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Protein

Zinc finger protein 700

Gene

ZNF700

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri194 – 216C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 502C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri508 – 530C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri648 – 670C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri676 – 698C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri704 – 726C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 700
Gene namesi
Name:ZNF700
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196757.7
HGNCiHGNC:25292 ZNF700
neXtProtiNX_Q9H0M5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196757
PharmGKBiPA142670497

Polymorphism and mutation databases

DMDMi74761386

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332801 – 742Zinc finger protein 700Add BLAST742

Proteomic databases

MaxQBiQ9H0M5
PaxDbiQ9H0M5
PeptideAtlasiQ9H0M5
PRIDEiQ9H0M5

PTM databases

iPTMnetiQ9H0M5
PhosphoSitePlusiQ9H0M5

Expressioni

Gene expression databases

BgeeiENSG00000196757
CleanExiHS_ZNF700
ExpressionAtlasiQ9H0M5 baseline and differential
GenevisibleiQ9H0M5 HS

Organism-specific databases

HPAiHPA047845

Interactioni

Protein-protein interaction databases

IntActiQ9H0M5, 1 interactor
STRINGi9606.ENSP00000254321

Structurei

3D structure databases

ProteinModelPortaliQ9H0M5
SMRiQ9H0M5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 104KRABPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri194 – 216C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 502C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri508 – 530C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri648 – 670C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri676 – 698C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri704 – 726C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140787
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9H0M5
KOiK09228
PhylomeDBiQ9H0M5
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 18 hits
PS50157 ZINC_FINGER_C2H2_2, 21 hits

Sequencei

Sequence statusi: Complete.

Q9H0M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCCSHRSCR EDPGTSESRE MDPVAFEDVA VNFTQEEWTL LDISQKNLFR
60 70 80 90 100
EVMLETFRNL TSIGKKWSDQ NIEYEYQNPR RSFRSLIEEK VNEIKEDSHC
110 120 130 140 150
GETFTQVPDD RLNFQEKKAS PEVKSCDSFV CAEVGIGNSS FNMSIRGDTG
160 170 180 190 200
HKAYEYQEYG PKPYKCQQPK NKKAFRYRPS IRTQERDHTG EKPYACKVCG
210 220 230 240 250
KTFIFHSSIR RHMVMHSGDG TYKCKFCGKA FHSFSLYLIH ERTHTGEKPY
260 270 280 290 300
ECKQCGKSFT YSATLQIHER THTGEKPYEC SKCDKAFHSS SSYHRHERSH
310 320 330 340 350
MGEKPYQCKE CGKAFAYTSS LRRHERTHSG KKPYECKQYG EGLSYLISFQ
360 370 380 390 400
THIRMNSGER PYKCKICGKG FYSAKSFQTH EKTHTGEKRY KCKQCGKAFN
410 420 430 440 450
LSSSFRYHER IHTGEKPYEC KQCGKAFRSA SQLRVHGGTH TGEKPYECKE
460 470 480 490 500
CGKAFRSTSH LRVHGRTHTG EKPYECKECG KAFRYVKHLQ IHERTEKHIR
510 520 530 540 550
MPSGERPYKC SICEKGFYSA KSFQTHEKTH TGEKPYECNQ CGKAFRCCNS
560 570 580 590 600
LRYHERTHTG EKPYECKQCG KAFRSASHLR MHERTHTGEK PYECKQCGKA
610 620 630 640 650
FSCASNLRKH GRTHTGEKPY ECKQCGKAFR SASNLQMHER THTGEKPYEC
660 670 680 690 700
KECEKAFCKF SSFQIHERKH RGEKPYECKH CGNGFTSAKI LQIHARTHIG
710 720 730 740
EKHYECKECG KAFNYFSSLH IHARTHMGEK PYECKDCGKA FS
Length:742
Mass (Da):86,232
Last modified:March 1, 2001 - v1
Checksum:i99EA4FE63E7D12DC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052897269E → G. Corresponds to variant dbSNP:rs12327617Ensembl.1
Natural variantiVAR_033591321L → V. Corresponds to variant dbSNP:rs17001730Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136732 mRNA Translation: CAB66666.1
CH471106 Genomic DNA Translation: EAW84251.1
BC136777 mRNA Translation: AAI36778.1
CCDSiCCDS32915.1
RefSeqiNP_001258777.1, NM_001271848.1
NP_653167.1, NM_144566.2
UniGeneiHs.528486

Genome annotation databases

EnsembliENST00000254321; ENSP00000254321; ENSG00000196757
GeneIDi90592
KEGGihsa:90592
UCSCiuc002msu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN700_HUMAN
AccessioniPrimary (citable) accession number: Q9H0M5
Secondary accession number(s): B9EGU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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