Reviewed, UniProtKB/Swiss-Prot Q9H0R3 (TM222_HUMAN)

Names and origin

Protein names

Recommended name:
    Transmembrane protein 222

Gene names

Name:	TMEM222
Synonyms:	C1orf160

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAT5	O95870	1	EBI-347385,EBI-348517

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H0R3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H0R3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Transmembrane protein 222		PRO_0000247963
Regions
	Topological domain	1 – 55	55	Extracellular Potential
	Transmembrane	56 – 76	21	Potential
	Topological domain	77 – 164	88	Cytoplasmic Potential
	Transmembrane	165 – 185	21	Potential
	Topological domain	186	1	Extracellular Potential
	Transmembrane	187 – 207	21	Potential
	Topological domain	208	1	Cytoplasmic Potential
Natural variations
	Alternative sequence	1 – 96	96	Missing in isoform 2.		VSP_020090
Experimental info
	Sequence conflict	101	1	K → E in BAD96362. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 22, 2006. Version 2. Checksum: D1FB041F151D7BB7	FASTA	208	23,230
	10 20 30 40 50 60 MAEAEGSSLL LLPPPPPPPR MAEVEAPTAA ETDMKQYQGS GGVAMDVERS RFPYCVVWTP 70 80 90 100 110 120 IPVLTWFFPI IGHMGICTST GVIRDFAGPY FVSEDNMAFG KPAKYWKLDP AQVYASGPNA 130 140 150 160 170 180 WDTAVHDASE EYKHRMHNLC CDNCHSHVAL ALNLMRYNNS TNWNMVTLCF FCLLYGKYVS 190 200 VGAFVKTWLP FILLLGIILT VSLVFNLR
	Isoform 2. Checksum: 0D493BF84AC069D5	FASTA	112	12,804
	10 20 30 40 50 60 MAFGKPAKYW KLDPAQVYAS GPNAWDTAVH DASEEYKHRM HNLCCDNCHS HVALALNLMR 70 80 90 100 110 YNNSTNWNMV TLCFFCLLYG KYVSVGAFVK TWLPFILLLG IILTVSLVFN LR

References

[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-208 (ISOFORM 1). Tissue: Lung carcinoma and Spinal ganglion.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-208 (ISOFORM 1). Tissue: Brain.
[4]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-208 (ISOFORM 1). Tissue: Cerebellum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL663123 Genomic DNA. Translation: CAI14790.2. BC011579 mRNA. Translation: AAH11579.2. BC090039 mRNA. Translation: AAH90039.1. AL136683 mRNA. Translation: CAB66618.1. Different initiation. AK222642 mRNA. Translation: BAD96362.1.
IPI	IPI00030236. IPI00940963.
RefSeq	NP_115501.2.
UniGene	Hs.469171
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H0R3. 2 interactions.
Proteomic databases
PRIDE	Q9H0R3.
Genome annotation databases
Ensembl	ENST00000374076; ENSP00000363189; ENSG00000186501; Homo sapiens. [Genome view]
GeneID	84065.
KEGG	hsa:84065.
UCSC	uc001bnr.2. human.
Organism-specific databases
CTD	84065.
GeneCards	GC01P027523.
HGNC	HGNC:25363. TMEM222.
PharmGKB	PA142672411.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG523321.
HOVERGEN	Q9H0R3.
InParanoid	Q9H0R3.
OrthoDB	EOG9WWV4P.
Gene expression databases
ArrayExpress	Q9H0R3.
Bgee	Q9H0R3.
CleanEx	HS_TMEM222.
Genevestigator	Q9H0R3.
Family and domain databases
InterPro	IPR008496. DUF778. [Graphical view]
PANTHER	PTHR20921. DUF778. 1 hit.
Pfam	PF05608. DUF778. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	73239.

Entry information

Entry name

TM222_HUMAN

Accession

Primary (citable) accession number: Q9H0R3
Secondary accession number(s): Q53HD8, Q5FVE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 15, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.