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Q9H112

- CST11_HUMAN

UniProt

Q9H112 - CST11_HUMAN

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Protein

Cystatin-11

Gene

CST11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.1 Publication

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-11
Gene namesi
Name:CST11
Synonyms:CST8L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15959. CST11.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication
Note: Nuclear and cytoplasmic in the epididymis. Localized to the postacrosomal and tail regions of sperm. Probably localized to the outer surface of sperm.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26974.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 138112Cystatin-11PRO_0000006658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi94 ↔ 102By similarity
Disulfide bondi115 ↔ 135By similarity
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H112.
PRIDEiQ9H112.

PTM databases

PhosphoSiteiQ9H112.

Expressioni

Tissue specificityi

Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level).1 Publication

Gene expression databases

BgeeiQ9H112.
CleanExiHS_CST11.
GenevestigatoriQ9H112.

Organism-specific databases

HPAiHPA053399.

Interactioni

Protein-protein interaction databases

BioGridi126748. 1 interaction.
STRINGi9606.ENSP00000366208.

Structurei

3D structure databases

ProteinModelPortaliQ9H112.
SMRiQ9H112. Positions 47-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi76 – 805Secondary area of contactSequence Analysis

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47633.
GeneTreeiENSGT00570000079039.
HOGENOMiHOG000231754.
HOVERGENiHBG096361.
InParanoidiQ9H112.
KOiK13906.
OMAiEMRRTTC.
OrthoDBiEOG7M98J9.
PhylomeDBiQ9H112.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H112-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAEPWQALQ LLLAILLTLM ALPYQARKKT FLSVHEVMAV ENYAKDSLQW
60 70 80 90 100
ITDQYNKESD DKYHFRIFRV LKVQRQVTDH LEYHLNVEMQ WTTCQKPETT
110 120 130
NCVPQERELH KQVNCFFSVF AVPWFEQYKI LNKSCSSD
Length:138
Mass (Da):16,506
Last modified:September 27, 2005 - v2
Checksum:iE49440ACA3585C64
GO
Isoform 2 (identifier: Q9H112-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-111: Missing.

Show »
Length:103
Mass (Da):12,285
Checksum:i05DD92C47387B022
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei77 – 11135Missing in isoform 2. 2 PublicationsVSP_001260Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335480 mRNA. Translation: AAL71991.1.
AF335481 mRNA. Translation: AAL71992.1.
AL096677 Genomic DNA. Translation: CAI20158.1.
AL096677 Genomic DNA. Translation: CAI20159.1.
CH471133 Genomic DNA. Translation: EAX10146.1.
BC121079 mRNA. Translation: AAI21080.1.
BC121080 mRNA. Translation: AAI21081.1.
CCDSiCCDS13154.1. [Q9H112-2]
CCDS13155.1. [Q9H112-1]
RefSeqiNP_543020.2. NM_080830.2. [Q9H112-2]
NP_570612.1. NM_130794.1. [Q9H112-1]
UniGeneiHs.128100.

Genome annotation databases

EnsembliENST00000377007; ENSP00000366206; ENSG00000125831. [Q9H112-2]
ENST00000377009; ENSP00000366208; ENSG00000125831. [Q9H112-1]
GeneIDi140880.
KEGGihsa:140880.
UCSCiuc002wtf.1. human. [Q9H112-1]
uc002wtg.1. human. [Q9H112-2]

Polymorphism databases

DMDMi76803548.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335480 mRNA. Translation: AAL71991.1 .
AF335481 mRNA. Translation: AAL71992.1 .
AL096677 Genomic DNA. Translation: CAI20158.1 .
AL096677 Genomic DNA. Translation: CAI20159.1 .
CH471133 Genomic DNA. Translation: EAX10146.1 .
BC121079 mRNA. Translation: AAI21080.1 .
BC121080 mRNA. Translation: AAI21081.1 .
CCDSi CCDS13154.1. [Q9H112-2 ]
CCDS13155.1. [Q9H112-1 ]
RefSeqi NP_543020.2. NM_080830.2. [Q9H112-2 ]
NP_570612.1. NM_130794.1. [Q9H112-1 ]
UniGenei Hs.128100.

3D structure databases

ProteinModelPortali Q9H112.
SMRi Q9H112. Positions 47-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126748. 1 interaction.
STRINGi 9606.ENSP00000366208.

Protein family/group databases

MEROPSi I25.027.

PTM databases

PhosphoSitei Q9H112.

Polymorphism databases

DMDMi 76803548.

Proteomic databases

PaxDbi Q9H112.
PRIDEi Q9H112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377007 ; ENSP00000366206 ; ENSG00000125831 . [Q9H112-2 ]
ENST00000377009 ; ENSP00000366208 ; ENSG00000125831 . [Q9H112-1 ]
GeneIDi 140880.
KEGGi hsa:140880.
UCSCi uc002wtf.1. human. [Q9H112-1 ]
uc002wtg.1. human. [Q9H112-2 ]

Organism-specific databases

CTDi 140880.
GeneCardsi GC20M023379.
HGNCi HGNC:15959. CST11.
HPAi HPA053399.
MIMi 609731. gene.
neXtProti NX_Q9H112.
PharmGKBi PA26974.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47633.
GeneTreei ENSGT00570000079039.
HOGENOMi HOG000231754.
HOVERGENi HBG096361.
InParanoidi Q9H112.
KOi K13906.
OMAi EMRRTTC.
OrthoDBi EOG7M98J9.
PhylomeDBi Q9H112.

Miscellaneous databases

GeneWikii CST11.
GenomeRNAii 140880.
NextBioi 84520.
PROi Q9H112.
SOURCEi Search...

Gene expression databases

Bgeei Q9H112.
CleanExi HS_CST11.
Genevestigatori Q9H112.

Family and domain databases

InterProi IPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
[Graphical view ]
PANTHERi PTHR11413. PTHR11413. 1 hit.
Pfami PF00031. Cystatin. 1 hit.
[Graphical view ]
SMARTi SM00043. CY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiCST11_HUMAN
AccessioniPrimary (citable) accession number: Q9H112
Secondary accession number(s): Q0VAF2
, Q0VAF3, Q8WXU5, Q8WXU6, Q9H113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3