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Protein

Ester hydrolase C11orf54

Gene

C11orf54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi266Zinc; catalytic1
Metal bindingi268Zinc; catalytic1
Metal bindingi278Zinc; catalytic1

GO - Molecular functioni

  • hydrolase activity, acting on ester bonds Source: FlyBase
  • zinc ion binding Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ester hydrolase C11orf54 (EC:3.1.-.-)
Gene namesi
ORF Names:LP4947, PTD012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30204. C11orf54.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182919.
PharmGKBiPA143485349.

Polymorphism and mutation databases

DMDMi74718025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002460291 – 315Ester hydrolase C11orf54Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0W9.
MaxQBiQ9H0W9.
PeptideAtlasiQ9H0W9.
PRIDEiQ9H0W9.

PTM databases

iPTMnetiQ9H0W9.
PhosphoSitePlusiQ9H0W9.

Expressioni

Gene expression databases

BgeeiENSG00000182919.
CleanExiHS_C11orf54.
ExpressionAtlasiQ9H0W9. baseline and differential.
GenevisibleiQ9H0W9. HS.

Organism-specific databases

HPAiHPA040088.
HPA040511.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SSX2IPQ9Y2D83EBI-740204,EBI-2212028
TRIP13Q156453EBI-740204,EBI-358993
VAC14Q08AM63EBI-740204,EBI-2107455

Protein-protein interaction databases

BioGridi118794. 34 interactors.
IntActiQ9H0W9. 3 interactors.
MINTiMINT-1455099.

Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi13 – 27Combined sources15
Beta strandi28 – 37Combined sources10
Turni44 – 46Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi54 – 56Combined sources3
Beta strandi58 – 63Combined sources6
Helixi65 – 67Combined sources3
Beta strandi69 – 71Combined sources3
Beta strandi77 – 79Combined sources3
Helixi80 – 86Combined sources7
Beta strandi93 – 99Combined sources7
Helixi102 – 105Combined sources4
Beta strandi110 – 112Combined sources3
Beta strandi114 – 116Combined sources3
Beta strandi129 – 133Combined sources5
Turni135 – 137Combined sources3
Beta strandi140 – 144Combined sources5
Helixi145 – 148Combined sources4
Beta strandi153 – 163Combined sources11
Beta strandi169 – 178Combined sources10
Helixi184 – 196Combined sources13
Beta strandi202 – 218Combined sources17
Helixi231 – 237Combined sources7
Beta strandi238 – 245Combined sources8
Beta strandi247 – 256Combined sources10
Beta strandi264 – 270Combined sources7
Beta strandi272 – 274Combined sources3
Beta strandi277 – 283Combined sources7
Turni285 – 287Combined sources3
Beta strandi289 – 296Combined sources8
Beta strandi298 – 304Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XCRX-ray1.70A/B2-315[»]
ProteinModelPortaliQ9H0W9.
SMRiQ9H0W9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0W9.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000017214.
HOVERGENiHBG081215.
InParanoidiQ9H0W9.
OMAiHTHCFSH.
OrthoDBiEOG091G0J69.
PhylomeDBiQ9H0W9.
TreeFamiTF313169.

Family and domain databases

InterProiIPR015021. DUF1907.
[Graphical view]
PfamiPF08925. DUF1907. 1 hit.
[Graphical view]
SMARTiSM01168. DUF1907. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV
60 70 80 90 100
KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG
110 120 130 140 150
PFQTLGFNSE FMPVIQTESE HKPPVNGSYF AHVNPADGGC LLEKYSEKCH
160 170 180 190 200
DFQCALLANL FASEGQPGKV IEVKAKRRTG PLNFVTCMRE TLEKHYGNKP
210 220 230 240 250
IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF YEMKAPLVCL
260 270 280 290 300
PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL
310
YRIDQPKETH SIGRD
Length:315
Mass (Da):35,117
Last modified:March 1, 2001 - v1
Checksum:iF084671CC1E3F72A
GO
Isoform 2 (identifier: Q9H0W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:296
Mass (Da):33,098
Checksum:i66962958EE2A4F17
GO
Isoform 3 (identifier: Q9H0W9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-219: Missing.

Note: Probably non-functional.
Show »
Length:265
Mass (Da):29,492
Checksum:i82F671A9F47F0906
GO
Isoform 4 (identifier: Q9H0W9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:204
Mass (Da):23,173
Checksum:iDBE4CAF56964ADFD
GO

Sequence cautioni

The sequence AAH07110 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP34483 differs from that shown. Reason: Frameshift at position 125.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10V → A in CAG38569 (Ref. 3) Curated1
Sequence conflicti184F → L in CAG38569 (Ref. 3) Curated1
Sequence conflicti304D → G in AAD40375 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0198171 – 111Missing in isoform 4. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0198181 – 19Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_019821170 – 219Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092133 mRNA. Translation: AAD40375.1.
AL136605 mRNA. Translation: CAB66540.1.
CR533538 mRNA. Translation: CAG38569.1.
AY203960 mRNA. Translation: AAP34483.1. Frameshift.
AK292215 mRNA. Translation: BAF84904.1.
CH471065 Genomic DNA. Translation: EAW66915.1.
BC007110 mRNA. Translation: AAH07110.2. Different initiation.
BC012298 mRNA. Translation: AAH12298.1.
CCDSiCCDS66204.1. [Q9H0W9-1]
CCDS73366.1. [Q9H0W9-2]
CCDS8294.1. [Q9H0W9-3]
RefSeqiNP_001272996.1. NM_001286067.1. [Q9H0W9-1]
NP_001272997.1. NM_001286068.1. [Q9H0W9-1]
NP_001272998.1. NM_001286069.1. [Q9H0W9-1]
NP_001272999.1. NM_001286070.1. [Q9H0W9-2]
NP_001273000.1. NM_001286071.1.
NP_054758.2. NM_014039.3. [Q9H0W9-3]
XP_006718887.1. XM_006718824.1. [Q9H0W9-1]
XP_011541083.1. XM_011542781.2. [Q9H0W9-1]
XP_011541084.1. XM_011542782.2. [Q9H0W9-1]
XP_016873102.1. XM_017017613.1. [Q9H0W9-1]
XP_016873103.1. XM_017017614.1. [Q9H0W9-1]
XP_016873104.1. XM_017017615.1. [Q9H0W9-1]
XP_016873105.1. XM_017017616.1. [Q9H0W9-3]
UniGeneiHs.8360.

Genome annotation databases

EnsembliENST00000331239; ENSP00000331209; ENSG00000182919. [Q9H0W9-1]
ENST00000354421; ENSP00000346403; ENSG00000182919. [Q9H0W9-1]
ENST00000528099; ENSP00000435113; ENSG00000182919. [Q9H0W9-1]
ENST00000528288; ENSP00000433721; ENSG00000182919. [Q9H0W9-3]
ENST00000540113; ENSP00000442094; ENSG00000182919. [Q9H0W9-2]
GeneIDi28970.
KEGGihsa:28970.
UCSCiuc001pef.5. human. [Q9H0W9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092133 mRNA. Translation: AAD40375.1.
AL136605 mRNA. Translation: CAB66540.1.
CR533538 mRNA. Translation: CAG38569.1.
AY203960 mRNA. Translation: AAP34483.1. Frameshift.
AK292215 mRNA. Translation: BAF84904.1.
CH471065 Genomic DNA. Translation: EAW66915.1.
BC007110 mRNA. Translation: AAH07110.2. Different initiation.
BC012298 mRNA. Translation: AAH12298.1.
CCDSiCCDS66204.1. [Q9H0W9-1]
CCDS73366.1. [Q9H0W9-2]
CCDS8294.1. [Q9H0W9-3]
RefSeqiNP_001272996.1. NM_001286067.1. [Q9H0W9-1]
NP_001272997.1. NM_001286068.1. [Q9H0W9-1]
NP_001272998.1. NM_001286069.1. [Q9H0W9-1]
NP_001272999.1. NM_001286070.1. [Q9H0W9-2]
NP_001273000.1. NM_001286071.1.
NP_054758.2. NM_014039.3. [Q9H0W9-3]
XP_006718887.1. XM_006718824.1. [Q9H0W9-1]
XP_011541083.1. XM_011542781.2. [Q9H0W9-1]
XP_011541084.1. XM_011542782.2. [Q9H0W9-1]
XP_016873102.1. XM_017017613.1. [Q9H0W9-1]
XP_016873103.1. XM_017017614.1. [Q9H0W9-1]
XP_016873104.1. XM_017017615.1. [Q9H0W9-1]
XP_016873105.1. XM_017017616.1. [Q9H0W9-3]
UniGeneiHs.8360.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XCRX-ray1.70A/B2-315[»]
ProteinModelPortaliQ9H0W9.
SMRiQ9H0W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118794. 34 interactors.
IntActiQ9H0W9. 3 interactors.
MINTiMINT-1455099.

PTM databases

iPTMnetiQ9H0W9.
PhosphoSitePlusiQ9H0W9.

Polymorphism and mutation databases

DMDMi74718025.

Proteomic databases

EPDiQ9H0W9.
MaxQBiQ9H0W9.
PeptideAtlasiQ9H0W9.
PRIDEiQ9H0W9.

Protocols and materials databases

DNASUi28970.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331239; ENSP00000331209; ENSG00000182919. [Q9H0W9-1]
ENST00000354421; ENSP00000346403; ENSG00000182919. [Q9H0W9-1]
ENST00000528099; ENSP00000435113; ENSG00000182919. [Q9H0W9-1]
ENST00000528288; ENSP00000433721; ENSG00000182919. [Q9H0W9-3]
ENST00000540113; ENSP00000442094; ENSG00000182919. [Q9H0W9-2]
GeneIDi28970.
KEGGihsa:28970.
UCSCiuc001pef.5. human. [Q9H0W9-1]

Organism-specific databases

CTDi28970.
GeneCardsiC11orf54.
H-InvDBHIX0010026.
HGNCiHGNC:30204. C11orf54.
HPAiHPA040088.
HPA040511.
MIMi615810. gene.
neXtProtiNX_Q9H0W9.
OpenTargetsiENSG00000182919.
PharmGKBiPA143485349.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000017214.
HOVERGENiHBG081215.
InParanoidiQ9H0W9.
OMAiHTHCFSH.
OrthoDBiEOG091G0J69.
PhylomeDBiQ9H0W9.
TreeFamiTF313169.

Miscellaneous databases

ChiTaRSiC11orf54. human.
EvolutionaryTraceiQ9H0W9.
GeneWikiiC11orf54.
GenomeRNAii28970.
PROiQ9H0W9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182919.
CleanExiHS_C11orf54.
ExpressionAtlasiQ9H0W9. baseline and differential.
GenevisibleiQ9H0W9. HS.

Family and domain databases

InterProiIPR015021. DUF1907.
[Graphical view]
PfamiPF08925. DUF1907. 1 hit.
[Graphical view]
SMARTiSM01168. DUF1907. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCK054_HUMAN
AccessioniPrimary (citable) accession number: Q9H0W9
Secondary accession number(s): A8K850
, Q6FI88, Q6XYB0, Q96EI3, Q96IX1, Q9Y6B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.