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Protein

Magnesium transporter protein 1

Gene

MAGT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg2+ transport in epithelial cells.2 Publications

GO - Molecular functioni

  • magnesium ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • cognition Source: UniProtKB
  • magnesium ion transport Source: UniProtKB
  • protein N-linked glycosylation Source: UniProtKB
  • protein N-linked glycosylation via asparagine Source: GO_Central
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102158-MONOMER.
ReactomeiR-HSA-446203. Asparagine N-linked glycosylation.
R-HSA-5223345. Miscellaneous transport and binding events.
R-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

TCDBi1.A.76.1.1. the magnesium transporter1 (magt1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter protein 1
Short name:
MagT1
Alternative name(s):
Implantation-associated protein
Short name:
IAP
Gene namesi
Name:MAGT1
Synonyms:IAG2
ORF Names:PSEC0084, UNQ628/PRO1244
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28880. MAGT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 184ExtracellularSequence analysisAdd BLAST155
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 209CytoplasmicSequence analysis4
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 270ExtracellularSequence analysisAdd BLAST40
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 300CytoplasmicSequence analysis9
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 335ExtracellularSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • oligosaccharyltransferase complex Source: HGNC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia (XMEN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by CD4 lymphopenia, severe chronic viral infections, and defective T-lymphocyte activation.
See also OMIM:300853

Organism-specific databases

DisGeNETi84061.
MalaCardsiMAGT1.
MIMi300853. phenotype.
OpenTargetsiENSG00000102158.
Orphaneti317476. X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia.
777. X-linked non-syndromic intellectual disability.
PharmGKBiPA162394900.

Polymorphism and mutation databases

BioMutaiMAGT1.
DMDMi74761391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000024605730 – 335Magnesium transporter protein 1Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi87 ↔ 90Redox-activeBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9H0U3.
MaxQBiQ9H0U3.
PaxDbiQ9H0U3.
PeptideAtlasiQ9H0U3.
PRIDEiQ9H0U3.

PTM databases

iPTMnetiQ9H0U3.
PhosphoSitePlusiQ9H0U3.
SwissPalmiQ9H0U3.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at very low levels in brain, lung and kidney.3 Publications

Inductioni

Up-regulated by low extracellular Mg2+.1 Publication

Gene expression databases

BgeeiENSG00000102158.
CleanExiHS_MAGT1.
ExpressionAtlasiQ9H0U3. baseline and differential.
GenevisibleiQ9H0U3. HS.

Organism-specific databases

HPAiHPA049851.

Interactioni

Subunit structurei

Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B.By similarity

Protein-protein interaction databases

BioGridi123856. 34 interactors.
IntActiQ9H0U3. 15 interactors.
MINTiMINT-3972987.
STRINGi9606.ENSP00000354649.

Structurei

3D structure databases

ProteinModelPortaliQ9H0U3.
SMRiQ9H0U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 175ThioredoxinAdd BLAST129

Sequence similaritiesi

Belongs to the OST3/OST6 family.Curated
Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2603. Eukaryota.
ENOG410XR1F. LUCA.
GeneTreeiENSGT00390000012030.
HOGENOMiHOG000143405.
HOVERGENiHBG002493.
InParanoidiQ9H0U3.
KOiK19478.
PhylomeDBiQ9H0U3.
TreeFamiTF314850.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006844. Mg_transporter-1.
IPR021149. OligosaccharylTrfase_OST3/OST6.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12692:SF2. PTHR12692:SF2. 1 hit.
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0U3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARWRFWCV SVTMVVALLI VCDVPSASAQ RKKEMVLSEK VSQLMEWTNK
60 70 80 90 100
RPVIRMNGDK FRRLVKAPPR NYSVIVMFTA LQLHRQCVVC KQADEEFQIL
110 120 130 140 150
ANSWRYSSAF TNRIFFAMVD FDEGSDVFQM LNMNSAPTFI NFPAKGKPKR
160 170 180 190 200
GDTYELQVRG FSAEQIARWI ADRTDVNIRV IRPPNYAGPL MLGLLLAVIG
210 220 230 240 250
GLVYLRRSNM EFLFNKTGWA FAALCFVLAM TSGQMWNHIR GPPYAHKNPH
260 270 280 290 300
TGHVNYIHGS SQAQFVAETH IVLLFNGGVT LGMVLLCEAA TSDMDIGKRK
310 320 330
IMCVAGIGLV VLFFSWMLSI FRSKYHGYPY SFLMS
Length:335
Mass (Da):38,037
Last modified:March 1, 2001 - v1
Checksum:i29B8E9888FDE593E
GO
Isoform 2 (identifier: Q9H0U3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-134: LNMN → FQVF
     135-335: Missing.

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):15,699
Checksum:i6F2B4EFDCB2CCD7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Q → K in BAC11592 (PubMed:16303743).Curated1
Sequence conflicti290A → V in BAD96851 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045837311V → G Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant rs145245774dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056556131 – 134LNMN → FQVF in isoform 2. 1 Publication4
Alternative sequenceiVSP_056557135 – 335Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ000004 mRNA. Translation: AAY18811.1.
AY358691 mRNA. Translation: AAQ89054.1.
AK075394 mRNA. Translation: BAC11592.1.
AL136636 mRNA. Translation: CAB66571.1.
AK223131 mRNA. Translation: BAD96851.1.
AK314309 mRNA. Translation: BAG36961.1.
AL138743, AL356235 Genomic DNA. Translation: CAI39753.1.
AL356235, AL138743 Genomic DNA. Translation: CAH70524.1.
CH471104 Genomic DNA. Translation: EAW98608.1.
CH471104 Genomic DNA. Translation: EAW98609.1.
CH471104 Genomic DNA. Translation: EAW98610.1.
BC041014 mRNA. Translation: AAH41014.1.
BC060842 mRNA. Translation: AAH60842.1.
BC063037 mRNA. Translation: AAH63037.1.
RefSeqiNP_115497.4. NM_032121.5.
UniGeneiHs.323562.

Genome annotation databases

EnsembliENST00000373336; ENSP00000362433; ENSG00000102158. [Q9H0U3-2]
ENST00000618282; ENSP00000480732; ENSG00000102158. [Q9H0U3-1]
GeneIDi84061.
KEGGihsa:84061.
UCSCiuc065abq.1. human. [Q9H0U3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ000004 mRNA. Translation: AAY18811.1.
AY358691 mRNA. Translation: AAQ89054.1.
AK075394 mRNA. Translation: BAC11592.1.
AL136636 mRNA. Translation: CAB66571.1.
AK223131 mRNA. Translation: BAD96851.1.
AK314309 mRNA. Translation: BAG36961.1.
AL138743, AL356235 Genomic DNA. Translation: CAI39753.1.
AL356235, AL138743 Genomic DNA. Translation: CAH70524.1.
CH471104 Genomic DNA. Translation: EAW98608.1.
CH471104 Genomic DNA. Translation: EAW98609.1.
CH471104 Genomic DNA. Translation: EAW98610.1.
BC041014 mRNA. Translation: AAH41014.1.
BC060842 mRNA. Translation: AAH60842.1.
BC063037 mRNA. Translation: AAH63037.1.
RefSeqiNP_115497.4. NM_032121.5.
UniGeneiHs.323562.

3D structure databases

ProteinModelPortaliQ9H0U3.
SMRiQ9H0U3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123856. 34 interactors.
IntActiQ9H0U3. 15 interactors.
MINTiMINT-3972987.
STRINGi9606.ENSP00000354649.

Protein family/group databases

TCDBi1.A.76.1.1. the magnesium transporter1 (magt1) family.

PTM databases

iPTMnetiQ9H0U3.
PhosphoSitePlusiQ9H0U3.
SwissPalmiQ9H0U3.

Polymorphism and mutation databases

BioMutaiMAGT1.
DMDMi74761391.

Proteomic databases

EPDiQ9H0U3.
MaxQBiQ9H0U3.
PaxDbiQ9H0U3.
PeptideAtlasiQ9H0U3.
PRIDEiQ9H0U3.

Protocols and materials databases

DNASUi84061.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373336; ENSP00000362433; ENSG00000102158. [Q9H0U3-2]
ENST00000618282; ENSP00000480732; ENSG00000102158. [Q9H0U3-1]
GeneIDi84061.
KEGGihsa:84061.
UCSCiuc065abq.1. human. [Q9H0U3-1]

Organism-specific databases

CTDi84061.
DisGeNETi84061.
GeneCardsiMAGT1.
GeneReviewsiMAGT1.
H-InvDBHIX0016886.
HGNCiHGNC:28880. MAGT1.
HPAiHPA049851.
MalaCardsiMAGT1.
MIMi300715. gene.
300853. phenotype.
neXtProtiNX_Q9H0U3.
OpenTargetsiENSG00000102158.
Orphaneti317476. X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia.
777. X-linked non-syndromic intellectual disability.
PharmGKBiPA162394900.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2603. Eukaryota.
ENOG410XR1F. LUCA.
GeneTreeiENSGT00390000012030.
HOGENOMiHOG000143405.
HOVERGENiHBG002493.
InParanoidiQ9H0U3.
KOiK19478.
PhylomeDBiQ9H0U3.
TreeFamiTF314850.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102158-MONOMER.
ReactomeiR-HSA-446203. Asparagine N-linked glycosylation.
R-HSA-5223345. Miscellaneous transport and binding events.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiMAGT1. human.
GeneWikiiRP11-217H1.1.
GenomeRNAii84061.
PROiQ9H0U3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102158.
CleanExiHS_MAGT1.
ExpressionAtlasiQ9H0U3. baseline and differential.
GenevisibleiQ9H0U3. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006844. Mg_transporter-1.
IPR021149. OligosaccharylTrfase_OST3/OST6.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12692:SF2. PTHR12692:SF2. 1 hit.
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMAGT1_HUMAN
AccessioniPrimary (citable) accession number: Q9H0U3
Secondary accession number(s): B2RAR4
, D3DTE3, Q53G00, Q6P577, Q8NBN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although MAGT1 has been reported to be involved in mental retardation (PubMed:18455129), its pathological role is questionable (PubMed:23871722).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.