Q9H0N0 (RAB6C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-6C

Alternative name(s):
Rab6-like protein WTH3

Gene names

Name:	RAB6C
Synonyms:	WTH3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: InterPro response to drug Inferred from direct assay Ref.7. Source: UniProtKB small GTPase mediated signal transduction Traceable author statement. Source: UniProtKB
Cellular component	intracellular Inferred by curator. Source: UniProtKB
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Ras-related protein Rab-6C		PRO_0000121117
Regions
	Nucleotide binding	20 – 27	8	GTP By similarity
	Nucleotide binding	68 – 72	5	GTP By similarity
	Nucleotide binding	126 – 129	4	GTP By similarity
	Motif	42 – 50	9	Effector region By similarity
Natural variations
	Natural variant	159	1	A → T. Ref.1 Ref.2 Ref.3 Ref.6 Ref.7		VAR_038161

Sequences

	Sequence		Length	Mass (Da)
	Q9H0N0 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 72A4D8DED771F754	FASTA	254	28,355
	10 20 30 40 50 60 MSAGGDFGNP LRKFKLVFLG EQSVAKTSLI TRFRYDSFDN TYQAIIGIDF LSKTMYLEDG 70 80 90 100 110 120 TIGLRLWDTA GQERLRSLIP RYIRDSAAAV VVYDITNVNS FQQTTKWIDD VRTERGSDVI 130 140 150 160 170 180 ITLVGNRTDL ADKRQVSVEE GERKAKGLNV TFIETRAKAG YNVKQLFRRV AAALPGMEST 190 200 210 220 230 240 QDGSREDMSD IKLEKPQEQT VSEGGCSCYS PMSSSTLPQK PPYSFIDCSV NIGLNLFPSL 250 ITFCNSSLLP VSWR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"WTH3, a new member of the Rab6 gene family, and multidrug resistance." Shan J., Yuan L., Budman D.R., Xu H.-P. Biochim. Biophys. Acta 1589:112-123(2002) [PubMed: 12007787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-159.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-159. Tissue: Kidney.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-159.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-159.
[7]	"Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells." Shan J., Mason J.M., Yuan L., Barcia M., Porti D., Calabro A., Budman D., Vinciguerra V., Xu H.-P. Gene 257:67-75(2000) [PubMed: 11054569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-175, VARIANT THR-159.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF309646 mRNA. Translation: AAN39685.1. AL136727 mRNA. Translation: CAB66661.1. CR533469 mRNA. Translation: CAG38500.1. AC079776 Genomic DNA. Translation: AAY15045.1. CH471103 Genomic DNA. Translation: EAW95362.1. CH471058 Genomic DNA. Translation: EAX11700.1. BC120999 mRNA. Translation: AAI21000.1. AF124200 Genomic DNA. Translation: AAF28422.1.
IPI	IPI00030304.
RefSeq	NP_115520.2. NM_032144.2.
UniGene	Hs.591552.
3D structure databases
ProteinModelPortal	Q9H0N0.
SMR	Q9H0N0. Positions 14-177.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H0N0. 1 interaction.
STRING	Q9H0N0.
Polymorphism databases
DMDM	166214970.
Proteomic databases
PRIDE	Q9H0N0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000410061; ENSP00000387307; ENSG00000222014.
GeneID	84084.
KEGG	hsa:84084.
UCSC	uc002tpx.1. human.
Organism-specific databases
CTD	84084.
GeneCards	GC02P130737.
H-InvDB	HIX0002449. HIX0023949.
HGNC	HGNC:16525. RAB6C.
MIM	612909. gene.
neXtProt	NX_Q9H0N0.
PharmGKB	PA34148.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG06208.
GeneTree	ENSGT00600000084341.
HOGENOM	HBG745225.
HOVERGEN	HBG009351.
InParanoid	Q9H0N0.
OMA	EGGCSCY.
OrthoDB	EOG4HMJB5.
PhylomeDB	Q9H0N0.
Gene expression databases
Bgee	Q9H0N0.
Genevestigator	Q9H0N0.
GermOnline	ENSG00000185023. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
KO	K07895.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	73315.
SOURCE	Search...

Entry information

Entry name

RAB6C_HUMAN

Accession

Primary (citable) accession number: Q9H0N0
Secondary accession number(s): Q53RU3, Q6FIF7, Q9P128

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.