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Q9H0K1

- SIK2_HUMAN

UniProt

Q9H0K1 - SIK2_HUMAN

Protein

Serine/threonine-protein kinase SIK2

Gene

SIK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.1 Publication

    Cofactori

    Magnesium.1 Publication

    Enzyme regulationi

    Activated by phosphorylation on Thr-175.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491ATPBy similarityPROSITE-ProRule annotation
    Active sitei142 – 1421Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 349ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. insulin receptor signaling pathway Source: Ensembl
    2. intracellular signal transduction Source: UniProtKB
    3. protein autophosphorylation Source: UniProtKB
    4. protein phosphorylation Source: UniProtKB
    5. regulation of insulin receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9H0K1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase SIK2 (EC:2.7.11.1)
    Alternative name(s):
    Qin-induced kinase
    Salt-inducible kinase 2
    Short name:
    SIK-2
    Serine/threonine-protein kinase SNF1-like kinase 2
    Gene namesi
    Name:SIK2
    Synonyms:KIAA0781Imported, QIK, SNF1LK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:21680. SIK2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi175 – 1751T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication
    Mutagenesisi175 – 1751T → E: Constitutively active. 1 Publication

    Organism-specific databases

    PharmGKBiPA164725750.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 926926Serine/threonine-protein kinase SIK2PRO_0000086662Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Phosphothreonine1 Publication
    Modified residuei53 – 531N6-acetyllysine; by EP3001 Publication
    Modified residuei175 – 1751Phosphothreonine; by LKB11 Publication
    Modified residuei587 – 5871Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.4 Publications
    Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9H0K1.
    PaxDbiQ9H0K1.
    PRIDEiQ9H0K1.

    PTM databases

    PhosphoSiteiQ9H0K1.

    Expressioni

    Gene expression databases

    BgeeiQ9H0K1.
    GenevestigatoriQ9H0K1.

    Organism-specific databases

    HPAiHPA016026.

    Interactioni

    Subunit structurei

    Interacts with and phosphorylates TORC2/CRTC2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CEP250Q9BV735EBI-1181664,EBI-1053100

    Protein-protein interaction databases

    BioGridi116840. 8 interactions.
    IntActiQ9H0K1. 7 interactions.
    STRINGi9606.ENSP00000305976.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0K1.
    SMRiQ9H0K1. Positions 17-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 271252Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini295 – 33541UBAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    InParanoidiQ9H0K1.
    KOiK16311.
    OMAiDCPRSSG.
    OrthoDBiEOG70ZZMM.
    PhylomeDBiQ9H0K1.
    TreeFamiTF315213.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR017090. Ser/Thr_kinase_SIK1/2.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037014. Ser/Thr_PK_SNF1-like. 1 hit.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H0K1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI    50
    IDKSQLDAVN LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK 100
    NGEIFDYLAN HGRLNESEAR RKFWQILSAV DYCHGRKIVH RDLKAENLLL 150
    DNNMNIKIAD FGFGNFFKSG ELLATWCGSP PYAAPEVFEG QQYEGPQLDI 200
    WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM SEDCEHLIRR 250
    MLVLDPSKRL TIAQIKEHKW MLIEVPVQRP VLYPQEQENE PSIGEFNEQV 300
    LRLMHSLGID QQKTIESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL 350
    DGRQRRPSTI AEQTVAKAQT VGLPVTMHSP NMRLLRSALL PQASNVEAFS 400
    FPASGCQAEA AFMEEECVDT PKVNGCLLDP VPPVLVRKGC QSLPSNMMET 450
    SIDEGLETEG EAEEDPAHAF EAFQSTRSGQ RRHTLSEVTN QLVVMPGAGK 500
    IFSMNDSPSL DSVDSEYDMG SVQRDLNFLE DNPSLKDIML ANQPSPRMTS 550
    PFISLRPTNP AMQALSSQKR EVHNRSPVSF REGRRASDTS LTQGIVAFRQ 600
    HLQNLARTKG ILELNKVQLL YEQIGPEADP NLAPAAPQLQ DLASSCPQEE 650
    VSQQQESVST LPASVHPQLS PRQSLETQYL QHRLQKPSLL SKAQNTCQLY 700
    CKEPPRSLEQ QLQEHRLQQK RLFLQKQSQL QAYFNQMQIA ESSYPQPSQQ 750
    LPLPRQETPP PSQQAPPFSL TQPLSPVLEP SSEQMQYSPF LSQYQEMQLQ 800
    PLPSTSGPRA APPLPTQLQQ QQPPPPPPPP PPRQPGAAPA PLQFSYQTCE 850
    LPSAASPAPD YPTPCQYPVD GAQQSDLTGP DCPRSPGLQE APSSYDPLAL 900
    SELPGLFDCE MLDAVDPQHN GYVLVN 926
    Length:926
    Mass (Da):103,915
    Last modified:March 1, 2001 - v1
    Checksum:i9D7F9BF81FD65CCF
    GO

    Sequence cautioni

    The sequence BAA34501.3 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921Q → H in BAF83922. (PubMed:14702039)Curated
    Sequence conflicti463 – 4631E → V in BAF83922. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti458 – 4581T → I.1 Publication
    Corresponds to variant rs35789057 [ dbSNP | Ensembl ].
    VAR_041093
    Natural varianti809 – 8091R → Q.1 Publication
    Corresponds to variant rs34223841 [ dbSNP | Ensembl ].
    VAR_041094
    Natural varianti825 – 8251P → L.1 Publication
    Corresponds to variant rs55889697 [ dbSNP | Ensembl ].
    VAR_041095
    Natural varianti828 – 8281P → L.
    Corresponds to variant rs45520245 [ dbSNP | Ensembl ].
    VAR_051667
    Natural varianti829 – 8291P → S.
    Corresponds to variant rs45586732 [ dbSNP | Ensembl ].
    VAR_051668

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018324 mRNA. Translation: BAA34501.3. Different initiation.
    AL136764 mRNA. Translation: CAB66698.1.
    AK291233 mRNA. Translation: BAF83922.1.
    EF445030 Genomic DNA. Translation: ACA06072.1.
    CH471065 Genomic DNA. Translation: EAW67148.1.
    BC013612 mRNA. Translation: AAH13612.1.
    BC078150 mRNA. Translation: AAH78150.1.
    BC113459 mRNA. Translation: AAI13460.1.
    BC117183 mRNA. Translation: AAI17184.1.
    AB084424 mRNA. Translation: BAB91442.1.
    CCDSiCCDS8347.1.
    RefSeqiNP_056006.1. NM_015191.1.
    UniGeneiHs.269128.

    Genome annotation databases

    EnsembliENST00000304987; ENSP00000305976; ENSG00000170145.
    GeneIDi23235.
    KEGGihsa:23235.
    UCSCiuc001plt.3. human.

    Polymorphism databases

    DMDMi59798973.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018324 mRNA. Translation: BAA34501.3 . Different initiation.
    AL136764 mRNA. Translation: CAB66698.1 .
    AK291233 mRNA. Translation: BAF83922.1 .
    EF445030 Genomic DNA. Translation: ACA06072.1 .
    CH471065 Genomic DNA. Translation: EAW67148.1 .
    BC013612 mRNA. Translation: AAH13612.1 .
    BC078150 mRNA. Translation: AAH78150.1 .
    BC113459 mRNA. Translation: AAI13460.1 .
    BC117183 mRNA. Translation: AAI17184.1 .
    AB084424 mRNA. Translation: BAB91442.1 .
    CCDSi CCDS8347.1.
    RefSeqi NP_056006.1. NM_015191.1.
    UniGenei Hs.269128.

    3D structure databases

    ProteinModelPortali Q9H0K1.
    SMRi Q9H0K1. Positions 17-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116840. 8 interactions.
    IntActi Q9H0K1. 7 interactions.
    STRINGi 9606.ENSP00000305976.

    Chemistry

    BindingDBi Q9H0K1.
    ChEMBLi CHEMBL5699.
    GuidetoPHARMACOLOGYi 2198.

    PTM databases

    PhosphoSitei Q9H0K1.

    Polymorphism databases

    DMDMi 59798973.

    Proteomic databases

    MaxQBi Q9H0K1.
    PaxDbi Q9H0K1.
    PRIDEi Q9H0K1.

    Protocols and materials databases

    DNASUi 23235.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304987 ; ENSP00000305976 ; ENSG00000170145 .
    GeneIDi 23235.
    KEGGi hsa:23235.
    UCSCi uc001plt.3. human.

    Organism-specific databases

    CTDi 23235.
    GeneCardsi GC11P111473.
    HGNCi HGNC:21680. SIK2.
    HPAi HPA016026.
    MIMi 608973. gene.
    neXtProti NX_Q9H0K1.
    PharmGKBi PA164725750.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    InParanoidi Q9H0K1.
    KOi K16311.
    OMAi DCPRSSG.
    OrthoDBi EOG70ZZMM.
    PhylomeDBi Q9H0K1.
    TreeFami TF315213.

    Enzyme and pathway databases

    SignaLinki Q9H0K1.

    Miscellaneous databases

    ChiTaRSi SIK2. human.
    GeneWikii SNF1LK2.
    GenomeRNAii 23235.
    NextBioi 35464214.
    PROi Q9H0K1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H0K1.
    Genevestigatori Q9H0K1.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR017090. Ser/Thr_kinase_SIK1/2.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037014. Ser/Thr_PK_SNF1-like. 1 hit.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."
      Lizcano J.M., Goeransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Maekelae T.P., Hardie D.G., Alessi D.R.
      EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ENZYME REGULATION, PHOSPHORYLATION AT THR-175, MUTAGENESIS OF THR-175.
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon, LungImported and TestisImported.
    9. "A cDNA fragment encoding an active serine-kinase, Homo sapiens KIAA0781 protein."
      Takemori H.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-926.
    10. "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."
      Screaton R.A., Conkright M.D., Katoh Y., Best J.L., Canettieri G., Jeffries S., Guzman E., Niessen S., Yates J.R. III, Takemori H., Okamoto M., Montminy M.
      Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRTC2, FUNCTION.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy."
      Yang F.C., Tan B.C., Chen W.H., Lin Y.H., Huang J.Y., Chang H.Y., Sun H.Y., Hsu P.H., Liou G.G., Shen J., Chang C.J., Han C.C., Tsai M.D., Lee S.C.
      J. Biol. Chem. 288:6227-6237(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION AT LYS-53.
    15. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-458; GLN-809 AND LEU-825.

    Entry informationi

    Entry nameiSIK2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0K1
    Secondary accession number(s): A8K5B8
    , B0YJ94, O94878, Q17RV0, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3