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Protein

Cleavage stimulation factor subunit 2 tau variant

Gene

CSTF2T

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).By similarity

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage stimulation factor subunit 2 tau variant
Alternative name(s):
CF-1 64 kDa subunit tau variant
Cleavage stimulation factor 64 kDa subunit tau variant
Short name:
CSTF 64 kDa subunit tau variant
TauCstF-64
Gene namesi
Name:CSTF2T
Synonyms:KIAA0689
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17086. CSTF2T.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. intracellular Source: LIFEdb
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933809.

Polymorphism and mutation databases

BioMutaiCSTF2T.
DMDMi71153234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Cleavage stimulation factor subunit 2 tau variantPRO_0000081534Add
BLAST

Proteomic databases

MaxQBiQ9H0L4.
PaxDbiQ9H0L4.
PeptideAtlasiQ9H0L4.
PRIDEiQ9H0L4.

2D gel databases

REPRODUCTION-2DPAGEIPI00550906.

PTM databases

PhosphoSiteiQ9H0L4.

Expressioni

Gene expression databases

BgeeiQ9H0L4.
CleanExiHS_CSTF2T.
GenevestigatoriQ9H0L4.

Organism-specific databases

HPAiHPA039216.
HPA062021.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HGSO149643EBI-747012,EBI-740220
UBQLN1Q9UMX04EBI-747012,EBI-741480
UBQLN1Q9UMX0-23EBI-747012,EBI-10173939

Protein-protein interaction databases

BioGridi116881. 19 interactions.
IntActiQ9H0L4. 5 interactions.
MINTiMINT-1461400.
STRINGi9606.ENSP00000332444.

Structurei

3D structure databases

ProteinModelPortaliQ9H0L4.
SMRiQ9H0L4. Positions 8-111, 568-615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9479RRMPROSITE-ProRule annotationAdd
BLAST
Repeati418 – 42251-1
Repeati423 – 42751-2; approximate
Repeati428 – 43251-3; approximate
Repeati433 – 43751-4; approximate
Repeati438 – 44251-5; approximate
Repeati443 – 44751-6
Repeati448 – 45251-7; approximate
Repeati453 – 45751-8; approximate
Repeati458 – 46251-9; approximate
Repeati505 – 50952-1
Repeati510 – 51452-2
Repeati515 – 51952-3
Repeati520 – 52452-4
Repeati525 – 52952-5; approximate
Repeati530 – 53452-6
Repeati535 – 53952-7; approximate
Repeati540 – 54452-8; approximate
Repeati545 – 54952-9; approximate

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni418 – 462459 X 5 AA tandem repeats of M-E-T-R-[AG]Add
BLAST
Regioni505 – 549459 X 5 AA tandem repeats of G-[AT]-G-[MI]-QAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi260 – 556297Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00760000119351.
HOGENOMiHOG000214373.
HOVERGENiHBG051145.
InParanoidiQ9H0L4.
KOiK14407.
OMAiLPMDGRG.
OrthoDBiEOG7N63NZ.
PhylomeDBiQ9H0L4.
TreeFamiTF314948.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025742. CSTF2_hinge.
IPR026896. CSTF_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF14327. CSTF2_hinge. 1 hit.
PF14304. CSTF_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLAVRDPA MDRSLRSVFV GNIPYEATEE QLKDIFSEVG SVVSFRLVYD
60 70 80 90 100
RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE
110 120 130 140 150
LKSLGPAAPI IDSPYGDPID PEDAPESITR AVASLPPEQM FELMKQMKLC
160 170 180 190 200
VQNSHQEARN MLLQNPQLAY ALLQAQVVMR IMDPEIALKI LHRKIHVTPL
210 220 230 240 250
IPGKSQSVSV SGPGPGPGPG LCPGPNVLLN QQNPPAPQPQ HLARRPVKDI
260 270 280 290 300
PPLMQTPIQG GIPAPGPIPA AVPGAGPGSL TPGGAMQPQL GMPGVGPVPL
310 320 330 340 350
ERGQVQMSDP RAPIPRGPVT PGGLPPRGLL GDAPNDPRGG TLLSVTGEVE
360 370 380 390 400
PRGYLGPPHQ GPPMHHASGH DTRGPSSHEM RGGPLGDPRL LIGEPRGPMI
410 420 430 440 450
DQRGLPMDGR GGRDSRAMET RAMETEVLET RVMERRGMET CAMETRGMEA
460 470 480 490 500
RGMDARGLEM RGPVPSSRGP MTGGIQGPGP INIGAGGPPQ GPRQVPGISG
510 520 530 540 550
VGNPGAGMQG TGIQGTGMQG AGIQGGGMQG AGIQGVSIQG GGIQGGGIQG
560 570 580 590 600
ASKQGGSQPS SFSPGQSQVT PQDQEKAALI MQVLQLTADQ IAMLPPEQRQ
610
SILILKEQIQ KSTGAS
Length:616
Mass (Da):64,437
Last modified:March 1, 2001 - v1
Checksum:i916BB9B0802AC847
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221N → S in BAD96294 (Ref. 4) Curated
Sequence conflicti553 – 5531K → R in AAH28239 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130299 mRNA. Translation: AAN05429.1.
AL136747 mRNA. Translation: CAB66681.1.
AK222574 mRNA. Translation: BAD96294.1.
AK314318 mRNA. Translation: BAG36966.1.
CH471083 Genomic DNA. Translation: EAW54142.1.
BC028239 mRNA. Translation: AAH28239.1.
AB014589 mRNA. Translation: BAA31664.1.
CCDSiCCDS7245.1.
RefSeqiNP_056050.1. NM_015235.2.
UniGeneiHs.591358.

Genome annotation databases

EnsembliENST00000331173; ENSP00000332444; ENSG00000177613.
GeneIDi23283.
KEGGihsa:23283.
UCSCiuc001jjp.3. human.

Polymorphism and mutation databases

BioMutaiCSTF2T.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130299 mRNA. Translation: AAN05429.1.
AL136747 mRNA. Translation: CAB66681.1.
AK222574 mRNA. Translation: BAD96294.1.
AK314318 mRNA. Translation: BAG36966.1.
CH471083 Genomic DNA. Translation: EAW54142.1.
BC028239 mRNA. Translation: AAH28239.1.
AB014589 mRNA. Translation: BAA31664.1.
CCDSiCCDS7245.1.
RefSeqiNP_056050.1. NM_015235.2.
UniGeneiHs.591358.

3D structure databases

ProteinModelPortaliQ9H0L4.
SMRiQ9H0L4. Positions 8-111, 568-615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116881. 19 interactions.
IntActiQ9H0L4. 5 interactions.
MINTiMINT-1461400.
STRINGi9606.ENSP00000332444.

PTM databases

PhosphoSiteiQ9H0L4.

Polymorphism and mutation databases

BioMutaiCSTF2T.
DMDMi71153234.

2D gel databases

REPRODUCTION-2DPAGEIPI00550906.

Proteomic databases

MaxQBiQ9H0L4.
PaxDbiQ9H0L4.
PeptideAtlasiQ9H0L4.
PRIDEiQ9H0L4.

Protocols and materials databases

DNASUi23283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331173; ENSP00000332444; ENSG00000177613.
GeneIDi23283.
KEGGihsa:23283.
UCSCiuc001jjp.3. human.

Organism-specific databases

CTDi23283.
GeneCardsiGC10M053455.
HGNCiHGNC:17086. CSTF2T.
HPAiHPA039216.
HPA062021.
MIMi611968. gene.
neXtProtiNX_Q9H0L4.
PharmGKBiPA134933809.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00760000119351.
HOGENOMiHOG000214373.
HOVERGENiHBG051145.
InParanoidiQ9H0L4.
KOiK14407.
OMAiLPMDGRG.
OrthoDBiEOG7N63NZ.
PhylomeDBiQ9H0L4.
TreeFamiTF314948.

Miscellaneous databases

GeneWikiiCSTF2T.
GenomeRNAii23283.
NextBioi45080.
PROiQ9H0L4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H0L4.
CleanExiHS_CSTF2T.
GenevestigatoriQ9H0L4.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025742. CSTF2_hinge.
IPR026896. CSTF_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF14327. CSTF2_hinge. 1 hit.
PF14304. CSTF_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein CstF-64, lacks introns and may be associated with male sterility."
    Dass B., McDaniel L., Schultz R.A., Attaya E., MacDonald C.C.
    Genomics 80:509-514(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Coronary artery.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-616.
    Tissue: Brain.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCSTFT_HUMAN
AccessioniPrimary (citable) accession number: Q9H0L4
Secondary accession number(s): B2RAR9
, O75174, Q53HK6, Q7LGE8, Q8N6T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.