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Protein

Beta-soluble NSF attachment protein

Gene

NAPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-soluble NSF attachment protein
Short name:
SNAP-beta
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein beta
Gene namesi
Name:NAPB
Synonyms:SNAPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15751. NAPB.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • SNARE complex Source: GO_Central
  • vacuolar membrane Source: GO_Central

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiNAPB.
OpenTargetsiENSG00000125814.
PharmGKBiPA31444.

Polymorphism and mutation databases

BioMutaiNAPB.
DMDMi18202933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190601 – 298Beta-soluble NSF attachment proteinAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H115.
MaxQBiQ9H115.
PaxDbiQ9H115.
PeptideAtlasiQ9H115.
PRIDEiQ9H115.

PTM databases

iPTMnetiQ9H115.
PhosphoSitePlusiQ9H115.

Expressioni

Gene expression databases

BgeeiENSG00000125814.
CleanExiHS_NAPB.
ExpressionAtlasiQ9H115. baseline and differential.
GenevisibleiQ9H115. HS.

Organism-specific databases

HPAiCAB037225.
CAB037227.
HPA046149.
HPA050196.

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121983. 17 interactors.
IntActiQ9H115. 20 interactors.
STRINGi9606.ENSP00000366225.

Structurei

3D structure databases

ProteinModelPortaliQ9H115.
SMRiQ9H115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiQ9H115.
PhylomeDBiQ9H115.
TreeFamiTF316547.

Family and domain databases

CDDicd15832. SNAP. 1 hit.
Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H115-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAA YAAQLEQYQK AIEIYEQVGA NTMDNPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE CKLLKKLLEA
260 270 280 290
HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK
Length:298
Mass (Da):33,557
Last modified:August 29, 2001 - v2
Checksum:i5B7BE0FB84BABD83
GO
Isoform 2 (identifier: Q9H115-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-98: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):29,453
Checksum:iE61D9F7BF5A19EBD
GO
Isoform 3 (identifier: Q9H115-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDNAGKEREAVQLMAEAEKR → MTLLPALWMLEMLTKRQIPK
     21-114: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,403
Checksum:iA15BFEAA5D5E0775
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05202661A → T. Corresponds to variant dbSNP:rs6036399Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552761 – 20MDNAG…EAEKR → MTLLPALWMLEMLTKRQIPK in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_05527721 – 114Missing in isoform 3. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_05527860 – 98Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296385 mRNA. Translation: BAG59056.1.
AL096677 Genomic DNA. Translation: CAI20156.1.
CH471133 Genomic DNA. Translation: EAX10152.1.
CH471133 Genomic DNA. Translation: EAX10156.1.
BC047426 mRNA. Translation: AAH47426.1.
BC060840 mRNA. Translation: AAH60840.1.
AL834445 mRNA. Translation: CAD39105.1.
CCDSiCCDS13152.1. [Q9H115-1]
CCDS63241.1. [Q9H115-3]
CCDS63242.1. [Q9H115-2]
RefSeqiNP_001269947.1. NM_001283018.1.
NP_001269949.1. NM_001283020.1. [Q9H115-2]
NP_001269955.1. NM_001283026.1. [Q9H115-3]
NP_071363.1. NM_022080.2. [Q9H115-1]
UniGeneiHs.269471.

Genome annotation databases

EnsembliENST00000377026; ENSP00000366225; ENSG00000125814. [Q9H115-1]
ENST00000398425; ENSP00000381459; ENSG00000125814. [Q9H115-3]
ENST00000432543; ENSP00000413600; ENSG00000125814. [Q9H115-2]
GeneIDi63908.
KEGGihsa:63908.
UCSCiuc002wta.4. human. [Q9H115-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSNAB_HUMAN
AccessioniPrimary (citable) accession number: Q9H115
Secondary accession number(s): B4DK44
, Q4G0M0, Q4G187, Q5JXF9, Q8N3C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: March 15, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families