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Protein

Zinc finger CW-type PWWP domain protein 1

Gene

ZCWPW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 304CW-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CW-type PWWP domain protein 1
Gene namesi
Name:ZCWPW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:23486. ZCWPW1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55063.
OpenTargetsiENSG00000078487.
PharmGKBiPA134913967.

Polymorphism and mutation databases

BioMutaiZCWPW1.
DMDMi209572701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665671 – 648Zinc finger CW-type PWWP domain protein 1Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei636PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9H0M4.
PeptideAtlasiQ9H0M4.
PRIDEiQ9H0M4.

PTM databases

iPTMnetiQ9H0M4.
PhosphoSitePlusiQ9H0M4.

Expressioni

Gene expression databases

BgeeiENSG00000078487.
CleanExiHS_ZCWPW1.
ExpressionAtlasiQ9H0M4. baseline and differential.
GenevisibleiQ9H0M4. HS.

Organism-specific databases

HPAiHPA020061.
HPA020911.

Interactioni

Protein-protein interaction databases

BioGridi120381. 2 interactors.
DIPiDIP-59044N.
IntActiQ9H0M4. 1 interactor.
MINTiMINT-8189789.
STRINGi9606.ENSP00000381109.

Structurei

Secondary structure

1648
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi247 – 249Combined sources3
Beta strandi256 – 258Combined sources3
Turni262 – 264Combined sources3
Beta strandi267 – 269Combined sources3
Turni276 – 278Combined sources3
Helixi285 – 287Combined sources3
Helixi291 – 293Combined sources3
Beta strandi295 – 298Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E61NMR-A246-307[»]
2RR4NMR-A246-307[»]
ProteinModelPortaliQ9H0M4.
SMRiQ9H0M4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0M4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 383PWWPPROSITE-ProRule annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 109Sequence analysisAdd BLAST36

Sequence similaritiesi

Contains 1 CW-type zinc finger.PROSITE-ProRule annotation
Contains 1 PWWP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 304CW-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGSV. Eukaryota.
ENOG4111P8M. LUCA.
GeneTreeiENSGT00560000077278.
HOGENOMiHOG000070115.
HOVERGENiHBG079373.
InParanoidiQ9H0M4.
OMAiKFKAPQS.
OrthoDBiEOG091G0MVW.
PhylomeDBiQ9H0M4.
TreeFamiTF336904.

Family and domain databases

InterProiIPR000313. PWWP_dom.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
PF07496. zf-CW. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
PS51050. ZF_CW. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0M4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE
60 70 80 90 100
ARISLPKASL KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT
110 120 130 140 150
NAEFEEIVQI VLQKSLQECL GMGSGLDFAE TSCAQPVVST QSDKEPGITA
160 170 180 190 200
SATDTDNANG EEVPHTQEIS VSWEGEAAPE IRTSKLGQPD PAPSKKKSNR
210 220 230 240 250
LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR DQQKGEISGF
260 270 280 290 300
GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE
310 320 330 340 350
ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH
360 370 380 390 400
LDSLPSKYHV TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK
410 420 430 440 450
LGVALMMAQE AEQISIQERV NLFGFWSRFN GSNSNGERKD LQLSGLNSPG
460 470 480 490 500
SCLEKKEKEE ELEKEEGEKT DPILPIRKRV KIQTQKTKPR GLGGDAGTAD
510 520 530 540 550
GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ PGPKKKFKAP
560 570 580 590 600
QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG
610 620 630 640
SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK
Length:648
Mass (Da):72,007
Last modified:October 14, 2008 - v2
Checksum:i4F267947AC00B1B4
GO
Isoform 2 (identifier: Q9H0M4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     289-289: T → TA
     453-466: LEKKEKEEELEKEE → TQNGKERRPREFRF
     467-648: Missing.

Note: No experimental confirmation available.
Show »
Length:468
Mass (Da):52,707
Checksum:i4C4FB22E68EBAB5C
GO
Isoform 3 (identifier: Q9H0M4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):45,754
Checksum:i1B5D2124275EF437
GO
Isoform 4 (identifier: Q9H0M4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     491-541: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):53,255
Checksum:i11CE8B21646182C3
GO
Isoform 5 (identifier: Q9H0M4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Show »
Length:524
Mass (Da):59,308
Checksum:i181EF4397C263B80
GO

Sequence cautioni

The sequence CAB66669 differs from that shown. Reason: Frameshift at position 487.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019659153T → A.2 PublicationsCorresponds to variant rs6465770dbSNPEnsembl.1
Natural variantiVAR_047050365E → K.Corresponds to variant rs6970350dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0114311 – 121Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST121
Alternative sequenceiVSP_011432211H → QD in isoform 2, isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_011433289T → TA in isoform 2. 1 Publication1
Alternative sequenceiVSP_011434453 – 466LEKKE…LEKEE → TQNGKERRPREFRF in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_035590467 – 648Missing in isoform 2. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_011436471 – 523DPILP…STAPP → ALRKNLKLPRARPWQPAFQR EKKLEQCQRTWAYQRVRGPA PHLRKKSPDTGNP in isoform 3 and isoform 5. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_035591491 – 541Missing in isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_035592524 – 648Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136735 mRNA. Translation: CAB66669.1. Frameshift.
AK000919 mRNA. Translation: BAA91424.1.
AK093038 mRNA. Translation: BAC04028.1.
AK300745 mRNA. Translation: BAG62414.1.
AC005071 Genomic DNA. No translation available.
AC092849 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76540.1.
CH471091 Genomic DNA. Translation: EAW76541.1.
BC002725 mRNA. Translation: AAH02725.1.
CCDSiCCDS43623.1. [Q9H0M4-1]
CCDS59067.1. [Q9H0M4-5]
RefSeqiNP_001244937.1. NM_001258008.1. [Q9H0M4-5]
NP_060454.3. NM_017984.4. [Q9H0M4-1]
UniGeneiHs.105191.
Hs.742544.

Genome annotation databases

EnsembliENST00000360951; ENSP00000354210; ENSG00000078487. [Q9H0M4-5]
ENST00000398027; ENSP00000381109; ENSG00000078487. [Q9H0M4-1]
ENST00000490721; ENSP00000419187; ENSG00000078487. [Q9H0M4-4]
GeneIDi55063.
KEGGihsa:55063.
UCSCiuc003uus.4. human. [Q9H0M4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136735 mRNA. Translation: CAB66669.1. Frameshift.
AK000919 mRNA. Translation: BAA91424.1.
AK093038 mRNA. Translation: BAC04028.1.
AK300745 mRNA. Translation: BAG62414.1.
AC005071 Genomic DNA. No translation available.
AC092849 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76540.1.
CH471091 Genomic DNA. Translation: EAW76541.1.
BC002725 mRNA. Translation: AAH02725.1.
CCDSiCCDS43623.1. [Q9H0M4-1]
CCDS59067.1. [Q9H0M4-5]
RefSeqiNP_001244937.1. NM_001258008.1. [Q9H0M4-5]
NP_060454.3. NM_017984.4. [Q9H0M4-1]
UniGeneiHs.105191.
Hs.742544.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E61NMR-A246-307[»]
2RR4NMR-A246-307[»]
ProteinModelPortaliQ9H0M4.
SMRiQ9H0M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120381. 2 interactors.
DIPiDIP-59044N.
IntActiQ9H0M4. 1 interactor.
MINTiMINT-8189789.
STRINGi9606.ENSP00000381109.

PTM databases

iPTMnetiQ9H0M4.
PhosphoSitePlusiQ9H0M4.

Polymorphism and mutation databases

BioMutaiZCWPW1.
DMDMi209572701.

Proteomic databases

PaxDbiQ9H0M4.
PeptideAtlasiQ9H0M4.
PRIDEiQ9H0M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360951; ENSP00000354210; ENSG00000078487. [Q9H0M4-5]
ENST00000398027; ENSP00000381109; ENSG00000078487. [Q9H0M4-1]
ENST00000490721; ENSP00000419187; ENSG00000078487. [Q9H0M4-4]
GeneIDi55063.
KEGGihsa:55063.
UCSCiuc003uus.4. human. [Q9H0M4-1]

Organism-specific databases

CTDi55063.
DisGeNETi55063.
GeneCardsiZCWPW1.
HGNCiHGNC:23486. ZCWPW1.
HPAiHPA020061.
HPA020911.
neXtProtiNX_Q9H0M4.
OpenTargetsiENSG00000078487.
PharmGKBiPA134913967.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGSV. Eukaryota.
ENOG4111P8M. LUCA.
GeneTreeiENSGT00560000077278.
HOGENOMiHOG000070115.
HOVERGENiHBG079373.
InParanoidiQ9H0M4.
OMAiKFKAPQS.
OrthoDBiEOG091G0MVW.
PhylomeDBiQ9H0M4.
TreeFamiTF336904.

Miscellaneous databases

EvolutionaryTraceiQ9H0M4.
GenomeRNAii55063.
PROiQ9H0M4.

Gene expression databases

BgeeiENSG00000078487.
CleanExiHS_ZCWPW1.
ExpressionAtlasiQ9H0M4. baseline and differential.
GenevisibleiQ9H0M4. HS.

Family and domain databases

InterProiIPR000313. PWWP_dom.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
PF07496. zf-CW. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
PS51050. ZF_CW. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZCPW1_HUMAN
AccessioniPrimary (citable) accession number: Q9H0M4
Secondary accession number(s): A8MVF5
, B4DUQ2, Q8NA98, Q9BUD0, Q9NWF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.