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Protein

Cleavage stimulation factor subunit 2 tau variant

Gene

CSTF2T

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).By similarity

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage stimulation factor subunit 2 tau variant
Alternative name(s):
CF-1 64 kDa subunit tau variant
Cleavage stimulation factor 64 kDa subunit tau variant
Short name:
CSTF 64 kDa subunit tau variant
TauCstF-64
Gene namesi
Name:CSTF2T
Synonyms:KIAA0689
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17086. CSTF2T.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23283.
OpenTargetsiENSG00000177613.
PharmGKBiPA134933809.

Polymorphism and mutation databases

BioMutaiCSTF2T.
DMDMi71153234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815341 – 616Cleavage stimulation factor subunit 2 tau variantAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei320PhosphothreonineCombined sources1
Modified residuei563PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0L4.
MaxQBiQ9H0L4.
PaxDbiQ9H0L4.
PeptideAtlasiQ9H0L4.
PRIDEiQ9H0L4.

2D gel databases

REPRODUCTION-2DPAGEIPI00550906.

PTM databases

iPTMnetiQ9H0L4.
PhosphoSitePlusiQ9H0L4.

Expressioni

Gene expression databases

BgeeiENSG00000177613.
CleanExiHS_CSTF2T.
GenevisibleiQ9H0L4. HS.

Organism-specific databases

HPAiHPA039216.
HPA062021.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HGSO149643EBI-747012,EBI-740220
UBQLN1Q9UMX04EBI-747012,EBI-741480
UBQLN1Q9UMX0-23EBI-747012,EBI-10173939

Protein-protein interaction databases

BioGridi116881. 30 interactors.
IntActiQ9H0L4. 17 interactors.
MINTiMINT-1461400.
STRINGi9606.ENSP00000332444.

Structurei

3D structure databases

ProteinModelPortaliQ9H0L4.
SMRiQ9H0L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 94RRMPROSITE-ProRule annotationAdd BLAST79
Repeati418 – 4221-15
Repeati423 – 4271-2; approximate5
Repeati428 – 4321-3; approximate5
Repeati433 – 4371-4; approximate5
Repeati438 – 4421-5; approximate5
Repeati443 – 4471-65
Repeati448 – 4521-7; approximate5
Repeati453 – 4571-8; approximate5
Repeati458 – 4621-9; approximate5
Repeati505 – 5092-15
Repeati510 – 5142-25
Repeati515 – 5192-35
Repeati520 – 5242-45
Repeati525 – 5292-5; approximate5
Repeati530 – 5342-65
Repeati535 – 5392-7; approximate5
Repeati540 – 5442-8; approximate5
Repeati545 – 5492-9; approximate5

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni418 – 4629 X 5 AA tandem repeats of M-E-T-R-[AG]Add BLAST45
Regioni505 – 5499 X 5 AA tandem repeats of G-[AT]-G-[MI]-QAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi260 – 556Gly-richAdd BLAST297

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0108. Eukaryota.
ENOG410XQBV. LUCA.
GeneTreeiENSGT00820000127074.
HOGENOMiHOG000214373.
HOVERGENiHBG051145.
InParanoidiQ9H0L4.
KOiK14407.
OMAiMHHASGH.
OrthoDBiEOG091G0A7G.
PhylomeDBiQ9H0L4.
TreeFamiTF314948.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025742. CSTF2_hinge.
IPR026896. CSTF_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF14327. CSTF2_hinge. 1 hit.
PF14304. CSTF_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLAVRDPA MDRSLRSVFV GNIPYEATEE QLKDIFSEVG SVVSFRLVYD
60 70 80 90 100
RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE
110 120 130 140 150
LKSLGPAAPI IDSPYGDPID PEDAPESITR AVASLPPEQM FELMKQMKLC
160 170 180 190 200
VQNSHQEARN MLLQNPQLAY ALLQAQVVMR IMDPEIALKI LHRKIHVTPL
210 220 230 240 250
IPGKSQSVSV SGPGPGPGPG LCPGPNVLLN QQNPPAPQPQ HLARRPVKDI
260 270 280 290 300
PPLMQTPIQG GIPAPGPIPA AVPGAGPGSL TPGGAMQPQL GMPGVGPVPL
310 320 330 340 350
ERGQVQMSDP RAPIPRGPVT PGGLPPRGLL GDAPNDPRGG TLLSVTGEVE
360 370 380 390 400
PRGYLGPPHQ GPPMHHASGH DTRGPSSHEM RGGPLGDPRL LIGEPRGPMI
410 420 430 440 450
DQRGLPMDGR GGRDSRAMET RAMETEVLET RVMERRGMET CAMETRGMEA
460 470 480 490 500
RGMDARGLEM RGPVPSSRGP MTGGIQGPGP INIGAGGPPQ GPRQVPGISG
510 520 530 540 550
VGNPGAGMQG TGIQGTGMQG AGIQGGGMQG AGIQGVSIQG GGIQGGGIQG
560 570 580 590 600
ASKQGGSQPS SFSPGQSQVT PQDQEKAALI MQVLQLTADQ IAMLPPEQRQ
610
SILILKEQIQ KSTGAS
Length:616
Mass (Da):64,437
Last modified:March 1, 2001 - v1
Checksum:i916BB9B0802AC847
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22N → S in BAD96294 (Ref. 4) Curated1
Sequence conflicti553K → R in AAH28239 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130299 mRNA. Translation: AAN05429.1.
AL136747 mRNA. Translation: CAB66681.1.
AK222574 mRNA. Translation: BAD96294.1.
AK314318 mRNA. Translation: BAG36966.1.
CH471083 Genomic DNA. Translation: EAW54142.1.
BC028239 mRNA. Translation: AAH28239.1.
AB014589 mRNA. Translation: BAA31664.1.
CCDSiCCDS7245.1.
RefSeqiNP_056050.1. NM_015235.2.
UniGeneiHs.591358.

Genome annotation databases

EnsembliENST00000331173; ENSP00000332444; ENSG00000177613.
GeneIDi23283.
KEGGihsa:23283.
UCSCiuc001jjp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130299 mRNA. Translation: AAN05429.1.
AL136747 mRNA. Translation: CAB66681.1.
AK222574 mRNA. Translation: BAD96294.1.
AK314318 mRNA. Translation: BAG36966.1.
CH471083 Genomic DNA. Translation: EAW54142.1.
BC028239 mRNA. Translation: AAH28239.1.
AB014589 mRNA. Translation: BAA31664.1.
CCDSiCCDS7245.1.
RefSeqiNP_056050.1. NM_015235.2.
UniGeneiHs.591358.

3D structure databases

ProteinModelPortaliQ9H0L4.
SMRiQ9H0L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116881. 30 interactors.
IntActiQ9H0L4. 17 interactors.
MINTiMINT-1461400.
STRINGi9606.ENSP00000332444.

PTM databases

iPTMnetiQ9H0L4.
PhosphoSitePlusiQ9H0L4.

Polymorphism and mutation databases

BioMutaiCSTF2T.
DMDMi71153234.

2D gel databases

REPRODUCTION-2DPAGEIPI00550906.

Proteomic databases

EPDiQ9H0L4.
MaxQBiQ9H0L4.
PaxDbiQ9H0L4.
PeptideAtlasiQ9H0L4.
PRIDEiQ9H0L4.

Protocols and materials databases

DNASUi23283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331173; ENSP00000332444; ENSG00000177613.
GeneIDi23283.
KEGGihsa:23283.
UCSCiuc001jjp.4. human.

Organism-specific databases

CTDi23283.
DisGeNETi23283.
GeneCardsiCSTF2T.
HGNCiHGNC:17086. CSTF2T.
HPAiHPA039216.
HPA062021.
MIMi611968. gene.
neXtProtiNX_Q9H0L4.
OpenTargetsiENSG00000177613.
PharmGKBiPA134933809.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0108. Eukaryota.
ENOG410XQBV. LUCA.
GeneTreeiENSGT00820000127074.
HOGENOMiHOG000214373.
HOVERGENiHBG051145.
InParanoidiQ9H0L4.
KOiK14407.
OMAiMHHASGH.
OrthoDBiEOG091G0A7G.
PhylomeDBiQ9H0L4.
TreeFamiTF314948.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177613-MONOMER.

Miscellaneous databases

GeneWikiiCSTF2T.
GenomeRNAii23283.
PROiQ9H0L4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177613.
CleanExiHS_CSTF2T.
GenevisibleiQ9H0L4. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025742. CSTF2_hinge.
IPR026896. CSTF_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF14327. CSTF2_hinge. 1 hit.
PF14304. CSTF_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSTFT_HUMAN
AccessioniPrimary (citable) accession number: Q9H0L4
Secondary accession number(s): B2RAR9
, O75174, Q53HK6, Q7LGE8, Q8N6T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.