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Q9H0M4

- ZCPW1_HUMAN

UniProt

Q9H0M4 - ZCPW1_HUMAN

Protein

Zinc finger CW-type PWWP domain protein 1

Gene

ZCWPW1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • Format
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri250 – 30455CW-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger CW-type PWWP domain protein 1
    Gene namesi
    Name:ZCWPW1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:23486. ZCWPW1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134913967.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 648648Zinc finger CW-type PWWP domain protein 1PRO_0000066567Add
    BLAST

    Proteomic databases

    PaxDbiQ9H0M4.
    PRIDEiQ9H0M4.

    PTM databases

    PhosphoSiteiQ9H0M4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H0M4.
    BgeeiQ9H0M4.
    CleanExiHS_ZCWPW1.
    GenevestigatoriQ9H0M4.

    Organism-specific databases

    HPAiHPA020061.
    HPA020911.

    Interactioni

    Protein-protein interaction databases

    BioGridi120381. 1 interaction.
    DIPiDIP-59044N.
    MINTiMINT-8189789.

    Structurei

    Secondary structure

    1
    648
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi247 – 2493
    Beta strandi256 – 2583
    Turni262 – 2643
    Beta strandi267 – 2693
    Turni276 – 2783
    Helixi285 – 2873
    Helixi291 – 2933
    Beta strandi295 – 2984

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2E61NMR-A246-307[»]
    2RR4NMR-A246-307[»]
    ProteinModelPortaliQ9H0M4.
    SMRiQ9H0M4. Positions 252-380.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H0M4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini317 – 38367PWWPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili74 – 10936Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CW-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PWWP domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri250 – 30455CW-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG129531.
    HOGENOMiHOG000070115.
    HOVERGENiHBG079373.
    InParanoidiQ9H0M4.
    OMAiKFKAPQS.
    OrthoDBiEOG7FXZZ3.
    PhylomeDBiQ9H0M4.
    TreeFamiTF336904.

    Family and domain databases

    InterProiIPR000313. PWWP_dom.
    IPR011124. Znf_CW.
    [Graphical view]
    PfamiPF00855. PWWP. 1 hit.
    PF07496. zf-CW. 1 hit.
    [Graphical view]
    PROSITEiPS50812. PWWP. 1 hit.
    PS51050. ZF_CW. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H0M4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE    50
    ARISLPKASL KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT 100
    NAEFEEIVQI VLQKSLQECL GMGSGLDFAE TSCAQPVVST QSDKEPGITA 150
    SATDTDNANG EEVPHTQEIS VSWEGEAAPE IRTSKLGQPD PAPSKKKSNR 200
    LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR DQQKGEISGF 250
    GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE 300
    ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH 350
    LDSLPSKYHV TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK 400
    LGVALMMAQE AEQISIQERV NLFGFWSRFN GSNSNGERKD LQLSGLNSPG 450
    SCLEKKEKEE ELEKEEGEKT DPILPIRKRV KIQTQKTKPR GLGGDAGTAD 500
    GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ PGPKKKFKAP 550
    QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG 600
    SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK 648
    Length:648
    Mass (Da):72,007
    Last modified:October 14, 2008 - v2
    Checksum:i4F267947AC00B1B4
    GO
    Isoform 2 (identifier: Q9H0M4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-211: H → QD
         289-289: T → TA
         453-466: LEKKEKEEELEKEE → TQNGKERRPREFRF
         467-648: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:468
    Mass (Da):52,707
    Checksum:i4C4FB22E68EBAB5C
    GO
    Isoform 3 (identifier: Q9H0M4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-121: Missing.
         211-211: H → QD
         471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
         524-648: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:403
    Mass (Da):45,754
    Checksum:i1B5D2124275EF437
    GO
    Isoform 4 (identifier: Q9H0M4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-121: Missing.
         211-211: H → QD
         491-541: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:477
    Mass (Da):53,255
    Checksum:i11CE8B21646182C3
    GO
    Isoform 5 (identifier: Q9H0M4-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-211: H → QD
         471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
         524-648: Missing.

    Show »
    Length:524
    Mass (Da):59,308
    Checksum:i181EF4397C263B80
    GO

    Sequence cautioni

    The sequence CAB66669.1 differs from that shown. Reason: Frameshift at position 487.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti153 – 1531T → A.2 Publications
    Corresponds to variant rs6465770 [ dbSNP | Ensembl ].
    VAR_019659
    Natural varianti365 – 3651E → K.
    Corresponds to variant rs6970350 [ dbSNP | Ensembl ].
    VAR_047050

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 121121Missing in isoform 3 and isoform 4. 2 PublicationsVSP_011431Add
    BLAST
    Alternative sequencei211 – 2111H → QD in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_011432
    Alternative sequencei289 – 2891T → TA in isoform 2. 1 PublicationVSP_011433
    Alternative sequencei453 – 46614LEKKE…LEKEE → TQNGKERRPREFRF in isoform 2. 1 PublicationVSP_011434Add
    BLAST
    Alternative sequencei467 – 648182Missing in isoform 2. 1 PublicationVSP_035590Add
    BLAST
    Alternative sequencei471 – 52353DPILP…STAPP → ALRKNLKLPRARPWQPAFQR EKKLEQCQRTWAYQRVRGPA PHLRKKSPDTGNP in isoform 3 and isoform 5. 1 PublicationVSP_011436Add
    BLAST
    Alternative sequencei491 – 54151Missing in isoform 4. 1 PublicationVSP_035591Add
    BLAST
    Alternative sequencei524 – 648125Missing in isoform 3 and isoform 5. 1 PublicationVSP_035592Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136735 mRNA. Translation: CAB66669.1. Frameshift.
    AK000919 mRNA. Translation: BAA91424.1.
    AK093038 mRNA. Translation: BAC04028.1.
    AK300745 mRNA. Translation: BAG62414.1.
    AC005071 Genomic DNA. No translation available.
    AC092849 Genomic DNA. No translation available.
    CH471091 Genomic DNA. Translation: EAW76540.1.
    CH471091 Genomic DNA. Translation: EAW76541.1.
    BC002725 mRNA. Translation: AAH02725.1.
    CCDSiCCDS43623.1. [Q9H0M4-1]
    CCDS59067.1. [Q9H0M4-5]
    RefSeqiNP_001244937.1. NM_001258008.1. [Q9H0M4-5]
    NP_060454.3. NM_017984.4. [Q9H0M4-1]
    UniGeneiHs.105191.
    Hs.742544.

    Genome annotation databases

    EnsembliENST00000360951; ENSP00000354210; ENSG00000078487. [Q9H0M4-5]
    ENST00000398027; ENSP00000381109; ENSG00000078487. [Q9H0M4-1]
    ENST00000490721; ENSP00000419187; ENSG00000078487. [Q9H0M4-4]
    GeneIDi55063.
    KEGGihsa:55063.
    UCSCiuc003uur.3. human. [Q9H0M4-3]
    uc003uus.3. human. [Q9H0M4-4]
    uc003uut.4. human. [Q9H0M4-1]
    uc003uuu.1. human. [Q9H0M4-2]
    uc011kjr.3. human.

    Polymorphism databases

    DMDMi209572701.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136735 mRNA. Translation: CAB66669.1 . Frameshift.
    AK000919 mRNA. Translation: BAA91424.1 .
    AK093038 mRNA. Translation: BAC04028.1 .
    AK300745 mRNA. Translation: BAG62414.1 .
    AC005071 Genomic DNA. No translation available.
    AC092849 Genomic DNA. No translation available.
    CH471091 Genomic DNA. Translation: EAW76540.1 .
    CH471091 Genomic DNA. Translation: EAW76541.1 .
    BC002725 mRNA. Translation: AAH02725.1 .
    CCDSi CCDS43623.1. [Q9H0M4-1 ]
    CCDS59067.1. [Q9H0M4-5 ]
    RefSeqi NP_001244937.1. NM_001258008.1. [Q9H0M4-5 ]
    NP_060454.3. NM_017984.4. [Q9H0M4-1 ]
    UniGenei Hs.105191.
    Hs.742544.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2E61 NMR - A 246-307 [» ]
    2RR4 NMR - A 246-307 [» ]
    ProteinModelPortali Q9H0M4.
    SMRi Q9H0M4. Positions 252-380.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120381. 1 interaction.
    DIPi DIP-59044N.
    MINTi MINT-8189789.

    PTM databases

    PhosphoSitei Q9H0M4.

    Polymorphism databases

    DMDMi 209572701.

    Proteomic databases

    PaxDbi Q9H0M4.
    PRIDEi Q9H0M4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360951 ; ENSP00000354210 ; ENSG00000078487 . [Q9H0M4-5 ]
    ENST00000398027 ; ENSP00000381109 ; ENSG00000078487 . [Q9H0M4-1 ]
    ENST00000490721 ; ENSP00000419187 ; ENSG00000078487 . [Q9H0M4-4 ]
    GeneIDi 55063.
    KEGGi hsa:55063.
    UCSCi uc003uur.3. human. [Q9H0M4-3 ]
    uc003uus.3. human. [Q9H0M4-4 ]
    uc003uut.4. human. [Q9H0M4-1 ]
    uc003uuu.1. human. [Q9H0M4-2 ]
    uc011kjr.3. human.

    Organism-specific databases

    CTDi 55063.
    GeneCardsi GC07M099998.
    HGNCi HGNC:23486. ZCWPW1.
    HPAi HPA020061.
    HPA020911.
    neXtProti NX_Q9H0M4.
    PharmGKBi PA134913967.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG129531.
    HOGENOMi HOG000070115.
    HOVERGENi HBG079373.
    InParanoidi Q9H0M4.
    OMAi KFKAPQS.
    OrthoDBi EOG7FXZZ3.
    PhylomeDBi Q9H0M4.
    TreeFami TF336904.

    Miscellaneous databases

    EvolutionaryTracei Q9H0M4.
    GenomeRNAii 55063.
    NextBioi 58561.
    PROi Q9H0M4.

    Gene expression databases

    ArrayExpressi Q9H0M4.
    Bgeei Q9H0M4.
    CleanExi HS_ZCWPW1.
    Genevestigatori Q9H0M4.

    Family and domain databases

    InterProi IPR000313. PWWP_dom.
    IPR011124. Znf_CW.
    [Graphical view ]
    Pfami PF00855. PWWP. 1 hit.
    PF07496. zf-CW. 1 hit.
    [Graphical view ]
    PROSITEi PS50812. PWWP. 1 hit.
    PS51050. ZF_CW. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5), VARIANT ALA-153.
      Tissue: Embryo and Testis.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT ALA-153.
      Tissue: Uterus.
    6. "Solution structure of the ZF-CW domain in zinc finger CW-type PWWP domain protein 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 245-307.

    Entry informationi

    Entry nameiZCPW1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0M4
    Secondary accession number(s): A8MVF5
    , B4DUQ2, Q8NA98, Q9BUD0, Q9NWF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3