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Protein

THAP domain-containing protein 2

Gene

THAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 80THAP-typePROSITE-ProRule annotationAdd BLAST80

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 2
Gene namesi
Name:THAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000173451.6.
HGNCiHGNC:20854. THAP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173451.
PharmGKBiPA134886354.

Polymorphism and mutation databases

BioMutaiTHAP2.
DMDMi29839633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686421 – 228THAP domain-containing protein 2Add BLAST228

Proteomic databases

MaxQBiQ9H0W7.
PaxDbiQ9H0W7.
PeptideAtlasiQ9H0W7.
PRIDEiQ9H0W7.

PTM databases

iPTMnetiQ9H0W7.
PhosphoSitePlusiQ9H0W7.

Expressioni

Gene expression databases

BgeeiENSG00000173451.
CleanExiHS_THAP2.
ExpressionAtlasiQ9H0W7. baseline and differential.
GenevisibleiQ9H0W7. HS.

Organism-specific databases

HPAiHPA039790.

Interactioni

Protein-protein interaction databases

BioGridi123687. 8 interactors.
ELMiQ9H0W7.
IntActiQ9H0W7. 2 interactors.
MINTiMINT-1199645.
STRINGi9606.ENSP00000310796.

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Helixi29 – 38Combined sources10
Beta strandi47 – 49Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8RNMR-A1-86[»]
ProteinModelPortaliQ9H0W7.
SMRiQ9H0W7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0W7.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi123 – 126HCFC1-binding motif (HBM)By similarity4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 80THAP-typePROSITE-ProRule annotationAdd BLAST80

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IKCR. Eukaryota.
ENOG41122AW. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000231117.
HOVERGENiHBG097575.
InParanoidiQ9H0W7.
OMAiWIRLVRR.
OrthoDBiEOG091G034R.
PhylomeDBiQ9H0W7.
TreeFamiTF330127.

Family and domain databases

InterProiView protein in InterPro
IPR026521. THAP2.
IPR006612. Znf_C2CH.
PANTHERiPTHR23080:SF84. PTHR23080:SF84. 1 hit.
PfamiView protein in Pfam
PF05485. THAP. 1 hit.
SMARTiView protein in SMART
SM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
PROSITEiView protein in PROSITE
PS50950. ZF_THAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H0W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTNCAAAGC ATTYNKHINI SFHRFPLDPK RRKEWVRLVR RKNFVPGKHT
60 70 80 90 100
FLCSKHFEAS CFDLTGQTRR LKMDAVPTIF DFCTHIKSMK LKSRNLLKKN
110 120 130 140 150
NSCSPAGPSN LKSNISSQQV LLEHSYAFRN PMEAKKRIIK LEKEIASLRR
160 170 180 190 200
KMKTCLQKER RATRRWIKAT CLVKNLEANS VLPKGTSEHM LPTALSSLPL
210 220
EDFKILEQDQ QDKTLLSLNL KQTKSTFI
Length:228
Mass (Da):26,260
Last modified:March 1, 2001 - v1
Checksum:i63D886376BC5CC4E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034551170T → M. Corresponds to variant dbSNP:rs17110155Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136607 mRNA. Translation: CAB66542.1.
AK313452 mRNA. Translation: BAG36240.1.
CH471054 Genomic DNA. Translation: EAW97265.1.
BC008358 mRNA. Translation: AAH08358.1.
CCDSiCCDS9001.1.
RefSeqiNP_113623.1. NM_031435.3.
UniGeneiHs.245798.

Genome annotation databases

EnsembliENST00000308086; ENSP00000310796; ENSG00000173451.
GeneIDi83591.
KEGGihsa:83591.
UCSCiuc001swq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTHAP2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0W7
Secondary accession number(s): B2R8P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references