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Q9H0X4

- ITFG3_HUMAN

UniProt

Q9H0X4 - ITFG3_HUMAN

Protein

Protein ITFG3

Gene

ITFG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ITFG3
    Gene namesi
    Name:ITFG3
    Synonyms:C16orf9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14163. ITFG3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25564.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Protein ITFG3PRO_0000247993Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211Phosphoserine1 Publication
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)1 Publication
    Glycosylationi389 – 3891N-linked (GlcNAc...)2 Publications
    Glycosylationi473 – 4731N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9H0X4.
    PaxDbiQ9H0X4.
    PRIDEiQ9H0X4.

    PTM databases

    PhosphoSiteiQ9H0X4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H0X4.
    BgeeiQ9H0X4.
    CleanExiHS_ITFG3.
    GenevestigatoriQ9H0X4.

    Organism-specific databases

    HPAiHPA011747.

    Interactioni

    Protein-protein interaction databases

    BioGridi123837. 3 interactions.
    IntActiQ9H0X4. 1 interaction.
    MINTiMINT-4724606.
    STRINGi9606.ENSP00000301678.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0X4.
    SMRiQ9H0X4. Positions 210-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini71 – 552482ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ITFG3 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79285.
    HOGENOMiHOG000069926.
    HOVERGENiHBG056541.
    InParanoidiQ9H0X4.
    KOiK17258.
    OMAiSTGHQIG.
    OrthoDBiEOG783MWS.
    PhylomeDBiQ9H0X4.
    TreeFamiTF327203.

    Family and domain databases

    InterProiIPR011047. Quinonprotein_ADH-like_supfam.
    [Graphical view]
    SUPFAMiSSF50998. SSF50998. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H0X4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLDHKDLEAE IHPLKNEERK SQENLGNPSK NEDNVKSAPP QSRLSRCRAA    50
    AFFLSLFLCL FVVFVVSFVI PCPDRPASQR MWRIDYSAAV IYDFLAVDDI 100
    NGDRIQDVLF LYKNTNSSNN FSRSCVDEGF SSPCTFAAAV SGANGSTLWE 150
    RPVAQDVALV ECAVPQPRGS EAPSACILVG RPSSFIAVNL FTGETLWNHS 200
    SSFSGNASIL SPLLQVPDVD GDGAPDLLVL TQEREEVSGH LYSGSTGHQI 250
    GLRGSLGVDG ESGFLLHVTR TGAHYILFPC ASSLCGCSVK GLYEKVTGSG 300
    GPFKSDPHWE SMLNATTRRM LSHSSGAVRY LMHVPGNAGA DVLLVGSEAF 350
    VLLDGQELTP RWTPKAAHVL RKPIFGRYKP DTLAVAVENG TGTDRQILFL 400
    DLGTGAVLCS LALPSLPGGP LSASLPTADH RSAFFFWGLH ELGSTSETET 450
    GEARHSLYMF HPTLPRVLLE LANVSTHIVA FDAVLFEPSR HAAYILLTGP 500
    ADSEAPGLVS VIKHKVRDLV PSSRVVRLGE GGPDSDQAIR DRFSRLRYQS 550
    EA 552
    Length:552
    Mass (Da):59,660
    Last modified:March 1, 2001 - v1
    Checksum:iAC81CB184EC3B043
    GO
    Isoform 2 (identifier: Q9H0X4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         516-540: VRDLVPSSRVVRLGEGGPDSDQAIR → AHTGRQRRGSWTGQSSRRDLHVRVL
         541-552: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:540
    Mass (Da):58,388
    Checksum:i4031F2348BA6637E
    GO

    Sequence cautioni

    The sequence AAK61220.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201K → E in BAB71374. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei516 – 54025VRDLV…DQAIR → AHTGRQRRGSWTGQSSRRDL HVRVL in isoform 2. 1 PublicationVSP_020121Add
    BLAST
    Alternative sequencei541 – 55212Missing in isoform 2. 1 PublicationVSP_020122Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136542 mRNA. Translation: CAB66477.1.
    AK057165 mRNA. Translation: BAB71374.1.
    AE006462 Genomic DNA. Translation: AAK61220.1. Sequence problems.
    CH471112 Genomic DNA. Translation: EAW85846.1.
    CH471112 Genomic DNA. Translation: EAW85847.1.
    BC010521 mRNA. Translation: AAH10521.1.
    BC013047 mRNA. Translation: AAH13047.1.
    BC032112 mRNA. Translation: AAH32112.1.
    CCDSiCCDS10402.1. [Q9H0X4-1]
    RefSeqiNP_001271426.1. NM_001284497.1. [Q9H0X4-1]
    NP_114428.1. NM_032039.3. [Q9H0X4-1]
    XP_005255679.1. XM_005255622.1. [Q9H0X4-1]
    XP_006721019.1. XM_006720956.1. [Q9H0X4-1]
    UniGeneiHs.513225.

    Genome annotation databases

    EnsembliENST00000301678; ENSP00000301678; ENSG00000167930. [Q9H0X4-1]
    ENST00000301679; ENSP00000301679; ENSG00000167930. [Q9H0X4-2]
    ENST00000399932; ENSP00000382814; ENSG00000167930. [Q9H0X4-1]
    GeneIDi83986.
    KEGGihsa:83986.
    UCSCiuc002cgf.3. human. [Q9H0X4-1]
    uc002cgg.2. human. [Q9H0X4-2]

    Polymorphism databases

    DMDMi74733531.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136542 mRNA. Translation: CAB66477.1 .
    AK057165 mRNA. Translation: BAB71374.1 .
    AE006462 Genomic DNA. Translation: AAK61220.1 . Sequence problems.
    CH471112 Genomic DNA. Translation: EAW85846.1 .
    CH471112 Genomic DNA. Translation: EAW85847.1 .
    BC010521 mRNA. Translation: AAH10521.1 .
    BC013047 mRNA. Translation: AAH13047.1 .
    BC032112 mRNA. Translation: AAH32112.1 .
    CCDSi CCDS10402.1. [Q9H0X4-1 ]
    RefSeqi NP_001271426.1. NM_001284497.1. [Q9H0X4-1 ]
    NP_114428.1. NM_032039.3. [Q9H0X4-1 ]
    XP_005255679.1. XM_005255622.1. [Q9H0X4-1 ]
    XP_006721019.1. XM_006720956.1. [Q9H0X4-1 ]
    UniGenei Hs.513225.

    3D structure databases

    ProteinModelPortali Q9H0X4.
    SMRi Q9H0X4. Positions 210-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123837. 3 interactions.
    IntActi Q9H0X4. 1 interaction.
    MINTi MINT-4724606.
    STRINGi 9606.ENSP00000301678.

    PTM databases

    PhosphoSitei Q9H0X4.

    Polymorphism databases

    DMDMi 74733531.

    Proteomic databases

    MaxQBi Q9H0X4.
    PaxDbi Q9H0X4.
    PRIDEi Q9H0X4.

    Protocols and materials databases

    DNASUi 83986.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301678 ; ENSP00000301678 ; ENSG00000167930 . [Q9H0X4-1 ]
    ENST00000301679 ; ENSP00000301679 ; ENSG00000167930 . [Q9H0X4-2 ]
    ENST00000399932 ; ENSP00000382814 ; ENSG00000167930 . [Q9H0X4-1 ]
    GeneIDi 83986.
    KEGGi hsa:83986.
    UCSCi uc002cgf.3. human. [Q9H0X4-1 ]
    uc002cgg.2. human. [Q9H0X4-2 ]

    Organism-specific databases

    CTDi 83986.
    GeneCardsi GC16P000294.
    HGNCi HGNC:14163. ITFG3.
    HPAi HPA011747.
    neXtProti NX_Q9H0X4.
    PharmGKBi PA25564.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79285.
    HOGENOMi HOG000069926.
    HOVERGENi HBG056541.
    InParanoidi Q9H0X4.
    KOi K17258.
    OMAi STGHQIG.
    OrthoDBi EOG783MWS.
    PhylomeDBi Q9H0X4.
    TreeFami TF327203.

    Miscellaneous databases

    GeneWikii ITFG3.
    GenomeRNAii 83986.
    NextBioi 73118.
    PROi Q9H0X4.

    Gene expression databases

    ArrayExpressi Q9H0X4.
    Bgeei Q9H0X4.
    CleanExi HS_ITFG3.
    Genevestigatori Q9H0X4.

    Family and domain databases

    InterProi IPR011047. Quinonprotein_ADH-like_supfam.
    [Graphical view ]
    SUPFAMi SSF50998. SSF50998. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Stomach.
    3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon, Glioblastoma and Ovary.
    6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-389.
      Tissue: Liver.
    7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314; ASN-389 AND ASN-473.
      Tissue: Leukemic T-cell.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiITFG3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0X4
    Secondary accession number(s): D3DU45
    , Q7L416, Q96FR1, Q96MC7, Q96S30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3