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Q9H0J9

- PAR12_HUMAN

UniProt

Q9H0J9 - PAR12_HUMAN

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Protein
Poly [ADP-ribose] polymerase 12
Gene
PARP12, ZC3HDC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri94 – 11926C3H1-type 1
Add
BLAST
Zinc fingeri150 – 17930C3H1-type 2
Add
BLAST
Zinc fingeri180 – 20223C3H1-type 3
Add
BLAST
Zinc fingeri270 – 29728C3H1-type 4
Add
BLAST
Zinc fingeri271 – 29626C3H1-type 3
Add
BLAST

GO - Molecular functioni

  1. NAD+ ADP-ribosyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly [ADP-ribose] polymerase 12 (EC:2.4.2.30)
    Short name:
    PARP-12
    Alternative name(s):
    ADP-ribosyltransferase diphtheria toxin-like 12
    Short name:
    ARTD12
    Zinc finger CCCH domain-containing protein 1
    Gene namesi
    Name:PARP12
    Synonyms:ZC3HDC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21919. PARP12.

    Subcellular locationi

    Nucleus Inferred

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134953063.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 701701Poly [ADP-ribose] polymerase 12
    PRO_0000211341Add
    BLAST

    Proteomic databases

    MaxQBiQ9H0J9.
    PaxDbiQ9H0J9.
    PRIDEiQ9H0J9.

    PTM databases

    PhosphoSiteiQ9H0J9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H0J9.
    BgeeiQ9H0J9.
    CleanExiHS_PARP12.
    GenevestigatoriQ9H0J9.

    Organism-specific databases

    HPAiHPA003584.

    Interactioni

    Protein-protein interaction databases

    BioGridi122274. 12 interactions.
    IntActiQ9H0J9. 4 interactions.
    STRINGi9606.ENSP00000263549.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi499 – 5024
    Helixi508 – 51811
    Beta strandi524 – 53310
    Helixi535 – 55016
    Turni551 – 5544
    Beta strandi559 – 5657
    Helixi568 – 5703
    Helixi571 – 5777
    Turni581 – 5844
    Beta strandi593 – 6008
    Helixi601 – 6055
    Beta strandi611 – 62313
    Beta strandi626 – 6294
    Beta strandi649 – 6535
    Beta strandi655 – 6573
    Beta strandi660 – 6645
    Helixi666 – 6683
    Beta strandi669 – 67911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PQFX-ray2.20A/B/C/D/E/F489-684[»]
    ProteinModelPortaliQ9H0J9.
    SMRiQ9H0J9. Positions 5-231, 496-680.

    Miscellaneous databases

    EvolutionaryTraceiQ9H0J9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini298 – 36164WWE 1
    Add
    BLAST
    Domaini364 – 45895WWE 2
    Add
    BLAST
    Domaini484 – 698215PARP catalytic
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 614Poly-Ala

    Sequence similaritiesi

    Contains 2 WWE domains.

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG83866.
    HOGENOMiHOG000236279.
    HOVERGENiHBG050384.
    InParanoidiQ9H0J9.
    KOiK15259.
    OMAiRWQFLDR.
    OrthoDBiEOG7P5T0J.
    PhylomeDBiQ9H0J9.
    TreeFamiTF338389.

    Family and domain databases

    Gene3Di3.90.228.10. 1 hit.
    InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR004170. WWE-dom.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF00644. PARP. 1 hit.
    PF00642. zf-CCCH. 1 hit.
    [Graphical view]
    SMARTiSM00356. ZnF_C3H1. 3 hits.
    [Graphical view]
    PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
    PS50918. WWE. 2 hits.
    PS50103. ZF_C3H1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H0J9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQAGVVGEV TQVLCAAGGA LELPELRRRL RMGLSADALE RLLRQRGRFV    50
    VAVRAGGAAA APERVVLAAS PLRLCRAHQG SKPGCVGLCA QLHLCRFMVY 100
    GACKFLRAGK NCRNSHSLTT EHNLSVLRTH GVDHLSYNEL CQLLFQNDPW 150
    LLPEICQHYN KGDGPHGSCA FQKQCIKLHI CQYFLQGECK FGTSCKRSHD 200
    FSNSENLEKL EKLGMSSDLV SRLPTIYRNA HDIKNKSSAP SRVPPLFVPQ 250
    GTSERKDSSG SVSPNTLSQE EGDQICLYHI RKSCSFQDKC HRVHFHLPYR 300
    WQFLDRGKWE DLDNMELIEE AYCNPKIERI LCSESASTFH SHCLNFNAMT 350
    YGATQARRLS TASSVTKPPH FILTTDWIWY WSDEFGSWQE YGRQGTVHPV 400
    TTVSSSDVEK AYLAYCTPGS DGQAATLKFQ AGKHNYELDF KAFVQKNLVY 450
    GTTKKVCRRP KYVSPQDVTT MQTCNTKFPG PKSIPDYWDS SALPDPGFQK 500
    ITLSSSSEEY QKVWNLFNRT LPFYFVQKIE RVQNLALWEV YQWQKGQMQK 550
    QNGGKAVDER QLFHGTSAIF VDAICQQNFD WRVCGVHGTS YGKGSYFARD 600
    AAYSHHYSKS DTQTHTMFLA RVLVGEFVRG NASFVRPPAK EGWSNAFYDS 650
    CVNSVSDPSI FVIFEKHQVY PEYVIQYTTS SKPSVTPSIL LALGSLFSSR 700
    Q 701
    Length:701
    Mass (Da):79,064
    Last modified:March 1, 2001 - v1
    Checksum:i35152182F24CD215
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti293 – 2931V → I.
    Corresponds to variant rs34111764 [ dbSNP | Ensembl ].
    VAR_050463
    Natural varianti463 – 4631V → M.
    Corresponds to variant rs35456446 [ dbSNP | Ensembl ].
    VAR_050464
    Natural varianti620 – 6201A → V.
    Corresponds to variant rs17161356 [ dbSNP | Ensembl ].
    VAR_050465

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti444 – 4507VQKNLVY → MGGFGQH1 Publication
    Sequence conflicti462 – 4621Y → C in BAB15457. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136766 mRNA. Translation: CAB66700.1.
    AL137255 mRNA. Translation: CAB70657.1.
    AC004849 Genomic DNA. Translation: AAS00360.1.
    AC025816 Genomic DNA. Translation: AAF66161.1.
    AC004961 Genomic DNA. No translation available.
    BC081541 mRNA. Translation: AAH81541.1.
    AK026346 mRNA. Translation: BAB15457.1.
    CCDSiCCDS5857.1.
    PIRiT46327.
    RefSeqiNP_073587.1. NM_022750.2.
    UniGeneiHs.12646.
    Hs.308710.

    Genome annotation databases

    EnsembliENST00000263549; ENSP00000263549; ENSG00000059378.
    GeneIDi64761.
    KEGGihsa:64761.
    UCSCiuc003vvl.1. human.

    Polymorphism databases

    DMDMi47117630.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136766 mRNA. Translation: CAB66700.1 .
    AL137255 mRNA. Translation: CAB70657.1 .
    AC004849 Genomic DNA. Translation: AAS00360.1 .
    AC025816 Genomic DNA. Translation: AAF66161.1 .
    AC004961 Genomic DNA. No translation available.
    BC081541 mRNA. Translation: AAH81541.1 .
    AK026346 mRNA. Translation: BAB15457.1 .
    CCDSi CCDS5857.1.
    PIRi T46327.
    RefSeqi NP_073587.1. NM_022750.2.
    UniGenei Hs.12646.
    Hs.308710.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PQF X-ray 2.20 A/B/C/D/E/F 489-684 [» ]
    ProteinModelPortali Q9H0J9.
    SMRi Q9H0J9. Positions 5-231, 496-680.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 122274. 12 interactions.
    IntActi Q9H0J9. 4 interactions.
    STRINGi 9606.ENSP00000263549.

    Chemistry

    ChEMBLi CHEMBL2429709.

    PTM databases

    PhosphoSitei Q9H0J9.

    Polymorphism databases

    DMDMi 47117630.

    Proteomic databases

    MaxQBi Q9H0J9.
    PaxDbi Q9H0J9.
    PRIDEi Q9H0J9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263549 ; ENSP00000263549 ; ENSG00000059378 .
    GeneIDi 64761.
    KEGGi hsa:64761.
    UCSCi uc003vvl.1. human.

    Organism-specific databases

    CTDi 64761.
    GeneCardsi GC07M139723.
    HGNCi HGNC:21919. PARP12.
    HPAi HPA003584.
    MIMi 612481. gene.
    neXtProti NX_Q9H0J9.
    PharmGKBi PA134953063.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83866.
    HOGENOMi HOG000236279.
    HOVERGENi HBG050384.
    InParanoidi Q9H0J9.
    KOi K15259.
    OMAi RWQFLDR.
    OrthoDBi EOG7P5T0J.
    PhylomeDBi Q9H0J9.
    TreeFami TF338389.

    Miscellaneous databases

    ChiTaRSi PARP12. human.
    EvolutionaryTracei Q9H0J9.
    GeneWikii PARP12.
    GenomeRNAii 64761.
    NextBioi 66743.
    PROi Q9H0J9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H0J9.
    Bgeei Q9H0J9.
    CleanExi HS_PARP12.
    Genevestigatori Q9H0J9.

    Family and domain databases

    Gene3Di 3.90.228.10. 1 hit.
    InterProi IPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR004170. WWE-dom.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF00644. PARP. 1 hit.
    PF00642. zf-CCCH. 1 hit.
    [Graphical view ]
    SMARTi SM00356. ZnF_C3H1. 3 hits.
    [Graphical view ]
    PROSITEi PS51059. PARP_CATALYTIC. 1 hit.
    PS50918. WWE. 2 hits.
    PS50103. ZF_C3H1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 444-701.
      Tissue: Small intestine.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
      Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
      Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiPAR12_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0J9
    Secondary accession number(s): Q9H610, Q9NP36, Q9NTI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 1, 2001
    Last modified: July 9, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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