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Q9H0U6

- RM18_HUMAN

UniProt

Q9H0U6 - RM18_HUMAN

Protein

39S ribosomal protein L18, mitochondrial

Gene

MRPL18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.1 Publication

    GO - Molecular functioni

    1. 5S rRNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. rRNA import into mitochondrion Source: UniProtKB
    2. translation Source: UniProtKB

    Keywords - Molecular functioni

    Chaperone, Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L18, mitochondrial
    Short name:
    L18mt
    Short name:
    MRP-L18
    Gene namesi
    Name:MRPL18
    ORF Names:HSPC071
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14477. MRPL18.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. mitochondrial ribosome Source: UniProtKB
    3. mitochondrion Source: LIFEdb

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30947.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 18039S ribosomal protein L18, mitochondrialPRO_0000030556
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ9H0U6.
    PaxDbiQ9H0U6.
    PRIDEiQ9H0U6.

    PTM databases

    PhosphoSiteiQ9H0U6.

    Expressioni

    Gene expression databases

    BgeeiQ9H0U6.
    CleanExiHS_MRPL18.
    GenevestigatoriQ9H0U6.

    Organism-specific databases

    HPAiHPA028774.
    HPA028775.

    Interactioni

    Protein-protein interaction databases

    BioGridi118846. 5 interactions.
    DIPiDIP-56844N.
    IntActiQ9H0U6. 3 interactions.
    MINTiMINT-3066109.
    STRINGi9606.ENSP00000356001.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0U6.
    SMRiQ9H0U6. Positions 79-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L18P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG326747.
    HOGENOMiHOG000043958.
    HOVERGENiHBG001529.
    InParanoidiQ9H0U6.
    KOiK02881.
    OMAiKERGWGT.
    OrthoDBiEOG7W9RW1.
    PhylomeDBiQ9H0U6.
    TreeFamiTF313292.

    Family and domain databases

    InterProiIPR005484. Ribosomal_L18/L5.
    [Graphical view]
    PfamiPF00861. Ribosomal_L18p. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H0U6-1 [UniParc]FASTAAdd to Basket

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    MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN    50
    RNPRNLELLS VARKERGWRT VFPSREFWHR LRVIRTQHHV EALVEHQNGK 100
    VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP 150
    WEAASDSMKR LQSAMTEGGV VLREPQRIYE 180
    Length:180
    Mass (Da):20,577
    Last modified:March 1, 2001 - v1
    Checksum:iC0CAD23465FE93B4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101Missing in AAF29043. (PubMed:11042152)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61R → Q.1 Publication
    Corresponds to variant rs1128670 [ dbSNP | Ensembl ].
    VAR_024609

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136633 mRNA. Translation: CAB66568.1.
    AF161556 mRNA. Translation: AAF29043.1.
    CR533491 mRNA. Translation: CAG38522.1.
    AL139045, AL135914 Genomic DNA. Translation: CAI19751.1.
    AL135914, AL139045 Genomic DNA. Translation: CAI21852.1.
    BC001623 mRNA. Translation: AAH01623.1.
    CCDSiCCDS5270.1.
    RefSeqiNP_054880.2. NM_014161.3.
    UniGeneiHs.416998.

    Genome annotation databases

    EnsembliENST00000367034; ENSP00000356001; ENSG00000112110.
    GeneIDi29074.
    KEGGihsa:29074.
    UCSCiuc003qsw.4. human.

    Polymorphism databases

    DMDMi41017797.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136633 mRNA. Translation: CAB66568.1 .
    AF161556 mRNA. Translation: AAF29043.1 .
    CR533491 mRNA. Translation: CAG38522.1 .
    AL139045 , AL135914 Genomic DNA. Translation: CAI19751.1 .
    AL135914 , AL139045 Genomic DNA. Translation: CAI21852.1 .
    BC001623 mRNA. Translation: AAH01623.1 .
    CCDSi CCDS5270.1.
    RefSeqi NP_054880.2. NM_014161.3.
    UniGenei Hs.416998.

    3D structure databases

    ProteinModelPortali Q9H0U6.
    SMRi Q9H0U6. Positions 79-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118846. 5 interactions.
    DIPi DIP-56844N.
    IntActi Q9H0U6. 3 interactions.
    MINTi MINT-3066109.
    STRINGi 9606.ENSP00000356001.

    PTM databases

    PhosphoSitei Q9H0U6.

    Polymorphism databases

    DMDMi 41017797.

    Proteomic databases

    MaxQBi Q9H0U6.
    PaxDbi Q9H0U6.
    PRIDEi Q9H0U6.

    Protocols and materials databases

    DNASUi 29074.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367034 ; ENSP00000356001 ; ENSG00000112110 .
    GeneIDi 29074.
    KEGGi hsa:29074.
    UCSCi uc003qsw.4. human.

    Organism-specific databases

    CTDi 29074.
    GeneCardsi GC06P160210.
    HGNCi HGNC:14477. MRPL18.
    HPAi HPA028774.
    HPA028775.
    MIMi 611831. gene.
    neXtProti NX_Q9H0U6.
    PharmGKBi PA30947.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG326747.
    HOGENOMi HOG000043958.
    HOVERGENi HBG001529.
    InParanoidi Q9H0U6.
    KOi K02881.
    OMAi KERGWGT.
    OrthoDBi EOG7W9RW1.
    PhylomeDBi Q9H0U6.
    TreeFami TF313292.

    Miscellaneous databases

    ChiTaRSi MRPL18. human.
    GeneWikii MRPL18.
    GenomeRNAii 29074.
    NextBioi 52035.
    PROi Q9H0U6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H0U6.
    CleanExi HS_MRPL18.
    Genevestigatori Q9H0U6.

    Family and domain databases

    InterProi IPR005484. Ribosomal_L18/L5.
    [Graphical view ]
    Pfami PF00861. Ribosomal_L18p. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-6.
      Tissue: Umbilical cord blood.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18."
      Smirnov A., Entelis N., Martin R.P., Tarassov I.
      Genes Dev. 25:1289-1305(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, RNA-BINDING.

    Entry informationi

    Entry nameiRM18_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0U6
    Secondary accession number(s): Q5TAP9, Q9NZW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3