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Q9H0L4 (CSTFT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cleavage stimulation factor subunit 2 tau variant
Alternative name(s):
CF-1 64 kDa subunit tau variant
Cleavage stimulation factor 64 kDa subunit tau variant
Short name=CSTF 64 kDa subunit tau variant
TauCstF-64
Gene names
Name:CSTF2T
Synonyms:KIAA0689
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentNucleus
   DomainRepeat
   LigandRNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from direct assay. Source: LIFEdb

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnucleotide binding

Inferred from electronic annotation. Source: InterPro

poly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 616616Cleavage stimulation factor subunit 2 tau variant
PRO_0000081534

Regions

Domain16 – 9479RRM
Repeat418 – 42251-1
Repeat423 – 42751-2; approximate
Repeat428 – 43251-3; approximate
Repeat433 – 43751-4; approximate
Repeat438 – 44251-5; approximate
Repeat443 – 44751-6
Repeat448 – 45251-7; approximate
Repeat453 – 45751-8; approximate
Repeat458 – 46251-9; approximate
Repeat505 – 50952-1
Repeat510 – 51452-2
Repeat515 – 51952-3
Repeat520 – 52452-4
Repeat525 – 52952-5; approximate
Repeat530 – 53452-6
Repeat535 – 53952-7; approximate
Repeat540 – 54452-8; approximate
Repeat545 – 54952-9; approximate
Region418 – 462459 X 5 AA tandem repeats of M-E-T-R-[AG]
Region505 – 549459 X 5 AA tandem repeats of G-[AT]-G-[MI]-Q
Compositional bias260 – 556297Gly-rich

Experimental info

Sequence conflict221N → S in BAD96294. Ref.4
Sequence conflict5531K → R in AAH28239. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9H0L4 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 916BB9B0802AC847

FASTA61664,437
        10         20         30         40         50         60 
MSSLAVRDPA MDRSLRSVFV GNIPYEATEE QLKDIFSEVG SVVSFRLVYD RETGKPKGYG 

        70         80         90        100        110        120 
FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGPAAPI IDSPYGDPID 

       130        140        150        160        170        180 
PEDAPESITR AVASLPPEQM FELMKQMKLC VQNSHQEARN MLLQNPQLAY ALLQAQVVMR 

       190        200        210        220        230        240 
IMDPEIALKI LHRKIHVTPL IPGKSQSVSV SGPGPGPGPG LCPGPNVLLN QQNPPAPQPQ 

       250        260        270        280        290        300 
HLARRPVKDI PPLMQTPIQG GIPAPGPIPA AVPGAGPGSL TPGGAMQPQL GMPGVGPVPL 

       310        320        330        340        350        360 
ERGQVQMSDP RAPIPRGPVT PGGLPPRGLL GDAPNDPRGG TLLSVTGEVE PRGYLGPPHQ 

       370        380        390        400        410        420 
GPPMHHASGH DTRGPSSHEM RGGPLGDPRL LIGEPRGPMI DQRGLPMDGR GGRDSRAMET 

       430        440        450        460        470        480 
RAMETEVLET RVMERRGMET CAMETRGMEA RGMDARGLEM RGPVPSSRGP MTGGIQGPGP 

       490        500        510        520        530        540 
INIGAGGPPQ GPRQVPGISG VGNPGAGMQG TGIQGTGMQG AGIQGGGMQG AGIQGVSIQG 

       550        560        570        580        590        600 
GGIQGGGIQG ASKQGGSQPS SFSPGQSQVT PQDQEKAALI MQVLQLTADQ IAMLPPEQRQ 

       610 
SILILKEQIQ KSTGAS 

« Hide

References

« Hide 'large scale' references
[1]"The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein CstF-64, lacks introns and may be associated with male sterility."
Dass B., McDaniel L., Schultz R.A., Attaya E., MacDonald C.C.
Genomics 80:509-514(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Coronary artery.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-616.
Tissue: Brain.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY130299 mRNA. Translation: AAN05429.1.
AL136747 mRNA. Translation: CAB66681.1.
AK222574 mRNA. Translation: BAD96294.1.
AK314318 mRNA. Translation: BAG36966.1.
CH471083 Genomic DNA. Translation: EAW54142.1.
BC028239 mRNA. Translation: AAH28239.1.
AB014589 mRNA. Translation: BAA31664.1.
RefSeqNP_056050.1. NM_015235.2.
UniGeneHs.591358.

3D structure databases

ProteinModelPortalQ9H0L4.
SMRQ9H0L4. Positions 8-164, 568-615.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116881. 8 interactions.
IntActQ9H0L4. 4 interactions.
MINTMINT-1461400.
STRING9606.ENSP00000332444.

PTM databases

PhosphoSiteQ9H0L4.

Polymorphism databases

DMDM71153234.

2D gel databases

REPRODUCTION-2DPAGEIPI00550906.

Proteomic databases

PaxDbQ9H0L4.
PeptideAtlasQ9H0L4.
PRIDEQ9H0L4.

Protocols and materials databases

DNASU23283.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331173; ENSP00000332444; ENSG00000177613.
GeneID23283.
KEGGhsa:23283.
UCSCuc001jjp.3. human.

Organism-specific databases

CTD23283.
GeneCardsGC10M053455.
HGNCHGNC:17086. CSTF2T.
HPAHPA039216.
MIM611968. gene.
neXtProtNX_Q9H0L4.
PharmGKBPA134933809.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0724.
HOGENOMHOG000214373.
HOVERGENHBG051145.
InParanoidQ9H0L4.
KOK14407.
OMARRGMETC.
OrthoDBEOG7N63NZ.
PhylomeDBQ9H0L4.
TreeFamTF314948.

Gene expression databases

BgeeQ9H0L4.
CleanExHS_CSTF2T.
GenevestigatorQ9H0L4.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR025742. CSTF2_hinge.
IPR026896. CSTF_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF14327. CSTF2_hinge. 1 hit.
PF14304. CSTF_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTSM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCSTF2T.
GenomeRNAi23283.
NextBio45080.
PROQ9H0L4.
SOURCESearch...

Entry information

Entry nameCSTFT_HUMAN
AccessionPrimary (citable) accession number: Q9H0L4
Secondary accession number(s): B2RAR9 expand/collapse secondary AC list , O75174, Q53HK6, Q7LGE8, Q8N6T1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM