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Q9H0M4

- ZCPW1_HUMAN

UniProt

Q9H0M4 - ZCPW1_HUMAN

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Protein

Zinc finger CW-type PWWP domain protein 1

Gene

ZCWPW1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri250 – 30455CW-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CW-type PWWP domain protein 1
Gene namesi
Name:ZCWPW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:23486. ZCWPW1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Zinc finger CW-type PWWP domain protein 1PRO_0000066567Add
BLAST

Proteomic databases

PaxDbiQ9H0M4.
PRIDEiQ9H0M4.

PTM databases

PhosphoSiteiQ9H0M4.

Expressioni

Gene expression databases

BgeeiQ9H0M4.
CleanExiHS_ZCWPW1.
ExpressionAtlasiQ9H0M4. baseline.
GenevestigatoriQ9H0M4.

Organism-specific databases

HPAiHPA020061.
HPA020911.

Interactioni

Protein-protein interaction databases

BioGridi120381. 1 interaction.
DIPiDIP-59044N.
MINTiMINT-8189789.

Structurei

Secondary structure

1
648
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi247 – 2493
Beta strandi256 – 2583
Turni262 – 2643
Beta strandi267 – 2693
Turni276 – 2783
Helixi285 – 2873
Helixi291 – 2933
Beta strandi295 – 2984

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E61NMR-A246-307[»]
2RR4NMR-A246-307[»]
ProteinModelPortaliQ9H0M4.
SMRiQ9H0M4. Positions 252-380.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0M4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini317 – 38367PWWPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili74 – 10936Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 CW-type zinc finger.PROSITE-ProRule annotation
Contains 1 PWWP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri250 – 30455CW-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG129531.
GeneTreeiENSGT00560000077278.
HOGENOMiHOG000070115.
HOVERGENiHBG079373.
InParanoidiQ9H0M4.
OMAiKFKAPQS.
OrthoDBiEOG7FXZZ3.
PhylomeDBiQ9H0M4.
TreeFamiTF336904.

Family and domain databases

InterProiIPR000313. PWWP_dom.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
PF07496. zf-CW. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
PS51050. ZF_CW. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H0M4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE
60 70 80 90 100
ARISLPKASL KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT
110 120 130 140 150
NAEFEEIVQI VLQKSLQECL GMGSGLDFAE TSCAQPVVST QSDKEPGITA
160 170 180 190 200
SATDTDNANG EEVPHTQEIS VSWEGEAAPE IRTSKLGQPD PAPSKKKSNR
210 220 230 240 250
LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR DQQKGEISGF
260 270 280 290 300
GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE
310 320 330 340 350
ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH
360 370 380 390 400
LDSLPSKYHV TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK
410 420 430 440 450
LGVALMMAQE AEQISIQERV NLFGFWSRFN GSNSNGERKD LQLSGLNSPG
460 470 480 490 500
SCLEKKEKEE ELEKEEGEKT DPILPIRKRV KIQTQKTKPR GLGGDAGTAD
510 520 530 540 550
GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ PGPKKKFKAP
560 570 580 590 600
QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG
610 620 630 640
SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK
Length:648
Mass (Da):72,007
Last modified:October 14, 2008 - v2
Checksum:i4F267947AC00B1B4
GO
Isoform 2 (identifier: Q9H0M4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     289-289: T → TA
     453-466: LEKKEKEEELEKEE → TQNGKERRPREFRF
     467-648: Missing.

Note: No experimental confirmation available.

Show »
Length:468
Mass (Da):52,707
Checksum:i4C4FB22E68EBAB5C
GO
Isoform 3 (identifier: Q9H0M4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Note: No experimental confirmation available.

Show »
Length:403
Mass (Da):45,754
Checksum:i1B5D2124275EF437
GO
Isoform 4 (identifier: Q9H0M4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     491-541: Missing.

Note: No experimental confirmation available.

Show »
Length:477
Mass (Da):53,255
Checksum:i11CE8B21646182C3
GO
Isoform 5 (identifier: Q9H0M4-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Show »
Length:524
Mass (Da):59,308
Checksum:i181EF4397C263B80
GO

Sequence cautioni

The sequence CAB66669.1 differs from that shown. Reason: Frameshift at position 487.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531T → A.2 Publications
Corresponds to variant rs6465770 [ dbSNP | Ensembl ].
VAR_019659
Natural varianti365 – 3651E → K.
Corresponds to variant rs6970350 [ dbSNP | Ensembl ].
VAR_047050

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 121121Missing in isoform 3 and isoform 4. 2 PublicationsVSP_011431Add
BLAST
Alternative sequencei211 – 2111H → QD in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_011432
Alternative sequencei289 – 2891T → TA in isoform 2. 1 PublicationVSP_011433
Alternative sequencei453 – 46614LEKKE…LEKEE → TQNGKERRPREFRF in isoform 2. 1 PublicationVSP_011434Add
BLAST
Alternative sequencei467 – 648182Missing in isoform 2. 1 PublicationVSP_035590Add
BLAST
Alternative sequencei471 – 52353DPILP…STAPP → ALRKNLKLPRARPWQPAFQR EKKLEQCQRTWAYQRVRGPA PHLRKKSPDTGNP in isoform 3 and isoform 5. 1 PublicationVSP_011436Add
BLAST
Alternative sequencei491 – 54151Missing in isoform 4. 1 PublicationVSP_035591Add
BLAST
Alternative sequencei524 – 648125Missing in isoform 3 and isoform 5. 1 PublicationVSP_035592Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136735 mRNA. Translation: CAB66669.1. Frameshift.
AK000919 mRNA. Translation: BAA91424.1.
AK093038 mRNA. Translation: BAC04028.1.
AK300745 mRNA. Translation: BAG62414.1.
AC005071 Genomic DNA. No translation available.
AC092849 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76540.1.
CH471091 Genomic DNA. Translation: EAW76541.1.
BC002725 mRNA. Translation: AAH02725.1.
CCDSiCCDS43623.1. [Q9H0M4-1]
CCDS59067.1. [Q9H0M4-5]
RefSeqiNP_001244937.1. NM_001258008.1. [Q9H0M4-5]
NP_060454.3. NM_017984.4. [Q9H0M4-1]
UniGeneiHs.105191.
Hs.742544.

Genome annotation databases

EnsembliENST00000360951; ENSP00000354210; ENSG00000078487. [Q9H0M4-5]
ENST00000398027; ENSP00000381109; ENSG00000078487. [Q9H0M4-1]
ENST00000490721; ENSP00000419187; ENSG00000078487. [Q9H0M4-4]
GeneIDi55063.
KEGGihsa:55063.
UCSCiuc003uur.3. human. [Q9H0M4-3]
uc003uus.3. human. [Q9H0M4-4]
uc003uut.4. human. [Q9H0M4-1]
uc003uuu.1. human. [Q9H0M4-2]
uc011kjr.3. human.

Polymorphism databases

DMDMi209572701.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136735 mRNA. Translation: CAB66669.1 . Frameshift.
AK000919 mRNA. Translation: BAA91424.1 .
AK093038 mRNA. Translation: BAC04028.1 .
AK300745 mRNA. Translation: BAG62414.1 .
AC005071 Genomic DNA. No translation available.
AC092849 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76540.1 .
CH471091 Genomic DNA. Translation: EAW76541.1 .
BC002725 mRNA. Translation: AAH02725.1 .
CCDSi CCDS43623.1. [Q9H0M4-1 ]
CCDS59067.1. [Q9H0M4-5 ]
RefSeqi NP_001244937.1. NM_001258008.1. [Q9H0M4-5 ]
NP_060454.3. NM_017984.4. [Q9H0M4-1 ]
UniGenei Hs.105191.
Hs.742544.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E61 NMR - A 246-307 [» ]
2RR4 NMR - A 246-307 [» ]
ProteinModelPortali Q9H0M4.
SMRi Q9H0M4. Positions 252-380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120381. 1 interaction.
DIPi DIP-59044N.
MINTi MINT-8189789.

PTM databases

PhosphoSitei Q9H0M4.

Polymorphism databases

DMDMi 209572701.

Proteomic databases

PaxDbi Q9H0M4.
PRIDEi Q9H0M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360951 ; ENSP00000354210 ; ENSG00000078487 . [Q9H0M4-5 ]
ENST00000398027 ; ENSP00000381109 ; ENSG00000078487 . [Q9H0M4-1 ]
ENST00000490721 ; ENSP00000419187 ; ENSG00000078487 . [Q9H0M4-4 ]
GeneIDi 55063.
KEGGi hsa:55063.
UCSCi uc003uur.3. human. [Q9H0M4-3 ]
uc003uus.3. human. [Q9H0M4-4 ]
uc003uut.4. human. [Q9H0M4-1 ]
uc003uuu.1. human. [Q9H0M4-2 ]
uc011kjr.3. human.

Organism-specific databases

CTDi 55063.
GeneCardsi GC07M099998.
HGNCi HGNC:23486. ZCWPW1.
HPAi HPA020061.
HPA020911.
neXtProti NX_Q9H0M4.
PharmGKBi PA134913967.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG129531.
GeneTreei ENSGT00560000077278.
HOGENOMi HOG000070115.
HOVERGENi HBG079373.
InParanoidi Q9H0M4.
OMAi KFKAPQS.
OrthoDBi EOG7FXZZ3.
PhylomeDBi Q9H0M4.
TreeFami TF336904.

Miscellaneous databases

EvolutionaryTracei Q9H0M4.
GenomeRNAii 55063.
NextBioi 58561.
PROi Q9H0M4.

Gene expression databases

Bgeei Q9H0M4.
CleanExi HS_ZCWPW1.
ExpressionAtlasi Q9H0M4. baseline.
Genevestigatori Q9H0M4.

Family and domain databases

InterProi IPR000313. PWWP_dom.
IPR011124. Znf_CW.
[Graphical view ]
Pfami PF00855. PWWP. 1 hit.
PF07496. zf-CW. 1 hit.
[Graphical view ]
PROSITEi PS50812. PWWP. 1 hit.
PS51050. ZF_CW. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5), VARIANT ALA-153.
    Tissue: Embryo and Testis.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT ALA-153.
    Tissue: Uterus.
  6. "Solution structure of the ZF-CW domain in zinc finger CW-type PWWP domain protein 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 245-307.

Entry informationi

Entry nameiZCPW1_HUMAN
AccessioniPrimary (citable) accession number: Q9H0M4
Secondary accession number(s): A8MVF5
, B4DUQ2, Q8NA98, Q9BUD0, Q9NWF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3