##gff-version 3 Q9H0K1 UniProtKB Chain 1 926 . . . ID=PRO_0000086662;Note=Serine/threonine-protein kinase SIK2 Q9H0K1 UniProtKB Domain 20 271 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q9H0K1 UniProtKB Domain 295 335 . . . Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 Q9H0K1 UniProtKB Region 644 666 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H0K1 UniProtKB Region 742 776 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H0K1 UniProtKB Region 801 896 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H0K1 UniProtKB Compositional bias 752 767 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H0K1 UniProtKB Compositional bias 801 816 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H0K1 UniProtKB Compositional bias 817 838 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H0K1 UniProtKB Active site 142 142 . . . Note=Proton acceptor;Ontology_term=ECO:0000250,ECO:0000255,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q13131,ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 Q9H0K1 UniProtKB Binding site 26 34 . . . Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q13131,ECO:0000255|PROSITE-ProRule:PRU00159 Q9H0K1 UniProtKB Binding site 49 49 . . . Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q8CFH6,ECO:0000255|PROSITE-ProRule:PRU00159 Q9H0K1 UniProtKB Modified residue 25 25 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Q9H0K1 UniProtKB Modified residue 53 53 . . . Note=N6-acetyllysine%3B by EP300;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23322770;Dbxref=PMID:23322770 Q9H0K1 UniProtKB Modified residue 175 175 . . . Note=Phosphothreonine%3B by LKB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14976552;Dbxref=PMID:14976552 Q9H0K1 UniProtKB Modified residue 484 484 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30586628;Dbxref=PMID:30586628 Q9H0K1 UniProtKB Modified residue 534 534 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFH6 Q9H0K1 UniProtKB Modified residue 587 587 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:24275569 Q9H0K1 UniProtKB Natural variant 458 458 . . . ID=VAR_041093;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35789057,PMID:17344846 Q9H0K1 UniProtKB Natural variant 809 809 . . . ID=VAR_041094;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34223841,PMID:17344846 Q9H0K1 UniProtKB Natural variant 825 825 . . . ID=VAR_041095;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889697,PMID:17344846 Q9H0K1 UniProtKB Natural variant 828 828 . . . ID=VAR_051667;Note=P->L;Dbxref=dbSNP:rs45520245 Q9H0K1 UniProtKB Natural variant 829 829 . . . ID=VAR_051668;Note=P->S;Dbxref=dbSNP:rs45586732 Q9H0K1 UniProtKB Mutagenesis 175 175 . . . Note=Prevents phosphorylation and activation by STK11/LKB1 complex. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14976552;Dbxref=PMID:14976552 Q9H0K1 UniProtKB Mutagenesis 175 175 . . . Note=Constitutively active. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14976552;Dbxref=PMID:14976552 Q9H0K1 UniProtKB Sequence conflict 192 192 . . . Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H0K1 UniProtKB Sequence conflict 463 463 . . . Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305