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Protein

Ras-related protein Rab-6C

Gene

RAB6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of centrosome duplication and cell cycle progression.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cell cycle process Source: UniProtKB
  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • regulation of centrosome duplication Source: UniProtKB
  • response to drug Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: GO_Central
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central
  • small GTPase mediated signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32036-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6C
Alternative name(s):
Rab6-like protein WTH3
Gene namesi
Name:RAB6C
Synonyms:WTH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16525. RAB6C.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytosol Source: GOC
  • Golgi apparatus Source: GO_Central
  • intracellular Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25A → G: No GTP binding. No GTP binding; when associated with T-45. 1 Publication1
Mutagenesisi45I → T: No GTP binding; when associated with G-25. 1 Publication1

Organism-specific databases

DisGeNETi84084.
OpenTargetsiENSG00000222014.
PharmGKBiPA34148.

Polymorphism and mutation databases

BioMutaiRAB6C.
DMDMi166214970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211171 – 254Ras-related protein Rab-6CAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82O-AMP-tyrosine; by Legionella DrrA1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0N0.
MaxQBiQ9H0N0.
PaxDbiQ9H0N0.
PeptideAtlasiQ9H0N0.
PRIDEiQ9H0N0.
TopDownProteomicsiQ9H0N0.

PTM databases

iPTMnetiQ9H0N0.
PhosphoSitePlusiQ9H0N0.

Expressioni

Tissue specificityi

Highest levels are found in fetal and adult brain, prostate, testis and spinal cord. Undetectable expression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary gland, and trachea. Detected in the HEK293, HEK293T, LNCaP, MCF-7, T-47D and EVSA-T cell lines (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000222014.
GenevisibleiQ9H0N0. HS.

Organism-specific databases

HPAiHPA059131.

Interactioni

Protein-protein interaction databases

BioGridi123878. 4 interactors.
IntActiQ9H0N0. 5 interactors.
MINTiMINT-2817186.
STRINGi9606.ENSP00000387307.

Structurei

3D structure databases

ProteinModelPortaliQ9H0N0.
SMRiQ9H0N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 174Required for centrosome localizationAdd BLAST174

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9H0N0.
KOiK07895.
OMAiRYIRDSA.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ9H0N0.
TreeFamiTF300803.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVAKTSLI TRFRYDSFDN TYQAIIGIDF
60 70 80 90 100
LSKTMYLEDG TIGLRLWDTA GQERLRSLIP RYIRDSAAAV VVYDITNVNS
110 120 130 140 150
FQQTTKWIDD VRTERGSDVI ITLVGNRTDL ADKRQVSVEE GERKAKGLNV
160 170 180 190 200
TFIETRAKAG YNVKQLFRRV AAALPGMEST QDGSREDMSD IKLEKPQEQT
210 220 230 240 250
VSEGGCSCYS PMSSSTLPQK PPYSFIDCSV NIGLNLFPSL ITFCNSSLLP

VSWR
Length:254
Mass (Da):28,355
Last modified:January 15, 2008 - v2
Checksum:i72A4D8DED771F754
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038161159A → T.5 PublicationsCorresponds to variant rs4662674dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309646 mRNA. Translation: AAN39685.1.
AL136727 mRNA. Translation: CAB66661.1.
CR533469 mRNA. Translation: CAG38500.1.
AC079776 Genomic DNA. Translation: AAY15045.1.
CH471103 Genomic DNA. Translation: EAW95362.1.
CH471058 Genomic DNA. Translation: EAX11700.1.
BC120999 mRNA. Translation: AAI21000.1.
AF124200 Genomic DNA. Translation: AAF28422.1.
CCDSiCCDS46408.1.
RefSeqiNP_115520.2. NM_032144.2.
UniGeneiHs.591552.

Genome annotation databases

EnsembliENST00000410061; ENSP00000387307; ENSG00000222014.
GeneIDi84084.
KEGGihsa:84084.
UCSCiuc002tpx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309646 mRNA. Translation: AAN39685.1.
AL136727 mRNA. Translation: CAB66661.1.
CR533469 mRNA. Translation: CAG38500.1.
AC079776 Genomic DNA. Translation: AAY15045.1.
CH471103 Genomic DNA. Translation: EAW95362.1.
CH471058 Genomic DNA. Translation: EAX11700.1.
BC120999 mRNA. Translation: AAI21000.1.
AF124200 Genomic DNA. Translation: AAF28422.1.
CCDSiCCDS46408.1.
RefSeqiNP_115520.2. NM_032144.2.
UniGeneiHs.591552.

3D structure databases

ProteinModelPortaliQ9H0N0.
SMRiQ9H0N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123878. 4 interactors.
IntActiQ9H0N0. 5 interactors.
MINTiMINT-2817186.
STRINGi9606.ENSP00000387307.

PTM databases

iPTMnetiQ9H0N0.
PhosphoSitePlusiQ9H0N0.

Polymorphism and mutation databases

BioMutaiRAB6C.
DMDMi166214970.

Proteomic databases

EPDiQ9H0N0.
MaxQBiQ9H0N0.
PaxDbiQ9H0N0.
PeptideAtlasiQ9H0N0.
PRIDEiQ9H0N0.
TopDownProteomicsiQ9H0N0.

Protocols and materials databases

DNASUi84084.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000410061; ENSP00000387307; ENSG00000222014.
GeneIDi84084.
KEGGihsa:84084.
UCSCiuc002tpx.2. human.

Organism-specific databases

CTDi84084.
DisGeNETi84084.
GeneCardsiRAB6C.
H-InvDBHIX0002449.
HIX0023949.
HGNCiHGNC:16525. RAB6C.
HPAiHPA059131.
MIMi612909. gene.
neXtProtiNX_Q9H0N0.
OpenTargetsiENSG00000222014.
PharmGKBiPA34148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9H0N0.
KOiK07895.
OMAiRYIRDSA.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ9H0N0.
TreeFamiTF300803.

Enzyme and pathway databases

BioCyciZFISH:G66-32036-MONOMER.

Miscellaneous databases

GeneWikiiRAB6C.
GenomeRNAii84084.
PROiQ9H0N0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000222014.
GenevisibleiQ9H0N0. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB6C_HUMAN
AccessioniPrimary (citable) accession number: Q9H0N0
Secondary accession number(s): Q53RU3, Q6FIF7, Q9P128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Primate-specific retrogene derived from isoform 2 of RAB6A transcript.
Previously reported to exhibit GTP-binding affinity comparable to that of RAB6A (PubMed:16103095). In contrast (PubMed:20064528) concludes that RAB6C is an inefficient GTP-binding.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.