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Protein

Radial spoke head protein 6 homolog A

Gene

RSPH6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Radial spoke head protein 6 homolog A
Alternative name(s):
Radial spoke head-like protein 1
Gene namesi
Name:RSPH6A
Synonyms:RSHL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14241. RSPH6A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34873.

Polymorphism and mutation databases

BioMutaiRSPH6A.
DMDMi74717992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Radial spoke head protein 6 homolog APRO_0000312760Add
BLAST

Proteomic databases

PaxDbiQ9H0K4.
PeptideAtlasiQ9H0K4.
PRIDEiQ9H0K4.

PTM databases

iPTMnetiQ9H0K4.

Expressioni

Gene expression databases

BgeeiQ9H0K4.
CleanExiHS_RSHL1.
ExpressionAtlasiQ9H0K4. baseline and differential.
GenevisibleiQ9H0K4. HS.

Organism-specific databases

HPAiHPA045382.

Interactioni

Protein-protein interaction databases

MINTiMINT-4713303.
STRINGi9606.ENSP00000221538.

Structurei

3D structure databases

ProteinModelPortaliQ9H0K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi359 – 39739Glu-richAdd
BLAST
Compositional biasi504 – 714211Glu-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IF1Z. Eukaryota.
ENOG410XQP5. LUCA.
GeneTreeiENSGT00500000044869.
HOGENOMiHOG000006653.
HOVERGENiHBG070874.
InParanoidiQ9H0K4.
OMAiEIMHLAP.
OrthoDBiEOG7K3TMX.
PhylomeDBiQ9H0K4.
TreeFamiTF324531.

Family and domain databases

InterProiIPR006802. Radial_spoke.
[Graphical view]
PANTHERiPTHR13159. PTHR13159. 1 hit.
PfamiPF04712. Radial_spoke. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLPPYPER PAQQPPGRRT SQASQRRHSR DQAQALAADP EERQQIPPDA
60 70 80 90 100
QRNAPGWSQR GSLSQQENLL MPQVFQAEEA RLGGMEYPSV NTGFPSEFQP
110 120 130 140 150
QPYSDESRMQ VAELTTSLML QRLQQGQSSL FQQLDPTFQE PPVNPLGQFN
160 170 180 190 200
LYQTDQFSEG AQHGPYIRDD PALQFLPSEL GFPHYSAQVP EPEPLELAVQ
210 220 230 240 250
NAKAYLLQTS INCDLSLYEH LVNLLTKILN QRPEDPLSVL ESLNRTTQWE
260 270 280 290 300
WFHPKLDTLR DDPEMQPTYK MAEKQKALFT RSGGGTEGEQ EMEEEVGETP
310 320 330 340 350
VPNIMETAFY FEQAGVGLSS DESFRIFLAM KQLVEQQPIH TCRFWGKILG
360 370 380 390 400
IKRSYLVAEV EFREGEEEAE EEEVEEMTEG GEVMEAHGEE EGEEDEEKAV
410 420 430 440 450
DIVPKSVWKP PPVIPKEESR SGANKYLYFV CNEPGLPWTR LPHVTPAQIV
460 470 480 490 500
NARKIKKFFT GYLDTPVVSY PPFPGNEANY LRAQIARISA ATQVSPLGFY
510 520 530 540 550
QFSEEEGDEE EEGGAGRDSY EENPDFEGIP VLELVDSMAN WVHHTQHILP
560 570 580 590 600
QGRCTWVNPL QKTEEEEDLG EEEEKADEGP EEVEQEVGPP LLTPLSEDAE
610 620 630 640 650
IMHLAPWTTR LSCSLCPQYS VAVVRSNLWP GAYAYASGKK FENIYIGWGH
660 670 680 690 700
KYSPESFNPA LPAPIQQEYP SGPEIMEMSD PTVEEEQALK AAQEQALGAT
710
EEEEEGEEEE EGEETDD
Length:717
Mass (Da):80,913
Last modified:March 1, 2001 - v1
Checksum:i120C31FA0726AD76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551P → S in BAD97067 (Ref. 2) Curated
Sequence conflicti139 – 1391Q → R in BAD97067 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501A → V.
Corresponds to variant rs12459916 [ dbSNP | Ensembl ].
VAR_037560

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136761 mRNA. Translation: CAB66695.1.
AK223347 mRNA. Translation: BAD97067.1.
CH471126 Genomic DNA. Translation: EAW57388.1.
BC057785 mRNA. Translation: AAH57785.1.
CCDSiCCDS12675.1.
RefSeqiNP_110412.1. NM_030785.3.
UniGeneiHs.146544.

Genome annotation databases

EnsembliENST00000221538; ENSP00000221538; ENSG00000104941.
GeneIDi81492.
KEGGihsa:81492.
UCSCiuc002pdm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136761 mRNA. Translation: CAB66695.1.
AK223347 mRNA. Translation: BAD97067.1.
CH471126 Genomic DNA. Translation: EAW57388.1.
BC057785 mRNA. Translation: AAH57785.1.
CCDSiCCDS12675.1.
RefSeqiNP_110412.1. NM_030785.3.
UniGeneiHs.146544.

3D structure databases

ProteinModelPortaliQ9H0K4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4713303.
STRINGi9606.ENSP00000221538.

PTM databases

iPTMnetiQ9H0K4.

Polymorphism and mutation databases

BioMutaiRSPH6A.
DMDMi74717992.

Proteomic databases

PaxDbiQ9H0K4.
PeptideAtlasiQ9H0K4.
PRIDEiQ9H0K4.

Protocols and materials databases

DNASUi81492.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221538; ENSP00000221538; ENSG00000104941.
GeneIDi81492.
KEGGihsa:81492.
UCSCiuc002pdm.4. human.

Organism-specific databases

CTDi81492.
GeneCardsiRSPH6A.
HGNCiHGNC:14241. RSPH6A.
HPAiHPA045382.
MIMi607548. gene.
neXtProtiNX_Q9H0K4.
PharmGKBiPA34873.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF1Z. Eukaryota.
ENOG410XQP5. LUCA.
GeneTreeiENSGT00500000044869.
HOGENOMiHOG000006653.
HOVERGENiHBG070874.
InParanoidiQ9H0K4.
OMAiEIMHLAP.
OrthoDBiEOG7K3TMX.
PhylomeDBiQ9H0K4.
TreeFamiTF324531.

Miscellaneous databases

GeneWikiiRSPH6A.
GenomeRNAii81492.
PROiQ9H0K4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H0K4.
CleanExiHS_RSHL1.
ExpressionAtlasiQ9H0K4. baseline and differential.
GenevisibleiQ9H0K4. HS.

Family and domain databases

InterProiIPR006802. Radial_spoke.
[Graphical view]
PANTHERiPTHR13159. PTHR13159. 1 hit.
PfamiPF04712. Radial_spoke. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-717.
    Tissue: Testis.

Entry informationi

Entry nameiRSH6A_HUMAN
AccessioniPrimary (citable) accession number: Q9H0K4
Secondary accession number(s): Q53FE2, Q6PEZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.