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Protein

Zinc finger CW-type PWWP domain protein 1

Gene

ZCWPW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 304CW-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CW-type PWWP domain protein 1
Gene namesi
Name:ZCWPW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000078487.17
HGNCiHGNC:23486 ZCWPW1
neXtProtiNX_Q9H0M4

Pathology & Biotechi

Organism-specific databases

DisGeNETi55063
OpenTargetsiENSG00000078487
PharmGKBiPA134913967

Polymorphism and mutation databases

BioMutaiZCWPW1
DMDMi209572701

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665671 – 648Zinc finger CW-type PWWP domain protein 1Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei636PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9H0M4
PeptideAtlasiQ9H0M4
PRIDEiQ9H0M4
ProteomicsDBi80298
80299 [Q9H0M4-2]
80300 [Q9H0M4-3]
80301 [Q9H0M4-4]

PTM databases

iPTMnetiQ9H0M4
PhosphoSitePlusiQ9H0M4

Expressioni

Gene expression databases

BgeeiENSG00000078487
CleanExiHS_ZCWPW1
ExpressionAtlasiQ9H0M4 baseline and differential
GenevisibleiQ9H0M4 HS

Organism-specific databases

HPAiHPA020911

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120381, 2 interactors
DIPiDIP-59044N
IntActiQ9H0M4, 3 interactors
MINTiQ9H0M4

Structurei

Secondary structure

1648
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi247 – 249Combined sources3
Beta strandi256 – 258Combined sources3
Turni262 – 264Combined sources3
Beta strandi267 – 269Combined sources3
Turni276 – 278Combined sources3
Helixi285 – 287Combined sources3
Helixi291 – 293Combined sources3
Beta strandi295 – 298Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E61NMR-A246-307[»]
2RR4NMR-A246-307[»]
ProteinModelPortaliQ9H0M4
SMRiQ9H0M4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0M4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 383PWWPPROSITE-ProRule annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 109Sequence analysisAdd BLAST36

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 304CW-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGSV Eukaryota
ENOG4111P8M LUCA
GeneTreeiENSGT00560000077278
HOGENOMiHOG000070115
HOVERGENiHBG079373
InParanoidiQ9H0M4
OMAiKFKAPQS
OrthoDBiEOG091G0MVW
PhylomeDBiQ9H0M4
TreeFamiTF336904

Family and domain databases

InterProiView protein in InterPro
IPR000313 PWWP_dom
IPR011124 Znf_CW
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
PF07496 zf-CW, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit
PS51050 ZF_CW, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0M4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE
60 70 80 90 100
ARISLPKASL KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT
110 120 130 140 150
NAEFEEIVQI VLQKSLQECL GMGSGLDFAE TSCAQPVVST QSDKEPGITA
160 170 180 190 200
SATDTDNANG EEVPHTQEIS VSWEGEAAPE IRTSKLGQPD PAPSKKKSNR
210 220 230 240 250
LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR DQQKGEISGF
260 270 280 290 300
GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE
310 320 330 340 350
ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH
360 370 380 390 400
LDSLPSKYHV TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK
410 420 430 440 450
LGVALMMAQE AEQISIQERV NLFGFWSRFN GSNSNGERKD LQLSGLNSPG
460 470 480 490 500
SCLEKKEKEE ELEKEEGEKT DPILPIRKRV KIQTQKTKPR GLGGDAGTAD
510 520 530 540 550
GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ PGPKKKFKAP
560 570 580 590 600
QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG
610 620 630 640
SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK
Length:648
Mass (Da):72,007
Last modified:October 14, 2008 - v2
Checksum:i4F267947AC00B1B4
GO
Isoform 2 (identifier: Q9H0M4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     289-289: T → TA
     453-466: LEKKEKEEELEKEE → TQNGKERRPREFRF
     467-648: Missing.

Note: No experimental confirmation available.
Show »
Length:468
Mass (Da):52,707
Checksum:i4C4FB22E68EBAB5C
GO
Isoform 3 (identifier: Q9H0M4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):45,754
Checksum:i1B5D2124275EF437
GO
Isoform 4 (identifier: Q9H0M4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     491-541: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):53,255
Checksum:i11CE8B21646182C3
GO
Isoform 5 (identifier: Q9H0M4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Show »
Length:524
Mass (Da):59,308
Checksum:i181EF4397C263B80
GO

Sequence cautioni

The sequence CAB66669 differs from that shown. Reason: Frameshift at position 487.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019659153T → A2 PublicationsCorresponds to variant dbSNP:rs6465770Ensembl.1
Natural variantiVAR_047050365E → K. Corresponds to variant dbSNP:rs6970350Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0114311 – 121Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST121
Alternative sequenceiVSP_011432211H → QD in isoform 2, isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_011433289T → TA in isoform 2. 1 Publication1
Alternative sequenceiVSP_011434453 – 466LEKKE…LEKEE → TQNGKERRPREFRF in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_035590467 – 648Missing in isoform 2. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_011436471 – 523DPILP…STAPP → ALRKNLKLPRARPWQPAFQR EKKLEQCQRTWAYQRVRGPA PHLRKKSPDTGNP in isoform 3 and isoform 5. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_035591491 – 541Missing in isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_035592524 – 648Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136735 mRNA Translation: CAB66669.1 Frameshift.
AK000919 mRNA Translation: BAA91424.1
AK093038 mRNA Translation: BAC04028.1
AK300745 mRNA Translation: BAG62414.1
AC005071 Genomic DNA No translation available.
AC092849 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76540.1
CH471091 Genomic DNA Translation: EAW76541.1
BC002725 mRNA Translation: AAH02725.1
CCDSiCCDS43623.1 [Q9H0M4-1]
CCDS59067.1 [Q9H0M4-5]
RefSeqiNP_001244937.1, NM_001258008.1 [Q9H0M4-5]
NP_060454.3, NM_017984.4 [Q9H0M4-1]
UniGeneiHs.105191
Hs.742544

Genome annotation databases

EnsembliENST00000360951; ENSP00000354210; ENSG00000078487 [Q9H0M4-5]
ENST00000398027; ENSP00000381109; ENSG00000078487 [Q9H0M4-1]
ENST00000490721; ENSP00000419187; ENSG00000078487 [Q9H0M4-4]
GeneIDi55063
KEGGihsa:55063
UCSCiuc003uus.4 human [Q9H0M4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZCPW1_HUMAN
AccessioniPrimary (citable) accession number: Q9H0M4
Secondary accession number(s): A8MVF5
, B4DUQ2, Q8NA98, Q9BUD0, Q9NWF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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