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Q9H0W9 (CK054_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ester hydrolase C11orf54

EC=3.1.-.-
Gene names
Name:C11orf54
ORF Names:LP4947, PTD012
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate. Ref.9

Subunit structure

Monomer. Ref.9

Subcellular location

Nucleus Ref.9.

Sequence caution

The sequence AAH07110.2 differs from that shown. Reason: Erroneous initiation.

The sequence AAP34483.1 differs from that shown. Reason: Frameshift at position 125.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

nucleus

Inferred from direct assay. Source: LIFEdb

   Molecular_functionhydrolase activity, acting on ester bonds

Inferred from direct assay Ref.9. Source: FlyBase

zinc ion binding

Inferred from direct assay Ref.9. Source: FlyBase

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TRIP13Q156453EBI-740204,EBI-358993

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H0W9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H0W9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.
Isoform 3 (identifier: Q9H0W9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     170-219: Missing.
Note: Probably non-functional.
Isoform 4 (identifier: Q9H0W9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Ester hydrolase C11orf54
PRO_0000246029

Sites

Metal binding2661Zinc; catalytic
Metal binding2681Zinc; catalytic
Metal binding2781Zinc; catalytic

Natural variations

Alternative sequence1 – 111111Missing in isoform 4.
VSP_019817
Alternative sequence1 – 1919Missing in isoform 2.
VSP_019818
Alternative sequence170 – 21950Missing in isoform 3.
VSP_019821

Experimental info

Sequence conflict101V → A in CAG38569. Ref.3
Sequence conflict1841F → L in CAG38569. Ref.3
Sequence conflict3041D → G in AAD40375. Ref.1

Secondary structure

............................................................. 315
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F084671CC1E3F72A

FASTA31535,117
        10         20         30         40         50         60 
MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV KGICGKTRIA 

        70         80         90        100        110        120 
EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG PFQTLGFNSE FMPVIQTESE 

       130        140        150        160        170        180 
HKPPVNGSYF AHVNPADGGC LLEKYSEKCH DFQCALLANL FASEGQPGKV IEVKAKRRTG 

       190        200        210        220        230        240 
PLNFVTCMRE TLEKHYGNKP IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF 

       250        260        270        280        290        300 
YEMKAPLVCL PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL 

       310 
YRIDQPKETH SIGRD 

« Hide

Isoform 2 [UniParc].

Checksum: 66962958EE2A4F17
Show »

FASTA29633,098
Isoform 3 [UniParc].

Checksum: 82F671A9F47F0906
Show »

FASTA26529,492
Isoform 4 [UniParc].

Checksum: DBE4CAF56964ADFD
Show »

FASTA20423,173

References

« Hide 'large scale' references
[1]"Human PTD012 mRNA, complete cds."
Mao Y., Song H., Peng Y., Huang Q., Dai M., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Pituitary tumor.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Esophagus.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Colon and Skeletal muscle.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold."
Manjasetty B.A., Buessow K., Fieber-Erdmann M., Roske Y., Gobom J., Scheich C., Goetz F., Niesen F.H., Heinemann U.
Protein Sci. 15:914-920(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2-315, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF092133 mRNA. Translation: AAD40375.1.
AL136605 mRNA. Translation: CAB66540.1.
CR533538 mRNA. Translation: CAG38569.1.
AY203960 mRNA. Translation: AAP34483.1. Frameshift.
AK292215 mRNA. Translation: BAF84904.1.
CH471065 Genomic DNA. Translation: EAW66915.1.
BC007110 mRNA. Translation: AAH07110.2. Different initiation.
BC012298 mRNA. Translation: AAH12298.1.
RefSeqNP_001272996.1. NM_001286067.1.
NP_001272997.1. NM_001286068.1.
NP_001272998.1. NM_001286069.1.
NP_001272999.1. NM_001286070.1.
NP_001273000.1. NM_001286071.1.
NP_054758.2. NM_014039.3.
XP_005273992.1. XM_005273935.1.
UniGeneHs.8360.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XCRX-ray1.70A/B2-315[»]
ProteinModelPortalQ9H0W9.
SMRQ9H0W9. Positions 3-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118794. 3 interactions.
IntActQ9H0W9. 1 interaction.
MINTMINT-1455099.
STRING9606.ENSP00000331209.

PTM databases

PhosphoSiteQ9H0W9.

Polymorphism databases

DMDM74718025.

Proteomic databases

PaxDbQ9H0W9.
PRIDEQ9H0W9.

Protocols and materials databases

DNASU28970.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331239; ENSP00000331209; ENSG00000182919. [Q9H0W9-1]
ENST00000354421; ENSP00000346403; ENSG00000182919. [Q9H0W9-1]
ENST00000528099; ENSP00000435113; ENSG00000182919. [Q9H0W9-1]
ENST00000528288; ENSP00000433721; ENSG00000182919. [Q9H0W9-3]
ENST00000540113; ENSP00000442094; ENSG00000182919. [Q9H0W9-2]
GeneID28970.
KEGGhsa:28970.
UCSCuc001pef.3. human. [Q9H0W9-3]
uc001peg.3. human. [Q9H0W9-1]

Organism-specific databases

CTD28970.
GeneCardsGC11P093474.
H-InvDBHIX0010026.
HGNCHGNC:30204. C11orf54.
HPAHPA040088.
HPA040511.
neXtProtNX_Q9H0W9.
PharmGKBPA143485349.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG330250.
HOVERGENHBG081215.
InParanoidQ9H0W9.
OMAEGGHYHY.
OrthoDBEOG78PV96.
PhylomeDBQ9H0W9.
TreeFamTF313169.

Gene expression databases

ArrayExpressQ9H0W9.
BgeeQ9H0W9.
CleanExHS_C11orf54.
GenevestigatorQ9H0W9.

Family and domain databases

InterProIPR015021. DUF1907.
[Graphical view]
PfamPF08925. DUF1907. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9H0W9.
GeneWikiC11orf54.
GenomeRNAi28970.
NextBio51831.

Entry information

Entry nameCK054_HUMAN
AccessionPrimary (citable) accession number: Q9H0W9
Secondary accession number(s): A8K850 expand/collapse secondary AC list , Q6FI88, Q6XYB0, Q96EI3, Q96IX1, Q9Y6B4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM