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Q9H0R3

- TM222_HUMAN

UniProt

Q9H0R3 - TM222_HUMAN

Protein

Transmembrane protein 222

Gene

TMEM222

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (22 Aug 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 222
    Gene namesi
    Name:TMEM222
    Synonyms:C1orf160
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25363. TMEM222.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162406598.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Transmembrane protein 222PRO_0000247963Add
    BLAST

    Proteomic databases

    MaxQBiQ9H0R3.
    PaxDbiQ9H0R3.
    PRIDEiQ9H0R3.

    PTM databases

    PhosphoSiteiQ9H0R3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H0R3.
    BgeeiQ9H0R3.
    CleanExiHS_TMEM222.
    GenevestigatoriQ9H0R3.

    Organism-specific databases

    HPAiHPA016579.
    HPA059374.

    Interactioni

    Protein-protein interaction databases

    BioGridi123860. 3 interactions.
    IntActiQ9H0R3. 2 interactions.
    MINTiMINT-1034622.
    STRINGi9606.ENSP00000363189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0R3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 16488CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 1861ExtracellularSequence Analysis
    Topological domaini208 – 2081CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG319739.
    HOGENOMiHOG000231333.
    HOVERGENiHBG055708.
    InParanoidiQ9H0R3.
    OMAiPPPRMAE.
    OrthoDBiEOG7673C7.
    PhylomeDBiQ9H0R3.
    TreeFamiTF105899.

    Family and domain databases

    InterProiIPR008496. DUF778.
    [Graphical view]
    PANTHERiPTHR20921. PTHR20921. 1 hit.
    PfamiPF05608. DUF778. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H0R3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEAEGSSLL LLPPPPPPPR MAEVEAPTAA ETDMKQYQGS GGVAMDVERS    50
    RFPYCVVWTP IPVLTWFFPI IGHMGICTST GVIRDFAGPY FVSEDNMAFG 100
    KPAKYWKLDP AQVYASGPNA WDTAVHDASE EYKHRMHNLC CDNCHSHVAL 150
    ALNLMRYNNS TNWNMVTLCF FCLLYGKYVS VGAFVKTWLP FILLLGIILT 200
    VSLVFNLR 208
    Length:208
    Mass (Da):23,230
    Last modified:August 22, 2006 - v2
    Checksum:iD1FB041F151D7BB7
    GO
    Isoform 2 (identifier: Q9H0R3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-96: Missing.

    Show »
    Length:112
    Mass (Da):12,804
    Checksum:i0D493BF84AC069D5
    GO

    Sequence cautioni

    The sequence CAB66618.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti101 – 1011K → E in BAD96362. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9696Missing in isoform 2. 1 PublicationVSP_020090Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO393419 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07764.1.
    CH471059 Genomic DNA. Translation: EAX07766.1.
    BC011579 mRNA. Translation: AAH11579.2.
    BC090039 mRNA. Translation: AAH90039.1.
    AL136683 mRNA. Translation: CAB66618.1. Different initiation.
    AK222642 mRNA. Translation: BAD96362.1.
    CCDSiCCDS297.2. [Q9H0R3-1]
    RefSeqiNP_115501.2. NM_032125.2. [Q9H0R3-1]
    UniGeneiHs.469171.

    Genome annotation databases

    EnsembliENST00000374076; ENSP00000363189; ENSG00000186501. [Q9H0R3-1]
    GeneIDi84065.
    KEGGihsa:84065.
    UCSCiuc001bnr.4. human. [Q9H0R3-1]

    Polymorphism databases

    DMDMi112823989.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO393419 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07764.1 .
    CH471059 Genomic DNA. Translation: EAX07766.1 .
    BC011579 mRNA. Translation: AAH11579.2 .
    BC090039 mRNA. Translation: AAH90039.1 .
    AL136683 mRNA. Translation: CAB66618.1 . Different initiation.
    AK222642 mRNA. Translation: BAD96362.1 .
    CCDSi CCDS297.2. [Q9H0R3-1 ]
    RefSeqi NP_115501.2. NM_032125.2. [Q9H0R3-1 ]
    UniGenei Hs.469171.

    3D structure databases

    ProteinModelPortali Q9H0R3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123860. 3 interactions.
    IntActi Q9H0R3. 2 interactions.
    MINTi MINT-1034622.
    STRINGi 9606.ENSP00000363189.

    PTM databases

    PhosphoSitei Q9H0R3.

    Polymorphism databases

    DMDMi 112823989.

    Proteomic databases

    MaxQBi Q9H0R3.
    PaxDbi Q9H0R3.
    PRIDEi Q9H0R3.

    Protocols and materials databases

    DNASUi 84065.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374076 ; ENSP00000363189 ; ENSG00000186501 . [Q9H0R3-1 ]
    GeneIDi 84065.
    KEGGi hsa:84065.
    UCSCi uc001bnr.4. human. [Q9H0R3-1 ]

    Organism-specific databases

    CTDi 84065.
    GeneCardsi GC01P027648.
    HGNCi HGNC:25363. TMEM222.
    HPAi HPA016579.
    HPA059374.
    neXtProti NX_Q9H0R3.
    PharmGKBi PA162406598.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319739.
    HOGENOMi HOG000231333.
    HOVERGENi HBG055708.
    InParanoidi Q9H0R3.
    OMAi PPPRMAE.
    OrthoDBi EOG7673C7.
    PhylomeDBi Q9H0R3.
    TreeFami TF105899.

    Miscellaneous databases

    ChiTaRSi TMEM222. human.
    GeneWikii Transmembrane_protein_222.
    GenomeRNAii 84065.
    NextBioi 73239.
    PROi Q9H0R3.

    Gene expression databases

    ArrayExpressi Q9H0R3.
    Bgeei Q9H0R3.
    CleanExi HS_TMEM222.
    Genevestigatori Q9H0R3.

    Family and domain databases

    InterProi IPR008496. DUF778.
    [Graphical view ]
    PANTHERi PTHR20921. PTHR20921. 1 hit.
    Pfami PF05608. DUF778. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-208 (ISOFORM 1).
      Tissue: Lung carcinoma and Spinal ganglion.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-208 (ISOFORM 1).
      Tissue: Brain.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-208 (ISOFORM 1).
      Tissue: Cerebellum.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTM222_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0R3
    Secondary accession number(s): D3DPL6, Q53HD8, Q5FVE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM

    External Data

    Dasty 3