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Protein

Cystatin-like 1

Gene

CSTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-like 1
Alternative name(s):
RCET11
Gene namesi
Name:CSTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15958. CSTL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26988.

Polymorphism and mutation databases

BioMutaiCSTL1.
DMDMi76803549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 145126Cystatin-like 1PRO_0000006662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 101By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 134By similarity
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H114.
PRIDEiQ9H114.

PTM databases

PhosphoSiteiQ9H114.

Expressioni

Gene expression databases

BgeeiENSG00000125823.
CleanExiHS_CSTL1.
ExpressionAtlasiQ9H114. baseline and differential.
GenevisibleiQ9H114. HS.

Organism-specific databases

HPAiCAB010267.

Structurei

3D structure databases

ProteinModelPortaliQ9H114.
SMRiQ9H114. Positions 51-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi73 – 775Secondary area of contactSequence analysis

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7C. Eukaryota.
ENOG41119TA. LUCA.
GeneTreeiENSGT00840000129787.
HOGENOMiHOG000231754.
HOVERGENiHBG096719.
InParanoidiQ9H114.
OMAiQLWNNSC.
OrthoDBiEOG091G0TP1.
PhylomeDBiQ9H114.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIGCWRNPL LLLIALVLSA KLGHFQRWEG FQQKLMSKKN MNSTLNFFIQ
60 70 80 90 100
SYNNASNDTY LYRVQRLIRS QMQLTTGVEY IVTVKIGWTK CKRNDTSNSS
110 120 130 140
CPLQSKKLRK SLICESLIYT MPWINYFQLW NNSCLEAEHV GRNLR
Length:145
Mass (Da):16,989
Last modified:September 27, 2005 - v2
Checksum:i7B247D02C2885464
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591T → A.
Corresponds to variant rs7361799 [ dbSNP | Ensembl ].
VAR_033841
Natural varianti62 – 621Y → F.
Corresponds to variant rs16985357 [ dbSNP | Ensembl ].
VAR_033842
Natural varianti66 – 661R → K.
Corresponds to variant rs17757442 [ dbSNP | Ensembl ].
VAR_033843
Natural varianti88 – 881W → R.1 Publication
Corresponds to variant rs3746736 [ dbSNP | Ensembl ].
VAR_024425
Natural varianti96 – 961T → M.
Corresponds to variant rs3746737 [ dbSNP | Ensembl ].
VAR_024426

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY707749 mRNA. Translation: AAU20813.1.
AL096677 Genomic DNA. Translation: CAI20157.1.
BC117396 mRNA. Translation: AAI17397.1.
CCDSiCCDS13153.1.
RefSeqiNP_612140.1. NM_138283.1.
UniGeneiHs.352134.

Genome annotation databases

EnsembliENST00000246020; ENSP00000246020; ENSG00000125823.
ENST00000347397; ENSP00000344907; ENSG00000125823.
GeneIDi128817.
KEGGihsa:128817.
UCSCiuc002wte.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY707749 mRNA. Translation: AAU20813.1.
AL096677 Genomic DNA. Translation: CAI20157.1.
BC117396 mRNA. Translation: AAI17397.1.
CCDSiCCDS13153.1.
RefSeqiNP_612140.1. NM_138283.1.
UniGeneiHs.352134.

3D structure databases

ProteinModelPortaliQ9H114.
SMRiQ9H114. Positions 51-136.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9H114.

Polymorphism and mutation databases

BioMutaiCSTL1.
DMDMi76803549.

Proteomic databases

PaxDbiQ9H114.
PRIDEiQ9H114.

Protocols and materials databases

DNASUi128817.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246020; ENSP00000246020; ENSG00000125823.
ENST00000347397; ENSP00000344907; ENSG00000125823.
GeneIDi128817.
KEGGihsa:128817.
UCSCiuc002wte.3. human.

Organism-specific databases

CTDi128817.
GeneCardsiCSTL1.
HGNCiHGNC:15958. CSTL1.
HPAiCAB010267.
neXtProtiNX_Q9H114.
PharmGKBiPA26988.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7C. Eukaryota.
ENOG41119TA. LUCA.
GeneTreeiENSGT00840000129787.
HOGENOMiHOG000231754.
HOVERGENiHBG096719.
InParanoidiQ9H114.
OMAiQLWNNSC.
OrthoDBiEOG091G0TP1.
PhylomeDBiQ9H114.

Miscellaneous databases

ChiTaRSiCSTL1. human.
GeneWikiiCSTL1.
GenomeRNAii128817.
PROiQ9H114.

Gene expression databases

BgeeiENSG00000125823.
CleanExiHS_CSTL1.
ExpressionAtlasiQ9H114. baseline and differential.
GenevisibleiQ9H114. HS.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCST1L_HUMAN
AccessioniPrimary (citable) accession number: Q9H114
Secondary accession number(s): Q17RA8, Q64FF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: September 27, 2005
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.