Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9H0W9

- CK054_HUMAN

UniProt

Q9H0W9 - CK054_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ester hydrolase C11orf54

Gene

C11orf54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi266 – 2661Zinc; catalytic
Metal bindingi268 – 2681Zinc; catalytic
Metal bindingi278 – 2781Zinc; catalytic

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: FlyBase
  2. zinc ion binding Source: FlyBase

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ester hydrolase C11orf54 (EC:3.1.-.-)
Gene namesi
ORF Names:LP4947, PTD012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30204. C11orf54.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Ester hydrolase C11orf54PRO_0000246029Add
BLAST

Proteomic databases

MaxQBiQ9H0W9.
PaxDbiQ9H0W9.
PRIDEiQ9H0W9.

PTM databases

PhosphoSiteiQ9H0W9.

Expressioni

Gene expression databases

BgeeiQ9H0W9.
CleanExiHS_C11orf54.
ExpressionAtlasiQ9H0W9. baseline and differential.
GenevestigatoriQ9H0W9.

Organism-specific databases

HPAiHPA040088.
HPA040511.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-740204,EBI-358993

Protein-protein interaction databases

BioGridi118794. 5 interactions.
IntActiQ9H0W9. 1 interaction.
MINTiMINT-1455099.
STRINGi9606.ENSP00000331209.

Structurei

Secondary structure

1
315
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Helixi13 – 2715Combined sources
Beta strandi28 – 3710Combined sources
Turni44 – 463Combined sources
Beta strandi49 – 513Combined sources
Beta strandi54 – 563Combined sources
Beta strandi58 – 636Combined sources
Helixi65 – 673Combined sources
Beta strandi69 – 713Combined sources
Beta strandi77 – 793Combined sources
Helixi80 – 867Combined sources
Beta strandi93 – 997Combined sources
Helixi102 – 1054Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi114 – 1163Combined sources
Beta strandi129 – 1335Combined sources
Turni135 – 1373Combined sources
Beta strandi140 – 1445Combined sources
Helixi145 – 1484Combined sources
Beta strandi153 – 16311Combined sources
Beta strandi169 – 17810Combined sources
Helixi184 – 19613Combined sources
Beta strandi202 – 21817Combined sources
Helixi231 – 2377Combined sources
Beta strandi238 – 2458Combined sources
Beta strandi247 – 25610Combined sources
Beta strandi264 – 2707Combined sources
Beta strandi272 – 2743Combined sources
Beta strandi277 – 2837Combined sources
Turni285 – 2873Combined sources
Beta strandi289 – 2968Combined sources
Beta strandi298 – 3047Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XCRX-ray1.70A/B2-315[»]
ProteinModelPortaliQ9H0W9.
SMRiQ9H0W9. Positions 3-315.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0W9.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG330250.
GeneTreeiENSGT00390000017214.
HOVERGENiHBG081215.
InParanoidiQ9H0W9.
OMAiEGGHYHY.
OrthoDBiEOG78PV96.
PhylomeDBiQ9H0W9.
TreeFamiTF313169.

Family and domain databases

InterProiIPR015021. DUF1907.
[Graphical view]
PfamiPF08925. DUF1907. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H0W9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV
60 70 80 90 100
KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG
110 120 130 140 150
PFQTLGFNSE FMPVIQTESE HKPPVNGSYF AHVNPADGGC LLEKYSEKCH
160 170 180 190 200
DFQCALLANL FASEGQPGKV IEVKAKRRTG PLNFVTCMRE TLEKHYGNKP
210 220 230 240 250
IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF YEMKAPLVCL
260 270 280 290 300
PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL
310
YRIDQPKETH SIGRD
Length:315
Mass (Da):35,117
Last modified:March 1, 2001 - v1
Checksum:iF084671CC1E3F72A
GO
Isoform 2 (identifier: Q9H0W9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:296
Mass (Da):33,098
Checksum:i66962958EE2A4F17
GO
Isoform 3 (identifier: Q9H0W9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-219: Missing.

Note: Probably non-functional.

Show »
Length:265
Mass (Da):29,492
Checksum:i82F671A9F47F0906
GO
Isoform 4 (identifier: Q9H0W9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:204
Mass (Da):23,173
Checksum:iDBE4CAF56964ADFD
GO

Sequence cautioni

The sequence AAH07110.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAP34483.1 differs from that shown. Reason: Frameshift at position 125. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101V → A in CAG38569. 1 PublicationCurated
Sequence conflicti184 – 1841F → L in CAG38569. 1 PublicationCurated
Sequence conflicti304 – 3041D → G in AAD40375. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform 4. 1 PublicationVSP_019817Add
BLAST
Alternative sequencei1 – 1919Missing in isoform 2. 1 PublicationVSP_019818Add
BLAST
Alternative sequencei170 – 21950Missing in isoform 3. 1 PublicationVSP_019821Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092133 mRNA. Translation: AAD40375.1.
AL136605 mRNA. Translation: CAB66540.1.
CR533538 mRNA. Translation: CAG38569.1.
AY203960 mRNA. Translation: AAP34483.1. Frameshift.
AK292215 mRNA. Translation: BAF84904.1.
CH471065 Genomic DNA. Translation: EAW66915.1.
BC007110 mRNA. Translation: AAH07110.2. Different initiation.
BC012298 mRNA. Translation: AAH12298.1.
CCDSiCCDS66204.1. [Q9H0W9-1]
CCDS73366.1. [Q9H0W9-2]
CCDS8294.1. [Q9H0W9-3]
RefSeqiNP_001272996.1. NM_001286067.1. [Q9H0W9-1]
NP_001272997.1. NM_001286068.1. [Q9H0W9-1]
NP_001272998.1. NM_001286069.1. [Q9H0W9-1]
NP_001272999.1. NM_001286070.1. [Q9H0W9-2]
NP_001273000.1. NM_001286071.1.
NP_054758.2. NM_014039.3. [Q9H0W9-3]
XP_005273992.1. XM_005273935.2. [Q9H0W9-1]
XP_006718887.1. XM_006718824.1. [Q9H0W9-1]
UniGeneiHs.8360.

Genome annotation databases

EnsembliENST00000331239; ENSP00000331209; ENSG00000182919. [Q9H0W9-1]
ENST00000354421; ENSP00000346403; ENSG00000182919. [Q9H0W9-1]
ENST00000528099; ENSP00000435113; ENSG00000182919. [Q9H0W9-1]
ENST00000528288; ENSP00000433721; ENSG00000182919. [Q9H0W9-3]
ENST00000540113; ENSP00000442094; ENSG00000182919. [Q9H0W9-2]
GeneIDi28970.
KEGGihsa:28970.
UCSCiuc001pef.3. human. [Q9H0W9-3]
uc001peg.3. human. [Q9H0W9-1]

Polymorphism databases

DMDMi74718025.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092133 mRNA. Translation: AAD40375.1 .
AL136605 mRNA. Translation: CAB66540.1 .
CR533538 mRNA. Translation: CAG38569.1 .
AY203960 mRNA. Translation: AAP34483.1 . Frameshift.
AK292215 mRNA. Translation: BAF84904.1 .
CH471065 Genomic DNA. Translation: EAW66915.1 .
BC007110 mRNA. Translation: AAH07110.2 . Different initiation.
BC012298 mRNA. Translation: AAH12298.1 .
CCDSi CCDS66204.1. [Q9H0W9-1 ]
CCDS73366.1. [Q9H0W9-2 ]
CCDS8294.1. [Q9H0W9-3 ]
RefSeqi NP_001272996.1. NM_001286067.1. [Q9H0W9-1 ]
NP_001272997.1. NM_001286068.1. [Q9H0W9-1 ]
NP_001272998.1. NM_001286069.1. [Q9H0W9-1 ]
NP_001272999.1. NM_001286070.1. [Q9H0W9-2 ]
NP_001273000.1. NM_001286071.1.
NP_054758.2. NM_014039.3. [Q9H0W9-3 ]
XP_005273992.1. XM_005273935.2. [Q9H0W9-1 ]
XP_006718887.1. XM_006718824.1. [Q9H0W9-1 ]
UniGenei Hs.8360.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XCR X-ray 1.70 A/B 2-315 [» ]
ProteinModelPortali Q9H0W9.
SMRi Q9H0W9. Positions 3-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118794. 5 interactions.
IntActi Q9H0W9. 1 interaction.
MINTi MINT-1455099.
STRINGi 9606.ENSP00000331209.

PTM databases

PhosphoSitei Q9H0W9.

Polymorphism databases

DMDMi 74718025.

Proteomic databases

MaxQBi Q9H0W9.
PaxDbi Q9H0W9.
PRIDEi Q9H0W9.

Protocols and materials databases

DNASUi 28970.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331239 ; ENSP00000331209 ; ENSG00000182919 . [Q9H0W9-1 ]
ENST00000354421 ; ENSP00000346403 ; ENSG00000182919 . [Q9H0W9-1 ]
ENST00000528099 ; ENSP00000435113 ; ENSG00000182919 . [Q9H0W9-1 ]
ENST00000528288 ; ENSP00000433721 ; ENSG00000182919 . [Q9H0W9-3 ]
ENST00000540113 ; ENSP00000442094 ; ENSG00000182919 . [Q9H0W9-2 ]
GeneIDi 28970.
KEGGi hsa:28970.
UCSCi uc001pef.3. human. [Q9H0W9-3 ]
uc001peg.3. human. [Q9H0W9-1 ]

Organism-specific databases

CTDi 28970.
GeneCardsi GC11P093474.
H-InvDB HIX0010026.
HGNCi HGNC:30204. C11orf54.
HPAi HPA040088.
HPA040511.
MIMi 615810. gene.
neXtProti NX_Q9H0W9.
PharmGKBi PA143485349.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG330250.
GeneTreei ENSGT00390000017214.
HOVERGENi HBG081215.
InParanoidi Q9H0W9.
OMAi EGGHYHY.
OrthoDBi EOG78PV96.
PhylomeDBi Q9H0W9.
TreeFami TF313169.

Miscellaneous databases

ChiTaRSi C11orf54. human.
EvolutionaryTracei Q9H0W9.
GeneWikii C11orf54.
GenomeRNAii 28970.
NextBioi 51831.
SOURCEi Search...

Gene expression databases

Bgeei Q9H0W9.
CleanExi HS_C11orf54.
ExpressionAtlasi Q9H0W9. baseline and differential.
Genevestigatori Q9H0W9.

Family and domain databases

InterProi IPR015021. DUF1907.
[Graphical view ]
Pfami PF08925. DUF1907. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human PTD012 mRNA, complete cds."
    Mao Y., Song H., Peng Y., Huang Q., Dai M., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Pituitary tumor.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Esophagus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Colon and Skeletal muscle.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold."
    Manjasetty B.A., Buessow K., Fieber-Erdmann M., Roske Y., Gobom J., Scheich C., Goetz F., Niesen F.H., Heinemann U.
    Protein Sci. 15:914-920(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2-315, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.

Entry informationi

Entry nameiCK054_HUMAN
AccessioniPrimary (citable) accession number: Q9H0W9
Secondary accession number(s): A8K850
, Q6FI88, Q6XYB0, Q96EI3, Q96IX1, Q9Y6B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3