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Q9H0X4 (ITFG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ITFG3
Gene names
Name:ITFG3
Synonyms:C16orf9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the ITFG3 family.

Sequence caution

The sequence AAK61220.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H0X4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H0X4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     516-540: VRDLVPSSRVVRLGEGGPDSDQAIR → AHTGRQRRGSWTGQSSRRDLHVRVL
     541-552: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Protein ITFG3
PRO_0000247993

Regions

Topological domain1 – 4949Cytoplasmic Potential
Transmembrane50 – 7021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain71 – 552482Extracellular Potential

Amino acid modifications

Modified residue211Phosphoserine Ref.8
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Ref.7
Glycosylation3891N-linked (GlcNAc...) Ref.6 Ref.7
Glycosylation4731N-linked (GlcNAc...) Ref.7

Natural variations

Alternative sequence516 – 54025VRDLV…DQAIR → AHTGRQRRGSWTGQSSRRDL HVRVL in isoform 2.
VSP_020121
Alternative sequence541 – 55212Missing in isoform 2.
VSP_020122

Experimental info

Sequence conflict201K → E in BAB71374. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: AC81CB184EC3B043

FASTA55259,660
        10         20         30         40         50         60 
MLDHKDLEAE IHPLKNEERK SQENLGNPSK NEDNVKSAPP QSRLSRCRAA AFFLSLFLCL 

        70         80         90        100        110        120 
FVVFVVSFVI PCPDRPASQR MWRIDYSAAV IYDFLAVDDI NGDRIQDVLF LYKNTNSSNN 

       130        140        150        160        170        180 
FSRSCVDEGF SSPCTFAAAV SGANGSTLWE RPVAQDVALV ECAVPQPRGS EAPSACILVG 

       190        200        210        220        230        240 
RPSSFIAVNL FTGETLWNHS SSFSGNASIL SPLLQVPDVD GDGAPDLLVL TQEREEVSGH 

       250        260        270        280        290        300 
LYSGSTGHQI GLRGSLGVDG ESGFLLHVTR TGAHYILFPC ASSLCGCSVK GLYEKVTGSG 

       310        320        330        340        350        360 
GPFKSDPHWE SMLNATTRRM LSHSSGAVRY LMHVPGNAGA DVLLVGSEAF VLLDGQELTP 

       370        380        390        400        410        420 
RWTPKAAHVL RKPIFGRYKP DTLAVAVENG TGTDRQILFL DLGTGAVLCS LALPSLPGGP 

       430        440        450        460        470        480 
LSASLPTADH RSAFFFWGLH ELGSTSETET GEARHSLYMF HPTLPRVLLE LANVSTHIVA 

       490        500        510        520        530        540 
FDAVLFEPSR HAAYILLTGP ADSEAPGLVS VIKHKVRDLV PSSRVVRLGE GGPDSDQAIR 

       550 
DRFSRLRYQS EA 

« Hide

Isoform 2 [UniParc].

Checksum: 4031F2348BA6637E
Show »

FASTA54058,388

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Stomach.
[3]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon, Glioblastoma and Ovary.
[6]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-389.
Tissue: Liver.
[7]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314; ASN-389 AND ASN-473.
Tissue: Leukemic T-cell.
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136542 mRNA. Translation: CAB66477.1.
AK057165 mRNA. Translation: BAB71374.1.
AE006462 Genomic DNA. Translation: AAK61220.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85846.1.
CH471112 Genomic DNA. Translation: EAW85847.1.
BC010521 mRNA. Translation: AAH10521.1.
BC013047 mRNA. Translation: AAH13047.1.
BC032112 mRNA. Translation: AAH32112.1.
CCDSCCDS10402.1. [Q9H0X4-1]
RefSeqNP_001271426.1. NM_001284497.1. [Q9H0X4-1]
NP_114428.1. NM_032039.3. [Q9H0X4-1]
XP_005255679.1. XM_005255622.1. [Q9H0X4-1]
XP_006721019.1. XM_006720956.1. [Q9H0X4-1]
UniGeneHs.513225.

3D structure databases

ProteinModelPortalQ9H0X4.
SMRQ9H0X4. Positions 210-247.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123837. 3 interactions.
IntActQ9H0X4. 1 interaction.
MINTMINT-4724606.
STRING9606.ENSP00000301678.

PTM databases

PhosphoSiteQ9H0X4.

Polymorphism databases

DMDM74733531.

Proteomic databases

MaxQBQ9H0X4.
PaxDbQ9H0X4.
PRIDEQ9H0X4.

Protocols and materials databases

DNASU83986.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301678; ENSP00000301678; ENSG00000167930. [Q9H0X4-1]
ENST00000301679; ENSP00000301679; ENSG00000167930. [Q9H0X4-2]
ENST00000399932; ENSP00000382814; ENSG00000167930. [Q9H0X4-1]
ENST00000450082; ENSP00000411394; ENSG00000167930. [Q9H0X4-2]
GeneID83986.
KEGGhsa:83986.
UCSCuc002cgf.3. human. [Q9H0X4-1]
uc002cgg.2. human. [Q9H0X4-2]

Organism-specific databases

CTD83986.
GeneCardsGC16P000294.
HGNCHGNC:14163. ITFG3.
HPAHPA011747.
neXtProtNX_Q9H0X4.
PharmGKBPA25564.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79285.
HOGENOMHOG000069926.
HOVERGENHBG056541.
InParanoidQ9H0X4.
KOK17258.
OMASTGHQIG.
OrthoDBEOG783MWS.
PhylomeDBQ9H0X4.
TreeFamTF327203.

Gene expression databases

ArrayExpressQ9H0X4.
BgeeQ9H0X4.
CleanExHS_ITFG3.
GenevestigatorQ9H0X4.

Family and domain databases

InterProIPR011047. Quinonprotein_ADH-like_supfam.
[Graphical view]
SUPFAMSSF50998. SSF50998. 2 hits.
ProtoNetSearch...

Other

GeneWikiITFG3.
GenomeRNAi83986.
NextBio73118.
PROQ9H0X4.

Entry information

Entry nameITFG3_HUMAN
AccessionPrimary (citable) accession number: Q9H0X4
Secondary accession number(s): D3DU45 expand/collapse secondary AC list , Q7L416, Q96FR1, Q96MC7, Q96S30
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM