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Protein

GDNF-inducible zinc finger protein 1

Gene

GZF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 34024C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37124C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 40024C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 56923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri575 – 59723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF-inducible zinc finger protein 1
Alternative name(s):
Zinc finger and BTB domain-containing protein 23
Zinc finger protein 336
Gene namesi
Name:GZF1
Synonyms:ZBTB23, ZNF336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15808. GZF1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi32 – 321D → N: Decreased repression activity. 1 Publication
Mutagenesisi50 – 501K → D: Decreased repression activity. 1 Publication

Organism-specific databases

PharmGKBiPA162390561.

Polymorphism and mutation databases

BioMutaiGZF1.
DMDMi23397004.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711GDNF-inducible zinc finger protein 1PRO_0000047539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei613 – 6131PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H116.
MaxQBiQ9H116.
PaxDbiQ9H116.
PeptideAtlasiQ9H116.
PRIDEiQ9H116.

PTM databases

iPTMnetiQ9H116.
PhosphoSiteiQ9H116.

Expressioni

Tissue specificityi

Expressed in adult brain, heart, skeletal muscle, kidney and liver. Also detected in fetal brain and kidney, and at lower levels in fetal lung and liver.1 Publication

Inductioni

By GDNF.1 Publication

Gene expression databases

BgeeiQ9H116.
CleanExiHS_GZF1.
ExpressionAtlasiQ9H116. baseline and differential.
GenevisibleiQ9H116. HS.

Organism-specific databases

HPAiHPA024520.

Interactioni

Subunit structurei

Interacts with NCL.1 Publication

Protein-protein interaction databases

BioGridi122164. 14 interactions.
STRINGi9606.ENSP00000338290.

Structurei

3D structure databases

ProteinModelPortaliQ9H116.
SMRiQ9H116. Positions 16-129, 309-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 10373BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 34024C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37124C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 40024C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 56923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri575 – 59723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111259.
HOVERGENiHBG054256.
InParanoidiQ9H116.
OMAiKHISTYH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9H116.
TreeFamiTF350965.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H116-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGAVLLES KSSPFNLLHE MHELRLLGHL CDVTVSVEYQ GVRKDFMAHK
60 70 80 90 100
AVLAATSKFF KEVFLNEKSV DGTRTNVYLN EVQVADFASF LEFVYTAKVQ
110 120 130 140 150
VEEDRVQRML EVAEKLKCLD LSETCFQLKK QMLESVLLEL QNFSESQEVE
160 170 180 190 200
VSSGSQVSAA PAPRASVATD GPHPSGLTDS LDYPGERASN GMSSDLPPKK
210 220 230 240 250
SKDKLDKKKE VVKPPYPKIR RASGRLAGRK VFVEIPKKKY TRRLREQQKT
260 270 280 290 300
AEGDVGDYRC PQDQSPDRVG TEMEQVSKNE GCQAGAELEE LSKKAGPEEE
310 320 330 340 350
EEEEEEDEEG EKKKSNFKCS ICEKAFLYEK SFLKHSKHRH GVATEVVYRC
360 370 380 390 400
DTCGQTFANR CNLKSHQRHV HSSERHFPCE LCGKKFKRKK DVKRHVLQVH
410 420 430 440 450
EGGGERHRCG QCGKGLSSKT ALRLHERTHT GDRPYGCTEC GARFSQPSAL
460 470 480 490 500
KTHMRIHTGE KPFVCDECGA RFTQNHMLIY HKRCHTGERP FMCETCGKSF
510 520 530 540 550
ASKEYLKHHN RIHTGSKPFK CEVCFRTFAQ RNSLYQHIKV HTGERPYCCD
560 570 580 590 600
QCGKQFTQLN ALQRHRRIHT GERPFMCNAC GRTFTDKSTL RRHTSIHDKN
610 620 630 640 650
TPWKSFLVIV DGSPKNDDGH KTEQPDEEYV SSKLSDKLLS FAENGHFHNL
660 670 680 690 700
AAVQDTVPTM QENSSADTAC KADDSVVSQD TLLATTISEL SELTPQTDSM
710
PTQLHSLSNM E
Length:711
Mass (Da):80,492
Last modified:March 1, 2001 - v1
Checksum:i9209B850193BCF1A
GO
Isoform 2 (identifier: Q9H116-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-491: Missing.

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):24,911
Checksum:i2DB284F0FFE27FFC
GO

Sequence cautioni

The sequence BAB15134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti520 – 5201K → R in BAG51726 (PubMed:14702039).Curated
Sequence conflicti628 – 6281E → G in BAG51726 (PubMed:14702039).Curated
Sequence conflicti632 – 6321S → P in BAB15134 (PubMed:14702039).Curated
Sequence conflicti694 – 6941T → A in BAG51726 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971A → V Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064718
Natural varianti190 – 1901N → S.
Corresponds to variant rs3810574 [ dbSNP | Ensembl ].
VAR_052735
Natural varianti275 – 2751Q → L.
Corresponds to variant rs6048760 [ dbSNP | Ensembl ].
VAR_059890
Natural varianti275 – 2751Q → P.1 Publication
Corresponds to variant rs6048760 [ dbSNP | Ensembl ].
VAR_024212
Natural varianti275 – 2751Q → R.
Corresponds to variant rs6048760 [ dbSNP | Ensembl ].
VAR_059891
Natural varianti318 – 3181K → N.
Corresponds to variant rs6114068 [ dbSNP | Ensembl ].
VAR_052736
Natural varianti667 – 6671D → N.
Corresponds to variant rs6048766 [ dbSNP | Ensembl ].
VAR_052737

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 491491Missing in isoform 2. 1 PublicationVSP_055933Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100265 mRNA. Translation: BAC98464.1.
AK025447 mRNA. Translation: BAB15134.1. Different initiation.
AK056159 mRNA. Translation: BAB71107.1. Different initiation.
AK056477 mRNA. Translation: BAG51726.1.
AK289814 mRNA. Translation: BAF82503.1.
AK293942 mRNA. Translation: BAG57319.1.
AK314599 mRNA. Translation: BAG37170.1.
AL096677 Genomic DNA. Translation: CAC03438.2.
CH471133 Genomic DNA. Translation: EAX10159.1.
CH471133 Genomic DNA. Translation: EAX10160.1.
CCDSiCCDS13151.1. [Q9H116-1]
RefSeqiNP_001303941.1. NM_001317012.1. [Q9H116-1]
NP_001303948.1. NM_001317019.1.
NP_071927.1. NM_022482.4. [Q9H116-1]
XP_011527623.1. XM_011529321.1. [Q9H116-1]
XP_011527624.1. XM_011529322.1. [Q9H116-1]
UniGeneiHs.709462.
Hs.740897.

Genome annotation databases

EnsembliENST00000338121; ENSP00000338290; ENSG00000125812. [Q9H116-1]
ENST00000377051; ENSP00000366250; ENSG00000125812. [Q9H116-1]
GeneIDi64412.
KEGGihsa:64412.
UCSCiuc002wsy.4. human. [Q9H116-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100265 mRNA. Translation: BAC98464.1.
AK025447 mRNA. Translation: BAB15134.1. Different initiation.
AK056159 mRNA. Translation: BAB71107.1. Different initiation.
AK056477 mRNA. Translation: BAG51726.1.
AK289814 mRNA. Translation: BAF82503.1.
AK293942 mRNA. Translation: BAG57319.1.
AK314599 mRNA. Translation: BAG37170.1.
AL096677 Genomic DNA. Translation: CAC03438.2.
CH471133 Genomic DNA. Translation: EAX10159.1.
CH471133 Genomic DNA. Translation: EAX10160.1.
CCDSiCCDS13151.1. [Q9H116-1]
RefSeqiNP_001303941.1. NM_001317012.1. [Q9H116-1]
NP_001303948.1. NM_001317019.1.
NP_071927.1. NM_022482.4. [Q9H116-1]
XP_011527623.1. XM_011529321.1. [Q9H116-1]
XP_011527624.1. XM_011529322.1. [Q9H116-1]
UniGeneiHs.709462.
Hs.740897.

3D structure databases

ProteinModelPortaliQ9H116.
SMRiQ9H116. Positions 16-129, 309-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122164. 14 interactions.
STRINGi9606.ENSP00000338290.

PTM databases

iPTMnetiQ9H116.
PhosphoSiteiQ9H116.

Polymorphism and mutation databases

BioMutaiGZF1.
DMDMi23397004.

Proteomic databases

EPDiQ9H116.
MaxQBiQ9H116.
PaxDbiQ9H116.
PeptideAtlasiQ9H116.
PRIDEiQ9H116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338121; ENSP00000338290; ENSG00000125812. [Q9H116-1]
ENST00000377051; ENSP00000366250; ENSG00000125812. [Q9H116-1]
GeneIDi64412.
KEGGihsa:64412.
UCSCiuc002wsy.4. human. [Q9H116-1]

Organism-specific databases

CTDi64412.
GeneCardsiGZF1.
HGNCiHGNC:15808. GZF1.
HPAiHPA024520.
MIMi613842. gene.
neXtProtiNX_Q9H116.
PharmGKBiPA162390561.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111259.
HOVERGENiHBG054256.
InParanoidiQ9H116.
OMAiKHISTYH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9H116.
TreeFamiTF350965.

Miscellaneous databases

ChiTaRSiGZF1. human.
GenomeRNAii64412.
PROiQ9H116.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H116.
CleanExiHS_GZF1.
ExpressionAtlasiQ9H116. baseline and differential.
GenevisibleiQ9H116. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis."
    Fukuda N., Ichihara M., Morinaga T., Kawai K., Hayashi H., Murakumo Y., Matsuo S., Takahashi M.
    J. Biol. Chem. 278:50386-50392(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, MUTAGENESIS OF ASP-32 AND LYS-50.
    Tissue: Neuroblastoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-275.
    Tissue: Brain, Cerebellum, Hepatoma, Teratocarcinoma and Trachea.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region."
    Morinaga T., Enomoto A., Shimono Y., Hirose F., Fukuda N., Dambara A., Jijiwa M., Kawai K., Hashimoto K., Ichihara M., Asai N., Murakumo Y., Matsuo S., Takahashi M.
    Nucleic Acids Res. 33:4191-4201(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation."
    Dambara A., Morinaga T., Fukuda N., Yamakawa Y., Kato T., Enomoto A., Asai N., Murakumo Y., Matsuo S., Takahashi M.
    Exp. Cell Res. 313:3755-3766(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCL, SUBCELLULAR LOCATION.
  7. Cited for: VARIANT VAL-97.

Entry informationi

Entry nameiGZF1_HUMAN
AccessioniPrimary (citable) accession number: Q9H116
Secondary accession number(s): A8K199
, B2RBC3, B3KPL4, B4DF58, D3DW39, Q54A22, Q96N08, Q9BQK9, Q9H117, Q9H6W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.