Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal-regulatory protein delta

Gene

SIRPD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125900-MONOMER.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein delta
Short name:
SIRP-delta
Alternative name(s):
Protein tyrosine phosphatase non-receptor type substrate 1-like 2
Gene namesi
Name:SIRPD
Synonyms:PTPNS1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16248. SIRPD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125900.
PharmGKBiPA34008.

Polymorphism and mutation databases

BioMutaiSIRPD.
DMDMi34395825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001491930 – 197Signal-regulatory protein deltaAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 117PROSITE-ProRule annotation
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H106.
PRIDEiQ9H106.

PTM databases

iPTMnetiQ9H106.
PhosphoSitePlusiQ9H106.

Expressioni

Gene expression databases

BgeeiENSG00000125900.
CleanExiHS_SIRPD.
ExpressionAtlasiQ9H106. baseline and differential.
GenevisibleiQ9H106. HS.

Organism-specific databases

HPAiHPA042663.

Interactioni

Protein-protein interaction databases

BioGridi126140. 5 interactors.
IntActiQ9H106. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9H106.
SMRiQ9H106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 135Ig-like V-typeAdd BLAST105

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410JDVW. Eukaryota.
ENOG410ZD7Y. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000230874.
HOVERGENiHBG053747.
InParanoidiQ9H106.
KOiK16827.
PhylomeDBiQ9H106.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIPASPLHP PLPSLLLYLL LELAGVTHVF HVQQTEMSQT VSTGESIILS
60 70 80 90 100
CSVPNTLPNG PVLWFKGTGP NRKLIYNFKQ GNFPRVKEIG DTTKPGNTDF
110 120 130 140 150
STRIREISLA DAGTYYCVKF IKGRAIKEYQ SGRGTQVFVT EQNPRPPKNR
160 170 180 190
PAGRAGSRAH HDAHTCLSAL PERNSTNYFV QPCCCLRLLG LTGLLSK
Length:197
Mass (Da):21,687
Last modified:August 29, 2003 - v2
Checksum:iC8A2F5638293E832
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05607855N → D.3 PublicationsCorresponds to variant rs2249317dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093083 mRNA. Translation: BAG52650.1.
AL049634 Genomic DNA. Translation: CAI21868.1.
CH471133 Genomic DNA. Translation: EAX10624.1.
BC033502 mRNA. Translation: AAH33502.1.
CCDSiCCDS13018.1.
RefSeqiNP_848555.2. NM_178460.2.
UniGeneiHs.729560.

Genome annotation databases

EnsembliENST00000381623; ENSP00000371036; ENSG00000125900.
GeneIDi128646.
KEGGihsa:128646.
UCSCiuc002wfi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093083 mRNA. Translation: BAG52650.1.
AL049634 Genomic DNA. Translation: CAI21868.1.
CH471133 Genomic DNA. Translation: EAX10624.1.
BC033502 mRNA. Translation: AAH33502.1.
CCDSiCCDS13018.1.
RefSeqiNP_848555.2. NM_178460.2.
UniGeneiHs.729560.

3D structure databases

ProteinModelPortaliQ9H106.
SMRiQ9H106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126140. 5 interactors.
IntActiQ9H106. 1 interactor.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiQ9H106.
PhosphoSitePlusiQ9H106.

Polymorphism and mutation databases

BioMutaiSIRPD.
DMDMi34395825.

Proteomic databases

PaxDbiQ9H106.
PRIDEiQ9H106.

Protocols and materials databases

DNASUi128646.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381623; ENSP00000371036; ENSG00000125900.
GeneIDi128646.
KEGGihsa:128646.
UCSCiuc002wfi.4. human.

Organism-specific databases

CTDi128646.
GeneCardsiSIRPD.
HGNCiHGNC:16248. SIRPD.
HPAiHPA042663.
neXtProtiNX_Q9H106.
OpenTargetsiENSG00000125900.
PharmGKBiPA34008.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDVW. Eukaryota.
ENOG410ZD7Y. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000230874.
HOVERGENiHBG053747.
InParanoidiQ9H106.
KOiK16827.
PhylomeDBiQ9H106.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125900-MONOMER.

Miscellaneous databases

GenomeRNAii128646.
PROiQ9H106.

Gene expression databases

BgeeiENSG00000125900.
CleanExiHS_SIRPD.
ExpressionAtlasiQ9H106. baseline and differential.
GenevisibleiQ9H106. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIRPD_HUMAN
AccessioniPrimary (citable) accession number: Q9H106
Secondary accession number(s): B3KS88, Q5TFQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.