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Protein

Haloacid dehalogenase-like hydrolase domain-containing protein 2

Gene

HDHD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13MagnesiumBy similarity1
Metal bindingi15Magnesium; via carbonyl oxygenBy similarity1
Binding sitei179SubstrateBy similarity1
Metal bindingi204MagnesiumBy similarity1

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • phosphatase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Haloacid dehalogenase-like hydrolase domain-containing protein 2
Gene namesi
Name:HDHD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:25364. HDHD2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi84064.
OpenTargetsiENSG00000167220.
PharmGKBiPA134952019.

Polymorphism and mutation databases

BioMutaiHDHD2.
DMDMi74733528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002872031 – 259Haloacid dehalogenase-like hydrolase domain-containing protein 2Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50N6-succinyllysineBy similarity1

Proteomic databases

EPDiQ9H0R4.
PaxDbiQ9H0R4.
PeptideAtlasiQ9H0R4.
PRIDEiQ9H0R4.

2D gel databases

OGPiQ9H0R4.
REPRODUCTION-2DPAGEIPI00783874.

PTM databases

iPTMnetiQ9H0R4.
PhosphoSitePlusiQ9H0R4.

Expressioni

Gene expression databases

BgeeiENSG00000167220.
CleanExiHS_HDHD2.
ExpressionAtlasiQ9H0R4. baseline and differential.
GenevisibleiQ9H0R4. HS.

Organism-specific databases

HPAiCAB045978.
HPA040697.
HPA059818.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-10304657,EBI-10172134

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123859. 7 interactors.
IntActiQ9H0R4. 1 interactor.
MINTiMINT-3066019.
STRINGi9606.ENSP00000300605.

Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 13Combined sources5
Turni15 – 17Combined sources3
Beta strandi18 – 24Combined sources7
Helixi28 – 37Combined sources10
Beta strandi41 – 46Combined sources6
Helixi53 – 62Combined sources10
Helixi69 – 71Combined sources3
Beta strandi72 – 74Combined sources3
Helixi75 – 86Combined sources12
Beta strandi90 – 94Combined sources5
Helixi96 – 102Combined sources7
Beta strandi112 – 115Combined sources4
Turni119 – 121Combined sources3
Helixi124 – 135Combined sources12
Beta strandi140 – 143Combined sources4
Beta strandi148 – 151Combined sources4
Beta strandi154 – 157Combined sources4
Helixi160 – 170Combined sources11
Helixi182 – 189Combined sources8
Turni190 – 193Combined sources4
Helixi196 – 198Combined sources3
Beta strandi199 – 204Combined sources6
Turni206 – 209Combined sources4
Helixi210 – 214Combined sources5
Turni215 – 217Combined sources3
Beta strandi219 – 225Combined sources7
Helixi232 – 235Combined sources4
Beta strandi236 – 238Combined sources3
Beta strandi241 – 246Combined sources6
Helixi247 – 257Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HLTX-ray2.30A/C1-259[»]
ProteinModelPortaliQ9H0R4.
SMRiQ9H0R4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0R4.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 15Substrate bindingBy similarity3
Regioni46 – 47Substrate bindingBy similarity2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 71Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3040. Eukaryota.
COG0647. LUCA.
GeneTreeiENSGT00510000046678.
HOGENOMiHOG000068106.
HOVERGENiHBG075146.
InParanoidiQ9H0R4.
OMAiDTRRYKD.
OrthoDBiEOG091G191B.
PhylomeDBiQ9H0R4.
TreeFamiTF314344.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10410. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006357. HAD-SF_hydro_IIA.
IPR006355. HAD-SF_hydro_IIA_hyp2.
IPR023215. NPhePase-like_dom.
[Graphical view]
PfamiPF13344. Hydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01460. HAD-SF-IIA. 1 hit.
TIGR01458. HAD-SF-IIA-hyp3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAACRALKAV LVDLSGTLHI EDAAVPGAQE ALKRLRGASV IIRFVTNTTK
60 70 80 90 100
ESKQDLLERL RKLEFDISED EIFTSLTAAR SLLERKQVRP MLLVDDRALP
110 120 130 140 150
DFKGIQTSDP NAVVMGLAPE HFHYQILNQA FRLLLDGAPL IAIHKARYYK
160 170 180 190 200
RKDGLALGPG PFVTALEYAT DTKATVVGKP EKTFFLEALR GTGCEPEEAV
210 220 230 240 250
MIGDDCRDDV GGAQDVGMLG ILVKTGKYRA SDEEKINPPP YLTCESFPHA

VDHILQHLL
Length:259
Mass (Da):28,536
Last modified:March 1, 2001 - v1
Checksum:i1367F65369CE1CBA
GO
Isoform 2 (identifier: Q9H0R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:169
Mass (Da):18,533
Checksum:iC0EACC07FF9A8078
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03228985R → Q.Corresponds to variant rs7230131dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253731 – 90Missing in isoform 2. 2 PublicationsAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136681 mRNA. Translation: CAB66616.1.
AK054590 mRNA. Translation: BAB70768.1.
AK292098 mRNA. Translation: BAF84787.1.
CR533487 mRNA. Translation: CAG38518.1.
CH471096 Genomic DNA. Translation: EAW62905.1.
BC011894 mRNA. Translation: AAH11894.1.
BC033031 mRNA. Translation: AAH33031.1.
BC038100 mRNA. Translation: AAH38100.1.
CCDSiCCDS32829.1. [Q9H0R4-1]
RefSeqiNP_001305694.1. NM_001318765.1. [Q9H0R4-2]
NP_115500.1. NM_032124.4. [Q9H0R4-1]
XP_006722620.1. XM_006722557.2. [Q9H0R4-2]
XP_011524529.1. XM_011526227.2. [Q9H0R4-1]
XP_011524530.1. XM_011526228.2. [Q9H0R4-1]
XP_016881528.1. XM_017026039.1. [Q9H0R4-1]
UniGeneiHs.465041.

Genome annotation databases

EnsembliENST00000300605; ENSP00000300605; ENSG00000167220. [Q9H0R4-1]
GeneIDi84064.
KEGGihsa:84064.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136681 mRNA. Translation: CAB66616.1.
AK054590 mRNA. Translation: BAB70768.1.
AK292098 mRNA. Translation: BAF84787.1.
CR533487 mRNA. Translation: CAG38518.1.
CH471096 Genomic DNA. Translation: EAW62905.1.
BC011894 mRNA. Translation: AAH11894.1.
BC033031 mRNA. Translation: AAH33031.1.
BC038100 mRNA. Translation: AAH38100.1.
CCDSiCCDS32829.1. [Q9H0R4-1]
RefSeqiNP_001305694.1. NM_001318765.1. [Q9H0R4-2]
NP_115500.1. NM_032124.4. [Q9H0R4-1]
XP_006722620.1. XM_006722557.2. [Q9H0R4-2]
XP_011524529.1. XM_011526227.2. [Q9H0R4-1]
XP_011524530.1. XM_011526228.2. [Q9H0R4-1]
XP_016881528.1. XM_017026039.1. [Q9H0R4-1]
UniGeneiHs.465041.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HLTX-ray2.30A/C1-259[»]
ProteinModelPortaliQ9H0R4.
SMRiQ9H0R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123859. 7 interactors.
IntActiQ9H0R4. 1 interactor.
MINTiMINT-3066019.
STRINGi9606.ENSP00000300605.

PTM databases

iPTMnetiQ9H0R4.
PhosphoSitePlusiQ9H0R4.

Polymorphism and mutation databases

BioMutaiHDHD2.
DMDMi74733528.

2D gel databases

OGPiQ9H0R4.
REPRODUCTION-2DPAGEIPI00783874.

Proteomic databases

EPDiQ9H0R4.
PaxDbiQ9H0R4.
PeptideAtlasiQ9H0R4.
PRIDEiQ9H0R4.

Protocols and materials databases

DNASUi84064.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300605; ENSP00000300605; ENSG00000167220. [Q9H0R4-1]
GeneIDi84064.
KEGGihsa:84064.

Organism-specific databases

CTDi84064.
DisGeNETi84064.
GeneCardsiHDHD2.
HGNCiHGNC:25364. HDHD2.
HPAiCAB045978.
HPA040697.
HPA059818.
neXtProtiNX_Q9H0R4.
OpenTargetsiENSG00000167220.
PharmGKBiPA134952019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3040. Eukaryota.
COG0647. LUCA.
GeneTreeiENSGT00510000046678.
HOGENOMiHOG000068106.
HOVERGENiHBG075146.
InParanoidiQ9H0R4.
OMAiDTRRYKD.
OrthoDBiEOG091G191B.
PhylomeDBiQ9H0R4.
TreeFamiTF314344.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167220-MONOMER.

Miscellaneous databases

ChiTaRSiHDHD2. human.
EvolutionaryTraceiQ9H0R4.
GeneWikiiHDHD2.
GenomeRNAii84064.
PROiQ9H0R4.

Gene expression databases

BgeeiENSG00000167220.
CleanExiHS_HDHD2.
ExpressionAtlasiQ9H0R4. baseline and differential.
GenevisibleiQ9H0R4. HS.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10410. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006357. HAD-SF_hydro_IIA.
IPR006355. HAD-SF_hydro_IIA_hyp2.
IPR023215. NPhePase-like_dom.
[Graphical view]
PfamiPF13344. Hydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01460. HAD-SF-IIA. 1 hit.
TIGR01458. HAD-SF-IIA-hyp3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHDHD2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0R4
Secondary accession number(s): A8K7T3, Q96NV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.