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Protein

Glutamine-rich protein 2

Gene

QRICH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine-rich protein 2
Gene namesi
Name:QRICH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25326. QRICH2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129646.
PharmGKBiPA142671107.

Polymorphism and mutation databases

BioMutaiQRICH2.
DMDMi74717987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958141 – 1663Glutamine-rich protein 2Add BLAST1663

Proteomic databases

EPDiQ9H0J4.
PaxDbiQ9H0J4.
PeptideAtlasiQ9H0J4.
PRIDEiQ9H0J4.

PTM databases

iPTMnetiQ9H0J4.
PhosphoSitePlusiQ9H0J4.

Expressioni

Gene expression databases

BgeeiENSG00000129646.
CleanExiHS_QRICH2.
ExpressionAtlasiQ9H0J4. baseline and differential.
GenevisibleiQ9H0J4. HS.

Organism-specific databases

HPAiHPA021935.
HPA052219.

Interactioni

Protein-protein interaction databases

BioGridi123869. 6 interactors.
DIPiDIP-50256N.

Structurei

3D structure databases

ProteinModelPortaliQ9H0J4.
SMRiQ9H0J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1085 – 1160Sequence analysisAdd BLAST76
Coiled coili1286 – 1325Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi381 – 759Gln-richAdd BLAST379

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JR2U. Eukaryota.
ENOG4111JFX. LUCA.
GeneTreeiENSGT00530000064549.
HOGENOMiHOG000154055.
HOVERGENiHBG104793.
InParanoidiQ9H0J4.
OMAiMDQHGLV.
OrthoDBiEOG091G01GZ.
PhylomeDBiQ9H0J4.
TreeFamiTF334838.

Family and domain databases

InterProiIPR032013. DUF4795.
[Graphical view]
PfamiPF16043. DUF4795. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0J4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDAAEELSF ARVLLQRVDE LEKLFKDREQ FLELVSRKLS LVPGAEEVTM
60 70 80 90 100
VTWEELEQAI TDGWRASQAG SETLMGFSKH GGFTSLTSPE GTLSGDSTKQ
110 120 130 140 150
PSIEQALDSA SGLGPDRTAS GSGGTAHPSD GVSSREQSKV PSGTGRQQQP
160 170 180 190 200
RARDEAGVPR LHQSSTFQFK SDSDRHRSRE KLTSTQPRRN ARPGPVQQDL
210 220 230 240 250
PLARDQPSSV PASQSQVHLR PDRRGLEPTG MNQPGLVPAS TYPHGVVPLS
260 270 280 290 300
MGQLGVPPPE MDDRELIPFV VDEQRMLPPS VPGRDQQGLE LPSTDQHGLV
310 320 330 340 350
SVSAYQHGMT FPGTDQRSME PLGMDQRGCV ISGMGQQGLV PPGIDQQGLT
360 370 380 390 400
LPVVDQHGLV LPFTDQHGLV SPGLMPISAD QQGFVQPSLE ATGFIQPGTE
410 420 430 440 450
QHDLIQSGRF QRALVQRGAY QPGLVQPGAD QRGLVRPGMD QSGLAQPGAD
460 470 480 490 500
QRGLVWPGMD QSGLAQPGRD QHGLIQPGTG QHDLVQSGTG QGVLVQPGVD
510 520 530 540 550
QPGMVQPGRF QRALVQPGAY QPGLVQPGAD QIDVVQPGAD QHGLVQSGAD
560 570 580 590 600
QSDLAQPGAV QHGLVQPGVD QRGLAQPRAD HQRGLVPPGA DQRGLVQPGA
610 620 630 640 650
DQHGLVQPGV DQHGLAQPGE VQRSLVQPGI VQRGLVQPGA VQRGLVQPGA
660 670 680 690 700
VQRGLVQPGV DQRGLVQPGA VQRGLVQPGA VQHGLVQPGA DQRGLVQPGV
710 720 730 740 750
DQRGLVQPGV DQRGLVQPGM DQRGLIQPGA DQPGLVQPGA GQLGMVQPGI
760 770 780 790 800
GQQGMVQPQA DPHGLVQPGA YPLGLVQPGA YLHDLSQSGT YPRGLVQPGM
810 820 830 840 850
DQYGLRQPGA YQPGLIAPGT KLRGSSTFQA DSTGFISVRP YQHGMVPPGR
860 870 880 890 900
EQYGQVSPLL ASQGLASPGI DRRSLVPPET YQQGLMHPGT DQHSPIPLST
910 920 930 940 950
GLGSTHPDQQ HVASPGPGEH DQVYPDAAQH GHAFSLFDSH DSMYPGYRGP
960 970 980 990 1000
GYLSADQHGQ EGLDPNRTRA SDRHGIPAQK APGQDVTLFR SPDSVDRVLS
1010 1020 1030 1040 1050
EGSEVSSEVL SERRNSLRRM SSSFPTAVET FHLMGELSSL YVGLKESMKD
1060 1070 1080 1090 1100
LDEEQAGQTD LEKIQFLLAQ MVKRTIPPEL QEQLKTVKTL AKEVWQEKAK
1110 1120 1130 1140 1150
VERLQRILEG EGNQEAGKEL KAGELRLQLG VLRVTVADIE KELAELRESQ
1160 1170 1180 1190 1200
DRGKAAMENS VSEASLYLQD QLDKLRMIIE SMLTSSSTLL SMSMAPHKAH
1210 1220 1230 1240 1250
TLAPGQIDPE ATCPACSLDV SHQVSTLVRR YEQLQDMVNS LAVSRPSKKA
1260 1270 1280 1290 1300
KLQRQDEELL GRVQSAILQV QGDCEKLNIT TSNLIEDHRQ KQKDIAMLYQ
1310 1320 1330 1340 1350
GLEKLEKEKA NREHLEMEID VKADKSALAT KVSRVQFDAT TEQLNHMMQE
1360 1370 1380 1390 1400
LVAKMSGQEQ DWQKMLDRLL TEMDNKLDRL ELDPVKQLLE DRWKSLRQQL
1410 1420 1430 1440 1450
RERPPLYQAD EAAAMRRQLL AHFHCLSCDR PLETPVTGHA IPVTPAGPGL
1460 1470 1480 1490 1500
PGHHSIRPYT VFELEQVRQH SRNLKLGSAF PRGDLAQMEQ SVGRLRSMHS
1510 1520 1530 1540 1550
KMLMNIEKVQ IHFGGSTKAS SQIIRELLHA QCLGSPCYKR VTDMADYTYS
1560 1570 1580 1590 1600
TVPRRCGGSH TLTYPYHRSR PQHLPRGLYP TEEIQIAMKH DEVDILGLDG
1610 1620 1630 1640 1650
HIYKGRMDTR LPGILRKDSS GTSKRKSQQP RPHVHRPPSL SSNGQLPSRP
1660
QSAQISAGNT SER
Length:1,663
Mass (Da):180,827
Last modified:March 1, 2001 - v1
Checksum:i62E1441FEF5C4DEE
GO
Isoform 2 (identifier: Q9H0J4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1375-1375: N → A
     1376-1609: Missing.

Note: No experimental confirmation available.
Show »
Length:1,429
Mass (Da):154,070
Checksum:iBE4BAC832CCEC479
GO
Isoform 3 (identifier: Q9H0J4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1156: Missing.

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):57,425
Checksum:iF41467537699549C
GO

Sequence cautioni

The sequence BAB71667 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051295202L → S.Corresponds to variant rs6501880dbSNPEnsembl.1
Natural variantiVAR_051296630I → T.Corresponds to variant rs6501878dbSNPEnsembl.1
Natural variantiVAR_059711630I → V.Corresponds to variant rs6501879dbSNPEnsembl.1
Natural variantiVAR_059712681V → D.Corresponds to variant rs6501874dbSNPEnsembl.1
Natural variantiVAR_051297906H → Y.Corresponds to variant rs2279054dbSNPEnsembl.1
Natural variantiVAR_051298974H → R.Corresponds to variant rs2279053dbSNPEnsembl.1
Natural variantiVAR_0512991036E → Q.1 PublicationCorresponds to variant rs2279052dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0271011 – 1156Missing in isoform 3. 1 PublicationAdd BLAST1156
Alternative sequenceiVSP_0271021375N → A in isoform 2. 1 Publication1
Alternative sequenceiVSP_0271031376 – 1609Missing in isoform 2. 1 PublicationAdd BLAST234

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136774 mRNA. Translation: CAB66708.1.
BC131559 mRNA. Translation: AAI31560.1.
AK058102 mRNA. Translation: BAB71667.1. Different initiation.
CCDSiCCDS32741.1. [Q9H0J4-1]
RefSeqiNP_115510.1. NM_032134.2. [Q9H0J4-1]
UniGeneiHs.252739.

Genome annotation databases

EnsembliENST00000262765; ENSP00000262765; ENSG00000129646. [Q9H0J4-1]
GeneIDi84074.
KEGGihsa:84074.
UCSCiuc002jrd.1. human. [Q9H0J4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136774 mRNA. Translation: CAB66708.1.
BC131559 mRNA. Translation: AAI31560.1.
AK058102 mRNA. Translation: BAB71667.1. Different initiation.
CCDSiCCDS32741.1. [Q9H0J4-1]
RefSeqiNP_115510.1. NM_032134.2. [Q9H0J4-1]
UniGeneiHs.252739.

3D structure databases

ProteinModelPortaliQ9H0J4.
SMRiQ9H0J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123869. 6 interactors.
DIPiDIP-50256N.

PTM databases

iPTMnetiQ9H0J4.
PhosphoSitePlusiQ9H0J4.

Polymorphism and mutation databases

BioMutaiQRICH2.
DMDMi74717987.

Proteomic databases

EPDiQ9H0J4.
PaxDbiQ9H0J4.
PeptideAtlasiQ9H0J4.
PRIDEiQ9H0J4.

Protocols and materials databases

DNASUi84074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262765; ENSP00000262765; ENSG00000129646. [Q9H0J4-1]
GeneIDi84074.
KEGGihsa:84074.
UCSCiuc002jrd.1. human. [Q9H0J4-1]

Organism-specific databases

CTDi84074.
GeneCardsiQRICH2.
HGNCiHGNC:25326. QRICH2.
HPAiHPA021935.
HPA052219.
neXtProtiNX_Q9H0J4.
OpenTargetsiENSG00000129646.
PharmGKBiPA142671107.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JR2U. Eukaryota.
ENOG4111JFX. LUCA.
GeneTreeiENSGT00530000064549.
HOGENOMiHOG000154055.
HOVERGENiHBG104793.
InParanoidiQ9H0J4.
OMAiMDQHGLV.
OrthoDBiEOG091G01GZ.
PhylomeDBiQ9H0J4.
TreeFamiTF334838.

Miscellaneous databases

ChiTaRSiQRICH2. human.
GenomeRNAii84074.
PROiQ9H0J4.

Gene expression databases

BgeeiENSG00000129646.
CleanExiHS_QRICH2.
ExpressionAtlasiQ9H0J4. baseline and differential.
GenevisibleiQ9H0J4. HS.

Family and domain databases

InterProiIPR032013. DUF4795.
[Graphical view]
PfamiPF16043. DUF4795. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQRIC2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0J4
Secondary accession number(s): A2RRE1, Q96LM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.