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Q9H0T7

- RAB17_HUMAN

UniProt

Q9H0T7 - RAB17_HUMAN

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Protein

Ras-related protein Rab-17

Gene

RAB17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338GTPBy similarity
Nucleotide bindingi73 – 775GTPBy similarity
Nucleotide bindingi132 – 1354GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. endocytic recycling Source: UniProtKB
  3. establishment of melanosome localization Source: UniProtKB
  4. filopodium assembly Source: UniProtKB
  5. GTP catabolic process Source: UniProtKB
  6. immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor Source: UniProtKB
  7. melanosome transport Source: UniProtKB
  8. protein transport Source: UniProtKB-KW
  9. regulation of dendrite development Source: UniProtKB
  10. regulation of filopodium assembly Source: UniProtKB
  11. regulation of synapse assembly Source: UniProtKB
  12. small GTPase mediated signal transduction Source: InterPro
  13. transcytosis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-17
Gene namesi
Name:RAB17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:16523. RAB17.

Subcellular locationi

Recycling endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cell projectiondendrite By similarity
Note: May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine (By similarity).By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. basolateral plasma membrane Source: UniProtKB
  3. dendrite Source: UniProtKB
  4. endocytic vesicle Source: UniProtKB
  5. extracellular vesicular exosome Source: UniProt
  6. intracellular Source: LIFEdb
  7. melanosome Source: UniProtKB
  8. neuronal cell body Source: UniProtKB
  9. recycling endosome Source: UniProtKB
  10. recycling endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ras-related protein Rab-17PRO_0000121191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi209 – 2091S-geranylgeranyl cysteineBy similarity
Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ9H0T7.
PaxDbiQ9H0T7.
PRIDEiQ9H0T7.

PTM databases

PhosphoSiteiQ9H0T7.

Expressioni

Tissue specificityi

Expressed in melanocytes (at protein level).1 Publication

Inductioni

Up-regulated by forskolin probably through the transcription factor MITF.1 Publication

Gene expression databases

BgeeiQ9H0T7.
CleanExiHS_RAB17.
ExpressionAtlasiQ9H0T7. baseline and differential.
GenevestigatoriQ9H0T7.

Organism-specific databases

HPAiHPA035176.

Interactioni

Protein-protein interaction databases

BioGridi122128. 9 interactions.
IntActiQ9H0T7. 2 interactions.
MINTiMINT-1422334.
STRINGi9606.ENSP00000264601.

Structurei

3D structure databases

ProteinModelPortaliQ9H0T7.
SMRiQ9H0T7. Positions 17-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 559Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9H0T7.
KOiK07909.
OMAiSVCHLYY.
PhylomeDBiQ9H0T7.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H0T7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV KNDFKSILPT
60 70 80 90 100
VGCAFFTKVV DVGATSLKLE IWDTAGQEKY HSVCHLYFRG ANAALLVYDI
110 120 130 140 150
TRKDSFLKAQ QWLKDLEEEL HPGEVLVMLV GNKTDLSQER EVTFQEGKEF
160 170 180 190 200
ADSQKLLFME TSAKLNHQVS EVFNTVAQEL LQRSDEEGQA LRGDAAVALN
210
KGPARQAKCC AH
Length:212
Mass (Da):23,491
Last modified:October 10, 2003 - v2
Checksum:i40E8CE5F445E5CF2
GO
Isoform 2 (identifier: Q9H0T7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.

Show »
Length:85
Mass (Da):9,394
Checksum:i5C22A7948C107A54
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571L → P in CAB66580. (PubMed:11230166)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191V → A.1 Publication
Corresponds to variant rs3751112 [ dbSNP | Ensembl ].
VAR_051711
Natural varianti184 – 1841S → G.
Corresponds to variant rs34311889 [ dbSNP | Ensembl ].
VAR_051712
Natural varianti191 – 1911L → P.
Corresponds to variant rs2280289 [ dbSNP | Ensembl ].
VAR_022102

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 127127Missing in isoform 2. 1 PublicationVSP_056400Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136645 mRNA. Translation: CAB66580.1.
AK022600 mRNA. Translation: BAB14121.1.
CR457282 mRNA. Translation: CAG33563.1.
AC104667 Genomic DNA. Translation: AAY24047.1.
CH471063 Genomic DNA. Translation: EAW71118.1.
CH471063 Genomic DNA. Translation: EAW71119.1.
BC000929 mRNA. Translation: AAH00929.1.
BC050426 mRNA. Translation: AAH50426.1.
BC007907 mRNA. Translation: AAH07907.1.
BC009827 mRNA. Translation: AAH09827.1.
CCDSiCCDS2520.1. [Q9H0T7-1]
RefSeqiNP_071894.1. NM_022449.3.
UniGeneiHs.44278.

Genome annotation databases

EnsembliENST00000264601; ENSP00000264601; ENSG00000124839. [Q9H0T7-1]
ENST00000409822; ENSP00000386589; ENSG00000124839. [Q9H0T7-2]
GeneIDi64284.
KEGGihsa:64284.
UCSCiuc002vwz.2. human. [Q9H0T7-1]

Polymorphism databases

DMDMi37999892.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136645 mRNA. Translation: CAB66580.1 .
AK022600 mRNA. Translation: BAB14121.1 .
CR457282 mRNA. Translation: CAG33563.1 .
AC104667 Genomic DNA. Translation: AAY24047.1 .
CH471063 Genomic DNA. Translation: EAW71118.1 .
CH471063 Genomic DNA. Translation: EAW71119.1 .
BC000929 mRNA. Translation: AAH00929.1 .
BC050426 mRNA. Translation: AAH50426.1 .
BC007907 mRNA. Translation: AAH07907.1 .
BC009827 mRNA. Translation: AAH09827.1 .
CCDSi CCDS2520.1. [Q9H0T7-1 ]
RefSeqi NP_071894.1. NM_022449.3.
UniGenei Hs.44278.

3D structure databases

ProteinModelPortali Q9H0T7.
SMRi Q9H0T7. Positions 17-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122128. 9 interactions.
IntActi Q9H0T7. 2 interactions.
MINTi MINT-1422334.
STRINGi 9606.ENSP00000264601.

PTM databases

PhosphoSitei Q9H0T7.

Polymorphism databases

DMDMi 37999892.

Proteomic databases

MaxQBi Q9H0T7.
PaxDbi Q9H0T7.
PRIDEi Q9H0T7.

Protocols and materials databases

DNASUi 64284.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264601 ; ENSP00000264601 ; ENSG00000124839 . [Q9H0T7-1 ]
ENST00000409822 ; ENSP00000386589 ; ENSG00000124839 . [Q9H0T7-2 ]
GeneIDi 64284.
KEGGi hsa:64284.
UCSCi uc002vwz.2. human. [Q9H0T7-1 ]

Organism-specific databases

CTDi 64284.
GeneCardsi GC02M238499.
HGNCi HGNC:16523. RAB17.
HPAi HPA035176.
MIMi 602206. gene.
neXtProti NX_Q9H0T7.
PharmGKBi PA34105.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119101.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q9H0T7.
KOi K07909.
OMAi SVCHLYY.
PhylomeDBi Q9H0T7.
TreeFami TF300199.

Miscellaneous databases

GeneWikii RAB17.
GenomeRNAii 64284.
NextBioi 66211.
PROi Q9H0T7.
SOURCEi Search...

Gene expression databases

Bgeei Q9H0T7.
CleanExi HS_RAB17.
ExpressionAtlasi Q9H0T7. baseline and differential.
Genevestigatori Q9H0T7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-19.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon, Eye, Ovary and Placenta.
  7. "The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking."
    Beaumont K.A., Hamilton N.A., Moores M.T., Brown D.L., Ohbayashi N., Cairncross O., Cook A.L., Smith A.G., Misaki R., Fukuda M., Taguchi T., Sturm R.A., Stow J.L.
    Traffic 12:627-643(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY FORSKOLIN.
  8. "ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-beta2."
    von Thun A., Birtwistle M., Kalna G., Grindlay J., Strachan D., Kolch W., von Kriegsheim A., Norman J.C.
    J. Cell Sci. 125:1465-1477(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL MIGRATION.

Entry informationi

Entry nameiRAB17_HUMAN
AccessioniPrimary (citable) accession number: Q9H0T7
Secondary accession number(s): Q53QV6
, Q6IA73, Q6PJZ0, Q9BVU1, Q9H9U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 10, 2003
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3