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Protein

39S ribosomal protein L18, mitochondrial

Gene

MRPL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.1 Publication

GO - Molecular functioni

  • 5S rRNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • rRNA import into mitochondrion Source: UniProtKB
  • translation Source: UniProtKB

Keywordsi

Molecular functionChaperone, Ribonucleoprotein, Ribosomal protein, RNA-binding
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L18, mitochondrial
Short name:
L18mt
Short name:
MRP-L18
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL18m1 Publication
Gene namesi
Name:MRPL18
ORF Names:HSPC071
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14477. MRPL18.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrial ribosome Source: UniProtKB
  • mitochondrion Source: LIFEdb

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi29074.
OpenTargetsiENSG00000112110.
PharmGKBiPA30947.

Polymorphism and mutation databases

BioMutaiMRPL18.
DMDMi41017797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030556? – 18039S ribosomal protein L18, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9H0U6.
MaxQBiQ9H0U6.
PaxDbiQ9H0U6.
PeptideAtlasiQ9H0U6.
PRIDEiQ9H0U6.
TopDownProteomicsiQ9H0U6.

PTM databases

iPTMnetiQ9H0U6.
PhosphoSitePlusiQ9H0U6.

Expressioni

Gene expression databases

BgeeiENSG00000112110.
CleanExiHS_MRPL18.
GenevisibleiQ9H0U6. HS.

Organism-specific databases

HPAiHPA028774.
HPA028775.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi118846. 49 interactors.
DIPiDIP-56844N.
IntActiQ9H0U6. 22 interactors.
MINTiMINT-3066109.
STRINGi9606.ENSP00000356001.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi55 – 58Combined sources4
Beta strandi69 – 73Combined sources5
Beta strandi78 – 80Combined sources3
Beta strandi83 – 85Combined sources3
Beta strandi90 – 95Combined sources6
Beta strandi101 – 105Combined sources5
Helixi107 – 109Combined sources3
Turni111 – 113Combined sources3
Helixi122 – 139Combined sources18
Helixi150 – 154Combined sources5
Helixi156 – 168Combined sources13
Beta strandi171 – 173Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40P1-180[»]
ProteinModelPortaliQ9H0U6.
SMRiQ9H0U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3333. Eukaryota.
ENOG4111MCR. LUCA.
GeneTreeiENSGT00390000006394.
HOGENOMiHOG000043958.
HOVERGENiHBG001529.
InParanoidiQ9H0U6.
KOiK02881.
OMAiSTSEWAI.
OrthoDBiEOG091G0P8F.
PhylomeDBiQ9H0U6.
TreeFamiTF313292.

Family and domain databases

InterProiView protein in InterPro
IPR005484. Ribosomal_L18.
PANTHERiPTHR12899. PTHR12899. 1 hit.
PfamiView protein in Pfam
PF00861. Ribosomal_L18p. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H0U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN
60 70 80 90 100
RNPRNLELLS VARKERGWRT VFPSREFWHR LRVIRTQHHV EALVEHQNGK
110 120 130 140 150
VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP
160 170 180
WEAASDSMKR LQSAMTEGGV VLREPQRIYE
Length:180
Mass (Da):20,577
Last modified:March 1, 2001 - v1
Checksum:iC0CAD23465FE93B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10Missing in AAF29043 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0246096R → Q1 PublicationCorresponds to variant dbSNP:rs1128670Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136633 mRNA. Translation: CAB66568.1.
AF161556 mRNA. Translation: AAF29043.1.
CR533491 mRNA. Translation: CAG38522.1.
AL139045, AL135914 Genomic DNA. Translation: CAI19751.1.
AL135914, AL139045 Genomic DNA. Translation: CAI21852.1.
BC001623 mRNA. Translation: AAH01623.1.
CCDSiCCDS5270.1.
RefSeqiNP_001305746.1. NM_001318817.1.
NP_054880.2. NM_014161.4.
UniGeneiHs.416998.

Genome annotation databases

EnsembliENST00000367034; ENSP00000356001; ENSG00000112110.
GeneIDi29074.
KEGGihsa:29074.
UCSCiuc003qsw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRM18_HUMAN
AccessioniPrimary (citable) accession number: Q9H0U6
Secondary accession number(s): Q5TAP9, Q9NZW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families