Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9H0R3 (TM222_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 222
Gene names
Name:TMEM222
Synonyms:C1orf160
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence caution

The sequence CAB66618.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H0R3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H0R3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Transmembrane protein 222
PRO_0000247963

Regions

Topological domain1 – 5555Extracellular Potential
Transmembrane56 – 7621Helical; Potential
Topological domain77 – 16488Cytoplasmic Potential
Transmembrane165 – 18521Helical; Potential
Topological domain1861Extracellular Potential
Transmembrane187 – 20721Helical; Potential
Topological domain2081Cytoplasmic Potential

Natural variations

Alternative sequence1 – 9696Missing in isoform 2.
VSP_020090

Experimental info

Sequence conflict1011K → E in BAD96362. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 22, 2006. Version 2.
Checksum: D1FB041F151D7BB7

FASTA20823,230
        10         20         30         40         50         60 
MAEAEGSSLL LLPPPPPPPR MAEVEAPTAA ETDMKQYQGS GGVAMDVERS RFPYCVVWTP 

        70         80         90        100        110        120 
IPVLTWFFPI IGHMGICTST GVIRDFAGPY FVSEDNMAFG KPAKYWKLDP AQVYASGPNA 

       130        140        150        160        170        180 
WDTAVHDASE EYKHRMHNLC CDNCHSHVAL ALNLMRYNNS TNWNMVTLCF FCLLYGKYVS 

       190        200 
VGAFVKTWLP FILLLGIILT VSLVFNLR 

« Hide

Isoform 2 [UniParc].

Checksum: 0D493BF84AC069D5
Show »

FASTA11212,804

References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-208 (ISOFORM 1).
Tissue: Lung carcinoma and Spinal ganglion.
[4]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-208 (ISOFORM 1).
Tissue: Brain.
[5]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-208 (ISOFORM 1).
Tissue: Cerebellum.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO393419 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07764.1.
CH471059 Genomic DNA. Translation: EAX07766.1.
BC011579 mRNA. Translation: AAH11579.2.
BC090039 mRNA. Translation: AAH90039.1.
AL136683 mRNA. Translation: CAB66618.1. Different initiation.
AK222642 mRNA. Translation: BAD96362.1.
RefSeqNP_115501.2. NM_032125.2.
UniGeneHs.469171.

3D structure databases

ProteinModelPortalQ9H0R3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123860. 3 interactions.
IntActQ9H0R3. 2 interactions.
MINTMINT-1034622.
STRING9606.ENSP00000363189.

PTM databases

PhosphoSiteQ9H0R3.

Polymorphism databases

DMDM112823989.

Proteomic databases

PaxDbQ9H0R3.
PRIDEQ9H0R3.

Protocols and materials databases

DNASU84065.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374076; ENSP00000363189; ENSG00000186501. [Q9H0R3-1]
GeneID84065.
KEGGhsa:84065.
UCSCuc001bnr.4. human. [Q9H0R3-1]

Organism-specific databases

CTD84065.
GeneCardsGC01P027648.
HGNCHGNC:25363. TMEM222.
HPAHPA016579.
HPA059374.
neXtProtNX_Q9H0R3.
PharmGKBPA162406598.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319739.
HOGENOMHOG000231333.
HOVERGENHBG055708.
InParanoidQ9H0R3.
OMAPPPRMAE.
OrthoDBEOG7673C7.
PhylomeDBQ9H0R3.
TreeFamTF105899.

Gene expression databases

ArrayExpressQ9H0R3.
BgeeQ9H0R3.
CleanExHS_TMEM222.
GenevestigatorQ9H0R3.

Family and domain databases

InterProIPR008496. DUF778.
[Graphical view]
PANTHERPTHR20921. PTHR20921. 1 hit.
PfamPF05608. DUF778. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMEM222. human.
GeneWikiTransmembrane_protein_222.
GenomeRNAi84065.
NextBio73239.
PROQ9H0R3.

Entry information

Entry nameTM222_HUMAN
AccessionPrimary (citable) accession number: Q9H0R3
Secondary accession number(s): D3DPL6, Q53HD8, Q5FVE9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: August 22, 2006
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM