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Protein

Transmembrane protein 222

Gene

TMEM222

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 222
Gene namesi
Name:TMEM222
Synonyms:C1orf160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25363. TMEM222.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Topological domaini77 – 16488CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Topological domaini186 – 1861ExtracellularSequence Analysis
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Topological domaini208 – 2081CytoplasmicSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406598.

Polymorphism and mutation databases

BioMutaiTMEM222.
DMDMi112823989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Transmembrane protein 222PRO_0000247963Add
BLAST

Proteomic databases

MaxQBiQ9H0R3.
PaxDbiQ9H0R3.
PRIDEiQ9H0R3.

PTM databases

PhosphoSiteiQ9H0R3.

Expressioni

Gene expression databases

BgeeiQ9H0R3.
CleanExiHS_TMEM222.
ExpressionAtlasiQ9H0R3. baseline and differential.
GenevestigatoriQ9H0R3.

Organism-specific databases

HPAiHPA016579.
HPA059374.

Interactioni

Protein-protein interaction databases

BioGridi123860. 6 interactions.
IntActiQ9H0R3. 2 interactions.
MINTiMINT-1034622.
STRINGi9606.ENSP00000363189.

Structurei

3D structure databases

ProteinModelPortaliQ9H0R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319739.
GeneTreeiENSGT00390000007371.
HOGENOMiHOG000231333.
HOVERGENiHBG055708.
InParanoidiQ9H0R3.
OrthoDBiEOG7673C7.
PhylomeDBiQ9H0R3.
TreeFamiTF105899.

Family and domain databases

InterProiIPR008496. DUF778.
[Graphical view]
PANTHERiPTHR20921. PTHR20921. 1 hit.
PfamiPF05608. DUF778. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0R3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEGSSLL LLPPPPPPPR MAEVEAPTAA ETDMKQYQGS GGVAMDVERS
60 70 80 90 100
RFPYCVVWTP IPVLTWFFPI IGHMGICTST GVIRDFAGPY FVSEDNMAFG
110 120 130 140 150
KPAKYWKLDP AQVYASGPNA WDTAVHDASE EYKHRMHNLC CDNCHSHVAL
160 170 180 190 200
ALNLMRYNNS TNWNMVTLCF FCLLYGKYVS VGAFVKTWLP FILLLGIILT

VSLVFNLR
Length:208
Mass (Da):23,230
Last modified:August 22, 2006 - v2
Checksum:iD1FB041F151D7BB7
GO
Isoform 2 (identifier: Q9H0R3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:112
Mass (Da):12,804
Checksum:i0D493BF84AC069D5
GO

Sequence cautioni

The sequence CAB66618.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011K → E in BAD96362 (Ref. 5) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9696Missing in isoform 2. 1 PublicationVSP_020090Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO393419 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07764.1.
CH471059 Genomic DNA. Translation: EAX07766.1.
BC011579 mRNA. Translation: AAH11579.2.
BC090039 mRNA. Translation: AAH90039.1.
AL136683 mRNA. Translation: CAB66618.1. Different initiation.
AK222642 mRNA. Translation: BAD96362.1.
CCDSiCCDS297.2. [Q9H0R3-1]
RefSeqiNP_115501.2. NM_032125.2. [Q9H0R3-1]
UniGeneiHs.469171.

Genome annotation databases

EnsembliENST00000374076; ENSP00000363189; ENSG00000186501. [Q9H0R3-1]
ENST00000611517; ENSP00000483276; ENSG00000186501. [Q9H0R3-1]
GeneIDi84065.
KEGGihsa:84065.
UCSCiuc001bnr.4. human. [Q9H0R3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO393419 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07764.1.
CH471059 Genomic DNA. Translation: EAX07766.1.
BC011579 mRNA. Translation: AAH11579.2.
BC090039 mRNA. Translation: AAH90039.1.
AL136683 mRNA. Translation: CAB66618.1. Different initiation.
AK222642 mRNA. Translation: BAD96362.1.
CCDSiCCDS297.2. [Q9H0R3-1]
RefSeqiNP_115501.2. NM_032125.2. [Q9H0R3-1]
UniGeneiHs.469171.

3D structure databases

ProteinModelPortaliQ9H0R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123860. 6 interactions.
IntActiQ9H0R3. 2 interactions.
MINTiMINT-1034622.
STRINGi9606.ENSP00000363189.

PTM databases

PhosphoSiteiQ9H0R3.

Polymorphism and mutation databases

BioMutaiTMEM222.
DMDMi112823989.

Proteomic databases

MaxQBiQ9H0R3.
PaxDbiQ9H0R3.
PRIDEiQ9H0R3.

Protocols and materials databases

DNASUi84065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374076; ENSP00000363189; ENSG00000186501. [Q9H0R3-1]
ENST00000611517; ENSP00000483276; ENSG00000186501. [Q9H0R3-1]
GeneIDi84065.
KEGGihsa:84065.
UCSCiuc001bnr.4. human. [Q9H0R3-1]

Organism-specific databases

CTDi84065.
GeneCardsiGC01P027648.
HGNCiHGNC:25363. TMEM222.
HPAiHPA016579.
HPA059374.
neXtProtiNX_Q9H0R3.
PharmGKBiPA162406598.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG319739.
GeneTreeiENSGT00390000007371.
HOGENOMiHOG000231333.
HOVERGENiHBG055708.
InParanoidiQ9H0R3.
OrthoDBiEOG7673C7.
PhylomeDBiQ9H0R3.
TreeFamiTF105899.

Miscellaneous databases

ChiTaRSiTMEM222. human.
GeneWikiiTransmembrane_protein_222.
GenomeRNAii84065.
NextBioi73239.
PROiQ9H0R3.

Gene expression databases

BgeeiQ9H0R3.
CleanExiHS_TMEM222.
ExpressionAtlasiQ9H0R3. baseline and differential.
GenevestigatoriQ9H0R3.

Family and domain databases

InterProiIPR008496. DUF778.
[Graphical view]
PANTHERiPTHR20921. PTHR20921. 1 hit.
PfamiPF05608. DUF778. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-208 (ISOFORM 1).
    Tissue: Lung carcinoma and Spinal ganglion.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-208 (ISOFORM 1).
    Tissue: Brain.
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-208 (ISOFORM 1).
    Tissue: Cerebellum.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM222_HUMAN
AccessioniPrimary (citable) accession number: Q9H0R3
Secondary accession number(s): D3DPL6, Q53HD8, Q5FVE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: August 22, 2006
Last modified: April 29, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.