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Protein

Poly [ADP-ribose] polymerase 12

Gene

PARP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri94 – 119C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri150 – 179C3H1-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri180 – 202C3H1-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 297C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri271 – 296C3H1-type 3PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • NAD+ ADP-ribosyltransferase activity Source: UniProtKB-EC
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS00729-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 12 (EC:2.4.2.30)
Short name:
PARP-12
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 12
Short name:
ARTD12
Zinc finger CCCH domain-containing protein 1
Gene namesi
Name:PARP12
Synonyms:ZC3HDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21919. PARP12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64761.
OpenTargetsiENSG00000059378.
PharmGKBiPA134953063.

Chemistry databases

ChEMBLiCHEMBL2429709.

Polymorphism and mutation databases

BioMutaiPARP12.
DMDMi47117630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113411 – 701Poly [ADP-ribose] polymerase 12Add BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0J9.
MaxQBiQ9H0J9.
PaxDbiQ9H0J9.
PeptideAtlasiQ9H0J9.
PRIDEiQ9H0J9.

PTM databases

iPTMnetiQ9H0J9.
PhosphoSitePlusiQ9H0J9.

Expressioni

Gene expression databases

BgeeiENSG00000059378.
CleanExiHS_PARP12.
ExpressionAtlasiQ9H0J9. baseline and differential.
GenevisibleiQ9H0J9. HS.

Organism-specific databases

HPAiHPA003584.

Interactioni

Protein-protein interaction databases

BioGridi122274. 16 interactors.
IntActiQ9H0J9. 5 interactors.
STRINGi9606.ENSP00000263549.

Structurei

Secondary structure

1701
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi499 – 502Combined sources4
Helixi508 – 518Combined sources11
Beta strandi524 – 533Combined sources10
Helixi535 – 550Combined sources16
Turni551 – 554Combined sources4
Beta strandi559 – 565Combined sources7
Helixi568 – 570Combined sources3
Helixi571 – 577Combined sources7
Turni581 – 584Combined sources4
Beta strandi593 – 600Combined sources8
Helixi601 – 605Combined sources5
Beta strandi611 – 623Combined sources13
Beta strandi626 – 629Combined sources4
Beta strandi649 – 653Combined sources5
Beta strandi655 – 657Combined sources3
Beta strandi660 – 664Combined sources5
Helixi666 – 668Combined sources3
Beta strandi669 – 679Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PQFX-ray2.20A/B/C/D/E/F489-684[»]
ProteinModelPortaliQ9H0J9.
SMRiQ9H0J9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0J9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini298 – 361WWE 1PROSITE-ProRule annotationAdd BLAST64
Domaini364 – 458WWE 2PROSITE-ProRule annotationAdd BLAST95
Domaini484 – 698PARP catalyticPROSITE-ProRule annotationAdd BLAST215

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 61Poly-Ala4

Sequence similaritiesi

Contains 4 C3H1-type zinc fingers.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 2 WWE domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri94 – 119C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri150 – 179C3H1-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri180 – 202C3H1-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 297C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri271 – 296C3H1-type 3PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEI4. Eukaryota.
ENOG410ZFB8. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
HOVERGENiHBG050384.
InParanoidiQ9H0J9.
KOiK15259.
OMAiRWQFLDR.
OrthoDBiEOG091G14UY.
PhylomeDBiQ9H0J9.
TreeFamiTF338389.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAGVVGEV TQVLCAAGGA LELPELRRRL RMGLSADALE RLLRQRGRFV
60 70 80 90 100
VAVRAGGAAA APERVVLAAS PLRLCRAHQG SKPGCVGLCA QLHLCRFMVY
110 120 130 140 150
GACKFLRAGK NCRNSHSLTT EHNLSVLRTH GVDHLSYNEL CQLLFQNDPW
160 170 180 190 200
LLPEICQHYN KGDGPHGSCA FQKQCIKLHI CQYFLQGECK FGTSCKRSHD
210 220 230 240 250
FSNSENLEKL EKLGMSSDLV SRLPTIYRNA HDIKNKSSAP SRVPPLFVPQ
260 270 280 290 300
GTSERKDSSG SVSPNTLSQE EGDQICLYHI RKSCSFQDKC HRVHFHLPYR
310 320 330 340 350
WQFLDRGKWE DLDNMELIEE AYCNPKIERI LCSESASTFH SHCLNFNAMT
360 370 380 390 400
YGATQARRLS TASSVTKPPH FILTTDWIWY WSDEFGSWQE YGRQGTVHPV
410 420 430 440 450
TTVSSSDVEK AYLAYCTPGS DGQAATLKFQ AGKHNYELDF KAFVQKNLVY
460 470 480 490 500
GTTKKVCRRP KYVSPQDVTT MQTCNTKFPG PKSIPDYWDS SALPDPGFQK
510 520 530 540 550
ITLSSSSEEY QKVWNLFNRT LPFYFVQKIE RVQNLALWEV YQWQKGQMQK
560 570 580 590 600
QNGGKAVDER QLFHGTSAIF VDAICQQNFD WRVCGVHGTS YGKGSYFARD
610 620 630 640 650
AAYSHHYSKS DTQTHTMFLA RVLVGEFVRG NASFVRPPAK EGWSNAFYDS
660 670 680 690 700
CVNSVSDPSI FVIFEKHQVY PEYVIQYTTS SKPSVTPSIL LALGSLFSSR

Q
Length:701
Mass (Da):79,064
Last modified:March 1, 2001 - v1
Checksum:i35152182F24CD215
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti444 – 450VQKNLVY → MGGFGQH (PubMed:14702039).Curated7
Sequence conflicti462Y → C in BAB15457 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050463293V → I.Corresponds to variant rs34111764dbSNPEnsembl.1
Natural variantiVAR_050464463V → M.Corresponds to variant rs35456446dbSNPEnsembl.1
Natural variantiVAR_050465620A → V.Corresponds to variant rs17161356dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136766 mRNA. Translation: CAB66700.1.
AL137255 mRNA. Translation: CAB70657.1.
AC004849 Genomic DNA. Translation: AAS00360.1.
AC025816 Genomic DNA. Translation: AAF66161.1.
AC004961 Genomic DNA. No translation available.
BC081541 mRNA. Translation: AAH81541.1.
AK026346 mRNA. Translation: BAB15457.1.
CCDSiCCDS5857.1.
PIRiT46327.
RefSeqiNP_073587.1. NM_022750.3.
UniGeneiHs.12646.
Hs.308710.

Genome annotation databases

EnsembliENST00000263549; ENSP00000263549; ENSG00000059378.
GeneIDi64761.
KEGGihsa:64761.
UCSCiuc003vvl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136766 mRNA. Translation: CAB66700.1.
AL137255 mRNA. Translation: CAB70657.1.
AC004849 Genomic DNA. Translation: AAS00360.1.
AC025816 Genomic DNA. Translation: AAF66161.1.
AC004961 Genomic DNA. No translation available.
BC081541 mRNA. Translation: AAH81541.1.
AK026346 mRNA. Translation: BAB15457.1.
CCDSiCCDS5857.1.
PIRiT46327.
RefSeqiNP_073587.1. NM_022750.3.
UniGeneiHs.12646.
Hs.308710.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PQFX-ray2.20A/B/C/D/E/F489-684[»]
ProteinModelPortaliQ9H0J9.
SMRiQ9H0J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122274. 16 interactors.
IntActiQ9H0J9. 5 interactors.
STRINGi9606.ENSP00000263549.

Chemistry databases

ChEMBLiCHEMBL2429709.

PTM databases

iPTMnetiQ9H0J9.
PhosphoSitePlusiQ9H0J9.

Polymorphism and mutation databases

BioMutaiPARP12.
DMDMi47117630.

Proteomic databases

EPDiQ9H0J9.
MaxQBiQ9H0J9.
PaxDbiQ9H0J9.
PeptideAtlasiQ9H0J9.
PRIDEiQ9H0J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263549; ENSP00000263549; ENSG00000059378.
GeneIDi64761.
KEGGihsa:64761.
UCSCiuc003vvl.2. human.

Organism-specific databases

CTDi64761.
DisGeNETi64761.
GeneCardsiPARP12.
HGNCiHGNC:21919. PARP12.
HPAiHPA003584.
MIMi612481. gene.
neXtProtiNX_Q9H0J9.
OpenTargetsiENSG00000059378.
PharmGKBiPA134953063.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEI4. Eukaryota.
ENOG410ZFB8. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
HOVERGENiHBG050384.
InParanoidiQ9H0J9.
KOiK15259.
OMAiRWQFLDR.
OrthoDBiEOG091G14UY.
PhylomeDBiQ9H0J9.
TreeFamiTF338389.

Enzyme and pathway databases

BioCyciZFISH:HS00729-MONOMER.

Miscellaneous databases

ChiTaRSiPARP12. human.
EvolutionaryTraceiQ9H0J9.
GeneWikiiPARP12.
GenomeRNAii64761.
PROiQ9H0J9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000059378.
CleanExiHS_PARP12.
ExpressionAtlasiQ9H0J9. baseline and differential.
GenevisibleiQ9H0J9. HS.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR12_HUMAN
AccessioniPrimary (citable) accession number: Q9H0J9
Secondary accession number(s): Q9H610, Q9NP36, Q9NTI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.