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Protein

RING finger protein 208

Gene

RNF208

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 190RING-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein autoubiquitination Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33815-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 208
Gene namesi
Name:RNF208
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25420. RNF208.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212864.
PharmGKBiPA162401649.

Polymorphism and mutation databases

BioMutaiRNF208.
DMDMi239938696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746131 – 261RING finger protein 208Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9H0X6.
PeptideAtlasiQ9H0X6.
PRIDEiQ9H0X6.

PTM databases

iPTMnetiQ9H0X6.
PhosphoSitePlusiQ9H0X6.

Expressioni

Gene expression databases

BgeeiENSG00000212864.
CleanExiHS_RNF208.
GenevisibleiQ9H0X6. HS.

Organism-specific databases

HPAiHPA021256.
HPA021429.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150386EBI-751555,EBI-724310
RPIAP492473EBI-751555,EBI-744831
UBQLN1Q9UMX03EBI-751555,EBI-741480

Protein-protein interaction databases

BioGridi608244. 4 interactors.
IntActiQ9H0X6. 7 interactors.
MINTiMINT-1472972.
STRINGi9606.ENSP00000375397.

Structurei

3D structure databases

ProteinModelPortaliQ9H0X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 190RING-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITEF. Eukaryota.
ENOG410XPDI. LUCA.
GeneTreeiENSGT00680000100126.
HOGENOMiHOG000154161.
HOVERGENiHBG080301.
InParanoidiQ9H0X6.
OMAiILMSCLK.
OrthoDBiEOG091G0GE1.
PhylomeDBiQ9H0X6.
TreeFamiTF331869.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDPGPEAG SGWPGLLMSC LKGPHVILKM EAMKIVHPEK FPELPAAPCF
60 70 80 90 100
PPAPRPTPTL APKRAWPSDT EIIVNQACGG DMPALEGAPH TPPLPRRPRK
110 120 130 140 150
GSSELGFPRV APEDEVIVNQ YVIRPGPSAS AASSAAAGEP LECPTCGHSY
160 170 180 190 200
NVTQRRPRVL SCLHSVCEQC LQILYESCPK YKFISCPTCR RETVLFTDYG
210 220 230 240 250
LAALAVNTSI LSRLPPEALT APSGGQWGAE PEGSCYQTFR QYCGAACTCH
260
VRNPLSACSI M
Length:261
Mass (Da):27,964
Last modified:June 16, 2009 - v2
Checksum:i5289AF5931E872E5
GO

Sequence cautioni

The sequence AAH16958 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH16958 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL16809 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB66475 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255925 Genomic DNA. Translation: CAM24146.1.
AL136540 mRNA. Translation: CAB66475.1. Different initiation.
AF416715 mRNA. Translation: AAL16809.1. Different initiation.
BC016958 mRNA. Translation: AAH16958.1. Sequence problems.
CCDSiCCDS7037.2.
RefSeqiNP_112587.2. NM_031297.4.
UniGeneiHs.512767.

Genome annotation databases

EnsembliENST00000391553; ENSP00000375397; ENSG00000212864.
ENST00000392827; ENSP00000376572; ENSG00000212864.
GeneIDi727800.
KEGGihsa:727800.
UCSCiuc004clz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255925 Genomic DNA. Translation: CAM24146.1.
AL136540 mRNA. Translation: CAB66475.1. Different initiation.
AF416715 mRNA. Translation: AAL16809.1. Different initiation.
BC016958 mRNA. Translation: AAH16958.1. Sequence problems.
CCDSiCCDS7037.2.
RefSeqiNP_112587.2. NM_031297.4.
UniGeneiHs.512767.

3D structure databases

ProteinModelPortaliQ9H0X6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608244. 4 interactors.
IntActiQ9H0X6. 7 interactors.
MINTiMINT-1472972.
STRINGi9606.ENSP00000375397.

PTM databases

iPTMnetiQ9H0X6.
PhosphoSitePlusiQ9H0X6.

Polymorphism and mutation databases

BioMutaiRNF208.
DMDMi239938696.

Proteomic databases

PaxDbiQ9H0X6.
PeptideAtlasiQ9H0X6.
PRIDEiQ9H0X6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391553; ENSP00000375397; ENSG00000212864.
ENST00000392827; ENSP00000376572; ENSG00000212864.
GeneIDi727800.
KEGGihsa:727800.
UCSCiuc004clz.2. human.

Organism-specific databases

CTDi727800.
GeneCardsiRNF208.
H-InvDBHIX0021289.
HGNCiHGNC:25420. RNF208.
HPAiHPA021256.
HPA021429.
neXtProtiNX_Q9H0X6.
OpenTargetsiENSG00000212864.
PharmGKBiPA162401649.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITEF. Eukaryota.
ENOG410XPDI. LUCA.
GeneTreeiENSGT00680000100126.
HOGENOMiHOG000154161.
HOVERGENiHBG080301.
InParanoidiQ9H0X6.
OMAiILMSCLK.
OrthoDBiEOG091G0GE1.
PhylomeDBiQ9H0X6.
TreeFamiTF331869.

Enzyme and pathway databases

BioCyciZFISH:G66-33815-MONOMER.

Miscellaneous databases

ChiTaRSiRNF208. human.
GenomeRNAii727800.
PROiQ9H0X6.

Gene expression databases

BgeeiENSG00000212864.
CleanExiHS_RNF208.
GenevisibleiQ9H0X6. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN208_HUMAN
AccessioniPrimary (citable) accession number: Q9H0X6
Secondary accession number(s): A2BFA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 16, 2009
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.