Q9H0V1 (TM168_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 168

Gene names

Name:

TMEM168

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	697 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM168 family.
Sequence caution	The sequence AAQ96836.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14624.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW transport vesicle Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 697	697	Transmembrane protein 168		PRO_0000284630
Regions
	Transmembrane	36 – 56	21	Helical; Potential
	Transmembrane	63 – 83	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	172 – 192	21	Helical; Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Transmembrane	223 – 243	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential
	Transmembrane	293 – 313	21	Helical; Potential
	Transmembrane	352 – 372	21	Helical; Potential
	Transmembrane	380 – 400	21	Helical; Potential
	Transmembrane	646 – 666	21	Helical; Potential
Amino acid modifications
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	533	1	N-linked (GlcNAc...) Potential
	Glycosylation	598	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	305	1	W → R in CAB66561. Ref.1
	Sequence conflict	333	1	H → P in BAB14624. Ref.2
	Sequence conflict	574	1	T → A in BAB14624. Ref.2
	Sequence conflict	600	1	S → C in CAB66561. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9H0V1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: F23471DFF43D28E0	FASTA	697	79,755
	10 20 30 40 50 60 MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RINLLVAICL GLYVRWEKTA 70 80 90 100 110 120 NSLILVIFIL GLFVLGIASI LYYYFSMEAA SLSLSNLWFG FLLGLLCFLD NSSFKNDVKE 130 140 150 160 170 180 ESTKYLLLTS IVLRILCSLV ERISGYVRHR PTLLTTVEFL ELVGFAIAST TMLVEKSLSV 190 200 210 220 230 240 ILLVVALAML IIDLRMKSFL AIPNLVIFAV LLFFSSLETP KNPIAFACFF ICLITDPFLD 250 260 270 280 290 300 IYFSGLSVTE RWKPFLYRGR ICRRLSVVFA GMIELTFFIL SAFKLRDTHL WYFVIPGFSI 310 320 330 340 350 360 FGIFWMICHI IFLLTLWGFH TKLNDCHKVY FTHRTDYNSL DRIMASKGMR HFCLISEQLV 370 380 390 400 410 420 FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF HELGNCLGGT SVGYAIVIPT 430 440 450 460 470 480 NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK 490 500 510 520 530 540 LKAFLELRTV DGPRHDTYIL YYSGHTHGTG EWALAGGDTL RLDTLIEWWR EKNGSFCSRL 550 560 570 580 590 600 IIVLDSENST PWVKEVRKIN DQYIAVQGAE LIKTVDIEEA DPPQLGDFTK DWVEYNCNSS 610 620 630 640 650 660 NNICWTEKGR TVKAVYGVSK RWSDYTLHLP TGSDVAKHWM LHFPRITYPL VHLANWLCGL 670 680 690 NLFWICKTCF RCLKRLKMSW FLPTVLDTGQ GFKLVKS

References

[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 213-697. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136626 mRNA. Translation: CAB66561.1. AK023638 mRNA. Translation: BAB14624.1. Different initiation. AK314460 mRNA. Translation: BAG37068.1. AC079621 Genomic DNA. Translation: AAQ96836.1. Different initiation. CH236947 Genomic DNA. Translation: EAL24373.1. CH471070 Genomic DNA. Translation: EAW83471.1. BC030804 mRNA. Translation: AAH30804.2.
IPI	IPI00152949.
RefSeq	NP_071929.3. NM_022484.4.
UniGene	Hs.709689.
3D structure databases
ProteinModelPortal	Q9H0V1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000323068.
PTM databases
PhosphoSite	Q9H0V1.
Polymorphism databases
DMDM	145566969.
Proteomic databases
PaxDb	Q9H0V1.
PeptideAtlas	Q9H0V1.
PRIDE	Q9H0V1.
Protocols and materials databases
DNASU	64418.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312814; ENSP00000323068; ENSG00000146802. ENST00000454074; ENSP00000390696; ENSG00000146802.
GeneID	64418.
KEGG	hsa:64418.
UCSC	uc003vgn.3. human.
Organism-specific databases
CTD	64418.
GeneCards	GC07M112405.
HGNC	HGNC:25826. TMEM168.
HPA	HPA020389.
neXtProt	NX_Q9H0V1.
PharmGKB	PA147357253.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43543.
HOGENOM	HOG000252915.
HOVERGEN	HBG073015.
InParanoid	Q9H0V1.
OMA	ASILYYY.
OrthoDB	EOG4G1MFW.
PhylomeDB	Q9H0V1.
Gene expression databases
ArrayExpress	Q9H0V1.
Bgee	Q9H0V1.
CleanEx	HS_TMEM168.
Genevestigator	Q9H0V1.
Family and domain databases
InterPro	IPR026758. TMEM168/TMEM168A. [Graphical view]
PANTHER	PTHR32314. PTHR32314. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	64418.
NextBio	66387.

Entry information

Entry name

TM168_HUMAN

Accession

Primary (citable) accession number: Q9H0V1
Secondary accession number(s): A4D0T9, Q8NEK4, Q9H8J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.