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Q9H0R8 (GBRL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor-associated protein-like 1
Alternative name(s):
Early estrogen-regulated protein
GABA(A) receptor-associated protein-like 1
Glandular epithelial cell protein 1
Short name=GEC-1
Gene names
Name:GABARAPL1
Synonyms:GEC1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Ref.7

Subunit structure

Interacts with GABRG2 and beta-tubulin By similarity. Interacts with OPRK1. Ref.7

Subcellular location

Cytoplasm › cytoskeleton. Membrane By similarity. Endoplasmic reticulum By similarity. Golgi apparatus By similarity.

Tissue specificity

Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. Ref.1 Ref.2

Sequence similarities

Belongs to the MAP1 LC3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 117117Gamma-aminobutyric acid receptor-associated protein-like 1
PRO_0000212369

Regions

Region1 – 2222Interaction with beta-tubulin By similarity
Region36 – 6833Interaction with GABRG2 By similarity

Secondary structure

1 ................. 117
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9H0R8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7F56E345255F564B

FASTA11714,044
        10         20         30         40         50         60 
MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF 

        70         80         90        100        110 
YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK

« Hide

References

« Hide 'large scale' references
[1]"A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP."
Vernier-Magnin S., Muller S., Sallot M., Radom J., Musard J.-F., Adami P., Dulieu P., Remy-Martin J.-P., Jouvenot M., Fraichard A.
Biochem. Biophys. Res. Commun. 284:118-125(2001) [PubMed: 11374880] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Placenta.
[2]"Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein."
Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R., Zhao S.
Genomics 74:408-413(2001) [PubMed: 11414770] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Colon.
[7]"GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor."
Chen C., Li J.-G., Chen Y., Huang P., Wang Y., Liu-Chen L.-Y.
J. Biol. Chem. 281:7983-7993(2006) [PubMed: 16431922] [Abstract]
Cited for: FUNCTION, INTERACTION WITH OPRK1.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Crystal structure of human gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAP1)."
Structural genomics consortium (SGC)
Submitted (SEP-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 3-111.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF287012 mRNA. Translation: AAK55962.1.
AF087847 mRNA. Translation: AAK20399.1.
AL136676 mRNA. Translation: CAB66611.1.
CR533480 mRNA. Translation: CAG38511.1.
CH471094 Genomic DNA. Translation: EAW96164.1.
BC009309 mRNA. Translation: AAH09309.1.
BC028315 mRNA. Translation: AAH28315.1.
IPIIPI00027733.
RefSeqNP_113600.1. NM_031412.2.
UniGeneHs.524250.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2L8JNMR-A2-115[»]
2R2QX-ray1.65A/B3-111[»]
ProteinModelPortalQ9H0R8.
SMRQ9H0R8. Positions 3-111.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9H0R8. 498 interactions.
MINTMINT-1456875.
STRINGQ9H0R8.

Polymorphism databases

DMDM44887973.

Proteomic databases

PRIDEQ9H0R8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266458; ENSP00000266458; ENSG00000139112.
GeneID23710.
KEGGhsa:23710.
UCSCuc001qxs.1. human.

Organism-specific databases

CTD23710.
GeneCardsGC12P010365.
H-InvDBHIX0010424.
HGNCHGNC:4068. GABARAPL1.
MIM607420. gene.
neXtProtNX_Q9H0R8.
PharmGKBPA28481.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20372.
GeneTreeENSGT00390000012937.
HOVERGENHBG051706.
InParanoidQ9H0R8.
OMAGNILECV.
OrthoDBEOG4T4CWW.
PhylomeDBQ9H0R8.

Gene expression databases

ArrayExpressQ9H0R8.
BgeeQ9H0R8.
CleanExHS_GABARAPL1.
GenevestigatorQ9H0R8.
GermOnlineENSG00000139112. Homo sapiens.

Family and domain databases

InterProIPR004241. Atg8_ubiquitin-like.
[Graphical view]
KOK08341.
PANTHERPTHR10969. MAP1_LC3. 1 hit.
PfamPF02991. Atg8. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio46611.
PMAP-CutDBQ9H0R8.
SOURCESearch...

Entry information

Entry nameGBRL1_HUMAN
AccessionPrimary (citable) accession number: Q9H0R8
Secondary accession number(s): Q6FIE6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents