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Q9H0R3

- TM222_HUMAN

UniProt

Q9H0R3 - TM222_HUMAN

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Protein

Transmembrane protein 222

Gene
TMEM222, C1orf160
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 222
Gene namesi
Name:TMEM222
Synonyms:C1orf160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25363. TMEM222.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555Extracellular Reviewed predictionAdd
BLAST
Transmembranei56 – 7621Helical; Reviewed predictionAdd
BLAST
Topological domaini77 – 16488Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Topological domaini186 – 1861Extracellular Reviewed prediction
Transmembranei187 – 20721Helical; Reviewed predictionAdd
BLAST
Topological domaini208 – 2081Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Transmembrane protein 222PRO_0000247963Add
BLAST

Proteomic databases

MaxQBiQ9H0R3.
PaxDbiQ9H0R3.
PRIDEiQ9H0R3.

PTM databases

PhosphoSiteiQ9H0R3.

Expressioni

Gene expression databases

ArrayExpressiQ9H0R3.
BgeeiQ9H0R3.
CleanExiHS_TMEM222.
GenevestigatoriQ9H0R3.

Organism-specific databases

HPAiHPA016579.
HPA059374.

Interactioni

Protein-protein interaction databases

BioGridi123860. 3 interactions.
IntActiQ9H0R3. 2 interactions.
MINTiMINT-1034622.
STRINGi9606.ENSP00000363189.

Structurei

3D structure databases

ProteinModelPortaliQ9H0R3.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319739.
HOGENOMiHOG000231333.
HOVERGENiHBG055708.
InParanoidiQ9H0R3.
OMAiPPPRMAE.
OrthoDBiEOG7673C7.
PhylomeDBiQ9H0R3.
TreeFamiTF105899.

Family and domain databases

InterProiIPR008496. DUF778.
[Graphical view]
PANTHERiPTHR20921. PTHR20921. 1 hit.
PfamiPF05608. DUF778. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H0R3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEAEGSSLL LLPPPPPPPR MAEVEAPTAA ETDMKQYQGS GGVAMDVERS    50
RFPYCVVWTP IPVLTWFFPI IGHMGICTST GVIRDFAGPY FVSEDNMAFG 100
KPAKYWKLDP AQVYASGPNA WDTAVHDASE EYKHRMHNLC CDNCHSHVAL 150
ALNLMRYNNS TNWNMVTLCF FCLLYGKYVS VGAFVKTWLP FILLLGIILT 200
VSLVFNLR 208
Length:208
Mass (Da):23,230
Last modified:August 22, 2006 - v2
Checksum:iD1FB041F151D7BB7
GO
Isoform 2 (identifier: Q9H0R3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:112
Mass (Da):12,804
Checksum:i0D493BF84AC069D5
GO

Sequence cautioni

The sequence CAB66618.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9696Missing in isoform 2. VSP_020090Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011K → E in BAD96362. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO393419 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07764.1.
CH471059 Genomic DNA. Translation: EAX07766.1.
BC011579 mRNA. Translation: AAH11579.2.
BC090039 mRNA. Translation: AAH90039.1.
AL136683 mRNA. Translation: CAB66618.1. Different initiation.
AK222642 mRNA. Translation: BAD96362.1.
CCDSiCCDS297.2. [Q9H0R3-1]
RefSeqiNP_115501.2. NM_032125.2. [Q9H0R3-1]
UniGeneiHs.469171.

Genome annotation databases

EnsembliENST00000374076; ENSP00000363189; ENSG00000186501. [Q9H0R3-1]
GeneIDi84065.
KEGGihsa:84065.
UCSCiuc001bnr.4. human. [Q9H0R3-1]

Polymorphism databases

DMDMi112823989.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO393419 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07764.1 .
CH471059 Genomic DNA. Translation: EAX07766.1 .
BC011579 mRNA. Translation: AAH11579.2 .
BC090039 mRNA. Translation: AAH90039.1 .
AL136683 mRNA. Translation: CAB66618.1 . Different initiation.
AK222642 mRNA. Translation: BAD96362.1 .
CCDSi CCDS297.2. [Q9H0R3-1 ]
RefSeqi NP_115501.2. NM_032125.2. [Q9H0R3-1 ]
UniGenei Hs.469171.

3D structure databases

ProteinModelPortali Q9H0R3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123860. 3 interactions.
IntActi Q9H0R3. 2 interactions.
MINTi MINT-1034622.
STRINGi 9606.ENSP00000363189.

PTM databases

PhosphoSitei Q9H0R3.

Polymorphism databases

DMDMi 112823989.

Proteomic databases

MaxQBi Q9H0R3.
PaxDbi Q9H0R3.
PRIDEi Q9H0R3.

Protocols and materials databases

DNASUi 84065.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374076 ; ENSP00000363189 ; ENSG00000186501 . [Q9H0R3-1 ]
GeneIDi 84065.
KEGGi hsa:84065.
UCSCi uc001bnr.4. human. [Q9H0R3-1 ]

Organism-specific databases

CTDi 84065.
GeneCardsi GC01P027648.
HGNCi HGNC:25363. TMEM222.
HPAi HPA016579.
HPA059374.
neXtProti NX_Q9H0R3.
PharmGKBi PA162406598.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319739.
HOGENOMi HOG000231333.
HOVERGENi HBG055708.
InParanoidi Q9H0R3.
OMAi PPPRMAE.
OrthoDBi EOG7673C7.
PhylomeDBi Q9H0R3.
TreeFami TF105899.

Miscellaneous databases

ChiTaRSi TMEM222. human.
GeneWikii Transmembrane_protein_222.
GenomeRNAii 84065.
NextBioi 73239.
PROi Q9H0R3.

Gene expression databases

ArrayExpressi Q9H0R3.
Bgeei Q9H0R3.
CleanExi HS_TMEM222.
Genevestigatori Q9H0R3.

Family and domain databases

InterProi IPR008496. DUF778.
[Graphical view ]
PANTHERi PTHR20921. PTHR20921. 1 hit.
Pfami PF05608. DUF778. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-208 (ISOFORM 1).
    Tissue: Lung carcinoma and Spinal ganglion.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-208 (ISOFORM 1).
    Tissue: Brain.
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-208 (ISOFORM 1).
    Tissue: Cerebellum.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM222_HUMAN
AccessioniPrimary (citable) accession number: Q9H0R3
Secondary accession number(s): D3DPL6, Q53HD8, Q5FVE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: August 22, 2006
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

External Data

Dasty 3

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