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Protein

NEDD4-like E3 ubiquitin-protein ligase WWP1

Gene

WWP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.3 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme regulationi

Activated by NDFIP1- and NDFIP2-binding.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei890Glycyl thioester intermediatePROSITE-ProRule annotation1
Sitei890Required for ubiquitin-thioester formationBy similarity1

GO - Molecular functioni

  • ubiquitin protein ligase activity Source: Ensembl
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  • central nervous system development Source: UniProtKB
  • ion transmembrane transport Source: Reactome
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
  • protein ubiquitination Source: UniProtKB
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: GO_Central
  • signal transduction Source: UniProtKB
  • viral entry into host cell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Host-virus interaction, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123124-MONOMER.
BRENDAi6.3.2.19. 2681.
ReactomeiR-HSA-1253288. Downregulation of ERBB4 signaling.
R-HSA-2672351. Stimuli-sensing channels.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ9H0M0.
SIGNORiQ9H0M0.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC:2.3.2.26)
Alternative name(s):
Atrophin-1-interacting protein 5
Short name:
AIP5
HECT-type E3 ubiquitin transferase WWP1
TGIF-interacting ubiquitin ligase 1
Short name:
Tiul1
WW domain-containing protein 1
Gene namesi
Name:WWP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:17004. WWP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleus Source: GO_Central
  • plasma membrane Source: UniProtKB-SubCell
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi614E → A: Reduces ubiquitin transfer. 1 Publication1
Mutagenesisi621H → A: Strongly reduces ubiquitin transfer. 1 Publication1
Mutagenesisi675D → A: Reduces ubiquitin transfer. 1 Publication1
Mutagenesisi798E → A: Reduces ubiquitin transfer. Strongly reduces ubiquitin transfer; when associated with A-845. 1 Publication1
Mutagenesisi804M → P: Strongly reduces ubiquitin transfer; when associated with P-806. 1 Publication1
Mutagenesisi806E → P: Strongly reduces ubiquitin transfer; when associated with P-804. 1 Publication1
Mutagenesisi845R → A: No effect. 1 Publication1
Mutagenesisi848Q → A: Abolishes ubiquitin transfer; when associated with A-855. 1 Publication1
Mutagenesisi855R → A: Abolishes ubiquitin transfer; when associated with A-848. 1 Publication1

Organism-specific databases

DisGeNETi11059.
OpenTargetsiENSG00000123124.
PharmGKBiPA134960138.

Polymorphism and mutation databases

BioMutaiWWP1.
DMDMi32171908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203361 – 922NEDD4-like E3 ubiquitin-protein ligase WWP1Add BLAST922

Post-translational modificationi

Auto-ubiquitinated and ubiquitinated by RNF11.3 Publications

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9H0M0.
PeptideAtlasiQ9H0M0.
PRIDEiQ9H0M0.

PTM databases

iPTMnetiQ9H0M0.
PhosphoSitePlusiQ9H0M0.

Expressioni

Tissue specificityi

Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1.2 Publications

Gene expression databases

BgeeiENSG00000123124.
CleanExiHS_WWP1.
ExpressionAtlasiQ9H0M0. baseline and differential.
GenevisibleiQ9H0M0. HS.

Organism-specific databases

HPAiHPA023180.

Interactioni

Subunit structurei

Binds KLF2 AND HIVEP3 (By similarity). Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII. Interacts with RNF11 (By similarity). Interacts with SPG20. Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2. Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3 ubiquitin-protein ligase. Interacts with TGIF.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q8WU023EBI-742157,EBI-747182
CPSF6Q166303EBI-742157,EBI-358410
FBXL18Q96D163EBI-742157,EBI-744419
SMAD3P840225EBI-742157,EBI-347161
TRAF4Q9BUZ43EBI-742157,EBI-3650647

Protein-protein interaction databases

BioGridi116243. 83 interactors.
IntActiQ9H0M0. 36 interactors.
MINTiMINT-199541.
STRINGi9606.ENSP00000265428.

Structurei

Secondary structure

1922
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi500 – 505Combined sources6
Turni509 – 511Combined sources3
Beta strandi513 – 518Combined sources6
Beta strandi521 – 523Combined sources3
Helixi547 – 559Combined sources13
Beta strandi564 – 571Combined sources8
Turni573 – 575Combined sources3
Helixi576 – 586Combined sources11
Helixi589 – 593Combined sources5
Beta strandi594 – 600Combined sources7
Turni601 – 603Combined sources3
Helixi611 – 623Combined sources13
Helixi626 – 628Combined sources3
Beta strandi629 – 636Combined sources8
Beta strandi641 – 643Combined sources3
Helixi645 – 649Combined sources5
Helixi653 – 669Combined sources17
Helixi680 – 686Combined sources7
Helixi693 – 699Combined sources7
Helixi701 – 712Combined sources12
Helixi715 – 718Combined sources4
Beta strandi723 – 730Combined sources8
Beta strandi733 – 740Combined sources8
Helixi743 – 745Combined sources3
Turni749 – 751Combined sources3
Helixi752 – 765Combined sources14
Turni766 – 769Combined sources4
Helixi770 – 783Combined sources14
Helixi786 – 791Combined sources6
Helixi794 – 802Combined sources9
Helixi809 – 814Combined sources6
Beta strandi817 – 820Combined sources4
Helixi826 – 837Combined sources12
Helixi840 – 851Combined sources12
Helixi860 – 863Combined sources4
Beta strandi867 – 870Combined sources4
Beta strandi874 – 876Combined sources3
Beta strandi881 – 883Combined sources3
Beta strandi886 – 888Combined sources3
Helixi889 – 891Combined sources3
Beta strandi893 – 895Combined sources3
Helixi902 – 914Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ND7X-ray2.10A546-917[»]
2OP7NMR-A494-532[»]
5HPSX-ray2.05A537-917[»]
5HPTX-ray2.84A/D/G537-917[»]
ProteinModelPortaliQ9H0M0.
SMRiQ9H0M0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0M0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 98C2PROSITE-ProRule annotationAdd BLAST94
Domaini349 – 382WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini381 – 414WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini456 – 489WW 3PROSITE-ProRule annotationAdd BLAST34
Domaini496 – 529WW 4PROSITE-ProRule annotationAdd BLAST34
Domaini588 – 922HECTPROSITE-ProRule annotationAdd BLAST335

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
Contains 4 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00760000118966.
HOGENOMiHOG000208453.
HOVERGENiHBG004134.
InParanoidiQ9H0M0.
KOiK05633.
OMAiLEMYFCV.
OrthoDBiEOG091G0SS8.
PhylomeDBiQ9H0M0.
TreeFamiTF323658.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR024928. E3_ub_ligase_SMURF1.
IPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 4 hits.
[Graphical view]
PIRSFiPIRSF001569. E3_ub_ligase_SMURF1. 1 hit.
SMARTiSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 4 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 4 hits.
PS50020. WW_DOMAIN_2. 4 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9H0M0-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI
60 70 80 90 100
TKTAKSSSSS NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID
110 120 130 140 150
LKQALLIHNR KLERVKEQLK LSLENKNGIA QTGELTVVLD GLVIEQENIT
160 170 180 190 200
NCSSSPTIEI QENGDALHEN GEPSARTTAR LAVEGTNGID NHVPTSTLVQ
210 220 230 240 250
NSCCSYVVNG DNTPSSPSQV AARPKNTPAP KPLASEPADD TVNGESSSFA
260 270 280 290 300
PTDNASVTGT PVVSEENALS PNCTSTTVED PPVQEILTSS ENNECIPSTS
310 320 330 340 350
AELESEARSI LEPDTSNSRS SSAFEAAKSR QPDGCMDPVR QQSGNANTET
360 370 380 390 400
LPSGWEQRKD PHGRTYYVDH NTRTTTWERP QPLPPGWERR VDDRRRVYYV
410 420 430 440 450
DHNTRTTTWQ RPTMESVRNF EQWQSQRNQL QGAMQQFNQR YLYSASMLAA
460 470 480 490 500
ENDPYGPLPP GWEKRVDSTD RVYFVNHNTK TTQWEDPRTQ GLQNEEPLPE
510 520 530 540 550
GWEIRYTREG VRYFVDHNTR TTTFKDPRNG KSSVTKGGPQ IAYERGFRWK
560 570 580 590 600
LAHFRYLCQS NALPSHVKIN VSRQTLFEDS FQQIMALKPY DLRRRLYVIF
610 620 630 640 650
RGEEGLDYGG LAREWFFLLS HEVLNPMYCL FEYAGKNNYC LQINPASTIN
660 670 680 690 700
PDHLSYFCFI GRFIAMALFH GKFIDTGFSL PFYKRMLSKK LTIKDLESID
710 720 730 740 750
TEFYNSLIWI RDNNIEECGL EMYFSVDMEI LGKVTSHDLK LGGSNILVTE
760 770 780 790 800
ENKDEYIGLM TEWRFSRGVQ EQTKAFLDGF NEVVPLQWLQ YFDEKELEVM
810 820 830 840 850
LCGMQEVDLA DWQRNTVYRH YTRNSKQIIW FWQFVKETDN EVRMRLLQFV
860 870 880 890 900
TGTCRLPLGG FAELMGSNGP QKFCIEKVGK DTWLPRSHTC FNRLDLPPYK
910 920
SYEQLKEKLL FAIEETEGFG QE
Length:922
Mass (Da):105,202
Last modified:March 1, 2001 - v1
Checksum:i35B6E1C03A3147DA
GO
Isoform 2 (identifier: Q9H0M0-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     112-120: LERVKEQLK → CWLLKARME
     121-922: Missing.

Show »
Length:120
Mass (Da):13,453
Checksum:i952B6A78C5D4B93D
GO
Isoform 3 (identifier: Q9H0M0-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     112-242: LERVKEQLKL...LASEPADDTV → F

Show »
Length:792
Mass (Da):91,548
Checksum:i833D351CC08D9998
GO
Isoform 4 (identifier: Q9H0M0-4)
Also known as: D
Sequence is not available
Length:
Mass (Da):
Isoform 5 (identifier: Q9H0M0-5)
Also known as: E
Sequence is not available
Length:
Mass (Da):
Isoform 6 (identifier: Q9H0M0-6) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     23-240: Missing.

Show »
Length:704
Mass (Da):81,649
Checksum:iB39DCB6841290CF0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052960852G → V.Corresponds to variant rs1059901dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00760023 – 240Missing in isoform 6. 1 PublicationAdd BLAST218
Alternative sequenceiVSP_007602112 – 242LERVK…ADDTV → F in isoform 3. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_007601112 – 120LERVKEQLK → CWLLKARME in isoform 2. 1 Publication9
Alternative sequenceiVSP_007603121 – 922Missing in isoform 2. 1 PublicationAdd BLAST802

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136739 mRNA. Translation: CAB66673.1.
AY043361 mRNA. Translation: AAK94668.1.
AY345857 mRNA. Translation: AAQ22764.1.
AC083845 Genomic DNA. No translation available.
AC103817 Genomic DNA. No translation available.
BC015380 mRNA. Translation: AAH15380.2.
BC036065 mRNA. Translation: AAH36065.1.
U96113 mRNA. Translation: AAC51324.1.
CCDSiCCDS6242.1. [Q9H0M0-1]
RefSeqiNP_008944.1. NM_007013.3. [Q9H0M0-1]
XP_005250817.1. XM_005250760.3. [Q9H0M0-1]
UniGeneiHs.655189.

Genome annotation databases

EnsembliENST00000265428; ENSP00000265428; ENSG00000123124. [Q9H0M0-1]
ENST00000517970; ENSP00000427793; ENSG00000123124. [Q9H0M0-1]
GeneIDi11059.
KEGGihsa:11059.
UCSCiuc003ydt.4. human. [Q9H0M0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136739 mRNA. Translation: CAB66673.1.
AY043361 mRNA. Translation: AAK94668.1.
AY345857 mRNA. Translation: AAQ22764.1.
AC083845 Genomic DNA. No translation available.
AC103817 Genomic DNA. No translation available.
BC015380 mRNA. Translation: AAH15380.2.
BC036065 mRNA. Translation: AAH36065.1.
U96113 mRNA. Translation: AAC51324.1.
CCDSiCCDS6242.1. [Q9H0M0-1]
RefSeqiNP_008944.1. NM_007013.3. [Q9H0M0-1]
XP_005250817.1. XM_005250760.3. [Q9H0M0-1]
UniGeneiHs.655189.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ND7X-ray2.10A546-917[»]
2OP7NMR-A494-532[»]
5HPSX-ray2.05A537-917[»]
5HPTX-ray2.84A/D/G537-917[»]
ProteinModelPortaliQ9H0M0.
SMRiQ9H0M0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116243. 83 interactors.
IntActiQ9H0M0. 36 interactors.
MINTiMINT-199541.
STRINGi9606.ENSP00000265428.

PTM databases

iPTMnetiQ9H0M0.
PhosphoSitePlusiQ9H0M0.

Polymorphism and mutation databases

BioMutaiWWP1.
DMDMi32171908.

Proteomic databases

PaxDbiQ9H0M0.
PeptideAtlasiQ9H0M0.
PRIDEiQ9H0M0.

Protocols and materials databases

DNASUi11059.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265428; ENSP00000265428; ENSG00000123124. [Q9H0M0-1]
ENST00000517970; ENSP00000427793; ENSG00000123124. [Q9H0M0-1]
GeneIDi11059.
KEGGihsa:11059.
UCSCiuc003ydt.4. human. [Q9H0M0-1]

Organism-specific databases

CTDi11059.
DisGeNETi11059.
GeneCardsiWWP1.
HGNCiHGNC:17004. WWP1.
HPAiHPA023180.
MIMi602307. gene.
neXtProtiNX_Q9H0M0.
OpenTargetsiENSG00000123124.
PharmGKBiPA134960138.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00760000118966.
HOGENOMiHOG000208453.
HOVERGENiHBG004134.
InParanoidiQ9H0M0.
KOiK05633.
OMAiLEMYFCV.
OrthoDBiEOG091G0SS8.
PhylomeDBiQ9H0M0.
TreeFamiTF323658.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000123124-MONOMER.
BRENDAi6.3.2.19. 2681.
ReactomeiR-HSA-1253288. Downregulation of ERBB4 signaling.
R-HSA-2672351. Stimuli-sensing channels.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ9H0M0.
SIGNORiQ9H0M0.

Miscellaneous databases

ChiTaRSiWWP1. human.
EvolutionaryTraceiQ9H0M0.
GeneWikiiWWP1.
GenomeRNAii11059.
PROiQ9H0M0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123124.
CleanExiHS_WWP1.
ExpressionAtlasiQ9H0M0. baseline and differential.
GenevisibleiQ9H0M0. HS.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR024928. E3_ub_ligase_SMURF1.
IPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 4 hits.
[Graphical view]
PIRSFiPIRSF001569. E3_ub_ligase_SMURF1. 1 hit.
SMARTiSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 4 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 4 hits.
PS50020. WW_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWWP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H0M0
Secondary accession number(s): O00307, Q5YLC1, Q96BP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.