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Q9H0M4 (ZCPW1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger CW-type PWWP domain protein 1
Gene names
Name:ZCWPW1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 CW-type zinc finger.

Contains 1 PWWP domain.

Sequence caution

The sequence CAB66669.1 differs from that shown. Reason: Frameshift at position 487.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H0M4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H0M4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     289-289: T → TA
     453-466: LEKKEKEEELEKEE → TQNGKERRPREFRF
     467-648: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9H0M4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9H0M4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     491-541: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q9H0M4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Zinc finger CW-type PWWP domain protein 1
PRO_0000066567

Regions

Domain317 – 38367PWWP
Zinc finger250 – 30455CW-type
Coiled coil74 – 10936 Potential

Natural variations

Alternative sequence1 – 121121Missing in isoform 3 and isoform 4.
VSP_011431
Alternative sequence2111H → QD in isoform 2, isoform 3, isoform 4 and isoform 5.
VSP_011432
Alternative sequence2891T → TA in isoform 2.
VSP_011433
Alternative sequence453 – 46614LEKKE…LEKEE → TQNGKERRPREFRF in isoform 2.
VSP_011434
Alternative sequence467 – 648182Missing in isoform 2.
VSP_035590
Alternative sequence471 – 52353DPILP…STAPP → ALRKNLKLPRARPWQPAFQR EKKLEQCQRTWAYQRVRGPA PHLRKKSPDTGNP in isoform 3 and isoform 5.
VSP_011436
Alternative sequence491 – 54151Missing in isoform 4.
VSP_035591
Alternative sequence524 – 648125Missing in isoform 3 and isoform 5.
VSP_035592
Natural variant1531T → A. Ref.2 Ref.5
Corresponds to variant rs6465770 [ dbSNP | Ensembl ].
VAR_019659
Natural variant3651E → K.
Corresponds to variant rs6970350 [ dbSNP | Ensembl ].
VAR_047050

Secondary structure

................. 648
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 4F267947AC00B1B4

FASTA64872,007
        10         20         30         40         50         60 
MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE ARISLPKASL 

        70         80         90        100        110        120 
KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT NAEFEEIVQI VLQKSLQECL 

       130        140        150        160        170        180 
GMGSGLDFAE TSCAQPVVST QSDKEPGITA SATDTDNANG EEVPHTQEIS VSWEGEAAPE 

       190        200        210        220        230        240 
IRTSKLGQPD PAPSKKKSNR LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR 

       250        260        270        280        290        300 
DQQKGEISGF GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE 

       310        320        330        340        350        360 
ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH LDSLPSKYHV 

       370        380        390        400        410        420 
TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK LGVALMMAQE AEQISIQERV 

       430        440        450        460        470        480 
NLFGFWSRFN GSNSNGERKD LQLSGLNSPG SCLEKKEKEE ELEKEEGEKT DPILPIRKRV 

       490        500        510        520        530        540 
KIQTQKTKPR GLGGDAGTAD GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ 

       550        560        570        580        590        600 
PGPKKKFKAP QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG 

       610        620        630        640 
SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK 

« Hide

Isoform 2 [UniParc].

Checksum: 4C4FB22E68EBAB5C
Show »

FASTA46852,707
Isoform 3 [UniParc].

Checksum: 1B5D2124275EF437
Show »

FASTA40345,754
Isoform 4 [UniParc].

Checksum: 11CE8B21646182C3
Show »

FASTA47753,255
Isoform 5 [UniParc].

Checksum: 181EF4397C263B80
Show »

FASTA52459,308

References

« Hide 'large scale' references
[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5), VARIANT ALA-153.
Tissue: Embryo and Testis.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT ALA-153.
Tissue: Uterus.
[6]"Solution structure of the ZF-CW domain in zinc finger CW-type PWWP domain protein 1."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 245-307.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136735 mRNA. Translation: CAB66669.1. Frameshift.
AK000919 mRNA. Translation: BAA91424.1.
AK093038 mRNA. Translation: BAC04028.1.
AK300745 mRNA. Translation: BAG62414.1.
AC005071 Genomic DNA. No translation available.
AC092849 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76540.1.
CH471091 Genomic DNA. Translation: EAW76541.1.
BC002725 mRNA. Translation: AAH02725.1.
CCDSCCDS43623.1. [Q9H0M4-1]
CCDS59067.1. [Q9H0M4-5]
RefSeqNP_001244937.1. NM_001258008.1. [Q9H0M4-5]
NP_060454.3. NM_017984.4. [Q9H0M4-1]
UniGeneHs.105191.
Hs.742544.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2E61NMR-A246-307[»]
2RR4NMR-A246-307[»]
ProteinModelPortalQ9H0M4.
SMRQ9H0M4. Positions 252-380.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120381. 1 interaction.
DIPDIP-59044N.
MINTMINT-8189789.

PTM databases

PhosphoSiteQ9H0M4.

Polymorphism databases

DMDM209572701.

Proteomic databases

PaxDbQ9H0M4.
PRIDEQ9H0M4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324725; ENSP00000314880; ENSG00000078487. [Q9H0M4-4]
ENST00000360951; ENSP00000354210; ENSG00000078487. [Q9H0M4-5]
ENST00000398027; ENSP00000381109; ENSG00000078487. [Q9H0M4-1]
ENST00000490721; ENSP00000419187; ENSG00000078487. [Q9H0M4-4]
GeneID55063.
KEGGhsa:55063.
UCSCuc003uur.3. human. [Q9H0M4-3]
uc003uus.3. human. [Q9H0M4-4]
uc003uut.4. human. [Q9H0M4-1]
uc003uuu.1. human. [Q9H0M4-2]
uc011kjr.3. human.

Organism-specific databases

CTD55063.
GeneCardsGC07M099998.
HGNCHGNC:23486. ZCWPW1.
HPAHPA020061.
HPA020911.
neXtProtNX_Q9H0M4.
PharmGKBPA134913967.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG129531.
HOGENOMHOG000070115.
HOVERGENHBG079373.
InParanoidQ9H0M4.
OMAKFKAPQS.
OrthoDBEOG7FXZZ3.
PhylomeDBQ9H0M4.
TreeFamTF336904.

Gene expression databases

ArrayExpressQ9H0M4.
BgeeQ9H0M4.
CleanExHS_ZCWPW1.
GenevestigatorQ9H0M4.

Family and domain databases

InterProIPR000313. PWWP_dom.
IPR011124. Znf_CW.
[Graphical view]
PfamPF00855. PWWP. 1 hit.
PF07496. zf-CW. 1 hit.
[Graphical view]
PROSITEPS50812. PWWP. 1 hit.
PS51050. ZF_CW. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9H0M4.
GenomeRNAi55063.
NextBio58561.
PROQ9H0M4.

Entry information

Entry nameZCPW1_HUMAN
AccessionPrimary (citable) accession number: Q9H0M4
Secondary accession number(s): A8MVF5 expand/collapse secondary AC list , B4DUQ2, Q8NA98, Q9BUD0, Q9NWF7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM