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Q9H0X4

- ITFG3_HUMAN

UniProt

Q9H0X4 - ITFG3_HUMAN

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Protein
Protein ITFG3
Gene
ITFG3, C16orf9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ITFG3
Gene namesi
Name:ITFG3
Synonyms:C16orf9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14163. ITFG3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei50 – 7021Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini71 – 552482Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Protein ITFG3
PRO_0000247993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine1 Publication
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...)1 Publication
Glycosylationi389 – 3891N-linked (GlcNAc...)2 Publications
Glycosylationi473 – 4731N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9H0X4.
PaxDbiQ9H0X4.
PRIDEiQ9H0X4.

PTM databases

PhosphoSiteiQ9H0X4.

Expressioni

Gene expression databases

ArrayExpressiQ9H0X4.
BgeeiQ9H0X4.
CleanExiHS_ITFG3.
GenevestigatoriQ9H0X4.

Organism-specific databases

HPAiHPA011747.

Interactioni

Protein-protein interaction databases

BioGridi123837. 3 interactions.
IntActiQ9H0X4. 1 interaction.
MINTiMINT-4724606.
STRINGi9606.ENSP00000301678.

Structurei

3D structure databases

ProteinModelPortaliQ9H0X4.
SMRiQ9H0X4. Positions 210-247.

Family & Domainsi

Sequence similaritiesi

Belongs to the ITFG3 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79285.
HOGENOMiHOG000069926.
HOVERGENiHBG056541.
InParanoidiQ9H0X4.
KOiK17258.
OMAiSTGHQIG.
OrthoDBiEOG783MWS.
PhylomeDBiQ9H0X4.
TreeFamiTF327203.

Family and domain databases

InterProiIPR011047. Quinonprotein_ADH-like_supfam.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H0X4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLDHKDLEAE IHPLKNEERK SQENLGNPSK NEDNVKSAPP QSRLSRCRAA    50
AFFLSLFLCL FVVFVVSFVI PCPDRPASQR MWRIDYSAAV IYDFLAVDDI 100
NGDRIQDVLF LYKNTNSSNN FSRSCVDEGF SSPCTFAAAV SGANGSTLWE 150
RPVAQDVALV ECAVPQPRGS EAPSACILVG RPSSFIAVNL FTGETLWNHS 200
SSFSGNASIL SPLLQVPDVD GDGAPDLLVL TQEREEVSGH LYSGSTGHQI 250
GLRGSLGVDG ESGFLLHVTR TGAHYILFPC ASSLCGCSVK GLYEKVTGSG 300
GPFKSDPHWE SMLNATTRRM LSHSSGAVRY LMHVPGNAGA DVLLVGSEAF 350
VLLDGQELTP RWTPKAAHVL RKPIFGRYKP DTLAVAVENG TGTDRQILFL 400
DLGTGAVLCS LALPSLPGGP LSASLPTADH RSAFFFWGLH ELGSTSETET 450
GEARHSLYMF HPTLPRVLLE LANVSTHIVA FDAVLFEPSR HAAYILLTGP 500
ADSEAPGLVS VIKHKVRDLV PSSRVVRLGE GGPDSDQAIR DRFSRLRYQS 550
EA 552
Length:552
Mass (Da):59,660
Last modified:March 1, 2001 - v1
Checksum:iAC81CB184EC3B043
GO
Isoform 2 (identifier: Q9H0X4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-540: VRDLVPSSRVVRLGEGGPDSDQAIR → AHTGRQRRGSWTGQSSRRDLHVRVL
     541-552: Missing.

Note: No experimental confirmation available.

Show »
Length:540
Mass (Da):58,388
Checksum:i4031F2348BA6637E
GO

Sequence cautioni

The sequence AAK61220.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei516 – 54025VRDLV…DQAIR → AHTGRQRRGSWTGQSSRRDL HVRVL in isoform 2.
VSP_020121Add
BLAST
Alternative sequencei541 – 55212Missing in isoform 2.
VSP_020122Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201K → E in BAB71374. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136542 mRNA. Translation: CAB66477.1.
AK057165 mRNA. Translation: BAB71374.1.
AE006462 Genomic DNA. Translation: AAK61220.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85846.1.
CH471112 Genomic DNA. Translation: EAW85847.1.
BC010521 mRNA. Translation: AAH10521.1.
BC013047 mRNA. Translation: AAH13047.1.
BC032112 mRNA. Translation: AAH32112.1.
CCDSiCCDS10402.1. [Q9H0X4-1]
RefSeqiNP_001271426.1. NM_001284497.1. [Q9H0X4-1]
NP_114428.1. NM_032039.3. [Q9H0X4-1]
XP_005255679.1. XM_005255622.1. [Q9H0X4-1]
XP_006721019.1. XM_006720956.1. [Q9H0X4-1]
UniGeneiHs.513225.

Genome annotation databases

EnsembliENST00000301678; ENSP00000301678; ENSG00000167930. [Q9H0X4-1]
ENST00000301679; ENSP00000301679; ENSG00000167930. [Q9H0X4-2]
ENST00000399932; ENSP00000382814; ENSG00000167930. [Q9H0X4-1]
ENST00000450082; ENSP00000411394; ENSG00000167930. [Q9H0X4-2]
GeneIDi83986.
KEGGihsa:83986.
UCSCiuc002cgf.3. human. [Q9H0X4-1]
uc002cgg.2. human. [Q9H0X4-2]

Polymorphism databases

DMDMi74733531.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136542 mRNA. Translation: CAB66477.1 .
AK057165 mRNA. Translation: BAB71374.1 .
AE006462 Genomic DNA. Translation: AAK61220.1 . Sequence problems.
CH471112 Genomic DNA. Translation: EAW85846.1 .
CH471112 Genomic DNA. Translation: EAW85847.1 .
BC010521 mRNA. Translation: AAH10521.1 .
BC013047 mRNA. Translation: AAH13047.1 .
BC032112 mRNA. Translation: AAH32112.1 .
CCDSi CCDS10402.1. [Q9H0X4-1 ]
RefSeqi NP_001271426.1. NM_001284497.1. [Q9H0X4-1 ]
NP_114428.1. NM_032039.3. [Q9H0X4-1 ]
XP_005255679.1. XM_005255622.1. [Q9H0X4-1 ]
XP_006721019.1. XM_006720956.1. [Q9H0X4-1 ]
UniGenei Hs.513225.

3D structure databases

ProteinModelPortali Q9H0X4.
SMRi Q9H0X4. Positions 210-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123837. 3 interactions.
IntActi Q9H0X4. 1 interaction.
MINTi MINT-4724606.
STRINGi 9606.ENSP00000301678.

PTM databases

PhosphoSitei Q9H0X4.

Polymorphism databases

DMDMi 74733531.

Proteomic databases

MaxQBi Q9H0X4.
PaxDbi Q9H0X4.
PRIDEi Q9H0X4.

Protocols and materials databases

DNASUi 83986.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301678 ; ENSP00000301678 ; ENSG00000167930 . [Q9H0X4-1 ]
ENST00000301679 ; ENSP00000301679 ; ENSG00000167930 . [Q9H0X4-2 ]
ENST00000399932 ; ENSP00000382814 ; ENSG00000167930 . [Q9H0X4-1 ]
ENST00000450082 ; ENSP00000411394 ; ENSG00000167930 . [Q9H0X4-2 ]
GeneIDi 83986.
KEGGi hsa:83986.
UCSCi uc002cgf.3. human. [Q9H0X4-1 ]
uc002cgg.2. human. [Q9H0X4-2 ]

Organism-specific databases

CTDi 83986.
GeneCardsi GC16P000294.
HGNCi HGNC:14163. ITFG3.
HPAi HPA011747.
neXtProti NX_Q9H0X4.
PharmGKBi PA25564.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79285.
HOGENOMi HOG000069926.
HOVERGENi HBG056541.
InParanoidi Q9H0X4.
KOi K17258.
OMAi STGHQIG.
OrthoDBi EOG783MWS.
PhylomeDBi Q9H0X4.
TreeFami TF327203.

Miscellaneous databases

GeneWikii ITFG3.
GenomeRNAii 83986.
NextBioi 73118.
PROi Q9H0X4.

Gene expression databases

ArrayExpressi Q9H0X4.
Bgeei Q9H0X4.
CleanExi HS_ITFG3.
Genevestigatori Q9H0X4.

Family and domain databases

InterProi IPR011047. Quinonprotein_ADH-like_supfam.
[Graphical view ]
SUPFAMi SSF50998. SSF50998. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Stomach.
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon, Glioblastoma and Ovary.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-389.
    Tissue: Liver.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314; ASN-389 AND ASN-473.
    Tissue: Leukemic T-cell.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiITFG3_HUMAN
AccessioniPrimary (citable) accession number: Q9H0X4
Secondary accession number(s): D3DU45
, Q7L416, Q96FR1, Q96MC7, Q96S30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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