Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

THAP domain-containing protein 2

Gene

THAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8080THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 2
Gene namesi
Name:THAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:20854. THAP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886354.

Polymorphism and mutation databases

BioMutaiTHAP2.
DMDMi29839633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228THAP domain-containing protein 2PRO_0000068642Add
BLAST

Proteomic databases

MaxQBiQ9H0W7.
PaxDbiQ9H0W7.
PeptideAtlasiQ9H0W7.
PRIDEiQ9H0W7.

PTM databases

iPTMnetiQ9H0W7.
PhosphoSiteiQ9H0W7.

Expressioni

Gene expression databases

BgeeiENSG00000173451.
CleanExiHS_THAP2.
ExpressionAtlasiQ9H0W7. baseline and differential.
GenevisibleiQ9H0W7. HS.

Organism-specific databases

HPAiHPA039790.

Interactioni

Protein-protein interaction databases

BioGridi123687. 8 interactions.
IntActiQ9H0W7. 2 interactions.
MINTiMINT-1199645.
STRINGi9606.ENSP00000310796.

Structurei

Secondary structure

1
228
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 93Combined sources
Helixi29 – 3810Combined sources
Beta strandi47 – 493Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D8RNMR-A1-86[»]
ProteinModelPortaliQ9H0W7.
SMRiQ9H0W7. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0W7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi123 – 1264HCFC1-binding motif (HBM)By similarity

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8080THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IKCR. Eukaryota.
ENOG41122AW. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000231117.
HOVERGENiHBG097575.
InParanoidiQ9H0W7.
OMAiWIRLVRR.
OrthoDBiEOG091G034R.
PhylomeDBiQ9H0W7.
TreeFamiTF330127.

Family and domain databases

InterProiIPR026521. THAP2.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF84. PTHR23080:SF84. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTNCAAAGC ATTYNKHINI SFHRFPLDPK RRKEWVRLVR RKNFVPGKHT
60 70 80 90 100
FLCSKHFEAS CFDLTGQTRR LKMDAVPTIF DFCTHIKSMK LKSRNLLKKN
110 120 130 140 150
NSCSPAGPSN LKSNISSQQV LLEHSYAFRN PMEAKKRIIK LEKEIASLRR
160 170 180 190 200
KMKTCLQKER RATRRWIKAT CLVKNLEANS VLPKGTSEHM LPTALSSLPL
210 220
EDFKILEQDQ QDKTLLSLNL KQTKSTFI
Length:228
Mass (Da):26,260
Last modified:March 1, 2001 - v1
Checksum:i63D886376BC5CC4E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701T → M.
Corresponds to variant rs17110155 [ dbSNP | Ensembl ].
VAR_034551

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136607 mRNA. Translation: CAB66542.1.
AK313452 mRNA. Translation: BAG36240.1.
CH471054 Genomic DNA. Translation: EAW97265.1.
BC008358 mRNA. Translation: AAH08358.1.
CCDSiCCDS9001.1.
RefSeqiNP_113623.1. NM_031435.3.
UniGeneiHs.245798.

Genome annotation databases

EnsembliENST00000308086; ENSP00000310796; ENSG00000173451.
GeneIDi83591.
KEGGihsa:83591.
UCSCiuc001swq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136607 mRNA. Translation: CAB66542.1.
AK313452 mRNA. Translation: BAG36240.1.
CH471054 Genomic DNA. Translation: EAW97265.1.
BC008358 mRNA. Translation: AAH08358.1.
CCDSiCCDS9001.1.
RefSeqiNP_113623.1. NM_031435.3.
UniGeneiHs.245798.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D8RNMR-A1-86[»]
ProteinModelPortaliQ9H0W7.
SMRiQ9H0W7. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123687. 8 interactions.
IntActiQ9H0W7. 2 interactions.
MINTiMINT-1199645.
STRINGi9606.ENSP00000310796.

PTM databases

iPTMnetiQ9H0W7.
PhosphoSiteiQ9H0W7.

Polymorphism and mutation databases

BioMutaiTHAP2.
DMDMi29839633.

Proteomic databases

MaxQBiQ9H0W7.
PaxDbiQ9H0W7.
PeptideAtlasiQ9H0W7.
PRIDEiQ9H0W7.

Protocols and materials databases

DNASUi83591.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308086; ENSP00000310796; ENSG00000173451.
GeneIDi83591.
KEGGihsa:83591.
UCSCiuc001swq.4. human.

Organism-specific databases

CTDi83591.
GeneCardsiTHAP2.
HGNCiHGNC:20854. THAP2.
HPAiHPA039790.
MIMi612531. gene.
neXtProtiNX_Q9H0W7.
PharmGKBiPA134886354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKCR. Eukaryota.
ENOG41122AW. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000231117.
HOVERGENiHBG097575.
InParanoidiQ9H0W7.
OMAiWIRLVRR.
OrthoDBiEOG091G034R.
PhylomeDBiQ9H0W7.
TreeFamiTF330127.

Miscellaneous databases

EvolutionaryTraceiQ9H0W7.
GeneWikiiTHAP2.
GenomeRNAii83591.
PROiQ9H0W7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173451.
CleanExiHS_THAP2.
ExpressionAtlasiQ9H0W7. baseline and differential.
GenevisibleiQ9H0W7. HS.

Family and domain databases

InterProiIPR026521. THAP2.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF84. PTHR23080:SF84. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0W7
Secondary accession number(s): B2R8P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.