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Protein

Transmembrane protein 168

Gene

TMEM168

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 168
Gene namesi
Name:TMEM168
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:25826. TMEM168.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST
Transmembranei646 – 66621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357253.

Polymorphism and mutation databases

DMDMi145566969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Transmembrane protein 168PRO_0000284630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence analysis
Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9H0V1.
MaxQBiQ9H0V1.
PaxDbiQ9H0V1.
PeptideAtlasiQ9H0V1.
PRIDEiQ9H0V1.

PTM databases

iPTMnetiQ9H0V1.
PhosphoSiteiQ9H0V1.
SwissPalmiQ9H0V1.

Expressioni

Gene expression databases

BgeeiQ9H0V1.
CleanExiHS_TMEM168.
ExpressionAtlasiQ9H0V1. baseline and differential.
GenevisibleiQ9H0V1. HS.

Organism-specific databases

HPAiHPA020389.

Interactioni

Protein-protein interaction databases

BioGridi122167. 5 interactions.
IntActiQ9H0V1. 2 interactions.
MINTiMINT-4723829.

Structurei

3D structure databases

ProteinModelPortaliQ9H0V1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM168 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3C. Eukaryota.
ENOG410Y9XB. LUCA.
GeneTreeiENSGT00390000005941.
HOGENOMiHOG000252915.
HOVERGENiHBG073015.
InParanoidiQ9H0V1.
OMAiCKACFRC.
OrthoDBiEOG7N63MZ.
PhylomeDBiQ9H0V1.
TreeFamiTF328518.

Family and domain databases

InterProiIPR029713. TMEM168.
[Graphical view]
PANTHERiPTHR14437. PTHR14437. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0V1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RINLLVAICL
60 70 80 90 100
GLYVRWEKTA NSLILVIFIL GLFVLGIASI LYYYFSMEAA SLSLSNLWFG
110 120 130 140 150
FLLGLLCFLD NSSFKNDVKE ESTKYLLLTS IVLRILCSLV ERISGYVRHR
160 170 180 190 200
PTLLTTVEFL ELVGFAIAST TMLVEKSLSV ILLVVALAML IIDLRMKSFL
210 220 230 240 250
AIPNLVIFAV LLFFSSLETP KNPIAFACFF ICLITDPFLD IYFSGLSVTE
260 270 280 290 300
RWKPFLYRGR ICRRLSVVFA GMIELTFFIL SAFKLRDTHL WYFVIPGFSI
310 320 330 340 350
FGIFWMICHI IFLLTLWGFH TKLNDCHKVY FTHRTDYNSL DRIMASKGMR
360 370 380 390 400
HFCLISEQLV FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF
410 420 430 440 450
HELGNCLGGT SVGYAIVIPT NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA
460 470 480 490 500
IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK LKAFLELRTV DGPRHDTYIL
510 520 530 540 550
YYSGHTHGTG EWALAGGDTL RLDTLIEWWR EKNGSFCSRL IIVLDSENST
560 570 580 590 600
PWVKEVRKIN DQYIAVQGAE LIKTVDIEEA DPPQLGDFTK DWVEYNCNSS
610 620 630 640 650
NNICWTEKGR TVKAVYGVSK RWSDYTLHLP TGSDVAKHWM LHFPRITYPL
660 670 680 690
VHLANWLCGL NLFWICKTCF RCLKRLKMSW FLPTVLDTGQ GFKLVKS
Length:697
Mass (Da):79,755
Last modified:April 17, 2007 - v2
Checksum:iF23471DFF43D28E0
GO
Isoform 2 (identifier: Q9H0V1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-384: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,634
Checksum:i89497F2E7E34F35F
GO

Sequence cautioni

The sequence AAQ96836.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14624.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3051W → R in CAB66561 (PubMed:11230166).Curated
Sequence conflicti333 – 3331H → P in BAB14624 (PubMed:14702039).Curated
Sequence conflicti574 – 5741T → A in BAB14624 (PubMed:14702039).Curated
Sequence conflicti600 – 6001S → C in CAB66561 (PubMed:11230166).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 384384Missing in isoform 2. 1 PublicationVSP_056846Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136626 mRNA. Translation: CAB66561.1.
AK023638 mRNA. Translation: BAB14624.1. Different initiation.
AK293311 mRNA. Translation: BAG56831.1.
AK314460 mRNA. Translation: BAG37068.1.
AC079621 Genomic DNA. Translation: AAQ96836.1. Different initiation.
CH236947 Genomic DNA. Translation: EAL24373.1.
CH471070 Genomic DNA. Translation: EAW83470.1.
CH471070 Genomic DNA. Translation: EAW83471.1.
BC030804 mRNA. Translation: AAH30804.2.
CCDSiCCDS5757.1. [Q9H0V1-1]
RefSeqiNP_001274426.1. NM_001287497.1. [Q9H0V1-1]
NP_071929.3. NM_022484.5. [Q9H0V1-1]
XP_011514772.1. XM_011516470.1. [Q9H0V1-1]
XP_011514773.1. XM_011516471.1. [Q9H0V1-1]
UniGeneiHs.606345.
Hs.709689.

Genome annotation databases

EnsembliENST00000312814; ENSP00000323068; ENSG00000146802. [Q9H0V1-1]
ENST00000447395; ENSP00000410307; ENSG00000146802. [Q9H0V1-2]
ENST00000454074; ENSP00000390696; ENSG00000146802. [Q9H0V1-1]
GeneIDi64418.
KEGGihsa:64418.
UCSCiuc003vgn.5. human. [Q9H0V1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136626 mRNA. Translation: CAB66561.1.
AK023638 mRNA. Translation: BAB14624.1. Different initiation.
AK293311 mRNA. Translation: BAG56831.1.
AK314460 mRNA. Translation: BAG37068.1.
AC079621 Genomic DNA. Translation: AAQ96836.1. Different initiation.
CH236947 Genomic DNA. Translation: EAL24373.1.
CH471070 Genomic DNA. Translation: EAW83470.1.
CH471070 Genomic DNA. Translation: EAW83471.1.
BC030804 mRNA. Translation: AAH30804.2.
CCDSiCCDS5757.1. [Q9H0V1-1]
RefSeqiNP_001274426.1. NM_001287497.1. [Q9H0V1-1]
NP_071929.3. NM_022484.5. [Q9H0V1-1]
XP_011514772.1. XM_011516470.1. [Q9H0V1-1]
XP_011514773.1. XM_011516471.1. [Q9H0V1-1]
UniGeneiHs.606345.
Hs.709689.

3D structure databases

ProteinModelPortaliQ9H0V1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122167. 5 interactions.
IntActiQ9H0V1. 2 interactions.
MINTiMINT-4723829.

PTM databases

iPTMnetiQ9H0V1.
PhosphoSiteiQ9H0V1.
SwissPalmiQ9H0V1.

Polymorphism and mutation databases

DMDMi145566969.

Proteomic databases

EPDiQ9H0V1.
MaxQBiQ9H0V1.
PaxDbiQ9H0V1.
PeptideAtlasiQ9H0V1.
PRIDEiQ9H0V1.

Protocols and materials databases

DNASUi64418.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312814; ENSP00000323068; ENSG00000146802. [Q9H0V1-1]
ENST00000447395; ENSP00000410307; ENSG00000146802. [Q9H0V1-2]
ENST00000454074; ENSP00000390696; ENSG00000146802. [Q9H0V1-1]
GeneIDi64418.
KEGGihsa:64418.
UCSCiuc003vgn.5. human. [Q9H0V1-1]

Organism-specific databases

CTDi64418.
GeneCardsiTMEM168.
HGNCiHGNC:25826. TMEM168.
HPAiHPA020389.
neXtProtiNX_Q9H0V1.
PharmGKBiPA147357253.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF3C. Eukaryota.
ENOG410Y9XB. LUCA.
GeneTreeiENSGT00390000005941.
HOGENOMiHOG000252915.
HOVERGENiHBG073015.
InParanoidiQ9H0V1.
OMAiCKACFRC.
OrthoDBiEOG7N63MZ.
PhylomeDBiQ9H0V1.
TreeFamiTF328518.

Miscellaneous databases

GenomeRNAii64418.
PROiQ9H0V1.

Gene expression databases

BgeeiQ9H0V1.
CleanExiHS_TMEM168.
ExpressionAtlasiQ9H0V1. baseline and differential.
GenevisibleiQ9H0V1. HS.

Family and domain databases

InterProiIPR029713. TMEM168.
[Graphical view]
PANTHERiPTHR14437. PTHR14437. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 213-697 (ISOFORM 1).
    Tissue: Prostate.

Entry informationi

Entry nameiTM168_HUMAN
AccessioniPrimary (citable) accession number: Q9H0V1
Secondary accession number(s): A4D0T9
, B4DDS0, Q8NEK4, Q9H8J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.