Q9H0T7Q53QV6Q6IA73Q6PJZ0Q9BVU1Q9H9U9RAB17_HUMANRas-related protein Rab-17RAB17Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoTowards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)VARIANT ALA-19Generation and annotation of the DNA sequences of human chromosomes 2 and 4.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking.TISSUE SPECIFICITYINDUCTION BY FORSKOLINERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-beta2.FUNCTION IN CELL MIGRATIONAn enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.Q9H0T7Q53S33false3Q9H0T7Q9H6J7false3Q9H0T7Q8IZU0false3Q9H0T7P43355false3Recycling endosome membraneLipid-anchorCytoplasmic sideMelanosomeCell projectionDendriteMay also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.Q9H0T7-11Q9H0T7-22Expressed in melanocytes (at protein level).Up-regulated by forskolin probably through the transcription factor MITF.Belongs to the small GTPase superfamily. Rab family.Alternative splicingCell projectionEndosomeGTP-bindingLipoproteinMembraneNucleotide-bindingPhosphoproteinPrenylationProtein transportReference proteomeTransportGTPGTPGTPVASGLPLPMAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAAVALNKGPARQAKCCAH
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