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Q9H156 (SLIK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SLIT and NTRK-like protein 2
Gene names
Name:SLITRK2
Synonyms:CXorf2, KIAA1854, SLITL1
ORF Names:UNQ9197/PRO34756
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length845 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Suppresses neurite outgrowth By similarity. UniProtKB Q810C0

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors. Ref.7

Sequence similarities

Belongs to the SLITRK family.

Contains 12 LRR (leucine-rich) repeats.

Contains 2 LRRCT domains.

Contains 1 LRRNT domain.

Sequence caution

The sequence BAB47483.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainLeucine-rich repeat
Repeat
Signal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxonogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H156-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H156-2)

The sequence of this isoform differs from the canonical sequence as follows:
     719-733: SYSNLEEKKEEPATP → KTSLENIWRPCLHKK
     734-845: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 845824SLIT and NTRK-like protein 2
PRO_0000032675

Regions

Topological domain22 – 621600Extracellular Potential
Transmembrane622 – 64221Helical; Potential
Topological domain643 – 845203Cytoplasmic Potential
Repeat63 – 8422LRR 1
Repeat87 – 10822LRR 2
Repeat111 – 13222LRR 3
Repeat135 – 15622LRR 4
Repeat159 – 18022LRR 5
Repeat182 – 20322LRR 6
Domain216 – 26550LRRCT 1
Domain331 – 37343LRRNT
Repeat376 – 39722LRR 7
Repeat400 – 42122LRR 8
Repeat424 – 44522LRR 9
Repeat448 – 46922LRR 10
Repeat472 – 49322LRR 11
Repeat495 – 51622LRR 12
Domain529 – 58052LRRCT 2

Amino acid modifications

Modified residue7561Phosphotyrosine By similarity
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation4211N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence719 – 73315SYSNL…EPATP → KTSLENIWRPCLHKK in isoform 2.
VSP_050706
Alternative sequence734 – 845112Missing in isoform 2.
VSP_050707
Natural variant6011S → P.
Corresponds to variant rs2295336 [ dbSNP | Ensembl ].
VAR_027756

Experimental info

Sequence conflict7211S → G in BAC03566. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 20E35DBD1584F9A4

FASTA84595,404
        10         20         30         40         50         60 
MLSGVWFLSV LTVAGILQTE SRKTAKDICK IRCLCEEKEN VLNINCENKG FTTVSLLQPP 

        70         80         90        100        110        120 
QYRIYQLFLN GNLLTRLYPN EFVNYSNAVT LHLGNNGLQE IRTGAFSGLK TLKRLHLNNN 

       130        140        150        160        170        180 
KLEILREDTF LGLESLEYLQ ADYNYISAIE AGAFSKLNKL KVLILNDNLL LSLPSNVFRF 

       190        200        210        220        230        240 
VLLTHLDLRG NRLKVMPFAG VLEHIGGIME IQLEENPWNC TCDLLPLKAW LDTITVFVGE 

       250        260        270        280        290        300 
IVCETPFRLH GKDVTQLTRQ DLCPRKSASD SSQRGSHADT HVQRLSPTMN PALNPTRAPK 

       310        320        330        340        350        360 
ASRPPKMRNR PTPRVTVSKD RQSFGPIMVY QTKSPVPLTC PSSCVCTSQS SDNGLNVNCQ 

       370        380        390        400        410        420 
ERKFTNISDL QPKPTSPKKL YLTGNYLQTV YKNDLLEYSS LDLLHLGNNR IAVIQEGAFT 

       430        440        450        460        470        480 
NLTSLRRLYL NGNYLEVLYP SMFDGLQSLQ YLYLEYNVIK EIKPLTFDAL INLQLLFLNN 

       490        500        510        520        530        540 
NLLRSLPDNI FGGTALTRLN LRNNHFSHLP VKGVLDQLPA FIQIDLQENP WDCTCDIMGL 

       550        560        570        580        590        600 
KDWTEHANSP VIINEVTCES PAKHAGEILK FLGREAICPD SPNLSDGTVL SMNHNTDTPR 

       610        620        630        640        650        660 
SLSVSPSSYP ELHTEVPLSV LILGLLVVFI LSVCFGAGLF VFVLKRRKGV PSVPRNTNNL 

       670        680        690        700        710        720 
DVSSFQLQYG SYNTETHDKT DGHVYNYIPP PVGQMCQNPI YMQKEGDPVA YYRNLQEFSY 

       730        740        750        760        770        780 
SNLEEKKEEP ATPAYTISAT ELLEKQATPR EPELLYQNIA ERVKELPSAG LVHYNFCTLP 

       790        800        810        820        830        840 
KRQFAPSYES RRQNQDRINK TVLYGTPRKC FVGQSKPNHP LLQAKPQSEP DYLEVLEKQT 


AISQL 

« Hide

Isoform 2 [UniParc].

Checksum: 3AB315438E97F2A8
Show »

FASTA73382,695

References

« Hide 'large scale' references
[1]"The structural characterization of the new gene SLITL1 reveals the presence of an other novel gene embedded within SLITL1 first intron."
Redolfi E., Susani L., Mumm S., Stephan A., Reinbold R.A., Labella T., Trent J.M., Vezzoni P., Zucchi T.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-566.
Tissue: Brain.
[7]"Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue."
Aruga J., Yokota N., Mikoshiba K.
Gene 315:87-94(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
Tissue: Brain and Brain tumor.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y19205 Genomic DNA. Translation: CAC80724.1.
AY358828 mRNA. Translation: AAQ89187.1.
AK091015 mRNA. Translation: BAC03566.1.
AK289732 mRNA. Translation: BAF82421.1.
AL109653 Genomic DNA. Translation: CAI41645.1.
AL109653 Genomic DNA. Translation: CAC18888.1.
BC113011 mRNA. Translation: AAI13012.1.
BC113012 mRNA. Translation: AAI13013.1.
AB058757 mRNA. Translation: BAB47483.1. Different initiation.
CCDSCCDS14680.1. [Q9H156-1]
RefSeqNP_001137475.1. NM_001144003.2. [Q9H156-1]
NP_001137476.1. NM_001144004.2. [Q9H156-1]
NP_001137477.1. NM_001144005.2. [Q9H156-1]
NP_001137478.1. NM_001144006.2. [Q9H156-1]
NP_001137480.1. NM_001144008.2. [Q9H156-1]
NP_001137481.1. NM_001144009.2. [Q9H156-1]
NP_001137482.1. NM_001144010.2. [Q9H156-1]
NP_115928.1. NM_032539.4. [Q9H156-1]
XP_005262399.1. XM_005262342.2. [Q9H156-1]
XP_005262400.1. XM_005262343.2. [Q9H156-1]
XP_005262401.1. XM_005262344.2. [Q9H156-1]
XP_005262402.1. XM_005262345.2. [Q9H156-1]
XP_005262403.1. XM_005262346.2. [Q9H156-1]
UniGeneHs.320368.

3D structure databases

ProteinModelPortalQ9H156.
SMRQ9H156. Positions 50-610.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000359521.

PTM databases

PhosphoSiteQ9H156.

Polymorphism databases

DMDM46397026.

Proteomic databases

PaxDbQ9H156.
PRIDEQ9H156.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370490; ENSP00000359521; ENSG00000185985. [Q9H156-1]
ENST00000413937; ENSP00000407347; ENSG00000185985. [Q9H156-1]
ENST00000428560; ENSP00000412010; ENSG00000185985. [Q9H156-1]
ENST00000434188; ENSP00000397015; ENSG00000185985. [Q9H156-1]
ENST00000447897; ENSP00000411681; ENSG00000185985. [Q9H156-1]
ENST00000596854; ENSP00000472699; ENSG00000268737. [Q9H156-1]
ENST00000597957; ENSP00000468887; ENSG00000268737. [Q9H156-1]
ENST00000597981; ENSP00000469687; ENSG00000268737. [Q9H156-1]
ENST00000600096; ENSP00000471447; ENSG00000268737. [Q9H156-1]
ENST00000601272; ENSP00000472603; ENSG00000268737. [Q9H156-1]
GeneID84631.
KEGGhsa:84631.
UCSCuc004fcd.3. human. [Q9H156-1]

Organism-specific databases

CTD84631.
GeneCardsGC0XP144900.
H-InvDBHIX0017096.
HIX0176721.
HGNCHGNC:13449. SLITRK2.
HPAHPA051847.
MIM300561. gene.
neXtProtNX_Q9H156.
PharmGKBPA134968225.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147171.
HOGENOMHOG000290667.
HOVERGENHBG056407.
InParanoidQ9H156.
OMALQADYNY.
PhylomeDBQ9H156.
TreeFamTF351826.

Gene expression databases

ArrayExpressQ9H156.
BgeeQ9H156.
CleanExHS_SLITRK2.
GenevestigatorQ9H156.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 2 hits.
[Graphical view]
PROSITEPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLITRK2. human.
GeneWikiSLITRK2.
GenomeRNAi84631.
NextBio74551.
PROQ9H156.
SOURCESearch...

Entry information

Entry nameSLIK2_HUMAN
AccessionPrimary (citable) accession number: Q9H156
Secondary accession number(s): A8K117 expand/collapse secondary AC list , Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM