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Q9H0W9

- CK054_HUMAN

UniProt

Q9H0W9 - CK054_HUMAN

Protein

Ester hydrolase C11orf54

Gene

C11orf54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi266 – 2661Zinc; catalytic
    Metal bindingi268 – 2681Zinc; catalytic
    Metal bindingi278 – 2781Zinc; catalytic

    GO - Molecular functioni

    1. hydrolase activity, acting on ester bonds Source: FlyBase
    2. protein binding Source: IntAct
    3. zinc ion binding Source: FlyBase

    GO - Biological processi

    1. metabolic process Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ester hydrolase C11orf54 (EC:3.1.-.-)
    Gene namesi
    ORF Names:LP4947, PTD012
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:30204. C11orf54.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleus Source: LIFEdb

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485349.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Ester hydrolase C11orf54PRO_0000246029Add
    BLAST

    Proteomic databases

    MaxQBiQ9H0W9.
    PaxDbiQ9H0W9.
    PRIDEiQ9H0W9.

    PTM databases

    PhosphoSiteiQ9H0W9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H0W9.
    BgeeiQ9H0W9.
    CleanExiHS_C11orf54.
    GenevestigatoriQ9H0W9.

    Organism-specific databases

    HPAiHPA040088.
    HPA040511.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRIP13Q156453EBI-740204,EBI-358993

    Protein-protein interaction databases

    BioGridi118794. 4 interactions.
    IntActiQ9H0W9. 1 interaction.
    MINTiMINT-1455099.
    STRINGi9606.ENSP00000331209.

    Structurei

    Secondary structure

    1
    315
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 74
    Helixi13 – 2715
    Beta strandi28 – 3710
    Turni44 – 463
    Beta strandi49 – 513
    Beta strandi54 – 563
    Beta strandi58 – 636
    Helixi65 – 673
    Beta strandi69 – 713
    Beta strandi77 – 793
    Helixi80 – 867
    Beta strandi93 – 997
    Helixi102 – 1054
    Beta strandi110 – 1123
    Beta strandi114 – 1163
    Beta strandi129 – 1335
    Turni135 – 1373
    Beta strandi140 – 1445
    Helixi145 – 1484
    Beta strandi153 – 16311
    Beta strandi169 – 17810
    Helixi184 – 19613
    Beta strandi202 – 21817
    Helixi231 – 2377
    Beta strandi238 – 2458
    Beta strandi247 – 25610
    Beta strandi264 – 2707
    Beta strandi272 – 2743
    Beta strandi277 – 2837
    Turni285 – 2873
    Beta strandi289 – 2968
    Beta strandi298 – 3047

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XCRX-ray1.70A/B2-315[»]
    ProteinModelPortaliQ9H0W9.
    SMRiQ9H0W9. Positions 3-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H0W9.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG330250.
    HOVERGENiHBG081215.
    InParanoidiQ9H0W9.
    OMAiEGGHYHY.
    OrthoDBiEOG78PV96.
    PhylomeDBiQ9H0W9.
    TreeFamiTF313169.

    Family and domain databases

    InterProiIPR015021. DUF1907.
    [Graphical view]
    PfamiPF08925. DUF1907. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H0W9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV    50
    KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG 100
    PFQTLGFNSE FMPVIQTESE HKPPVNGSYF AHVNPADGGC LLEKYSEKCH 150
    DFQCALLANL FASEGQPGKV IEVKAKRRTG PLNFVTCMRE TLEKHYGNKP 200
    IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF YEMKAPLVCL 250
    PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL 300
    YRIDQPKETH SIGRD 315
    Length:315
    Mass (Da):35,117
    Last modified:March 1, 2001 - v1
    Checksum:iF084671CC1E3F72A
    GO
    Isoform 2 (identifier: Q9H0W9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-19: Missing.

    Show »
    Length:296
    Mass (Da):33,098
    Checksum:i66962958EE2A4F17
    GO
    Isoform 3 (identifier: Q9H0W9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         170-219: Missing.

    Note: Probably non-functional.

    Show »
    Length:265
    Mass (Da):29,492
    Checksum:i82F671A9F47F0906
    GO
    Isoform 4 (identifier: Q9H0W9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-111: Missing.

    Show »
    Length:204
    Mass (Da):23,173
    Checksum:iDBE4CAF56964ADFD
    GO

    Sequence cautioni

    The sequence AAP34483.1 differs from that shown. Reason: Frameshift at position 125.
    The sequence AAH07110.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101V → A in CAG38569. 1 PublicationCurated
    Sequence conflicti184 – 1841F → L in CAG38569. 1 PublicationCurated
    Sequence conflicti304 – 3041D → G in AAD40375. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 111111Missing in isoform 4. 1 PublicationVSP_019817Add
    BLAST
    Alternative sequencei1 – 1919Missing in isoform 2. 1 PublicationVSP_019818Add
    BLAST
    Alternative sequencei170 – 21950Missing in isoform 3. 1 PublicationVSP_019821Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092133 mRNA. Translation: AAD40375.1.
    AL136605 mRNA. Translation: CAB66540.1.
    CR533538 mRNA. Translation: CAG38569.1.
    AY203960 mRNA. Translation: AAP34483.1. Frameshift.
    AK292215 mRNA. Translation: BAF84904.1.
    CH471065 Genomic DNA. Translation: EAW66915.1.
    BC007110 mRNA. Translation: AAH07110.2. Different initiation.
    BC012298 mRNA. Translation: AAH12298.1.
    CCDSiCCDS66204.1. [Q9H0W9-1]
    CCDS8294.1. [Q9H0W9-3]
    RefSeqiNP_001272996.1. NM_001286067.1. [Q9H0W9-1]
    NP_001272997.1. NM_001286068.1. [Q9H0W9-1]
    NP_001272998.1. NM_001286069.1. [Q9H0W9-1]
    NP_001272999.1. NM_001286070.1. [Q9H0W9-2]
    NP_001273000.1. NM_001286071.1.
    NP_054758.2. NM_014039.3. [Q9H0W9-3]
    XP_005273992.1. XM_005273935.2. [Q9H0W9-1]
    XP_006718887.1. XM_006718824.1. [Q9H0W9-1]
    UniGeneiHs.8360.

    Genome annotation databases

    EnsembliENST00000331239; ENSP00000331209; ENSG00000182919. [Q9H0W9-1]
    ENST00000354421; ENSP00000346403; ENSG00000182919. [Q9H0W9-1]
    ENST00000528099; ENSP00000435113; ENSG00000182919. [Q9H0W9-1]
    ENST00000528288; ENSP00000433721; ENSG00000182919. [Q9H0W9-3]
    ENST00000540113; ENSP00000442094; ENSG00000182919. [Q9H0W9-2]
    GeneIDi28970.
    KEGGihsa:28970.
    UCSCiuc001pef.3. human. [Q9H0W9-3]
    uc001peg.3. human. [Q9H0W9-1]

    Polymorphism databases

    DMDMi74718025.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092133 mRNA. Translation: AAD40375.1 .
    AL136605 mRNA. Translation: CAB66540.1 .
    CR533538 mRNA. Translation: CAG38569.1 .
    AY203960 mRNA. Translation: AAP34483.1 . Frameshift.
    AK292215 mRNA. Translation: BAF84904.1 .
    CH471065 Genomic DNA. Translation: EAW66915.1 .
    BC007110 mRNA. Translation: AAH07110.2 . Different initiation.
    BC012298 mRNA. Translation: AAH12298.1 .
    CCDSi CCDS66204.1. [Q9H0W9-1 ]
    CCDS8294.1. [Q9H0W9-3 ]
    RefSeqi NP_001272996.1. NM_001286067.1. [Q9H0W9-1 ]
    NP_001272997.1. NM_001286068.1. [Q9H0W9-1 ]
    NP_001272998.1. NM_001286069.1. [Q9H0W9-1 ]
    NP_001272999.1. NM_001286070.1. [Q9H0W9-2 ]
    NP_001273000.1. NM_001286071.1.
    NP_054758.2. NM_014039.3. [Q9H0W9-3 ]
    XP_005273992.1. XM_005273935.2. [Q9H0W9-1 ]
    XP_006718887.1. XM_006718824.1. [Q9H0W9-1 ]
    UniGenei Hs.8360.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XCR X-ray 1.70 A/B 2-315 [» ]
    ProteinModelPortali Q9H0W9.
    SMRi Q9H0W9. Positions 3-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118794. 4 interactions.
    IntActi Q9H0W9. 1 interaction.
    MINTi MINT-1455099.
    STRINGi 9606.ENSP00000331209.

    PTM databases

    PhosphoSitei Q9H0W9.

    Polymorphism databases

    DMDMi 74718025.

    Proteomic databases

    MaxQBi Q9H0W9.
    PaxDbi Q9H0W9.
    PRIDEi Q9H0W9.

    Protocols and materials databases

    DNASUi 28970.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331239 ; ENSP00000331209 ; ENSG00000182919 . [Q9H0W9-1 ]
    ENST00000354421 ; ENSP00000346403 ; ENSG00000182919 . [Q9H0W9-1 ]
    ENST00000528099 ; ENSP00000435113 ; ENSG00000182919 . [Q9H0W9-1 ]
    ENST00000528288 ; ENSP00000433721 ; ENSG00000182919 . [Q9H0W9-3 ]
    ENST00000540113 ; ENSP00000442094 ; ENSG00000182919 . [Q9H0W9-2 ]
    GeneIDi 28970.
    KEGGi hsa:28970.
    UCSCi uc001pef.3. human. [Q9H0W9-3 ]
    uc001peg.3. human. [Q9H0W9-1 ]

    Organism-specific databases

    CTDi 28970.
    GeneCardsi GC11P093474.
    H-InvDB HIX0010026.
    HGNCi HGNC:30204. C11orf54.
    HPAi HPA040088.
    HPA040511.
    MIMi 615810. gene.
    neXtProti NX_Q9H0W9.
    PharmGKBi PA143485349.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330250.
    HOVERGENi HBG081215.
    InParanoidi Q9H0W9.
    OMAi EGGHYHY.
    OrthoDBi EOG78PV96.
    PhylomeDBi Q9H0W9.
    TreeFami TF313169.

    Miscellaneous databases

    EvolutionaryTracei Q9H0W9.
    GeneWikii C11orf54.
    GenomeRNAii 28970.
    NextBioi 51831.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H0W9.
    Bgeei Q9H0W9.
    CleanExi HS_C11orf54.
    Genevestigatori Q9H0W9.

    Family and domain databases

    InterProi IPR015021. DUF1907.
    [Graphical view ]
    Pfami PF08925. DUF1907. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human PTD012 mRNA, complete cds."
      Mao Y., Song H., Peng Y., Huang Q., Dai M., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Pituitary tumor.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Esophagus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Colon and Skeletal muscle.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold."
      Manjasetty B.A., Buessow K., Fieber-Erdmann M., Roske Y., Gobom J., Scheich C., Goetz F., Niesen F.H., Heinemann U.
      Protein Sci. 15:914-920(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2-315, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.

    Entry informationi

    Entry nameiCK054_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0W9
    Secondary accession number(s): A8K850
    , Q6FI88, Q6XYB0, Q96EI3, Q96IX1, Q9Y6B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3