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Q9H112

- CST11_HUMAN

UniProt

Q9H112 - CST11_HUMAN

Protein

Cystatin-11

Gene

CST11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.1 Publication

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Protease inhibitor, Thiol protease inhibitor

    Protein family/group databases

    MEROPSiI25.027.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cystatin-11
    Gene namesi
    Name:CST11
    Synonyms:CST8L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15959. CST11.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Nuclear and cytoplasmic in the epididymis. Localized to the postacrosomal and tail regions of sperm. Probably localized to the outer surface of sperm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26974.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 138112Cystatin-11PRO_0000006658Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi94 ↔ 102By similarity
    Disulfide bondi115 ↔ 135By similarity
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H112.
    PRIDEiQ9H112.

    PTM databases

    PhosphoSiteiQ9H112.

    Expressioni

    Tissue specificityi

    Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level).1 Publication

    Gene expression databases

    BgeeiQ9H112.
    CleanExiHS_CST11.
    GenevestigatoriQ9H112.

    Organism-specific databases

    HPAiHPA053399.

    Interactioni

    Protein-protein interaction databases

    BioGridi126748. 1 interaction.
    STRINGi9606.ENSP00000366208.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H112.
    SMRiQ9H112. Positions 47-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi76 – 805Secondary area of contactSequence Analysis

    Sequence similaritiesi

    Belongs to the cystatin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47633.
    HOGENOMiHOG000231754.
    HOVERGENiHBG096361.
    InParanoidiQ9H112.
    KOiK13906.
    OMAiEMRRTTC.
    OrthoDBiEOG7M98J9.
    PhylomeDBiQ9H112.

    Family and domain databases

    InterProiIPR027214. Cystatin.
    IPR000010. Prot_inh_cystat.
    [Graphical view]
    PANTHERiPTHR11413. PTHR11413. 1 hit.
    PfamiPF00031. Cystatin. 1 hit.
    [Graphical view]
    SMARTiSM00043. CY. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H112-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMAEPWQALQ LLLAILLTLM ALPYQARKKT FLSVHEVMAV ENYAKDSLQW    50
    ITDQYNKESD DKYHFRIFRV LKVQRQVTDH LEYHLNVEMQ WTTCQKPETT 100
    NCVPQERELH KQVNCFFSVF AVPWFEQYKI LNKSCSSD 138
    Length:138
    Mass (Da):16,506
    Last modified:September 27, 2005 - v2
    Checksum:iE49440ACA3585C64
    GO
    Isoform 2 (identifier: Q9H112-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-111: Missing.

    Show »
    Length:103
    Mass (Da):12,285
    Checksum:i05DD92C47387B022
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei77 – 11135Missing in isoform 2. 2 PublicationsVSP_001260Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF335480 mRNA. Translation: AAL71991.1.
    AF335481 mRNA. Translation: AAL71992.1.
    AL096677 Genomic DNA. Translation: CAI20158.1.
    AL096677 Genomic DNA. Translation: CAI20159.1.
    CH471133 Genomic DNA. Translation: EAX10146.1.
    BC121079 mRNA. Translation: AAI21080.1.
    BC121080 mRNA. Translation: AAI21081.1.
    CCDSiCCDS13154.1. [Q9H112-2]
    CCDS13155.1. [Q9H112-1]
    RefSeqiNP_543020.2. NM_080830.2. [Q9H112-2]
    NP_570612.1. NM_130794.1. [Q9H112-1]
    UniGeneiHs.128100.

    Genome annotation databases

    EnsembliENST00000377007; ENSP00000366206; ENSG00000125831. [Q9H112-2]
    ENST00000377009; ENSP00000366208; ENSG00000125831. [Q9H112-1]
    GeneIDi140880.
    KEGGihsa:140880.
    UCSCiuc002wtf.1. human. [Q9H112-1]
    uc002wtg.1. human. [Q9H112-2]

    Polymorphism databases

    DMDMi76803548.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF335480 mRNA. Translation: AAL71991.1 .
    AF335481 mRNA. Translation: AAL71992.1 .
    AL096677 Genomic DNA. Translation: CAI20158.1 .
    AL096677 Genomic DNA. Translation: CAI20159.1 .
    CH471133 Genomic DNA. Translation: EAX10146.1 .
    BC121079 mRNA. Translation: AAI21080.1 .
    BC121080 mRNA. Translation: AAI21081.1 .
    CCDSi CCDS13154.1. [Q9H112-2 ]
    CCDS13155.1. [Q9H112-1 ]
    RefSeqi NP_543020.2. NM_080830.2. [Q9H112-2 ]
    NP_570612.1. NM_130794.1. [Q9H112-1 ]
    UniGenei Hs.128100.

    3D structure databases

    ProteinModelPortali Q9H112.
    SMRi Q9H112. Positions 47-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126748. 1 interaction.
    STRINGi 9606.ENSP00000366208.

    Protein family/group databases

    MEROPSi I25.027.

    PTM databases

    PhosphoSitei Q9H112.

    Polymorphism databases

    DMDMi 76803548.

    Proteomic databases

    PaxDbi Q9H112.
    PRIDEi Q9H112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377007 ; ENSP00000366206 ; ENSG00000125831 . [Q9H112-2 ]
    ENST00000377009 ; ENSP00000366208 ; ENSG00000125831 . [Q9H112-1 ]
    GeneIDi 140880.
    KEGGi hsa:140880.
    UCSCi uc002wtf.1. human. [Q9H112-1 ]
    uc002wtg.1. human. [Q9H112-2 ]

    Organism-specific databases

    CTDi 140880.
    GeneCardsi GC20M023379.
    HGNCi HGNC:15959. CST11.
    HPAi HPA053399.
    MIMi 609731. gene.
    neXtProti NX_Q9H112.
    PharmGKBi PA26974.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47633.
    HOGENOMi HOG000231754.
    HOVERGENi HBG096361.
    InParanoidi Q9H112.
    KOi K13906.
    OMAi EMRRTTC.
    OrthoDBi EOG7M98J9.
    PhylomeDBi Q9H112.

    Miscellaneous databases

    GeneWikii CST11.
    GenomeRNAii 140880.
    NextBioi 84520.
    PROi Q9H112.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H112.
    CleanExi HS_CST11.
    Genevestigatori Q9H112.

    Family and domain databases

    InterProi IPR027214. Cystatin.
    IPR000010. Prot_inh_cystat.
    [Graphical view ]
    PANTHERi PTHR11413. PTHR11413. 1 hit.
    Pfami PF00031. Cystatin. 1 hit.
    [Graphical view ]
    SMARTi SM00043. CY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiCST11_HUMAN
    AccessioniPrimary (citable) accession number: Q9H112
    Secondary accession number(s): Q0VAF2
    , Q0VAF3, Q8WXU5, Q8WXU6, Q9H113
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3