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Q9H0L4

- CSTFT_HUMAN

UniProt

Q9H0L4 - CSTFT_HUMAN

Protein

Cleavage stimulation factor subunit 2 tau variant

Gene

CSTF2T

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs By similarity.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cleavage stimulation factor subunit 2 tau variant
    Alternative name(s):
    CF-1 64 kDa subunit tau variant
    Cleavage stimulation factor 64 kDa subunit tau variant
    Short name:
    CSTF 64 kDa subunit tau variant
    TauCstF-64
    Gene namesi
    Name:CSTF2T
    Synonyms:KIAA0689
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:17086. CSTF2T.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. intracellular Source: LIFEdb
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134933809.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 616616Cleavage stimulation factor subunit 2 tau variantPRO_0000081534Add
    BLAST

    Proteomic databases

    MaxQBiQ9H0L4.
    PaxDbiQ9H0L4.
    PeptideAtlasiQ9H0L4.
    PRIDEiQ9H0L4.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00550906.

    PTM databases

    PhosphoSiteiQ9H0L4.

    Expressioni

    Gene expression databases

    BgeeiQ9H0L4.
    CleanExiHS_CSTF2T.
    GenevestigatoriQ9H0L4.

    Organism-specific databases

    HPAiHPA039216.

    Interactioni

    Protein-protein interaction databases

    BioGridi116881. 8 interactions.
    IntActiQ9H0L4. 4 interactions.
    MINTiMINT-1461400.
    STRINGi9606.ENSP00000332444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0L4.
    SMRiQ9H0L4. Positions 8-111, 568-615.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 9479RRMPROSITE-ProRule annotationAdd
    BLAST
    Repeati418 – 42251-1
    Repeati423 – 42751-2; approximate
    Repeati428 – 43251-3; approximate
    Repeati433 – 43751-4; approximate
    Repeati438 – 44251-5; approximate
    Repeati443 – 44751-6
    Repeati448 – 45251-7; approximate
    Repeati453 – 45751-8; approximate
    Repeati458 – 46251-9; approximate
    Repeati505 – 50952-1
    Repeati510 – 51452-2
    Repeati515 – 51952-3
    Repeati520 – 52452-4
    Repeati525 – 52952-5; approximate
    Repeati530 – 53452-6
    Repeati535 – 53952-7; approximate
    Repeati540 – 54452-8; approximate
    Repeati545 – 54952-9; approximate

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni418 – 462459 X 5 AA tandem repeats of M-E-T-R-[AG]Add
    BLAST
    Regioni505 – 549459 X 5 AA tandem repeats of G-[AT]-G-[MI]-QAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi260 – 556297Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    HOGENOMiHOG000214373.
    HOVERGENiHBG051145.
    InParanoidiQ9H0L4.
    KOiK14407.
    OMAiRRGMETC.
    OrthoDBiEOG7N63NZ.
    PhylomeDBiQ9H0L4.
    TreeFamiTF314948.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR025742. CSTF2_hinge.
    IPR026896. CSTF_C.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF14327. CSTF2_hinge. 1 hit.
    PF14304. CSTF_C. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H0L4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLAVRDPA MDRSLRSVFV GNIPYEATEE QLKDIFSEVG SVVSFRLVYD    50
    RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE 100
    LKSLGPAAPI IDSPYGDPID PEDAPESITR AVASLPPEQM FELMKQMKLC 150
    VQNSHQEARN MLLQNPQLAY ALLQAQVVMR IMDPEIALKI LHRKIHVTPL 200
    IPGKSQSVSV SGPGPGPGPG LCPGPNVLLN QQNPPAPQPQ HLARRPVKDI 250
    PPLMQTPIQG GIPAPGPIPA AVPGAGPGSL TPGGAMQPQL GMPGVGPVPL 300
    ERGQVQMSDP RAPIPRGPVT PGGLPPRGLL GDAPNDPRGG TLLSVTGEVE 350
    PRGYLGPPHQ GPPMHHASGH DTRGPSSHEM RGGPLGDPRL LIGEPRGPMI 400
    DQRGLPMDGR GGRDSRAMET RAMETEVLET RVMERRGMET CAMETRGMEA 450
    RGMDARGLEM RGPVPSSRGP MTGGIQGPGP INIGAGGPPQ GPRQVPGISG 500
    VGNPGAGMQG TGIQGTGMQG AGIQGGGMQG AGIQGVSIQG GGIQGGGIQG 550
    ASKQGGSQPS SFSPGQSQVT PQDQEKAALI MQVLQLTADQ IAMLPPEQRQ 600
    SILILKEQIQ KSTGAS 616
    Length:616
    Mass (Da):64,437
    Last modified:March 1, 2001 - v1
    Checksum:i916BB9B0802AC847
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221N → S in BAD96294. 1 PublicationCurated
    Sequence conflicti553 – 5531K → R in AAH28239. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY130299 mRNA. Translation: AAN05429.1.
    AL136747 mRNA. Translation: CAB66681.1.
    AK222574 mRNA. Translation: BAD96294.1.
    AK314318 mRNA. Translation: BAG36966.1.
    CH471083 Genomic DNA. Translation: EAW54142.1.
    BC028239 mRNA. Translation: AAH28239.1.
    AB014589 mRNA. Translation: BAA31664.1.
    CCDSiCCDS7245.1.
    RefSeqiNP_056050.1. NM_015235.2.
    UniGeneiHs.591358.

    Genome annotation databases

    EnsembliENST00000331173; ENSP00000332444; ENSG00000177613.
    GeneIDi23283.
    KEGGihsa:23283.
    UCSCiuc001jjp.3. human.

    Polymorphism databases

    DMDMi71153234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY130299 mRNA. Translation: AAN05429.1 .
    AL136747 mRNA. Translation: CAB66681.1 .
    AK222574 mRNA. Translation: BAD96294.1 .
    AK314318 mRNA. Translation: BAG36966.1 .
    CH471083 Genomic DNA. Translation: EAW54142.1 .
    BC028239 mRNA. Translation: AAH28239.1 .
    AB014589 mRNA. Translation: BAA31664.1 .
    CCDSi CCDS7245.1.
    RefSeqi NP_056050.1. NM_015235.2.
    UniGenei Hs.591358.

    3D structure databases

    ProteinModelPortali Q9H0L4.
    SMRi Q9H0L4. Positions 8-111, 568-615.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116881. 8 interactions.
    IntActi Q9H0L4. 4 interactions.
    MINTi MINT-1461400.
    STRINGi 9606.ENSP00000332444.

    PTM databases

    PhosphoSitei Q9H0L4.

    Polymorphism databases

    DMDMi 71153234.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00550906.

    Proteomic databases

    MaxQBi Q9H0L4.
    PaxDbi Q9H0L4.
    PeptideAtlasi Q9H0L4.
    PRIDEi Q9H0L4.

    Protocols and materials databases

    DNASUi 23283.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331173 ; ENSP00000332444 ; ENSG00000177613 .
    GeneIDi 23283.
    KEGGi hsa:23283.
    UCSCi uc001jjp.3. human.

    Organism-specific databases

    CTDi 23283.
    GeneCardsi GC10M053455.
    HGNCi HGNC:17086. CSTF2T.
    HPAi HPA039216.
    MIMi 611968. gene.
    neXtProti NX_Q9H0L4.
    PharmGKBi PA134933809.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0724.
    HOGENOMi HOG000214373.
    HOVERGENi HBG051145.
    InParanoidi Q9H0L4.
    KOi K14407.
    OMAi RRGMETC.
    OrthoDBi EOG7N63NZ.
    PhylomeDBi Q9H0L4.
    TreeFami TF314948.

    Miscellaneous databases

    GeneWikii CSTF2T.
    GenomeRNAii 23283.
    NextBioi 45080.
    PROi Q9H0L4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H0L4.
    CleanExi HS_CSTF2T.
    Genevestigatori Q9H0L4.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR025742. CSTF2_hinge.
    IPR026896. CSTF_C.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF14327. CSTF2_hinge. 1 hit.
    PF14304. CSTF_C. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein CstF-64, lacks introns and may be associated with male sterility."
      Dass B., McDaniel L., Schultz R.A., Attaya E., MacDonald C.C.
      Genomics 80:509-514(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Coronary artery.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-616.
      Tissue: Brain.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCSTFT_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0L4
    Secondary accession number(s): B2RAR9
    , O75174, Q53HK6, Q7LGE8, Q8N6T1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3