSequence analysisAdd BLAST203

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84631.
OpenTargetsiENSG00000185985.
PharmGKBiPA134968225.

Polymorphism and mutation databases

BioMutaiSLITRK2.
DMDMi46397026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003267522 – 845SLIT and NTRK-like protein 2Sequence analysisAdd BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 35By similarity
Disulfide bondi33 ↔ 46By similarity
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 243By similarity
Disulfide bondi222 ↔ 263By similarity
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei756PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9H156.
PeptideAtlasiQ9H156.
PRIDEiQ9H156.

PTM databases

iPTMnetiQ9H156.
PhosphoSitePlusiQ9H156.

Expressioni

Tissue specificityi

Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.1 Publication

Gene expression databases

BgeeiENSG00000185985.
CleanExiHS_SLITRK2.
ExpressionAtlasiQ9H156. baseline and differential.
GenevisibleiQ9H156. HS.

Interactioni

Subunit structurei

Interacts with PTPRD; this interaction is PTPRD splicing-dependent and may induces pre-synaptic differentiation.By similarity

Protein-protein interaction databases

BioGridi124160. 1 interactor.
STRINGi9606.ENSP00000359521.

Structurei

3D structure databases

ProteinModelPortaliQ9H156.
SMRiQ9H156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 84LRR 1Add BLAST22
Repeati87 – 108LRR 2Add BLAST22
Repeati111 – 132LRR 3Add BLAST22
Repeati135 – 156LRR 4Add BLAST22
Repeati159 – 180LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Domaini216 – 265LRRCT 1Add BLAST50
Domaini331 – 373LRRNTAdd BLAST43
Repeati376 – 397LRR 7Add BLAST22
Repeati400 – 421LRR 8Add BLAST22
Repeati424 – 445LRR 9Add BLAST22
Repeati448 – 469LRR 10Add BLAST22
Repeati472 – 493LRR 11Add BLAST22
Repeati495 – 516LRR 12Add BLAST22
Domaini529 – 580LRRCT 2Add BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni167 – 215Required for interaction with PTPRDBy similarityAdd BLAST49

Sequence similaritiesi

Belongs to the SLITRK family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ9H156.
OMAiVLREDTF.
OrthoDBiEOG091G02AI.
PhylomeDBiQ9H156.
TreeFamiTF351826.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF13855. LRR_8. 2 hits.
SMARTiView protein in SMART
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 2 hits.
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiView protein in PROSITE
PS51450. LRR. 12 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: Q9H156-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSGVWFLSV LTVAGILQTE SRKTAKDICK IRCLCEEKEN VLNINCENKG
60 70 80 90 100
FTTVSLLQPP QYRIYQLFLN GNLLTRLYPN EFVNYSNAVT LHLGNNGLQE
110 120 130 140 150
IRTGAFSGLK TLKRLHLNNN KLEILREDTF LGLESLEYLQ ADYNYISAIE
160 170 180 190 200
AGAFSKLNKL KVLILNDNLL LSLPSNVFRF VLLTHLDLRG NRLKVMPFAG
210 220 230 240 250
VLEHIGGIME IQLEENPWNC TCDLLPLKAW LDTITVFVGE IVCETPFRLH
260 270 280 290 300
GKDVTQLTRQ DLCPRKSASD SSQRGSHADT HVQRLSPTMN PALNPTRAPK
310 320 330 340 350
ASRPPKMRNR PTPRVTVSKD RQSFGPIMVY QTKSPVPLTC PSSCVCTSQS
360 370 380 390 400
SDNGLNVNCQ ERKFTNISDL QPKPTSPKKL YLTGNYLQTV YKNDLLEYSS
410 420 430 440 450
LDLLHLGNNR IAVIQEGAFT NLTSLRRLYL NGNYLEVLYP SMFDGLQSLQ
460 470 480 490 500
YLYLEYNVIK EIKPLTFDAL INLQLLFLNN NLLRSLPDNI FGGTALTRLN
510 520 530 540 550
LRNNHFSHLP VKGVLDQLPA FIQIDLQENP WDCTCDIMGL KDWTEHANSP
560 570 580 590 600
VIINEVTCES PAKHAGEILK FLGREAICPD SPNLSDGTVL SMNHNTDTPR
610 620 630 640 650
SLSVSPSSYP ELHTEVPLSV LILGLLVVFI LSVCFGAGLF VFVLKRRKGV
660 670 680 690 700
PSVPRNTNNL DVSSFQLQYG SYNTETHDKT DGHVYNYIPP PVGQMCQNPI
710 720 730 740 750
YMQKEGDPVA YYRNLQEFSY SNLEEKKEEP ATPAYTISAT ELLEKQATPR
760 770 780 790 800
EPELLYQNIA ERVKELPSAG LVHYNFCTLP KRQFAPSYES RRQNQDRINK
810 820 830 840
TVLYGTPRKC FVGQSKPNHP LLQAKPQSEP DYLEVLEKQT AISQL
Length:845
Mass (Da):95,404
Last modified:March 1, 2001 - v1
Checksum:i20E35DBD1584F9A4
GO
Isoform 2Curated (identifier: Q9H156-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     719-733: SYSNLEEKKEEPATP → KTSLENIWRPCLHKK
     734-845: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:733
Mass (Da):82,695
Checksum:i3AB315438E97F2A8
GO

Sequence cautioni

The sequence BAB47483 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti721S → G in BAC03566 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07763089V → M Found in a patient with schizophrenia; unknown pathological significance; does not impair synaptogenesis; no effect on localization to cell membrane. 2 Publications1
Natural variantiVAR_077631549S → F Found in a patient with schizophrenia; unknown pathological significance; does not impair synaptogenesis; no effect on localization to cell membrane. 2 Publications1
Natural variantiVAR_027756601S → P Polymorphism; does not affect synaptogenesis; no effect on localization to cell membrane. 1 PublicationCorresponds to variant dbSNP:rs2295336Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050706719 – 733SYSNL…EPATP → KTSLENIWRPCLHKK in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_050707734 – 845Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19205 Genomic DNA. Translation: CAC80724.1.
AY358828 mRNA. Translation: AAQ89187.1.
AK091015 mRNA. Translation: BAC03566.1.
AK289732 mRNA. Translation: BAF82421.1.
AL109653 Genomic DNA. Translation: CAI41645.1.
AL109653 Genomic DNA. Translation: CAC18888.1.
BC113011 mRNA. Translation: AAI13012.1.
BC113012 mRNA. Translation: AAI13013.1.
AB058757 mRNA. Translation: BAB47483.1. Different initiation.
CCDSiCCDS14680.1. [Q9H156-1]
RefSeqiNP_001137475.1. NM_001144003.2. [Q9H156-1]
NP_001137476.1. NM_001144004.2. [Q9H156-1]
NP_001137477.1. NM_001144005.2. [Q9H156-1]
NP_001137478.1. NM_001144006.2. [Q9H156-1]
NP_001137480.1. NM_001144008.2. [Q9H156-1]
NP_001137481.1. NM_001144009.2. [Q9H156-1]
NP_001137482.1. NM_001144010.2. [Q9H156-1]
NP_115928.1. NM_032539.4. [Q9H156-1]
XP_005262399.1. XM_005262342.3. [Q9H156-1]
XP_005262400.1. XM_005262343.3. [Q9H156-1]
XP_005262401.1. XM_005262344.3. [Q9H156-1]
XP_005262402.1. XM_005262345.3. [Q9H156-1]
UniGeneiHs.320368.

Genome annotation databases

EnsembliENST00000370490; ENSP00000359521; ENSG00000185985. [Q9H156-1]
GeneIDi84631.
KEGGihsa:84631.
UCSCiuc033eyj.2. human. [Q9H156-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSLIK2_HUMAN
AccessioniPrimary (citable) accession number: Q9H156
Secondary accession number(s): A8K117
, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families