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Q9H0U6 (RM18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L18, mitochondrial

Short name=L18mt
Short name=MRP-L18
Gene names
Name:MRPL18
ORF Names:HSPC071
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. Ref.8

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the ribosomal protein L18P family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 18039S ribosomal protein L18, mitochondrialPRO_0000030556

Natural variations

Natural variant61R → Q. Ref.2
Corresponds to variant rs1128670 [ dbSNP | Ensembl ].
VAR_024609

Experimental info

Sequence conflict101Missing in AAF29043. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9H0U6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C0CAD23465FE93B4

FASTA18020,577
        10         20         30         40         50         60 
MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN RNPRNLELLS 

        70         80         90        100        110        120 
VARKERGWRT VFPSREFWHR LRVIRTQHHV EALVEHQNGK VVVSASTREW AIKKHLYSTR 

       130        140        150        160        170        180 
NVVACESIGR VLAQRCLEAG INFMVYQPTP WEAASDSMKR LQSAMTEGGV VLREPQRIYE 

« Hide

References

« Hide 'large scale' references
[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-6.
Tissue: Umbilical cord blood.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[6]"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18."
Smirnov A., Entelis N., Martin R.P., Tarassov I.
Genes Dev. 25:1289-1305(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, RNA-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136633 mRNA. Translation: CAB66568.1.
AF161556 mRNA. Translation: AAF29043.1.
CR533491 mRNA. Translation: CAG38522.1.
AL139045, AL135914 Genomic DNA. Translation: CAI19751.1.
AL135914, AL139045 Genomic DNA. Translation: CAI21852.1.
BC001623 mRNA. Translation: AAH01623.1.
CCDSCCDS5270.1.
RefSeqNP_054880.2. NM_014161.3.
UniGeneHs.416998.

3D structure databases

ProteinModelPortalQ9H0U6.
SMRQ9H0U6. Positions 79-172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118846. 5 interactions.
DIPDIP-56844N.
IntActQ9H0U6. 3 interactions.
MINTMINT-3066109.
STRING9606.ENSP00000356001.

PTM databases

PhosphoSiteQ9H0U6.

Polymorphism databases

DMDM41017797.

Proteomic databases

MaxQBQ9H0U6.
PaxDbQ9H0U6.
PRIDEQ9H0U6.

Protocols and materials databases

DNASU29074.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367034; ENSP00000356001; ENSG00000112110.
GeneID29074.
KEGGhsa:29074.
UCSCuc003qsw.4. human.

Organism-specific databases

CTD29074.
GeneCardsGC06P160210.
HGNCHGNC:14477. MRPL18.
HPAHPA028774.
HPA028775.
MIM611831. gene.
neXtProtNX_Q9H0U6.
PharmGKBPA30947.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG326747.
HOGENOMHOG000043958.
HOVERGENHBG001529.
InParanoidQ9H0U6.
KOK02881.
OMAKERGWGT.
OrthoDBEOG7W9RW1.
PhylomeDBQ9H0U6.
TreeFamTF313292.

Gene expression databases

BgeeQ9H0U6.
CleanExHS_MRPL18.
GenevestigatorQ9H0U6.

Family and domain databases

InterProIPR005484. Ribosomal_L18/L5.
[Graphical view]
PfamPF00861. Ribosomal_L18p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMRPL18. human.
GeneWikiMRPL18.
GenomeRNAi29074.
NextBio52035.
PROQ9H0U6.
SOURCESearch...

Entry information

Entry nameRM18_HUMAN
AccessionPrimary (citable) accession number: Q9H0U6
Secondary accession number(s): Q5TAP9, Q9NZW8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM