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Protein

Ubiquitin-like-conjugating enzyme ATG10

Gene

ATG10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166Glycyl thioester intermediateBy similarity1

GO - Molecular functioni

  • Atg12 transferase activity Source: UniProtKB

GO - Biological processi

  • autophagy Source: UniProtKB
  • ER overload response Source: BHF-UCL
  • macroautophagy Source: Reactome
  • positive regulation of protein modification process Source: UniProtKB
  • protein lipidation Source: UniProtKB
  • protein modification by small protein conjugation Source: UniProtKB
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionTransferase
Biological processAutophagy, Protein transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
SIGNORiQ9H0Y0

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like-conjugating enzyme ATG10 (EC:2.3.2.-)
Alternative name(s):
Autophagy-related protein 10
Short name:
APG10-like
Gene namesi
Name:ATG10
Synonyms:APG10L
ORF Names:PP12616
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000152348.15
HGNCiHGNC:20315 ATG10
MIMi610800 gene
neXtProtiNX_Q9H0Y0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi83734
OpenTargetsiENSG00000152348
PharmGKBiPA134872167

Polymorphism and mutation databases

BioMutaiATG10
DMDMi62286633

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000961831 – 220Ubiquitin-like-conjugating enzyme ATG10Add BLAST220

Proteomic databases

MaxQBiQ9H0Y0
PaxDbiQ9H0Y0
PeptideAtlasiQ9H0Y0
PRIDEiQ9H0Y0

PTM databases

PhosphoSitePlusiQ9H0Y0

Expressioni

Gene expression databases

BgeeiENSG00000152348
CleanExiHS_ATG10
ExpressionAtlasiQ9H0Y0 baseline and differential
GenevisibleiQ9H0Y0 HS

Organism-specific databases

HPAiHPA044163

Interactioni

Subunit structurei

Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). Interacts with IRGM.By similarity1 Publication

Protein-protein interaction databases

BioGridi123745, 11 interactors
IntActiQ9H0Y0, 16 interactors
STRINGi9606.ENSP00000282185

Structurei

3D structure databases

ProteinModelPortaliQ9H0Y0
SMRiQ9H0Y0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG10 family.Curated

Phylogenomic databases

eggNOGiKOG4741 Eukaryota
ENOG4111W4Q LUCA
GeneTreeiENSGT00390000000924
HOGENOMiHOG000034127
HOVERGENiHBG080874
InParanoidiQ9H0Y0
KOiK17888
OMAiTSKDCSD
OrthoDBiEOG091G0KGP
PhylomeDBiQ9H0Y0
TreeFamiTF314016

Family and domain databases

InterProiView protein in InterPro
IPR007135 Autophagy-rel_prot_3
PfamiView protein in Pfam
PF03987 Autophagy_act_C, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0Y0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI
60 70 80 90 100
KNGSVMSHLG ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV
110 120 130 140 150
LYSCSYQVPV LYFRASFLDG RPLTLKDIWE GVHECYKMRL LQGPWDTITQ
160 170 180 190 200
QEHPILGQPF FVLHPCKTNE FMTPVLKNSQ KINKNVNYIT SWLSIVGPVV
210 220
GLNLPLSYAK ATSQDERNVP
Length:220
Mass (Da):25,279
Last modified:March 1, 2001 - v1
Checksum:i1EDA80E385779B69
GO
Isoform 2 (identifier: Q9H0Y0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-125: EAFELPLDDC...SFLDGRPLTL → VKSCSVTQAG...PLHLANFLYF
     126-220: Missing.

Show »
Length:125
Mass (Da):14,217
Checksum:i57CE9269957F02CA
GO

Sequence cautioni

The sequence BC004551 differs from that shown. Reason: Frameshift at position 26.Curated
The sequence BC027718 differs from that shown. Reason: Frameshift at position 26.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02437062S → P. Corresponds to variant dbSNP:rs3734114Ensembl.1
Natural variantiVAR_021562212T → M1 PublicationCorresponds to variant dbSNP:rs1864183Ensembl.1
Natural variantiVAR_021563220P → H1 PublicationCorresponds to variant dbSNP:rs1864182Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01327273 – 125EAFEL…RPLTL → VKSCSVTQAGVQLRDLSSLQ PPPSGFKQFSCLSLPSNWDY RGSPLHLANFLYF in isoform 2. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_013273126 – 220Missing in isoform 2. 2 PublicationsAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318326 mRNA Translation: AAL55833.1
AK024016 mRNA Translation: BAB14778.1
AK315752 mRNA Translation: BAG38106.1
AL136912 mRNA Translation: CAB66846.1
BC004551 mRNA No translation available.
BC027718 mRNA No translation available.
BC029268 mRNA Translation: AAH29268.1
CCDSiCCDS4057.1 [Q9H0Y0-1]
RefSeqiNP_001124500.1, NM_001131028.1 [Q9H0Y0-1]
NP_113670.1, NM_031482.4 [Q9H0Y0-1]
XP_005248667.1, XM_005248610.4 [Q9H0Y0-1]
XP_005248668.1, XM_005248611.4 [Q9H0Y0-1]
UniGeneiHs.713698

Genome annotation databases

EnsembliENST00000282185; ENSP00000282185; ENSG00000152348 [Q9H0Y0-1]
ENST00000355178; ENSP00000347309; ENSG00000152348 [Q9H0Y0-2]
ENST00000458350; ENSP00000404938; ENSG00000152348 [Q9H0Y0-1]
ENST00000513443; ENSP00000425182; ENSG00000152348 [Q9H0Y0-2]
GeneIDi83734
KEGGihsa:83734
UCSCiuc003khq.2 human [Q9H0Y0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiATG10_HUMAN
AccessioniPrimary (citable) accession number: Q9H0Y0
Secondary accession number(s): B2RE09, Q6PIX1, Q9H842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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