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Protein

Protein ITFG3

Gene

ITFG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ITFG3
Gene namesi
Name:ITFG3
Synonyms:C16orf9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14163. ITFG3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei50 – 7021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini71 – 552482ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Protein ITFG3PRO_0000247993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)1 Publication
Glycosylationi389 – 3891N-linked (GlcNAc...)2 Publications
Glycosylationi473 – 4731N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9H0X4.
PaxDbiQ9H0X4.
PRIDEiQ9H0X4.

PTM databases

PhosphoSiteiQ9H0X4.

Expressioni

Gene expression databases

BgeeiQ9H0X4.
CleanExiHS_ITFG3.
ExpressionAtlasiQ9H0X4. baseline and differential.
GenevestigatoriQ9H0X4.

Organism-specific databases

HPAiHPA011747.

Interactioni

Protein-protein interaction databases

BioGridi123837. 4 interactions.
IntActiQ9H0X4. 1 interaction.
MINTiMINT-4724606.
STRINGi9606.ENSP00000301678.

Structurei

3D structure databases

ProteinModelPortaliQ9H0X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ITFG3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79285.
GeneTreeiENSGT00530000063694.
HOGENOMiHOG000069926.
HOVERGENiHBG056541.
InParanoidiQ9H0X4.
KOiK17258.
OMAiSTGHQIG.
OrthoDBiEOG783MWS.
PhylomeDBiQ9H0X4.
TreeFamiTF327203.

Family and domain databases

InterProiIPR011047. Quinonprotein_ADH-like_supfam.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLDHKDLEAE IHPLKNEERK SQENLGNPSK NEDNVKSAPP QSRLSRCRAA
60 70 80 90 100
AFFLSLFLCL FVVFVVSFVI PCPDRPASQR MWRIDYSAAV IYDFLAVDDI
110 120 130 140 150
NGDRIQDVLF LYKNTNSSNN FSRSCVDEGF SSPCTFAAAV SGANGSTLWE
160 170 180 190 200
RPVAQDVALV ECAVPQPRGS EAPSACILVG RPSSFIAVNL FTGETLWNHS
210 220 230 240 250
SSFSGNASIL SPLLQVPDVD GDGAPDLLVL TQEREEVSGH LYSGSTGHQI
260 270 280 290 300
GLRGSLGVDG ESGFLLHVTR TGAHYILFPC ASSLCGCSVK GLYEKVTGSG
310 320 330 340 350
GPFKSDPHWE SMLNATTRRM LSHSSGAVRY LMHVPGNAGA DVLLVGSEAF
360 370 380 390 400
VLLDGQELTP RWTPKAAHVL RKPIFGRYKP DTLAVAVENG TGTDRQILFL
410 420 430 440 450
DLGTGAVLCS LALPSLPGGP LSASLPTADH RSAFFFWGLH ELGSTSETET
460 470 480 490 500
GEARHSLYMF HPTLPRVLLE LANVSTHIVA FDAVLFEPSR HAAYILLTGP
510 520 530 540 550
ADSEAPGLVS VIKHKVRDLV PSSRVVRLGE GGPDSDQAIR DRFSRLRYQS

EA
Length:552
Mass (Da):59,660
Last modified:February 28, 2001 - v1
Checksum:iAC81CB184EC3B043
GO
Isoform 2 (identifier: Q9H0X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-540: VRDLVPSSRVVRLGEGGPDSDQAIR → AHTGRQRRGSWTGQSSRRDLHVRVL
     541-552: Missing.

Note: No experimental confirmation available.

Show »
Length:540
Mass (Da):58,388
Checksum:i4031F2348BA6637E
GO

Sequence cautioni

The sequence AAK61220.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201K → E in BAB71374 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei516 – 54025VRDLV…DQAIR → AHTGRQRRGSWTGQSSRRDL HVRVL in isoform 2. 1 PublicationVSP_020121Add
BLAST
Alternative sequencei541 – 55212Missing in isoform 2. 1 PublicationVSP_020122Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136542 mRNA. Translation: CAB66477.1.
AK057165 mRNA. Translation: BAB71374.1.
AE006462 Genomic DNA. Translation: AAK61220.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85846.1.
CH471112 Genomic DNA. Translation: EAW85847.1.
BC010521 mRNA. Translation: AAH10521.1.
BC013047 mRNA. Translation: AAH13047.1.
BC032112 mRNA. Translation: AAH32112.1.
CCDSiCCDS10402.1. [Q9H0X4-1]
RefSeqiNP_001271426.1. NM_001284497.1. [Q9H0X4-1]
NP_114428.1. NM_032039.3. [Q9H0X4-1]
XP_005255679.1. XM_005255622.1. [Q9H0X4-1]
XP_006721019.1. XM_006720956.1. [Q9H0X4-1]
UniGeneiHs.513225.

Genome annotation databases

EnsembliENST00000301678; ENSP00000301678; ENSG00000167930. [Q9H0X4-1]
ENST00000301679; ENSP00000301679; ENSG00000167930. [Q9H0X4-2]
ENST00000399932; ENSP00000382814; ENSG00000167930. [Q9H0X4-1]
GeneIDi83986.
KEGGihsa:83986.
UCSCiuc002cgf.3. human. [Q9H0X4-1]
uc002cgg.2. human. [Q9H0X4-2]

Polymorphism databases

DMDMi74733531.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136542 mRNA. Translation: CAB66477.1.
AK057165 mRNA. Translation: BAB71374.1.
AE006462 Genomic DNA. Translation: AAK61220.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85846.1.
CH471112 Genomic DNA. Translation: EAW85847.1.
BC010521 mRNA. Translation: AAH10521.1.
BC013047 mRNA. Translation: AAH13047.1.
BC032112 mRNA. Translation: AAH32112.1.
CCDSiCCDS10402.1. [Q9H0X4-1]
RefSeqiNP_001271426.1. NM_001284497.1. [Q9H0X4-1]
NP_114428.1. NM_032039.3. [Q9H0X4-1]
XP_005255679.1. XM_005255622.1. [Q9H0X4-1]
XP_006721019.1. XM_006720956.1. [Q9H0X4-1]
UniGeneiHs.513225.

3D structure databases

ProteinModelPortaliQ9H0X4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123837. 4 interactions.
IntActiQ9H0X4. 1 interaction.
MINTiMINT-4724606.
STRINGi9606.ENSP00000301678.

PTM databases

PhosphoSiteiQ9H0X4.

Polymorphism databases

DMDMi74733531.

Proteomic databases

MaxQBiQ9H0X4.
PaxDbiQ9H0X4.
PRIDEiQ9H0X4.

Protocols and materials databases

DNASUi83986.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301678; ENSP00000301678; ENSG00000167930. [Q9H0X4-1]
ENST00000301679; ENSP00000301679; ENSG00000167930. [Q9H0X4-2]
ENST00000399932; ENSP00000382814; ENSG00000167930. [Q9H0X4-1]
GeneIDi83986.
KEGGihsa:83986.
UCSCiuc002cgf.3. human. [Q9H0X4-1]
uc002cgg.2. human. [Q9H0X4-2]

Organism-specific databases

CTDi83986.
GeneCardsiGC16P000305.
HGNCiHGNC:14163. ITFG3.
HPAiHPA011747.
neXtProtiNX_Q9H0X4.
PharmGKBiPA25564.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79285.
GeneTreeiENSGT00530000063694.
HOGENOMiHOG000069926.
HOVERGENiHBG056541.
InParanoidiQ9H0X4.
KOiK17258.
OMAiSTGHQIG.
OrthoDBiEOG783MWS.
PhylomeDBiQ9H0X4.
TreeFamiTF327203.

Miscellaneous databases

GeneWikiiITFG3.
GenomeRNAii83986.
NextBioi73118.
PROiQ9H0X4.

Gene expression databases

BgeeiQ9H0X4.
CleanExiHS_ITFG3.
ExpressionAtlasiQ9H0X4. baseline and differential.
GenevestigatoriQ9H0X4.

Family and domain databases

InterProiIPR011047. Quinonprotein_ADH-like_supfam.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Stomach.
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon, Glioblastoma and Ovary.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-389.
    Tissue: Liver.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314; ASN-389 AND ASN-473.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiITFG3_HUMAN
AccessioniPrimary (citable) accession number: Q9H0X4
Secondary accession number(s): D3DU45
, Q7L416, Q96FR1, Q96MC7, Q96S30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 4, 2006
Last sequence update: February 28, 2001
Last modified: March 3, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.