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Q9H0T7

- RAB17_HUMAN

UniProt

Q9H0T7 - RAB17_HUMAN

Protein

Ras-related protein Rab-17

Gene

RAB17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development By similarity. May also play a role in cell migration.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 338GTPBy similarity
    Nucleotide bindingi73 – 775GTPBy similarity
    Nucleotide bindingi132 – 1354GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. endocytic recycling Source: UniProtKB
    2. establishment of melanosome localization Source: UniProtKB
    3. filopodium assembly Source: UniProtKB
    4. immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor Source: UniProtKB
    5. melanosome transport Source: UniProtKB
    6. protein transport Source: UniProtKB-KW
    7. regulation of dendrite development Source: UniProtKB
    8. regulation of filopodium assembly Source: UniProtKB
    9. regulation of synapse assembly Source: UniProtKB
    10. small GTPase mediated signal transduction Source: InterPro
    11. transcytosis Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-17
    Gene namesi
    Name:RAB17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:16523. RAB17.

    Subcellular locationi

    Recycling endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cell projectiondendrite By similarity
    Note: May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine By similarity.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basolateral plasma membrane Source: UniProtKB
    3. dendrite Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. intracellular Source: LIFEdb
    6. melanosome Source: UniProtKB
    7. neuronal cell body Source: UniProtKB
    8. recycling endosome Source: UniProtKB
    9. recycling endosome membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34105.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Ras-related protein Rab-17PRO_0000121191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi209 – 2091S-geranylgeranyl cysteineBy similarity
    Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    MaxQBiQ9H0T7.
    PaxDbiQ9H0T7.
    PRIDEiQ9H0T7.

    PTM databases

    PhosphoSiteiQ9H0T7.

    Expressioni

    Tissue specificityi

    Expressed in melanocytes (at protein level).1 Publication

    Inductioni

    Up-regulated by forskolin probably through the transcription factor MITF.1 Publication

    Gene expression databases

    ArrayExpressiQ9H0T7.
    BgeeiQ9H0T7.
    CleanExiHS_RAB17.
    GenevestigatoriQ9H0T7.

    Organism-specific databases

    HPAiHPA035176.

    Interactioni

    Protein-protein interaction databases

    BioGridi122128. 3 interactions.
    IntActiQ9H0T7. 2 interactions.
    MINTiMINT-1422334.
    STRINGi9606.ENSP00000264601.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0T7.
    SMRiQ9H0T7. Positions 17-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi47 – 559Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ9H0T7.
    KOiK07909.
    OMAiSVCHLYY.
    PhylomeDBiQ9H0T7.
    TreeFamiTF300199.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H0T7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV KNDFKSILPT    50
    VGCAFFTKVV DVGATSLKLE IWDTAGQEKY HSVCHLYFRG ANAALLVYDI 100
    TRKDSFLKAQ QWLKDLEEEL HPGEVLVMLV GNKTDLSQER EVTFQEGKEF 150
    ADSQKLLFME TSAKLNHQVS EVFNTVAQEL LQRSDEEGQA LRGDAAVALN 200
    KGPARQAKCC AH 212
    Length:212
    Mass (Da):23,491
    Last modified:October 10, 2003 - v2
    Checksum:i40E8CE5F445E5CF2
    GO
    Isoform 2 (identifier: Q9H0T7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-127: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:85
    Mass (Da):9,394
    Checksum:i5C22A7948C107A54
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti157 – 1571L → P in CAB66580. (PubMed:11230166)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191V → A.1 Publication
    Corresponds to variant rs3751112 [ dbSNP | Ensembl ].
    VAR_051711
    Natural varianti184 – 1841S → G.
    Corresponds to variant rs34311889 [ dbSNP | Ensembl ].
    VAR_051712
    Natural varianti191 – 1911L → P.
    Corresponds to variant rs2280289 [ dbSNP | Ensembl ].
    VAR_022102

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 127127Missing in isoform 2. 1 PublicationVSP_056400Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136645 mRNA. Translation: CAB66580.1.
    AK022600 mRNA. Translation: BAB14121.1.
    CR457282 mRNA. Translation: CAG33563.1.
    AC104667 Genomic DNA. Translation: AAY24047.1.
    CH471063 Genomic DNA. Translation: EAW71118.1.
    CH471063 Genomic DNA. Translation: EAW71119.1.
    BC000929 mRNA. Translation: AAH00929.1.
    BC050426 mRNA. Translation: AAH50426.1.
    BC007907 mRNA. Translation: AAH07907.1.
    BC009827 mRNA. Translation: AAH09827.1.
    CCDSiCCDS2520.1.
    RefSeqiNP_071894.1. NM_022449.3.
    UniGeneiHs.44278.

    Genome annotation databases

    EnsembliENST00000264601; ENSP00000264601; ENSG00000124839.
    ENST00000409822; ENSP00000386589; ENSG00000124839.
    GeneIDi64284.
    KEGGihsa:64284.
    UCSCiuc002vwz.2. human.

    Polymorphism databases

    DMDMi37999892.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136645 mRNA. Translation: CAB66580.1 .
    AK022600 mRNA. Translation: BAB14121.1 .
    CR457282 mRNA. Translation: CAG33563.1 .
    AC104667 Genomic DNA. Translation: AAY24047.1 .
    CH471063 Genomic DNA. Translation: EAW71118.1 .
    CH471063 Genomic DNA. Translation: EAW71119.1 .
    BC000929 mRNA. Translation: AAH00929.1 .
    BC050426 mRNA. Translation: AAH50426.1 .
    BC007907 mRNA. Translation: AAH07907.1 .
    BC009827 mRNA. Translation: AAH09827.1 .
    CCDSi CCDS2520.1.
    RefSeqi NP_071894.1. NM_022449.3.
    UniGenei Hs.44278.

    3D structure databases

    ProteinModelPortali Q9H0T7.
    SMRi Q9H0T7. Positions 17-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122128. 3 interactions.
    IntActi Q9H0T7. 2 interactions.
    MINTi MINT-1422334.
    STRINGi 9606.ENSP00000264601.

    PTM databases

    PhosphoSitei Q9H0T7.

    Polymorphism databases

    DMDMi 37999892.

    Proteomic databases

    MaxQBi Q9H0T7.
    PaxDbi Q9H0T7.
    PRIDEi Q9H0T7.

    Protocols and materials databases

    DNASUi 64284.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264601 ; ENSP00000264601 ; ENSG00000124839 .
    ENST00000409822 ; ENSP00000386589 ; ENSG00000124839 .
    GeneIDi 64284.
    KEGGi hsa:64284.
    UCSCi uc002vwz.2. human.

    Organism-specific databases

    CTDi 64284.
    GeneCardsi GC02M238499.
    HGNCi HGNC:16523. RAB17.
    HPAi HPA035176.
    MIMi 602206. gene.
    neXtProti NX_Q9H0T7.
    PharmGKBi PA34105.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q9H0T7.
    KOi K07909.
    OMAi SVCHLYY.
    PhylomeDBi Q9H0T7.
    TreeFami TF300199.

    Miscellaneous databases

    GeneWikii RAB17.
    GenomeRNAii 64284.
    NextBioi 66211.
    PROi Q9H0T7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H0T7.
    Bgeei Q9H0T7.
    CleanExi HS_RAB17.
    Genevestigatori Q9H0T7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-19.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon, Eye, Ovary and Placenta.
    7. "The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking."
      Beaumont K.A., Hamilton N.A., Moores M.T., Brown D.L., Ohbayashi N., Cairncross O., Cook A.L., Smith A.G., Misaki R., Fukuda M., Taguchi T., Sturm R.A., Stow J.L.
      Traffic 12:627-643(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION BY FORSKOLIN.
    8. "ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-beta2."
      von Thun A., Birtwistle M., Kalna G., Grindlay J., Strachan D., Kolch W., von Kriegsheim A., Norman J.C.
      J. Cell Sci. 125:1465-1477(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL MIGRATION.

    Entry informationi

    Entry nameiRAB17_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0T7
    Secondary accession number(s): Q53QV6
    , Q6IA73, Q6PJZ0, Q9BVU1, Q9H9U9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3