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Protein

Ras-related protein Rab-6C

Gene

RAB6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of centrosome duplication and cell cycle progression.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cell cycle process Source: UniProtKB
  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • protein transport Source: InterPro
  • regulation of centrosome duplication Source: UniProtKB
  • response to drug Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: GO_Central
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central
  • small GTPase mediated signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6C
Alternative name(s):
Rab6-like protein WTH3
Gene namesi
Name:RAB6C
Synonyms:WTH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16525. RAB6C.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • Golgi apparatus Source: GO_Central
  • intracellular Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi25 – 251A → G: No GTP binding. No GTP binding; when associated with T-45. 1 Publication
Mutagenesisi45 – 451I → T: No GTP binding; when associated with G-25. 1 Publication

Organism-specific databases

PharmGKBiPA34148.

Polymorphism and mutation databases

BioMutaiRAB6C.
DMDMi166214970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Ras-related protein Rab-6CPRO_0000121117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821O-AMP-tyrosine; by Legionella DrrA1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0N0.
MaxQBiQ9H0N0.
PaxDbiQ9H0N0.
PRIDEiQ9H0N0.
TopDownProteomicsiQ9H0N0.

PTM databases

iPTMnetiQ9H0N0.
PhosphoSiteiQ9H0N0.

Expressioni

Tissue specificityi

Highest levels are found in fetal and adult brain, prostate, testis and spinal cord. Undetectable expression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary gland, and trachea. Detected in the HEK293, HEK293T, LNCaP, MCF-7, T-47D and EVSA-T cell lines (at protein level).1 Publication

Gene expression databases

BgeeiQ9H0N0.
GenevisibleiQ9H0N0. HS.

Organism-specific databases

HPAiHPA059131.

Interactioni

Protein-protein interaction databases

BioGridi123878. 4 interactions.
IntActiQ9H0N0. 2 interactions.
MINTiMINT-2817186.
STRINGi9606.ENSP00000387307.

Structurei

3D structure databases

ProteinModelPortaliQ9H0N0.
SMRiQ9H0N0. Positions 14-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 174174Required for centrosome localizationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9H0N0.
KOiK07895.
OMAiRYIRDSA.
OrthoDBiEOG77DJ7M.
PhylomeDBiQ9H0N0.
TreeFamiTF300803.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVAKTSLI TRFRYDSFDN TYQAIIGIDF
60 70 80 90 100
LSKTMYLEDG TIGLRLWDTA GQERLRSLIP RYIRDSAAAV VVYDITNVNS
110 120 130 140 150
FQQTTKWIDD VRTERGSDVI ITLVGNRTDL ADKRQVSVEE GERKAKGLNV
160 170 180 190 200
TFIETRAKAG YNVKQLFRRV AAALPGMEST QDGSREDMSD IKLEKPQEQT
210 220 230 240 250
VSEGGCSCYS PMSSSTLPQK PPYSFIDCSV NIGLNLFPSL ITFCNSSLLP

VSWR
Length:254
Mass (Da):28,355
Last modified:January 15, 2008 - v2
Checksum:i72A4D8DED771F754
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591A → T.5 Publications
VAR_038161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309646 mRNA. Translation: AAN39685.1.
AL136727 mRNA. Translation: CAB66661.1.
CR533469 mRNA. Translation: CAG38500.1.
AC079776 Genomic DNA. Translation: AAY15045.1.
CH471103 Genomic DNA. Translation: EAW95362.1.
CH471058 Genomic DNA. Translation: EAX11700.1.
BC120999 mRNA. Translation: AAI21000.1.
AF124200 Genomic DNA. Translation: AAF28422.1.
CCDSiCCDS46408.1.
RefSeqiNP_115520.2. NM_032144.2.
UniGeneiHs.591552.

Genome annotation databases

EnsembliENST00000410061; ENSP00000387307; ENSG00000222014.
GeneIDi84084.
KEGGihsa:84084.
UCSCiuc002tpx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309646 mRNA. Translation: AAN39685.1.
AL136727 mRNA. Translation: CAB66661.1.
CR533469 mRNA. Translation: CAG38500.1.
AC079776 Genomic DNA. Translation: AAY15045.1.
CH471103 Genomic DNA. Translation: EAW95362.1.
CH471058 Genomic DNA. Translation: EAX11700.1.
BC120999 mRNA. Translation: AAI21000.1.
AF124200 Genomic DNA. Translation: AAF28422.1.
CCDSiCCDS46408.1.
RefSeqiNP_115520.2. NM_032144.2.
UniGeneiHs.591552.

3D structure databases

ProteinModelPortaliQ9H0N0.
SMRiQ9H0N0. Positions 14-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123878. 4 interactions.
IntActiQ9H0N0. 2 interactions.
MINTiMINT-2817186.
STRINGi9606.ENSP00000387307.

PTM databases

iPTMnetiQ9H0N0.
PhosphoSiteiQ9H0N0.

Polymorphism and mutation databases

BioMutaiRAB6C.
DMDMi166214970.

Proteomic databases

EPDiQ9H0N0.
MaxQBiQ9H0N0.
PaxDbiQ9H0N0.
PRIDEiQ9H0N0.
TopDownProteomicsiQ9H0N0.

Protocols and materials databases

DNASUi84084.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000410061; ENSP00000387307; ENSG00000222014.
GeneIDi84084.
KEGGihsa:84084.
UCSCiuc002tpx.2. human.

Organism-specific databases

CTDi84084.
GeneCardsiRAB6C.
H-InvDBHIX0002449.
HIX0023949.
HGNCiHGNC:16525. RAB6C.
HPAiHPA059131.
MIMi612909. gene.
neXtProtiNX_Q9H0N0.
PharmGKBiPA34148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9H0N0.
KOiK07895.
OMAiRYIRDSA.
OrthoDBiEOG77DJ7M.
PhylomeDBiQ9H0N0.
TreeFamiTF300803.

Miscellaneous databases

GeneWikiiRAB6C.
GenomeRNAii84084.
NextBioi73315.
PROiQ9H0N0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H0N0.
GenevisibleiQ9H0N0. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "WTH3, a new member of the Rab6 gene family, and multidrug resistance."
    Shan J., Yuan L., Budman D.R., Xu H.-P.
    Biochim. Biophys. Acta 1589:112-123(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-159.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-159.
    Tissue: Kidney.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-159.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-159.
  7. "Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells."
    Shan J., Mason J.M., Yuan L., Barcia M., Porti D., Calabro A., Budman D., Vinciguerra V., Xu H.-P.
    Gene 257:67-75(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-175, VARIANT THR-159.
  8. "WTH3, which encodes a small G protein, is differentially regulated in multidrug-resistant and sensitive MCF7 cells."
    Tian K., Jurukovski V., Yuan L., Shan J., Xu H.
    Cancer Res. 65:7421-7428(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GTP-BINDING, SUBCELLULAR LOCATION.
  9. "WTH3 is a direct target of the p53 protein."
    Tian K., Wang Y., Xu H.
    Br. J. Cancer 96:1579-1586(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression."
    Tian K., Wang Y., Huang Y., Sun B., Li Y., Xu H.
    BMC Cancer 8:327-327(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "RAB6C is a retrogene that encodes a centrosomal protein involved in cell cycle progression."
    Young J., Menetrey J., Goud B.
    J. Mol. Biol. 397:69-88(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: RETROGENE, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF ALA-25 AND ILE-45.
  12. "Modulation of Rab GTPase function by a protein phosphocholine transferase."
    Mukherjee S., Liu X., Arasaki K., McDonough J., Galan J.E., Roy C.R.
    Nature 477:103-106(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: AMPYLATION AT TYR-82.

Entry informationi

Entry nameiRAB6C_HUMAN
AccessioniPrimary (citable) accession number: Q9H0N0
Secondary accession number(s): Q53RU3, Q6FIF7, Q9P128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 15, 2008
Last modified: May 11, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Primate-specific retrogene derived from isoform 2 of RAB6A transcript.
Previously reported to exhibit GTP-binding affinity comparable to that of RAB6A (PubMed:16103095). In contrast (PubMed:20064528) concludes that RAB6C is an inefficient GTP-binding.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.