SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9H0U6

- RM18_HUMAN

UniProt

Q9H0U6 - RM18_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

39S ribosomal protein L18, mitochondrial

Gene
MRPL18, HSPC071
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.1 Publication

GO - Molecular functioni

  1. 5S rRNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. rRNA import into mitochondrion Source: UniProtKB
  2. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L18, mitochondrial
Short name:
L18mt
Short name:
MRP-L18
Gene namesi
Name:MRPL18
ORF Names:HSPC071
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14477. MRPL18.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. mitochondrial ribosome Source: UniProtKB
  3. mitochondrion Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 18039S ribosomal protein L18, mitochondrialPRO_0000030556
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiQ9H0U6.
PaxDbiQ9H0U6.
PRIDEiQ9H0U6.

PTM databases

PhosphoSiteiQ9H0U6.

Expressioni

Gene expression databases

BgeeiQ9H0U6.
CleanExiHS_MRPL18.
GenevestigatoriQ9H0U6.

Organism-specific databases

HPAiHPA028774.
HPA028775.

Interactioni

Protein-protein interaction databases

BioGridi118846. 5 interactions.
DIPiDIP-56844N.
IntActiQ9H0U6. 3 interactions.
MINTiMINT-3066109.
STRINGi9606.ENSP00000356001.

Structurei

3D structure databases

ProteinModelPortaliQ9H0U6.
SMRiQ9H0U6. Positions 79-172.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG326747.
HOGENOMiHOG000043958.
HOVERGENiHBG001529.
InParanoidiQ9H0U6.
KOiK02881.
OMAiKERGWGT.
OrthoDBiEOG7W9RW1.
PhylomeDBiQ9H0U6.
TreeFamiTF313292.

Family and domain databases

InterProiIPR005484. Ribosomal_L18/L5.
[Graphical view]
PfamiPF00861. Ribosomal_L18p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H0U6-1 [UniParc]FASTAAdd to Basket

« Hide

MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN    50
RNPRNLELLS VARKERGWRT VFPSREFWHR LRVIRTQHHV EALVEHQNGK 100
VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP 150
WEAASDSMKR LQSAMTEGGV VLREPQRIYE 180
Length:180
Mass (Da):20,577
Last modified:March 1, 2001 - v1
Checksum:iC0CAD23465FE93B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → Q.1 Publication
Corresponds to variant rs1128670 [ dbSNP | Ensembl ].
VAR_024609

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101Missing in AAF29043. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136633 mRNA. Translation: CAB66568.1.
AF161556 mRNA. Translation: AAF29043.1.
CR533491 mRNA. Translation: CAG38522.1.
AL139045, AL135914 Genomic DNA. Translation: CAI19751.1.
AL135914, AL139045 Genomic DNA. Translation: CAI21852.1.
BC001623 mRNA. Translation: AAH01623.1.
CCDSiCCDS5270.1.
RefSeqiNP_054880.2. NM_014161.3.
UniGeneiHs.416998.

Genome annotation databases

EnsembliENST00000367034; ENSP00000356001; ENSG00000112110.
GeneIDi29074.
KEGGihsa:29074.
UCSCiuc003qsw.4. human.

Polymorphism databases

DMDMi41017797.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136633 mRNA. Translation: CAB66568.1 .
AF161556 mRNA. Translation: AAF29043.1 .
CR533491 mRNA. Translation: CAG38522.1 .
AL139045 , AL135914 Genomic DNA. Translation: CAI19751.1 .
AL135914 , AL139045 Genomic DNA. Translation: CAI21852.1 .
BC001623 mRNA. Translation: AAH01623.1 .
CCDSi CCDS5270.1.
RefSeqi NP_054880.2. NM_014161.3.
UniGenei Hs.416998.

3D structure databases

ProteinModelPortali Q9H0U6.
SMRi Q9H0U6. Positions 79-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118846. 5 interactions.
DIPi DIP-56844N.
IntActi Q9H0U6. 3 interactions.
MINTi MINT-3066109.
STRINGi 9606.ENSP00000356001.

PTM databases

PhosphoSitei Q9H0U6.

Polymorphism databases

DMDMi 41017797.

Proteomic databases

MaxQBi Q9H0U6.
PaxDbi Q9H0U6.
PRIDEi Q9H0U6.

Protocols and materials databases

DNASUi 29074.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367034 ; ENSP00000356001 ; ENSG00000112110 .
GeneIDi 29074.
KEGGi hsa:29074.
UCSCi uc003qsw.4. human.

Organism-specific databases

CTDi 29074.
GeneCardsi GC06P160210.
HGNCi HGNC:14477. MRPL18.
HPAi HPA028774.
HPA028775.
MIMi 611831. gene.
neXtProti NX_Q9H0U6.
PharmGKBi PA30947.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326747.
HOGENOMi HOG000043958.
HOVERGENi HBG001529.
InParanoidi Q9H0U6.
KOi K02881.
OMAi KERGWGT.
OrthoDBi EOG7W9RW1.
PhylomeDBi Q9H0U6.
TreeFami TF313292.

Miscellaneous databases

ChiTaRSi MRPL18. human.
GeneWikii MRPL18.
GenomeRNAii 29074.
NextBioi 52035.
PROi Q9H0U6.
SOURCEi Search...

Gene expression databases

Bgeei Q9H0U6.
CleanExi HS_MRPL18.
Genevestigatori Q9H0U6.

Family and domain databases

InterProi IPR005484. Ribosomal_L18/L5.
[Graphical view ]
Pfami PF00861. Ribosomal_L18p. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-6.
    Tissue: Umbilical cord blood.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18."
    Smirnov A., Entelis N., Martin R.P., Tarassov I.
    Genes Dev. 25:1289-1305(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING.

Entry informationi

Entry nameiRM18_HUMAN
AccessioniPrimary (citable) accession number: Q9H0U6
Secondary accession number(s): Q5TAP9, Q9NZW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi