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Protein

39S ribosomal protein L18, mitochondrial

Gene

MRPL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.1 Publication

GO - Molecular functioni

  1. 5S rRNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
  6. rRNA import into mitochondrion Source: UniProtKB
  7. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L18, mitochondrial
Short name:
L18mt
Short name:
MRP-L18
Gene namesi
Name:MRPL18
ORF Names:HSPC071
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14477. MRPL18.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial ribosome Source: UniProtKB
  4. mitochondrion Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30947.

Polymorphism and mutation databases

BioMutaiMRPL18.
DMDMi41017797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 18039S ribosomal protein L18, mitochondrialPRO_0000030556
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ9H0U6.
PaxDbiQ9H0U6.
PRIDEiQ9H0U6.

PTM databases

PhosphoSiteiQ9H0U6.

Expressioni

Gene expression databases

BgeeiQ9H0U6.
CleanExiHS_MRPL18.
GenevestigatoriQ9H0U6.

Organism-specific databases

HPAiHPA028774.
HPA028775.

Interactioni

Protein-protein interaction databases

BioGridi118846. 12 interactions.
DIPiDIP-56844N.
IntActiQ9H0U6. 3 interactions.
MINTiMINT-3066109.
STRINGi9606.ENSP00000356001.

Structurei

3D structure databases

ProteinModelPortaliQ9H0U6.
SMRiQ9H0U6. Positions 79-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L18P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG326747.
GeneTreeiENSGT00390000006394.
HOGENOMiHOG000043958.
HOVERGENiHBG001529.
InParanoidiQ9H0U6.
KOiK02881.
OMAiKERGWGT.
OrthoDBiEOG7W9RW1.
PhylomeDBiQ9H0U6.
TreeFamiTF313292.

Family and domain databases

InterProiIPR005484. Ribosomal_L18/L5.
[Graphical view]
PfamiPF00861. Ribosomal_L18p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H0U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN
60 70 80 90 100
RNPRNLELLS VARKERGWRT VFPSREFWHR LRVIRTQHHV EALVEHQNGK
110 120 130 140 150
VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP
160 170 180
WEAASDSMKR LQSAMTEGGV VLREPQRIYE
Length:180
Mass (Da):20,577
Last modified:March 1, 2001 - v1
Checksum:iC0CAD23465FE93B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101Missing in AAF29043 (PubMed:11042152).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → Q.1 Publication
Corresponds to variant rs1128670 [ dbSNP | Ensembl ].
VAR_024609

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136633 mRNA. Translation: CAB66568.1.
AF161556 mRNA. Translation: AAF29043.1.
CR533491 mRNA. Translation: CAG38522.1.
AL139045, AL135914 Genomic DNA. Translation: CAI19751.1.
AL135914, AL139045 Genomic DNA. Translation: CAI21852.1.
BC001623 mRNA. Translation: AAH01623.1.
CCDSiCCDS5270.1.
RefSeqiNP_054880.2. NM_014161.3.
UniGeneiHs.416998.

Genome annotation databases

GeneIDi29074.
KEGGihsa:29074.
UCSCiuc003qsw.4. human.

Polymorphism and mutation databases

BioMutaiMRPL18.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136633 mRNA. Translation: CAB66568.1.
AF161556 mRNA. Translation: AAF29043.1.
CR533491 mRNA. Translation: CAG38522.1.
AL139045, AL135914 Genomic DNA. Translation: CAI19751.1.
AL135914, AL139045 Genomic DNA. Translation: CAI21852.1.
BC001623 mRNA. Translation: AAH01623.1.
CCDSiCCDS5270.1.
RefSeqiNP_054880.2. NM_014161.3.
UniGeneiHs.416998.

3D structure databases

ProteinModelPortaliQ9H0U6.
SMRiQ9H0U6. Positions 79-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118846. 12 interactions.
DIPiDIP-56844N.
IntActiQ9H0U6. 3 interactions.
MINTiMINT-3066109.
STRINGi9606.ENSP00000356001.

PTM databases

PhosphoSiteiQ9H0U6.

Polymorphism and mutation databases

BioMutaiMRPL18.
DMDMi41017797.

Proteomic databases

MaxQBiQ9H0U6.
PaxDbiQ9H0U6.
PRIDEiQ9H0U6.

Protocols and materials databases

DNASUi29074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29074.
KEGGihsa:29074.
UCSCiuc003qsw.4. human.

Organism-specific databases

CTDi29074.
GeneCardsiGC06P160210.
HGNCiHGNC:14477. MRPL18.
HPAiHPA028774.
HPA028775.
MIMi611831. gene.
neXtProtiNX_Q9H0U6.
PharmGKBiPA30947.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG326747.
GeneTreeiENSGT00390000006394.
HOGENOMiHOG000043958.
HOVERGENiHBG001529.
InParanoidiQ9H0U6.
KOiK02881.
OMAiKERGWGT.
OrthoDBiEOG7W9RW1.
PhylomeDBiQ9H0U6.
TreeFamiTF313292.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL18. human.
GeneWikiiMRPL18.
GenomeRNAii29074.
NextBioi52035.
PROiQ9H0U6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H0U6.
CleanExiHS_MRPL18.
GenevestigatoriQ9H0U6.

Family and domain databases

InterProiIPR005484. Ribosomal_L18/L5.
[Graphical view]
PfamiPF00861. Ribosomal_L18p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-6.
    Tissue: Umbilical cord blood.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18."
    Smirnov A., Entelis N., Martin R.P., Tarassov I.
    Genes Dev. 25:1289-1305(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING.

Entry informationi

Entry nameiRM18_HUMAN
AccessioniPrimary (citable) accession number: Q9H0U6
Secondary accession number(s): Q5TAP9, Q9NZW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.