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Protein

Beta-soluble NSF attachment protein

Gene

NAPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-soluble NSF attachment protein
Short name:
SNAP-beta
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein beta
Gene namesi
Name:NAPB
Synonyms:SNAPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15751. NAPB.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • SNARE complex Source: GO_Central
  • vacuolar membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiNAPB.
PharmGKBiPA31444.

Polymorphism and mutation databases

BioMutaiNAPB.
DMDMi18202933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Beta-soluble NSF attachment proteinPRO_0000219060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei26 – 261PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H115.
MaxQBiQ9H115.
PaxDbiQ9H115.
PRIDEiQ9H115.

PTM databases

iPTMnetiQ9H115.
PhosphoSiteiQ9H115.

Expressioni

Gene expression databases

BgeeiQ9H115.
CleanExiHS_NAPB.
ExpressionAtlasiQ9H115. baseline and differential.
GenevisibleiQ9H115. HS.

Organism-specific databases

HPAiCAB037225.
CAB037227.
HPA046149.
HPA050196.

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150413EBI-3921185,EBI-714543
SNAP23A8K2873EBI-3921185,EBI-10188497
SNAP23O001613EBI-3921185,EBI-745000
STX16O146623EBI-3921185,EBI-2853548
STX3Q132773EBI-3921185,EBI-1394295
STX4Q128463EBI-3921185,EBI-744942
STX5Q131903EBI-3921185,EBI-714206
STX6O437524EBI-3921185,EBI-2695795
TFECO149483EBI-3921185,EBI-3916574

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121983. 17 interactions.
IntActiQ9H115. 11 interactions.
STRINGi9606.ENSP00000366225.

Structurei

3D structure databases

ProteinModelPortaliQ9H115.
SMRiQ9H115. Positions 19-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiQ9H115.
OrthoDBiEOG7FNC80.
PhylomeDBiQ9H115.
TreeFamiTF316547.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H115-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAA YAAQLEQYQK AIEIYEQVGA NTMDNPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE CKLLKKLLEA
260 270 280 290
HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK
Length:298
Mass (Da):33,557
Last modified:August 29, 2001 - v2
Checksum:i5B7BE0FB84BABD83
GO
Isoform 2 (identifier: Q9H115-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-98: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):29,453
Checksum:iE61D9F7BF5A19EBD
GO
Isoform 3 (identifier: Q9H115-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDNAGKEREAVQLMAEAEKR → MTLLPALWMLEMLTKRQIPK
     21-114: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,403
Checksum:iA15BFEAA5D5E0775
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611A → T.
Corresponds to variant rs6036399 [ dbSNP | Ensembl ].
VAR_052026

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020MDNAG…EAEKR → MTLLPALWMLEMLTKRQIPK in isoform 3. 1 PublicationVSP_055276Add
BLAST
Alternative sequencei21 – 11494Missing in isoform 3. 1 PublicationVSP_055277Add
BLAST
Alternative sequencei60 – 9839Missing in isoform 2. 1 PublicationVSP_055278Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296385 mRNA. Translation: BAG59056.1.
AL096677 Genomic DNA. Translation: CAI20156.1.
CH471133 Genomic DNA. Translation: EAX10152.1.
CH471133 Genomic DNA. Translation: EAX10156.1.
BC047426 mRNA. Translation: AAH47426.1.
BC060840 mRNA. Translation: AAH60840.1.
AL834445 mRNA. Translation: CAD39105.1.
CCDSiCCDS13152.1. [Q9H115-1]
CCDS63241.1. [Q9H115-3]
CCDS63242.1. [Q9H115-2]
RefSeqiNP_001269947.1. NM_001283018.1.
NP_001269949.1. NM_001283020.1. [Q9H115-2]
NP_001269955.1. NM_001283026.1. [Q9H115-3]
NP_071363.1. NM_022080.2. [Q9H115-1]
XP_011527616.1. XM_011529314.1. [Q9H115-3]
UniGeneiHs.269471.

Genome annotation databases

EnsembliENST00000377026; ENSP00000366225; ENSG00000125814. [Q9H115-1]
ENST00000398425; ENSP00000381459; ENSG00000125814. [Q9H115-3]
ENST00000432543; ENSP00000413600; ENSG00000125814. [Q9H115-2]
GeneIDi63908.
KEGGihsa:63908.
UCSCiuc002wta.4. human. [Q9H115-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296385 mRNA. Translation: BAG59056.1.
AL096677 Genomic DNA. Translation: CAI20156.1.
CH471133 Genomic DNA. Translation: EAX10152.1.
CH471133 Genomic DNA. Translation: EAX10156.1.
BC047426 mRNA. Translation: AAH47426.1.
BC060840 mRNA. Translation: AAH60840.1.
AL834445 mRNA. Translation: CAD39105.1.
CCDSiCCDS13152.1. [Q9H115-1]
CCDS63241.1. [Q9H115-3]
CCDS63242.1. [Q9H115-2]
RefSeqiNP_001269947.1. NM_001283018.1.
NP_001269949.1. NM_001283020.1. [Q9H115-2]
NP_001269955.1. NM_001283026.1. [Q9H115-3]
NP_071363.1. NM_022080.2. [Q9H115-1]
XP_011527616.1. XM_011529314.1. [Q9H115-3]
UniGeneiHs.269471.

3D structure databases

ProteinModelPortaliQ9H115.
SMRiQ9H115. Positions 19-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121983. 17 interactions.
IntActiQ9H115. 11 interactions.
STRINGi9606.ENSP00000366225.

PTM databases

iPTMnetiQ9H115.
PhosphoSiteiQ9H115.

Polymorphism and mutation databases

BioMutaiNAPB.
DMDMi18202933.

Proteomic databases

EPDiQ9H115.
MaxQBiQ9H115.
PaxDbiQ9H115.
PRIDEiQ9H115.

Protocols and materials databases

DNASUi63908.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377026; ENSP00000366225; ENSG00000125814. [Q9H115-1]
ENST00000398425; ENSP00000381459; ENSG00000125814. [Q9H115-3]
ENST00000432543; ENSP00000413600; ENSG00000125814. [Q9H115-2]
GeneIDi63908.
KEGGihsa:63908.
UCSCiuc002wta.4. human. [Q9H115-1]

Organism-specific databases

CTDi63908.
GeneCardsiNAPB.
HGNCiHGNC:15751. NAPB.
HPAiCAB037225.
CAB037227.
HPA046149.
HPA050196.
MalaCardsiNAPB.
MIMi611270. gene.
neXtProtiNX_Q9H115.
PharmGKBiPA31444.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiQ9H115.
OrthoDBiEOG7FNC80.
PhylomeDBiQ9H115.
TreeFamiTF316547.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

ChiTaRSiNAPB. human.
GeneWikiiNAPB.
GenomeRNAii63908.
NextBioi35472697.
PROiQ9H115.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H115.
CleanExiHS_NAPB.
ExpressionAtlasiQ9H115. baseline and differential.
GenevisibleiQ9H115. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-298 (ISOFORM 1/2).
    Tissue: Amygdala.

Entry informationi

Entry nameiSNAB_HUMAN
AccessioniPrimary (citable) accession number: Q9H115
Secondary accession number(s): B4DK44
, Q4G0M0, Q4G187, Q5JXF9, Q8N3C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: March 16, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.