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Q9H0Y0

- ATG10_HUMAN

UniProt

Q9H0Y0 - ATG10_HUMAN

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Protein

Ubiquitin-like-conjugating enzyme ATG10

Gene

ATG10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei166 – 1661Glycyl thioester intermediateBy similarity

GO - Molecular functioni

  1. Atg12 ligase activity Source: UniProtKB

GO - Biological processi

  1. autophagy Source: UniProtKB
  2. autophagy in response to ER overload Source: UniProtKB
  3. positive regulation of protein modification process Source: UniProtKB
  4. protein lipidation Source: UniProtKB
  5. protein modification by small protein conjugation Source: UniProtKB
  6. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Autophagy, Protein transport, Transport, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like-conjugating enzyme ATG10 (EC:6.3.2.-)
Alternative name(s):
Autophagy-related protein 10
Short name:
APG10-like
Gene namesi
Name:ATG10
Synonyms:APG10L
ORF Names:PP12616
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:20315. ATG10.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. intracellular Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134872167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Ubiquitin-like-conjugating enzyme ATG10PRO_0000096183Add
BLAST

Proteomic databases

MaxQBiQ9H0Y0.
PaxDbiQ9H0Y0.
PRIDEiQ9H0Y0.

Expressioni

Gene expression databases

BgeeiQ9H0Y0.
CleanExiHS_ATG10.
ExpressionAtlasiQ9H0Y0. baseline and differential.
GenevestigatoriQ9H0Y0.

Organism-specific databases

HPAiCAB037232.
HPA044163.

Interactioni

Subunit structurei

Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). Interacts with IRGM.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG12O948171EBI-1048913,EBI-746742
GABARAPO951661EBI-1048913,EBI-712001
GABARAPL1Q9H0R81EBI-1048913,EBI-746969
GABARAPL2P605201EBI-1048913,EBI-720116
MAP1LC3BQ9GZQ81EBI-1048913,EBI-373144
MAP1LC3CQ9BXW41EBI-1048913,EBI-2603996

Protein-protein interaction databases

BioGridi123745. 12 interactions.
IntActiQ9H0Y0. 15 interactions.
MINTiMINT-4712407.
STRINGi9606.ENSP00000282185.

Structurei

3D structure databases

ProteinModelPortaliQ9H0Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG10 family.Curated

Phylogenomic databases

eggNOGiNOG258154.
GeneTreeiENSGT00390000000924.
HOGENOMiHOG000034127.
HOVERGENiHBG080874.
InParanoidiQ9H0Y0.
KOiK17888.
OMAiLQQGPWD.
OrthoDBiEOG7K3TN4.
PhylomeDBiQ9H0Y0.
TreeFamiTF314016.

Family and domain databases

InterProiIPR007135. Autophagy-rel_prot_3.
[Graphical view]
PfamiPF03987. Autophagy_act_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H0Y0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI
60 70 80 90 100
KNGSVMSHLG ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV
110 120 130 140 150
LYSCSYQVPV LYFRASFLDG RPLTLKDIWE GVHECYKMRL LQGPWDTITQ
160 170 180 190 200
QEHPILGQPF FVLHPCKTNE FMTPVLKNSQ KINKNVNYIT SWLSIVGPVV
210 220
GLNLPLSYAK ATSQDERNVP
Length:220
Mass (Da):25,279
Last modified:March 1, 2001 - v1
Checksum:i1EDA80E385779B69
GO
Isoform 2 (identifier: Q9H0Y0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-125: EAFELPLDDC...SFLDGRPLTL → VKSCSVTQAG...PLHLANFLYF
     126-220: Missing.

Show »
Length:125
Mass (Da):14,217
Checksum:i57CE9269957F02CA
GO

Sequence cautioni

The sequence BC004551 differs from that shown. Reason: Frameshift at position 26. Curated
The sequence BC027718 differs from that shown. Reason: Frameshift at position 26. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621S → P.
Corresponds to variant rs3734114 [ dbSNP | Ensembl ].
VAR_024370
Natural varianti212 – 2121T → M.1 Publication
Corresponds to variant rs1864183 [ dbSNP | Ensembl ].
VAR_021562
Natural varianti220 – 2201P → H.1 Publication
Corresponds to variant rs1864182 [ dbSNP | Ensembl ].
VAR_021563

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei73 – 12553EAFEL…RPLTL → VKSCSVTQAGVQLRDLSSLQ PPPSGFKQFSCLSLPSNWDY RGSPLHLANFLYF in isoform 2. 2 PublicationsVSP_013272Add
BLAST
Alternative sequencei126 – 22095Missing in isoform 2. 2 PublicationsVSP_013273Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318326 mRNA. Translation: AAL55833.1.
AK024016 mRNA. Translation: BAB14778.1.
AK315752 mRNA. Translation: BAG38106.1.
AL136912 mRNA. Translation: CAB66846.1.
BC004551 mRNA. No translation available.
BC027718 mRNA. No translation available.
BC029268 mRNA. Translation: AAH29268.1.
CCDSiCCDS4057.1. [Q9H0Y0-1]
RefSeqiNP_001124500.1. NM_001131028.1. [Q9H0Y0-1]
NP_113670.1. NM_031482.4. [Q9H0Y0-1]
XP_005248667.1. XM_005248610.2. [Q9H0Y0-1]
XP_005248668.1. XM_005248611.2. [Q9H0Y0-1]
UniGeneiHs.713698.

Genome annotation databases

EnsembliENST00000282185; ENSP00000282185; ENSG00000152348. [Q9H0Y0-1]
ENST00000355178; ENSP00000347309; ENSG00000152348. [Q9H0Y0-2]
ENST00000458350; ENSP00000404938; ENSG00000152348. [Q9H0Y0-1]
ENST00000513443; ENSP00000425182; ENSG00000152348. [Q9H0Y0-2]
GeneIDi83734.
KEGGihsa:83734.
UCSCiuc003khq.2. human. [Q9H0Y0-2]
uc003khr.3. human. [Q9H0Y0-1]

Polymorphism databases

DMDMi62286633.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318326 mRNA. Translation: AAL55833.1 .
AK024016 mRNA. Translation: BAB14778.1 .
AK315752 mRNA. Translation: BAG38106.1 .
AL136912 mRNA. Translation: CAB66846.1 .
BC004551 mRNA. No translation available.
BC027718 mRNA. No translation available.
BC029268 mRNA. Translation: AAH29268.1 .
CCDSi CCDS4057.1. [Q9H0Y0-1 ]
RefSeqi NP_001124500.1. NM_001131028.1. [Q9H0Y0-1 ]
NP_113670.1. NM_031482.4. [Q9H0Y0-1 ]
XP_005248667.1. XM_005248610.2. [Q9H0Y0-1 ]
XP_005248668.1. XM_005248611.2. [Q9H0Y0-1 ]
UniGenei Hs.713698.

3D structure databases

ProteinModelPortali Q9H0Y0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123745. 12 interactions.
IntActi Q9H0Y0. 15 interactions.
MINTi MINT-4712407.
STRINGi 9606.ENSP00000282185.

Polymorphism databases

DMDMi 62286633.

Proteomic databases

MaxQBi Q9H0Y0.
PaxDbi Q9H0Y0.
PRIDEi Q9H0Y0.

Protocols and materials databases

DNASUi 83734.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282185 ; ENSP00000282185 ; ENSG00000152348 . [Q9H0Y0-1 ]
ENST00000355178 ; ENSP00000347309 ; ENSG00000152348 . [Q9H0Y0-2 ]
ENST00000458350 ; ENSP00000404938 ; ENSG00000152348 . [Q9H0Y0-1 ]
ENST00000513443 ; ENSP00000425182 ; ENSG00000152348 . [Q9H0Y0-2 ]
GeneIDi 83734.
KEGGi hsa:83734.
UCSCi uc003khq.2. human. [Q9H0Y0-2 ]
uc003khr.3. human. [Q9H0Y0-1 ]

Organism-specific databases

CTDi 83734.
GeneCardsi GC05P081267.
HGNCi HGNC:20315. ATG10.
HPAi CAB037232.
HPA044163.
MIMi 610800. gene.
neXtProti NX_Q9H0Y0.
PharmGKBi PA134872167.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258154.
GeneTreei ENSGT00390000000924.
HOGENOMi HOG000034127.
HOVERGENi HBG080874.
InParanoidi Q9H0Y0.
KOi K17888.
OMAi LQQGPWD.
OrthoDBi EOG7K3TN4.
PhylomeDBi Q9H0Y0.
TreeFami TF314016.

Miscellaneous databases

GeneWikii ATG10.
GenomeRNAii 83734.
NextBioi 72737.
PROi Q9H0Y0.
SOURCEi Search...

Gene expression databases

Bgeei Q9H0Y0.
CleanExi HS_ATG10.
ExpressionAtlasi Q9H0Y0. baseline and differential.
Genevestigatori Q9H0Y0.

Family and domain databases

InterProi IPR007135. Autophagy-rel_prot_3.
[Graphical view ]
Pfami PF03987. Autophagy_act_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-212 AND HIS-220.
    Tissue: Placenta and Testis.
  5. "Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity."
    Jiang H., White E.J., Rios-Vicil C.I., Xu J., Gomez-Manzano C., Fueyo J.
    J. Virol. 85:4720-4729(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: INTERACTION WITH IRGM.

Entry informationi

Entry nameiATG10_HUMAN
AccessioniPrimary (citable) accession number: Q9H0Y0
Secondary accession number(s): B2RE09, Q6PIX1, Q9H842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3