Q9H0U6 (RM18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L18, mitochondrial
Short name=L18mt
Short name=MRP-L18

Gene names

Name:	MRPL18
ORF Names:	HSPC071

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. Ref.8
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein L18P family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Ligand	RNA-binding
Molecular function	Chaperone Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	rRNA import into mitochondrion Inferred from direct assay Ref.8. Source: UniProtKB translation Non-traceable author statement PubMed 11543634. Source: UniProtKB
Cellular_component	mitochondrial ribosome Non-traceable author statement PubMed 11543634. Source: UniProtKB
Molecular_function	5S rRNA binding Inferred from direct assay Ref.8. Source: UniProtKB structural constituent of ribosome Non-traceable author statement PubMed 11543634. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 180		39S ribosomal protein L18, mitochondrial		PRO_0000030556
Natural variations
	Natural variant	6	1	R → Q. Ref.2 Corresponds to variant rs1128670 [ dbSNP | Ensembl ].		VAR_024609
Experimental info
	Sequence conflict	10	1	Missing in AAF29043. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H0U6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: C0CAD23465FE93B4	FASTA	180	20,577
	10 20 30 40 50 60 MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN RNPRNLELLS 70 80 90 100 110 120 VARKERGWRT VFPSREFWHR LRVIRTQHHV EALVEHQNGK VVVSASTREW AIKKHLYSTR 130 140 150 160 170 180 NVVACESIGR VLAQRCLEAG INFMVYQPTP WEAASDSMKR LQSAMTEGGV VLREPQRIYE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-6. Tissue: Umbilical cord blood.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[6]	"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18." Smirnov A., Entelis N., Martin R.P., Tarassov I. Genes Dev. 25:1289-1305(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, RNA-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136633 mRNA. Translation: CAB66568.1. AF161556 mRNA. Translation: AAF29043.1. CR533491 mRNA. Translation: CAG38522.1. AL139045, AL135914 Genomic DNA. Translation: CAI19751.1. AL135914, AL139045 Genomic DNA. Translation: CAI21852.1. BC001623 mRNA. Translation: AAH01623.1.
IPI	IPI00160421.
RefSeq	NP_054880.2. NM_014161.3.
UniGene	Hs.416998.
3D structure databases
ProteinModelPortal	Q9H0U6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H0U6. 2 interactions.
MINT	MINT-3066109.
STRING	9606.ENSP00000356001.
PTM databases
PhosphoSite	Q9H0U6.
Polymorphism databases
DMDM	41017797.
Proteomic databases
PaxDb	Q9H0U6.
PRIDE	Q9H0U6.
Protocols and materials databases
DNASU	29074.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367034; ENSP00000356001; ENSG00000112110.
GeneID	29074.
KEGG	hsa:29074.
UCSC	uc003qsw.4. human.
Organism-specific databases
CTD	29074.
GeneCards	GC06P160210.
HGNC	HGNC:14477. MRPL18.
HPA	HPA028774. HPA028775.
MIM	611831. gene.
neXtProt	NX_Q9H0U6.
PharmGKB	PA30947.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG326747.
HOGENOM	HOG000043958.
HOVERGEN	HBG001529.
InParanoid	Q9H0U6.
KO	K02881.
OMA	KERGWGT.
OrthoDB	EOG46T32P.
PhylomeDB	Q9H0U6.
Gene expression databases
Bgee	Q9H0U6.
CleanEx	HS_MRPL18.
Genevestigator	Q9H0U6.
GermOnline	ENSG00000112110. Homo sapiens.
Family and domain databases
InterPro	IPR005484. Ribosomal_L18/L5. [Graphical view]
Pfam	PF00861. Ribosomal_L18p. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPL18. human.
GenomeRNAi	29074.
NextBio	52035.
SOURCE	Search...

Entry information

Entry name

RM18_HUMAN

Accession

Primary (citable) accession number: Q9H0U6
Secondary accession number(s): Q5TAP9, Q9NZW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.