Reviewed,
UniProtKB/Swiss-Prot Q9H0R6 (QRSL1_HUMAN)
Last modified
June 16, 2009.
Version 48.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glutamyl-tRNA(Gln) amidotransferase subunit A homolog EC=6.3.5.- Alternative name(s): Glutaminyl-tRNA synthase-like protein 1 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 528 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. |
| Sequence similarities | Belongs to the amidase family. |
| Sequence caution | The sequence CAH72094.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Gene Ontology (GO) | |
| Biological process | translation Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW carbon-nitrogen ligase activity, with glutamine as amido-N-donorInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9H0R6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9H0R6-2) The sequence of this isoform differs from the canonical sequence as follows: 284-304: EYLVPELSSEVQSLWSKAADL → VTFSFHYFTEILSSPIESTD 305-528: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 528 | 528 | Glutamyl-tRNA(Gln) amidotransferase subunit A homolog | PRO_0000316767 | |||||
Sites | |||||||||
| Active site | 76 | 1 | Charge relay system By similarity | ||||||
| Active site | 171 | 1 | Charge relay system By similarity | ||||||
| Active site | 195 | 1 | Acyl-ester intermediate By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 284 – 304 | 21 | EYLVP…KAADL → VTFSFHYFTEILSSPIESTD in isoform 2. | VSP_030773 | |||||
| Alternative sequence | 305 – 528 | 224 | Missing in isoform 2. | VSP_030774 | |||||
| Natural variant | 11 | 1 | A → V: dbSNP rs36016898. | VAR_038389 | |||||
| Natural variant | 263 | 1 | N → S: dbSNP rs34221917. | VAR_038390 | |||||
Experimental info | |||||||||
| Sequence conflict | 34 | 1 | T → A in CAB66614. Ref.1 | ||||||
| Sequence conflict | 147 | 1 | Q → R in CAB66614. Ref.1 | ||||||
| Sequence conflict | 172 | 1 | S → P in CAB66614. Ref.1 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AL136679 mRNA. Translation: CAB66614.1. AK001851 mRNA. Translation: BAA91941.1. AK022251 mRNA. Translation: BAB13996.1. AK023509 mRNA. Translation: BAB14592.1. AL390074 Genomic DNA. Translation: CAH72093.1. AL390074 Genomic DNA. Translation: CAH72094.1. Sequence problems. CH471051 Genomic DNA. Translation: EAW48407.1. BC006084 mRNA. Translation: AAH06084.1. BC014389 mRNA. Translation: AAH14389.1. | |
| IPI | IPI00090720. IPI00386916. |
| RefSeq | NP_060762.3. |
| UniGene | Hs.406917 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1M21 based on UniProtKB Q8RJN5. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9H0R6. |
Genome annotation databases | |
| Ensembl | ENSG00000130348. Homo sapiens. [Contig view] |
| GeneID | 55278. |
| KEGG | hsa:55278. |
Organism-specific databases | |
| GeneCards | GC06P107185. |
| HGNC | HGNC:21020. QRSL1. |
| PharmGKB | PA128394680. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9H0R6. |
| HOVERGEN | Q9H0R6. |
| OMA | Q9H0R6. MIAYASS. |
Gene expression databases | |
| ArrayExpress | Q9H0R6. |
| Bgee | Q9H0R6. |
| CleanEx | HS_QRSL1. |
Family and domain databases | |
| InterPro | IPR000120. Amidase_sig_enz. IPR004412. GatA. [Graphical view] |
| Gene3D | G3DSA:3.90.1300.10. Amidase_sig_enz. 1 hit. |
| PANTHER | PTHR11895. Amidase. 1 hit. |
| Pfam | PF01425. Amidase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00132. gatA. 1 hit. |
| PROSITE | PS00571. AMIDASES. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 59416. |
Entry information
| Entry name | QRSL1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9H0R6 Secondary accession number(s): Q5VWJ4, Q9HA60, Q9NV19 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


