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Protein

Haloacid dehalogenase-like hydrolase domain-containing protein 2

Gene

HDHD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131MagnesiumBy similarity
Metal bindingi15 – 151Magnesium; via carbonyl oxygenBy similarity
Binding sitei179 – 1791SubstrateBy similarity
Metal bindingi204 – 2041MagnesiumBy similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • phosphatase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Haloacid dehalogenase-like hydrolase domain-containing protein 2
Gene namesi
Name:HDHD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:25364. HDHD2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952019.

Polymorphism and mutation databases

BioMutaiHDHD2.
DMDMi74733528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Haloacid dehalogenase-like hydrolase domain-containing protein 2PRO_0000287203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501N6-succinyllysineBy similarity

Proteomic databases

EPDiQ9H0R4.
PaxDbiQ9H0R4.
PRIDEiQ9H0R4.

2D gel databases

OGPiQ9H0R4.
REPRODUCTION-2DPAGEIPI00783874.

PTM databases

iPTMnetiQ9H0R4.
PhosphoSiteiQ9H0R4.

Expressioni

Gene expression databases

BgeeiQ9H0R4.
CleanExiHS_HDHD2.
ExpressionAtlasiQ9H0R4. baseline and differential.
GenevisibleiQ9H0R4. HS.

Organism-specific databases

HPAiCAB045978.
HPA040697.
HPA059818.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-10304657,EBI-10172134

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123859. 7 interactions.
IntActiQ9H0R4. 1 interaction.
MINTiMINT-3066019.
STRINGi9606.ENSP00000300605.

Structurei

Secondary structure

1
259
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 135Combined sources
Turni15 – 173Combined sources
Beta strandi18 – 247Combined sources
Helixi28 – 3710Combined sources
Beta strandi41 – 466Combined sources
Helixi53 – 6210Combined sources
Helixi69 – 713Combined sources
Beta strandi72 – 743Combined sources
Helixi75 – 8612Combined sources
Beta strandi90 – 945Combined sources
Helixi96 – 1027Combined sources
Beta strandi112 – 1154Combined sources
Turni119 – 1213Combined sources
Helixi124 – 13512Combined sources
Beta strandi140 – 1434Combined sources
Beta strandi148 – 1514Combined sources
Beta strandi154 – 1574Combined sources
Helixi160 – 17011Combined sources
Helixi182 – 1898Combined sources
Turni190 – 1934Combined sources
Helixi196 – 1983Combined sources
Beta strandi199 – 2046Combined sources
Turni206 – 2094Combined sources
Helixi210 – 2145Combined sources
Turni215 – 2173Combined sources
Beta strandi219 – 2257Combined sources
Helixi232 – 2354Combined sources
Beta strandi236 – 2383Combined sources
Beta strandi241 – 2466Combined sources
Helixi247 – 25711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HLTX-ray2.30A/C1-259[»]
ProteinModelPortaliQ9H0R4.
SMRiQ9H0R4. Positions 5-259.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0R4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 153Substrate bindingBy similarity
Regioni46 – 472Substrate bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili47 – 7125Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3040. Eukaryota.
COG0647. LUCA.
HOGENOMiHOG000068106.
HOVERGENiHBG075146.
InParanoidiQ9H0R4.
OMAiDTRRYKD.
OrthoDBiEOG7P2XT1.
PhylomeDBiQ9H0R4.
TreeFamiTF314344.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10410. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006357. HAD-SF_hydro_IIA.
IPR006355. HAD-SF_hydro_IIA_hyp2.
IPR023215. NPhePase-like_dom.
[Graphical view]
PfamiPF13344. Hydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01460. HAD-SF-IIA. 1 hit.
TIGR01458. HAD-SF-IIA-hyp3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAACRALKAV LVDLSGTLHI EDAAVPGAQE ALKRLRGASV IIRFVTNTTK
60 70 80 90 100
ESKQDLLERL RKLEFDISED EIFTSLTAAR SLLERKQVRP MLLVDDRALP
110 120 130 140 150
DFKGIQTSDP NAVVMGLAPE HFHYQILNQA FRLLLDGAPL IAIHKARYYK
160 170 180 190 200
RKDGLALGPG PFVTALEYAT DTKATVVGKP EKTFFLEALR GTGCEPEEAV
210 220 230 240 250
MIGDDCRDDV GGAQDVGMLG ILVKTGKYRA SDEEKINPPP YLTCESFPHA

VDHILQHLL
Length:259
Mass (Da):28,536
Last modified:March 1, 2001 - v1
Checksum:i1367F65369CE1CBA
GO
Isoform 2 (identifier: Q9H0R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:169
Mass (Da):18,533
Checksum:iC0EACC07FF9A8078
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851R → Q.
Corresponds to variant rs7230131 [ dbSNP | Ensembl ].
VAR_032289

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090Missing in isoform 2. 2 PublicationsVSP_025373Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136681 mRNA. Translation: CAB66616.1.
AK054590 mRNA. Translation: BAB70768.1.
AK292098 mRNA. Translation: BAF84787.1.
CR533487 mRNA. Translation: CAG38518.1.
CH471096 Genomic DNA. Translation: EAW62905.1.
BC011894 mRNA. Translation: AAH11894.1.
BC033031 mRNA. Translation: AAH33031.1.
BC038100 mRNA. Translation: AAH38100.1.
CCDSiCCDS32829.1. [Q9H0R4-1]
RefSeqiNP_001305694.1. NM_001318765.1. [Q9H0R4-2]
NP_115500.1. NM_032124.4. [Q9H0R4-1]
XP_006722620.1. XM_006722557.2. [Q9H0R4-2]
XP_011524529.1. XM_011526227.1. [Q9H0R4-1]
XP_011524530.1. XM_011526228.1. [Q9H0R4-1]
UniGeneiHs.465041.

Genome annotation databases

EnsembliENST00000300605; ENSP00000300605; ENSG00000167220. [Q9H0R4-1]
GeneIDi84064.
KEGGihsa:84064.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136681 mRNA. Translation: CAB66616.1.
AK054590 mRNA. Translation: BAB70768.1.
AK292098 mRNA. Translation: BAF84787.1.
CR533487 mRNA. Translation: CAG38518.1.
CH471096 Genomic DNA. Translation: EAW62905.1.
BC011894 mRNA. Translation: AAH11894.1.
BC033031 mRNA. Translation: AAH33031.1.
BC038100 mRNA. Translation: AAH38100.1.
CCDSiCCDS32829.1. [Q9H0R4-1]
RefSeqiNP_001305694.1. NM_001318765.1. [Q9H0R4-2]
NP_115500.1. NM_032124.4. [Q9H0R4-1]
XP_006722620.1. XM_006722557.2. [Q9H0R4-2]
XP_011524529.1. XM_011526227.1. [Q9H0R4-1]
XP_011524530.1. XM_011526228.1. [Q9H0R4-1]
UniGeneiHs.465041.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HLTX-ray2.30A/C1-259[»]
ProteinModelPortaliQ9H0R4.
SMRiQ9H0R4. Positions 5-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123859. 7 interactions.
IntActiQ9H0R4. 1 interaction.
MINTiMINT-3066019.
STRINGi9606.ENSP00000300605.

PTM databases

iPTMnetiQ9H0R4.
PhosphoSiteiQ9H0R4.

Polymorphism and mutation databases

BioMutaiHDHD2.
DMDMi74733528.

2D gel databases

OGPiQ9H0R4.
REPRODUCTION-2DPAGEIPI00783874.

Proteomic databases

EPDiQ9H0R4.
PaxDbiQ9H0R4.
PRIDEiQ9H0R4.

Protocols and materials databases

DNASUi84064.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300605; ENSP00000300605; ENSG00000167220. [Q9H0R4-1]
GeneIDi84064.
KEGGihsa:84064.

Organism-specific databases

CTDi84064.
GeneCardsiHDHD2.
HGNCiHGNC:25364. HDHD2.
HPAiCAB045978.
HPA040697.
HPA059818.
neXtProtiNX_Q9H0R4.
PharmGKBiPA134952019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3040. Eukaryota.
COG0647. LUCA.
HOGENOMiHOG000068106.
HOVERGENiHBG075146.
InParanoidiQ9H0R4.
OMAiDTRRYKD.
OrthoDBiEOG7P2XT1.
PhylomeDBiQ9H0R4.
TreeFamiTF314344.

Miscellaneous databases

ChiTaRSiHDHD2. human.
EvolutionaryTraceiQ9H0R4.
GeneWikiiHDHD2.
GenomeRNAii84064.
PROiQ9H0R4.

Gene expression databases

BgeeiQ9H0R4.
CleanExiHS_HDHD2.
ExpressionAtlasiQ9H0R4. baseline and differential.
GenevisibleiQ9H0R4. HS.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10410. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006357. HAD-SF_hydro_IIA.
IPR006355. HAD-SF_hydro_IIA_hyp2.
IPR023215. NPhePase-like_dom.
[Graphical view]
PfamiPF13344. Hydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01460. HAD-SF-IIA. 1 hit.
TIGR01458. HAD-SF-IIA-hyp3. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Neuroblastoma and Synovium.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Lung carcinoma and Testis.
  6. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 153-173, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "The crystal structure of human haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2)."
    Structural genomics consortium (SGC)
    Submitted (JUL-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Entry informationi

Entry nameiHDHD2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0R4
Secondary accession number(s): A8K7T3, Q96NV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.