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Q9H0Y0

- ATG10_HUMAN

UniProt

Q9H0Y0 - ATG10_HUMAN

Protein

Ubiquitin-like-conjugating enzyme ATG10

Gene

ATG10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 By similarity. Plays a role in adenovirus-mediated cell lysis.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661Glycyl thioester intermediateBy similarity

    GO - Molecular functioni

    1. Atg12 ligase activity Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB
    2. autophagy in response to ER overload Source: UniProtKB
    3. positive regulation of protein modification process Source: UniProtKB
    4. protein lipidation Source: UniProtKB
    5. protein modification by small protein conjugation Source: UniProtKB
    6. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Autophagy, Protein transport, Transport, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like-conjugating enzyme ATG10 (EC:6.3.2.-)
    Alternative name(s):
    Autophagy-related protein 10
    Short name:
    APG10-like
    Gene namesi
    Name:ATG10
    Synonyms:APG10L
    ORF Names:PP12616
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:20315. ATG10.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. intracellular Source: LIFEdb

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134872167.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Ubiquitin-like-conjugating enzyme ATG10PRO_0000096183Add
    BLAST

    Proteomic databases

    PaxDbiQ9H0Y0.
    PRIDEiQ9H0Y0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H0Y0.
    BgeeiQ9H0Y0.
    CleanExiHS_ATG10.
    GenevestigatoriQ9H0Y0.

    Organism-specific databases

    HPAiCAB037232.
    HPA044163.

    Interactioni

    Subunit structurei

    Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 By similarity. Interacts with IRGM.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATG12O948171EBI-1048913,EBI-746742
    GABARAPO951661EBI-1048913,EBI-712001
    GABARAPL1Q9H0R81EBI-1048913,EBI-746969
    GABARAPL2P605201EBI-1048913,EBI-720116
    MAP1LC3BQ9GZQ81EBI-1048913,EBI-373144
    MAP1LC3CQ9BXW41EBI-1048913,EBI-2603996

    Protein-protein interaction databases

    BioGridi123745. 12 interactions.
    IntActiQ9H0Y0. 15 interactions.
    MINTiMINT-4712407.
    STRINGi9606.ENSP00000282185.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0Y0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG10 family.Curated

    Phylogenomic databases

    eggNOGiNOG258154.
    HOGENOMiHOG000034127.
    HOVERGENiHBG080874.
    InParanoidiQ9H0Y0.
    KOiK17888.
    OMAiLQQGPWD.
    OrthoDBiEOG7K3TN4.
    PhylomeDBiQ9H0Y0.
    TreeFamiTF314016.

    Family and domain databases

    InterProiIPR007135. Autophagy-rel_prot_3.
    [Graphical view]
    PfamiPF03987. Autophagy_act_C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H0Y0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI    50
    KNGSVMSHLG ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV 100
    LYSCSYQVPV LYFRASFLDG RPLTLKDIWE GVHECYKMRL LQGPWDTITQ 150
    QEHPILGQPF FVLHPCKTNE FMTPVLKNSQ KINKNVNYIT SWLSIVGPVV 200
    GLNLPLSYAK ATSQDERNVP 220
    Length:220
    Mass (Da):25,279
    Last modified:March 1, 2001 - v1
    Checksum:i1EDA80E385779B69
    GO
    Isoform 2 (identifier: Q9H0Y0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-125: EAFELPLDDC...SFLDGRPLTL → VKSCSVTQAG...PLHLANFLYF
         126-220: Missing.

    Show »
    Length:125
    Mass (Da):14,217
    Checksum:i57CE9269957F02CA
    GO

    Sequence cautioni

    The sequence BC004551 differs from that shown. Reason: Frameshift at position 26.
    The sequence BC027718 differs from that shown. Reason: Frameshift at position 26.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti62 – 621S → P.
    Corresponds to variant rs3734114 [ dbSNP | Ensembl ].
    VAR_024370
    Natural varianti212 – 2121T → M.1 Publication
    Corresponds to variant rs1864183 [ dbSNP | Ensembl ].
    VAR_021562
    Natural varianti220 – 2201P → H.1 Publication
    Corresponds to variant rs1864182 [ dbSNP | Ensembl ].
    VAR_021563

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei73 – 12553EAFEL…RPLTL → VKSCSVTQAGVQLRDLSSLQ PPPSGFKQFSCLSLPSNWDY RGSPLHLANFLYF in isoform 2. 2 PublicationsVSP_013272Add
    BLAST
    Alternative sequencei126 – 22095Missing in isoform 2. 2 PublicationsVSP_013273Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF318326 mRNA. Translation: AAL55833.1.
    AK024016 mRNA. Translation: BAB14778.1.
    AK315752 mRNA. Translation: BAG38106.1.
    AL136912 mRNA. Translation: CAB66846.1.
    BC004551 mRNA. No translation available.
    BC027718 mRNA. No translation available.
    BC029268 mRNA. Translation: AAH29268.1.
    CCDSiCCDS4057.1. [Q9H0Y0-1]
    RefSeqiNP_001124500.1. NM_001131028.1. [Q9H0Y0-1]
    NP_113670.1. NM_031482.4. [Q9H0Y0-1]
    XP_005248667.1. XM_005248610.2. [Q9H0Y0-1]
    XP_005248668.1. XM_005248611.2. [Q9H0Y0-1]
    UniGeneiHs.713698.

    Genome annotation databases

    EnsembliENST00000282185; ENSP00000282185; ENSG00000152348. [Q9H0Y0-1]
    ENST00000355178; ENSP00000347309; ENSG00000152348. [Q9H0Y0-2]
    ENST00000458350; ENSP00000404938; ENSG00000152348. [Q9H0Y0-1]
    ENST00000513443; ENSP00000425182; ENSG00000152348. [Q9H0Y0-2]
    GeneIDi83734.
    KEGGihsa:83734.
    UCSCiuc003khq.2. human. [Q9H0Y0-2]
    uc003khr.3. human. [Q9H0Y0-1]

    Polymorphism databases

    DMDMi62286633.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF318326 mRNA. Translation: AAL55833.1 .
    AK024016 mRNA. Translation: BAB14778.1 .
    AK315752 mRNA. Translation: BAG38106.1 .
    AL136912 mRNA. Translation: CAB66846.1 .
    BC004551 mRNA. No translation available.
    BC027718 mRNA. No translation available.
    BC029268 mRNA. Translation: AAH29268.1 .
    CCDSi CCDS4057.1. [Q9H0Y0-1 ]
    RefSeqi NP_001124500.1. NM_001131028.1. [Q9H0Y0-1 ]
    NP_113670.1. NM_031482.4. [Q9H0Y0-1 ]
    XP_005248667.1. XM_005248610.2. [Q9H0Y0-1 ]
    XP_005248668.1. XM_005248611.2. [Q9H0Y0-1 ]
    UniGenei Hs.713698.

    3D structure databases

    ProteinModelPortali Q9H0Y0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123745. 12 interactions.
    IntActi Q9H0Y0. 15 interactions.
    MINTi MINT-4712407.
    STRINGi 9606.ENSP00000282185.

    Polymorphism databases

    DMDMi 62286633.

    Proteomic databases

    PaxDbi Q9H0Y0.
    PRIDEi Q9H0Y0.

    Protocols and materials databases

    DNASUi 83734.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282185 ; ENSP00000282185 ; ENSG00000152348 . [Q9H0Y0-1 ]
    ENST00000355178 ; ENSP00000347309 ; ENSG00000152348 . [Q9H0Y0-2 ]
    ENST00000458350 ; ENSP00000404938 ; ENSG00000152348 . [Q9H0Y0-1 ]
    ENST00000513443 ; ENSP00000425182 ; ENSG00000152348 . [Q9H0Y0-2 ]
    GeneIDi 83734.
    KEGGi hsa:83734.
    UCSCi uc003khq.2. human. [Q9H0Y0-2 ]
    uc003khr.3. human. [Q9H0Y0-1 ]

    Organism-specific databases

    CTDi 83734.
    GeneCardsi GC05P081267.
    HGNCi HGNC:20315. ATG10.
    HPAi CAB037232.
    HPA044163.
    MIMi 610800. gene.
    neXtProti NX_Q9H0Y0.
    PharmGKBi PA134872167.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258154.
    HOGENOMi HOG000034127.
    HOVERGENi HBG080874.
    InParanoidi Q9H0Y0.
    KOi K17888.
    OMAi LQQGPWD.
    OrthoDBi EOG7K3TN4.
    PhylomeDBi Q9H0Y0.
    TreeFami TF314016.

    Miscellaneous databases

    GeneWikii ATG10.
    GenomeRNAii 83734.
    NextBioi 72737.
    PROi Q9H0Y0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H0Y0.
    Bgeei Q9H0Y0.
    CleanExi HS_ATG10.
    Genevestigatori Q9H0Y0.

    Family and domain databases

    InterProi IPR007135. Autophagy-rel_prot_3.
    [Graphical view ]
    Pfami PF03987. Autophagy_act_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-212 AND HIS-220.
      Tissue: Placenta and Testis.
    5. "Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity."
      Jiang H., White E.J., Rios-Vicil C.I., Xu J., Gomez-Manzano C., Fueyo J.
      J. Virol. 85:4720-4729(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: INTERACTION WITH IRGM.

    Entry informationi

    Entry nameiATG10_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0Y0
    Secondary accession number(s): B2RE09, Q6PIX1, Q9H842
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3