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Protein

Cystatin-like 1

Gene

CSTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125823-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-like 1
Alternative name(s):
RCET11
Gene namesi
Name:CSTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15958. CSTL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi128817.
OpenTargetsiENSG00000125823.
PharmGKBiPA26988.

Polymorphism and mutation databases

BioMutaiCSTL1.
DMDMi76803549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000666220 – 145Cystatin-like 1Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi91 ↔ 101By similarity
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 134By similarity
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H114.
PRIDEiQ9H114.

PTM databases

PhosphoSitePlusiQ9H114.

Expressioni

Gene expression databases

BgeeiENSG00000125823.
CleanExiHS_CSTL1.
ExpressionAtlasiQ9H114. baseline and differential.
GenevisibleiQ9H114. HS.

Organism-specific databases

HPAiCAB010267.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9H114.
SMRiQ9H114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi73 – 77Secondary area of contactSequence analysis5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7C. Eukaryota.
ENOG41119TA. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG096719.
InParanoidiQ9H114.
OMAiQLWNNSC.
OrthoDBiEOG091G0TP1.
PhylomeDBiQ9H114.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIGCWRNPL LLLIALVLSA KLGHFQRWEG FQQKLMSKKN MNSTLNFFIQ
60 70 80 90 100
SYNNASNDTY LYRVQRLIRS QMQLTTGVEY IVTVKIGWTK CKRNDTSNSS
110 120 130 140
CPLQSKKLRK SLICESLIYT MPWINYFQLW NNSCLEAEHV GRNLR
Length:145
Mass (Da):16,989
Last modified:September 27, 2005 - v2
Checksum:i7B247D02C2885464
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03384159T → A.Corresponds to variant rs7361799dbSNPEnsembl.1
Natural variantiVAR_03384262Y → F.Corresponds to variant rs16985357dbSNPEnsembl.1
Natural variantiVAR_03384366R → K.Corresponds to variant rs17757442dbSNPEnsembl.1
Natural variantiVAR_02442588W → R.1 PublicationCorresponds to variant rs3746736dbSNPEnsembl.1
Natural variantiVAR_02442696T → M.Corresponds to variant rs3746737dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY707749 mRNA. Translation: AAU20813.1.
AL096677 Genomic DNA. Translation: CAI20157.1.
BC117396 mRNA. Translation: AAI17397.1.
CCDSiCCDS13153.1.
RefSeqiNP_612140.1. NM_138283.1.
UniGeneiHs.352134.

Genome annotation databases

EnsembliENST00000246020; ENSP00000246020; ENSG00000125823.
ENST00000347397; ENSP00000344907; ENSG00000125823.
GeneIDi128817.
KEGGihsa:128817.
UCSCiuc002wte.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY707749 mRNA. Translation: AAU20813.1.
AL096677 Genomic DNA. Translation: CAI20157.1.
BC117396 mRNA. Translation: AAI17397.1.
CCDSiCCDS13153.1.
RefSeqiNP_612140.1. NM_138283.1.
UniGeneiHs.352134.

3D structure databases

ProteinModelPortaliQ9H114.
SMRiQ9H114.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ9H114.

Polymorphism and mutation databases

BioMutaiCSTL1.
DMDMi76803549.

Proteomic databases

PaxDbiQ9H114.
PRIDEiQ9H114.

Protocols and materials databases

DNASUi128817.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246020; ENSP00000246020; ENSG00000125823.
ENST00000347397; ENSP00000344907; ENSG00000125823.
GeneIDi128817.
KEGGihsa:128817.
UCSCiuc002wte.3. human.

Organism-specific databases

CTDi128817.
DisGeNETi128817.
GeneCardsiCSTL1.
HGNCiHGNC:15958. CSTL1.
HPAiCAB010267.
neXtProtiNX_Q9H114.
OpenTargetsiENSG00000125823.
PharmGKBiPA26988.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7C. Eukaryota.
ENOG41119TA. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG096719.
InParanoidiQ9H114.
OMAiQLWNNSC.
OrthoDBiEOG091G0TP1.
PhylomeDBiQ9H114.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125823-MONOMER.

Miscellaneous databases

ChiTaRSiCSTL1. human.
GeneWikiiCSTL1.
GenomeRNAii128817.
PROiQ9H114.

Gene expression databases

BgeeiENSG00000125823.
CleanExiHS_CSTL1.
ExpressionAtlasiQ9H114. baseline and differential.
GenevisibleiQ9H114. HS.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCST1L_HUMAN
AccessioniPrimary (citable) accession number: Q9H114
Secondary accession number(s): Q17RA8, Q64FF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: September 27, 2005
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.