ID ENKD1_HUMAN Reviewed; 346 AA. AC Q9H0I2; Q6UWD7; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 27-MAR-2024, entry version 160. DE RecName: Full=Enkurin domain-containing protein 1; GN Name=ENKD1; Synonyms=C16orf48; ORFNames=UNQ6410/PRO21183; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=11230166; DOI=10.1101/gr.gr1547r; RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B., RA Klein M., Poustka A.; RT "Towards a catalog of human genes and proteins: sequencing and analysis of RT 500 novel complete protein coding human cDNAs."; RL Genome Res. 11:422-435(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91 AND SER-136, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [5] RP FUNCTION, INTERACTION WITH ALPHA-TUBULIN, AND DEVELOPMENTAL STAGE. RX PubMed=35197565; DOI=10.1038/s41418-022-00958-5; RA Zhong T., Wu X., Xie W., Luo X., Song T., Sun S., Luo Y., Li D., Liu M., RA Xie S., Zhou J.; RT "ENKD1 promotes epidermal stratification by regulating spindle orientation RT in basal keratinocytes."; RL Cell Death Differ. 0:0-0(2022). RN [6] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=35301795; DOI=10.15252/embr.202154090; RA Song T., Yang Y., Zhou P., Ran J., Zhang L., Wu X., Xie W., Zhong T., RA Liu H., Liu M., Li D., Zhao H., Zhou J.; RT "ENKD1 promotes CP110 removal through competing with CEP97 to initiate RT ciliogenesis."; RL EMBO Rep. 23:e54090-e54090(2022). RN [7] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=35072334; DOI=10.1111/febs.16367; RA Tiryaki F., Deretic J., Firat-Karalar E.N.; RT "ENKD1 is a centrosomal and ciliary microtubule-associated protein RT important for primary cilium content regulation."; RL FEBS J. 289:3789-3812(2022). CC -!- FUNCTION: Microtubule-binding protein which regulates microtubule CC organization and stability (PubMed:35197565, PubMed:35072334). Promotes CC the stability of astral microtubules and facilitates the proper CC orientation of the mitotic spindle (PubMed:35197565). This allows the CC oriented division of basal keratinocytes and contributes to epidermal CC stratification (By similarity). Required for the assembly of both CC primary and motile cilia (PubMed:35301795). Destabilizes the CC interaction between CCP110 and CEP97 by competing with CEP97 for CC binding to CCP110 which promotes the removal of CCP110 and CEP97 from CC the mother centriole and allows the initiation of ciliogenesis CC (PubMed:35301795). {ECO:0000250|UniProtKB:Q7TSV9, CC ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35197565, CC ECO:0000269|PubMed:35301795}. CC -!- SUBUNIT: Interacts with alpha-tubulin (PubMed:35197565). Interacts (via CC central region) with CCP110 (via N-terminal region); competes with CC CEP97 for binding to CCP110 (By similarity). CC {ECO:0000250|UniProtKB:Q7TSV9, ECO:0000269|PubMed:35197565}. CC -!- INTERACTION: CC Q9H0I2; Q8IZP0-5: ABI1; NbExp=3; IntAct=EBI-744099, EBI-11743294; CC Q9H0I2; Q9NYB9-2: ABI2; NbExp=6; IntAct=EBI-744099, EBI-11096309; CC Q9H0I2; O00154-4: ACOT7; NbExp=3; IntAct=EBI-744099, EBI-12007918; CC Q9H0I2; Q5BKX5-3: ACTMAP; NbExp=3; IntAct=EBI-744099, EBI-11976299; CC Q9H0I2; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-744099, EBI-357530; CC Q9H0I2; Q86SG2: ANKRD23; NbExp=3; IntAct=EBI-744099, EBI-5661893; CC Q9H0I2; Q8WVL7: ANKRD49; NbExp=3; IntAct=EBI-744099, EBI-9381820; CC Q9H0I2; Q96C12: ARMC5; NbExp=3; IntAct=EBI-744099, EBI-6425121; CC Q9H0I2; P15289: ARSA; NbExp=3; IntAct=EBI-744099, EBI-2117357; CC Q9H0I2; Q9Y575-3: ASB3; NbExp=3; IntAct=EBI-744099, EBI-14199987; CC Q9H0I2; Q5T686: AVPI1; NbExp=3; IntAct=EBI-744099, EBI-8640233; CC Q9H0I2; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-744099, EBI-11524452; CC Q9H0I2; O75934: BCAS2; NbExp=3; IntAct=EBI-744099, EBI-1050106; CC Q9H0I2; Q8TDM0-3: BCAS4; NbExp=3; IntAct=EBI-744099, EBI-13025473; CC Q9H0I2; Q9BUH8: BEGAIN; NbExp=4; IntAct=EBI-744099, EBI-742722; CC Q9H0I2; Q00994: BEX3; NbExp=3; IntAct=EBI-744099, EBI-741753; CC Q9H0I2; Q9H2G9: BLZF1; NbExp=5; IntAct=EBI-744099, EBI-2548012; CC Q9H0I2; Q6PJG6: BRAT1; NbExp=3; IntAct=EBI-744099, EBI-10826195; CC Q9H0I2; O95561: C1orf105; NbExp=3; IntAct=EBI-744099, EBI-10191951; CC Q9H0I2; Q9P1Z2: CALCOCO1; NbExp=3; IntAct=EBI-744099, EBI-749920; CC Q9H0I2; Q13137: CALCOCO2; NbExp=4; IntAct=EBI-744099, EBI-739580; CC Q9H0I2; Q9Y3M2: CBY1; NbExp=3; IntAct=EBI-744099, EBI-947308; CC Q9H0I2; Q8NA61: CBY2; NbExp=3; IntAct=EBI-744099, EBI-741724; CC Q9H0I2; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-744099, EBI-11524851; CC Q9H0I2; Q68D86: CCDC102B; NbExp=6; IntAct=EBI-744099, EBI-10171570; CC Q9H0I2; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-744099, EBI-10961312; CC Q9H0I2; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-744099, EBI-10171416; CC Q9H0I2; Q9BUN5-3: CCDC28B; NbExp=3; IntAct=EBI-744099, EBI-12920646; CC Q9H0I2; Q9BXL8: CDCA4; NbExp=3; IntAct=EBI-744099, EBI-1773949; CC Q9H0I2; Q6NVV7: CDPF1; NbExp=3; IntAct=EBI-744099, EBI-2802782; CC Q9H0I2; Q01850: CDR2; NbExp=6; IntAct=EBI-744099, EBI-1181367; CC Q9H0I2; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-744099, EBI-747776; CC Q9H0I2; Q8NHQ1: CEP70; NbExp=4; IntAct=EBI-744099, EBI-739624; CC Q9H0I2; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-744099, EBI-743375; CC Q9H0I2; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-744099, EBI-741528; CC Q9H0I2; Q6WN34-2: CHRDL2; NbExp=3; IntAct=EBI-744099, EBI-12593838; CC Q9H0I2; Q96BR5: COA7; NbExp=3; IntAct=EBI-744099, EBI-6269632; CC Q9H0I2; P56545-3: CTBP2; NbExp=3; IntAct=EBI-744099, EBI-10171902; CC Q9H0I2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-744099, EBI-3867333; CC Q9H0I2; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-744099, EBI-740680; CC Q9H0I2; Q16610: ECM1; NbExp=3; IntAct=EBI-744099, EBI-947964; CC Q9H0I2; Q5T9C2: EEIG1; NbExp=3; IntAct=EBI-744099, EBI-10246318; CC Q9H0I2; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-744099, EBI-2349927; CC Q9H0I2; Q04637-9: EIF4G1; NbExp=3; IntAct=EBI-744099, EBI-12012124; CC Q9H0I2; O00167-2: EYA2; NbExp=3; IntAct=EBI-744099, EBI-12807776; CC Q9H0I2; Q86X51: EZHIP; NbExp=3; IntAct=EBI-744099, EBI-12827735; CC Q9H0I2; Q86W67: FAM228A; NbExp=3; IntAct=EBI-744099, EBI-12958227; CC Q9H0I2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-744099, EBI-6658203; CC Q9H0I2; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-744099, EBI-11958845; CC Q9H0I2; O75344: FKBP6; NbExp=3; IntAct=EBI-744099, EBI-744771; CC Q9H0I2; P01100: FOS; NbExp=3; IntAct=EBI-744099, EBI-852851; CC Q9H0I2; P53539: FOSB; NbExp=3; IntAct=EBI-744099, EBI-2806743; CC Q9H0I2; O95073: FSBP; NbExp=3; IntAct=EBI-744099, EBI-1059030; CC Q9H0I2; A1L4K1: FSD2; NbExp=3; IntAct=EBI-744099, EBI-5661036; CC Q9H0I2; O95257: GADD45G; NbExp=5; IntAct=EBI-744099, EBI-448202; CC Q9H0I2; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-744099, EBI-372506; CC Q9H0I2; Q7L5D6: GET4; NbExp=3; IntAct=EBI-744099, EBI-711823; CC Q9H0I2; P14136: GFAP; NbExp=3; IntAct=EBI-744099, EBI-744302; CC Q9H0I2; O75420: GIGYF1; NbExp=3; IntAct=EBI-744099, EBI-947774; CC Q9H0I2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-744099, EBI-618309; CC Q9H0I2; Q9NYA3: GOLGA6A; NbExp=3; IntAct=EBI-744099, EBI-11163335; CC Q9H0I2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-744099, EBI-5916454; CC Q9H0I2; Q6PI77: GPRASP3; NbExp=3; IntAct=EBI-744099, EBI-11519926; CC Q9H0I2; Q8TE85-2: GRHL3; NbExp=3; IntAct=EBI-744099, EBI-12827521; CC Q9H0I2; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-744099, EBI-717919; CC Q9H0I2; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-744099, EBI-2549423; CC Q9H0I2; Q9UGU5: HMGXB4; NbExp=3; IntAct=EBI-744099, EBI-7261162; CC Q9H0I2; P31943: HNRNPH1; NbExp=3; IntAct=EBI-744099, EBI-351590; CC Q9H0I2; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-744099, EBI-10961706; CC Q9H0I2; P49639: HOXA1; NbExp=5; IntAct=EBI-744099, EBI-740785; CC Q9H0I2; O75031: HSF2BP; NbExp=3; IntAct=EBI-744099, EBI-7116203; CC Q9H0I2; Q16082: HSPB2; NbExp=3; IntAct=EBI-744099, EBI-739395; CC Q9H0I2; Q02363: ID2; NbExp=3; IntAct=EBI-744099, EBI-713450; CC Q9H0I2; P05019-2: IGF1; NbExp=3; IntAct=EBI-744099, EBI-12837046; CC Q9H0I2; P24592: IGFBP6; NbExp=3; IntAct=EBI-744099, EBI-947015; CC Q9H0I2; Q9Y6K9: IKBKG; NbExp=3; IntAct=EBI-744099, EBI-81279; CC Q9H0I2; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-744099, EBI-747204; CC Q9H0I2; Q96N16: JAKMIP1; NbExp=3; IntAct=EBI-744099, EBI-2680803; CC Q9H0I2; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-744099, EBI-3437878; CC Q9H0I2; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-744099, EBI-14069005; CC Q9H0I2; Q9BS75: KLHL20; NbExp=3; IntAct=EBI-744099, EBI-10693436; CC Q9H0I2; Q53HC5: KLHL26; NbExp=3; IntAct=EBI-744099, EBI-724915; CC Q9H0I2; P02533: KRT14; NbExp=3; IntAct=EBI-744099, EBI-702178; CC Q9H0I2; P19012: KRT15; NbExp=3; IntAct=EBI-744099, EBI-739566; CC Q9H0I2; Q15323: KRT31; NbExp=3; IntAct=EBI-744099, EBI-948001; CC Q9H0I2; Q92764: KRT35; NbExp=3; IntAct=EBI-744099, EBI-1058674; CC Q9H0I2; Q6A162: KRT40; NbExp=3; IntAct=EBI-744099, EBI-10171697; CC Q9H0I2; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-744099, EBI-10172150; CC Q9H0I2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-744099, EBI-10171774; CC Q9H0I2; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-744099, EBI-1052037; CC Q9H0I2; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-744099, EBI-10210845; CC Q9H0I2; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-744099, EBI-11953846; CC Q9H0I2; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-744099, EBI-12811111; CC Q9H0I2; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-744099, EBI-1048945; CC Q9H0I2; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-744099, EBI-12805508; CC Q9H0I2; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-744099, EBI-10302392; CC Q9H0I2; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-744099, EBI-3958099; CC Q9H0I2; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-744099, EBI-11962084; CC Q9H0I2; Q8IYD9: LAS2; NbExp=3; IntAct=EBI-744099, EBI-749878; CC Q9H0I2; O95751: LDOC1; NbExp=3; IntAct=EBI-744099, EBI-740738; CC Q9H0I2; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-744099, EBI-12039345; CC Q9H0I2; Q9HAP6: LIN7B; NbExp=3; IntAct=EBI-744099, EBI-821335; CC Q9H0I2; P25791-3: LMO2; NbExp=3; IntAct=EBI-744099, EBI-11959475; CC Q9H0I2; Q9BV99: LRRC61; NbExp=3; IntAct=EBI-744099, EBI-2350424; CC Q9H0I2; Q96LR2: LURAP1; NbExp=3; IntAct=EBI-744099, EBI-741355; CC Q9H0I2; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-744099, EBI-1216080; CC Q9H0I2; P45984: MAPK9; NbExp=3; IntAct=EBI-744099, EBI-713568; CC Q9H0I2; O95460-2: MATN4; NbExp=3; IntAct=EBI-744099, EBI-12072296; CC Q9H0I2; Q99750: MDFI; NbExp=8; IntAct=EBI-744099, EBI-724076; CC Q9H0I2; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-744099, EBI-18582591; CC Q9H0I2; Q14696: MESD; NbExp=3; IntAct=EBI-744099, EBI-6165891; CC Q9H0I2; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-744099, EBI-8487781; CC Q9H0I2; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-744099, EBI-10172526; CC Q9H0I2; A9UHW6-2: MIF4GD; NbExp=3; IntAct=EBI-744099, EBI-9118295; CC Q9H0I2; Q8TD10: MIPOL1; NbExp=6; IntAct=EBI-744099, EBI-2548751; CC Q9H0I2; Q8IVT2: MISP; NbExp=3; IntAct=EBI-744099, EBI-2555085; CC Q9H0I2; Q13064: MKRN3; NbExp=4; IntAct=EBI-744099, EBI-2340269; CC Q9H0I2; P40692: MLH1; NbExp=3; IntAct=EBI-744099, EBI-744248; CC Q9H0I2; Q6PF18: MORN3; NbExp=3; IntAct=EBI-744099, EBI-9675802; CC Q9H0I2; Q5VZ52: MORN5; NbExp=3; IntAct=EBI-744099, EBI-12835568; CC Q9H0I2; Q6NTE8: MRNIP; NbExp=3; IntAct=EBI-744099, EBI-2857471; CC Q9H0I2; Q13084: MRPL28; NbExp=3; IntAct=EBI-744099, EBI-723426; CC Q9H0I2; Q96DV4: MRPL38; NbExp=3; IntAct=EBI-744099, EBI-720441; CC Q9H0I2; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-744099, EBI-11522433; CC Q9H0I2; P13349: MYF5; NbExp=5; IntAct=EBI-744099, EBI-17491620; CC Q9H0I2; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-744099, EBI-5662487; CC Q9H0I2; O15049: N4BP3; NbExp=3; IntAct=EBI-744099, EBI-2512055; CC Q9H0I2; Q15742: NAB2; NbExp=3; IntAct=EBI-744099, EBI-8641936; CC Q9H0I2; Q9NZQ3-3: NCKIPSD; NbExp=3; IntAct=EBI-744099, EBI-10963850; CC Q9H0I2; P17568: NDUFB7; NbExp=3; IntAct=EBI-744099, EBI-1246238; CC Q9H0I2; I6L9F6: NEFL; NbExp=3; IntAct=EBI-744099, EBI-10178578; CC Q9H0I2; P25963: NFKBIA; NbExp=3; IntAct=EBI-744099, EBI-307386; CC Q9H0I2; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-744099, EBI-12868744; CC Q9H0I2; A6NGQ2: OOEP; NbExp=3; IntAct=EBI-744099, EBI-18583589; CC Q9H0I2; Q9P286: PAK5; NbExp=3; IntAct=EBI-744099, EBI-741896; CC Q9H0I2; Q9NVD7: PARVA; NbExp=3; IntAct=EBI-744099, EBI-747655; CC Q9H0I2; Q9NR12: PDLIM7; NbExp=6; IntAct=EBI-744099, EBI-350517; CC Q9H0I2; Q17RL8: PDZD4; NbExp=3; IntAct=EBI-744099, EBI-10239064; CC Q9H0I2; Q8IXK0: PHC2; NbExp=4; IntAct=EBI-744099, EBI-713786; CC Q9H0I2; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-744099, EBI-14066006; CC Q9H0I2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-744099, EBI-79165; CC Q9H0I2; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-744099, EBI-10232538; CC Q9H0I2; Q92569: PIK3R3; NbExp=3; IntAct=EBI-744099, EBI-79893; CC Q9H0I2; Q96KN3: PKNOX2; NbExp=3; IntAct=EBI-744099, EBI-2692890; CC Q9H0I2; Q8ND90: PNMA1; NbExp=4; IntAct=EBI-744099, EBI-302345; CC Q9H0I2; Q9UL42: PNMA2; NbExp=7; IntAct=EBI-744099, EBI-302355; CC Q9H0I2; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-744099, EBI-5452779; CC Q9H0I2; Q969Q6: PPP2R3C; NbExp=3; IntAct=EBI-744099, EBI-2561661; CC Q9H0I2; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-744099, EBI-3957793; CC Q9H0I2; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-744099, EBI-11320284; CC Q9H0I2; Q9BYM8: RBCK1; NbExp=3; IntAct=EBI-744099, EBI-2340624; CC Q9H0I2; P57052: RBM11; NbExp=3; IntAct=EBI-744099, EBI-741332; CC Q9H0I2; Q15293: RCN1; NbExp=3; IntAct=EBI-744099, EBI-948278; CC Q9H0I2; Q92622: RUBCN; NbExp=3; IntAct=EBI-744099, EBI-2952709; CC Q9H0I2; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-744099, EBI-11957366; CC Q9H0I2; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-744099, EBI-748621; CC Q9H0I2; Q16348: SLC15A2; NbExp=3; IntAct=EBI-744099, EBI-12806032; CC Q9H0I2; Q9H7B4: SMYD3; NbExp=3; IntAct=EBI-744099, EBI-347919; CC Q9H0I2; Q6IEG0: SNRNP48; NbExp=3; IntAct=EBI-744099, EBI-2876632; CC Q9H0I2; O60504: SORBS3; NbExp=3; IntAct=EBI-744099, EBI-741237; CC Q9H0I2; Q5T0L3: SPATA46; NbExp=3; IntAct=EBI-744099, EBI-750105; CC Q9H0I2; O95238: SPDEF; NbExp=3; IntAct=EBI-744099, EBI-12811275; CC Q9H0I2; Q92563: SPOCK2; NbExp=3; IntAct=EBI-744099, EBI-311086; CC Q9H0I2; Q6PJ21: SPSB3; NbExp=6; IntAct=EBI-744099, EBI-3937206; CC Q9H0I2; Q8IXS7: SRGAP3; NbExp=3; IntAct=EBI-744099, EBI-18616594; CC Q9H0I2; Q96MF2: STAC3; NbExp=4; IntAct=EBI-744099, EBI-745680; CC Q9H0I2; Q9NZ72: STMN3; NbExp=3; IntAct=EBI-744099, EBI-725557; CC Q9H0I2; Q08AL9: STXBP4; NbExp=3; IntAct=EBI-744099, EBI-10318905; CC Q9H0I2; Q96A09: TENT5B; NbExp=3; IntAct=EBI-744099, EBI-752030; CC Q9H0I2; P19237: TNNI1; NbExp=3; IntAct=EBI-744099, EBI-746692; CC Q9H0I2; Q63HR2: TNS2; NbExp=3; IntAct=EBI-744099, EBI-949753; CC Q9H0I2; Q96NM4-3: TOX2; NbExp=3; IntAct=EBI-744099, EBI-12815137; CC Q9H0I2; Q13077: TRAF1; NbExp=3; IntAct=EBI-744099, EBI-359224; CC Q9H0I2; Q12933: TRAF2; NbExp=7; IntAct=EBI-744099, EBI-355744; CC Q9H0I2; P36406: TRIM23; NbExp=3; IntAct=EBI-744099, EBI-740098; CC Q9H0I2; P14373: TRIM27; NbExp=3; IntAct=EBI-744099, EBI-719493; CC Q9H0I2; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-744099, EBI-17716262; CC Q9H0I2; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-744099, EBI-2130429; CC Q9H0I2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-744099, EBI-12806590; CC Q9H0I2; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-744099, EBI-372432; CC Q9H0I2; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-744099, EBI-9090990; CC Q9H0I2; Q5T124: UBXN11; NbExp=3; IntAct=EBI-744099, EBI-746004; CC Q9H0I2; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-744099, EBI-11524408; CC Q9H0I2; Q9Y6N9-4: USH1C; NbExp=3; IntAct=EBI-744099, EBI-11523636; CC Q9H0I2; Q495M9: USH1G; NbExp=3; IntAct=EBI-744099, EBI-8601749; CC Q9H0I2; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-744099, EBI-739895; CC Q9H0I2; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-744099, EBI-14096082; CC Q9H0I2; P61758: VBP1; NbExp=3; IntAct=EBI-744099, EBI-357430; CC Q9H0I2; Q9H9H4: VPS37B; NbExp=3; IntAct=EBI-744099, EBI-4400866; CC Q9H0I2; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-744099, EBI-11957238; CC Q9H0I2; O43379: WDR62; NbExp=4; IntAct=EBI-744099, EBI-714790; CC Q9H0I2; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-744099, EBI-12040603; CC Q9H0I2; O43829: ZBTB14; NbExp=3; IntAct=EBI-744099, EBI-10176632; CC Q9H0I2; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-744099, EBI-14104088; CC Q9H0I2; Q8TF47: ZFP90; NbExp=3; IntAct=EBI-744099, EBI-11419867; CC Q9H0I2; P52747: ZNF143; NbExp=3; IntAct=EBI-744099, EBI-2849334; CC Q9H0I2; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-744099, EBI-743265; CC Q9H0I2; Q9C0F3: ZNF436; NbExp=3; IntAct=EBI-744099, EBI-8489702; CC Q9H0I2; Q8NB15: ZNF511; NbExp=3; IntAct=EBI-744099, EBI-10269136; CC Q9H0I2; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-744099, EBI-745520; CC Q9H0I2; P36508: ZNF76; NbExp=3; IntAct=EBI-744099, EBI-7254550; CC Q9H0I2; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-744099, EBI-10251462; CC Q9H0I2; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-744099, EBI-527853; CC Q9H0I2; A0A1U9X8X8; NbExp=3; IntAct=EBI-744099, EBI-17234977; CC Q9H0I2; Q6ZN96; NbExp=3; IntAct=EBI-744099, EBI-10255097; CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing CC center, centrosome {ECO:0000269|PubMed:35072334, CC ECO:0000269|PubMed:35301795}. Cytoplasm, cytoskeleton, microtubule CC organizing center, centrosome, centriole {ECO:0000269|PubMed:35301795}. CC Cytoplasm, cytoskeleton, cilium basal body CC {ECO:0000269|PubMed:35301795}. Cell projection, cilium CC {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, spindle CC {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, spindle pole CC {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, cilium axoneme CC {ECO:0000269|PubMed:35072334}. Note=Localized at the centrosome and CC accumulates at the parental centrioles during centriole duplication in CC cycling cells (PubMed:35301795). In ciliated cells, detected at the CC basal body of the cilium (PubMed:35301795). Localizes to the centrosome CC during interphase, to the primary cilium at G0, to the spindle poles CC during mitosis and to the centrosomes and central spindle during CC telophase and cytokinesis (PubMed:35072334). CC {ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35301795}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9H0I2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9H0I2-2; Sequence=VSP_021904, VSP_021905; CC -!- DEVELOPMENTAL STAGE: During the cell cycle, highly expressed in S, G2 CC and M phases. {ECO:0000269|PubMed:35197565}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL136786; CAB66720.1; -; mRNA. DR EMBL; AY358834; AAQ89193.1; -; mRNA. DR EMBL; BC008284; AAH08284.1; -; mRNA. DR CCDS; CCDS10844.1; -. [Q9H0I2-1] DR RefSeq; NP_115516.1; NM_032140.2. [Q9H0I2-1] DR AlphaFoldDB; Q9H0I2; -. DR SMR; Q9H0I2; -. DR BioGRID; 123875; 224. DR IntAct; Q9H0I2; 226. DR MINT; Q9H0I2; -. DR STRING; 9606.ENSP00000243878; -. DR iPTMnet; Q9H0I2; -. DR PhosphoSitePlus; Q9H0I2; -. DR BioMuta; ENKD1; -. DR DMDM; 74752565; -. DR EPD; Q9H0I2; -. DR jPOST; Q9H0I2; -. DR MassIVE; Q9H0I2; -. DR MaxQB; Q9H0I2; -. DR PaxDb; 9606-ENSP00000243878; -. DR PeptideAtlas; Q9H0I2; -. DR ProteomicsDB; 80281; -. [Q9H0I2-1] DR ProteomicsDB; 80282; -. [Q9H0I2-2] DR Pumba; Q9H0I2; -. DR Antibodypedia; 29606; 150 antibodies from 18 providers. DR DNASU; 84080; -. DR Ensembl; ENST00000243878.9; ENSP00000243878.4; ENSG00000124074.12. [Q9H0I2-1] DR GeneID; 84080; -. DR KEGG; hsa:84080; -. DR MANE-Select; ENST00000243878.9; ENSP00000243878.4; NM_032140.3; NP_115516.1. DR UCSC; uc002etw.2; human. [Q9H0I2-1] DR AGR; HGNC:25246; -. DR CTD; 84080; -. DR DisGeNET; 84080; -. DR GeneCards; ENKD1; -. DR HGNC; HGNC:25246; ENKD1. DR HPA; ENSG00000124074; Low tissue specificity. DR neXtProt; NX_Q9H0I2; -. DR OpenTargets; ENSG00000124074; -. DR PharmGKB; PA142672256; -. DR VEuPathDB; HostDB:ENSG00000124074; -. DR eggNOG; ENOG502QU1P; Eukaryota. DR GeneTree; ENSGT00940000153866; -. DR HOGENOM; CLU_068901_0_0_1; -. DR InParanoid; Q9H0I2; -. DR OMA; ERKDHWR; -. DR OrthoDB; 3184110at2759; -. DR PhylomeDB; Q9H0I2; -. DR TreeFam; TF328494; -. DR PathwayCommons; Q9H0I2; -. DR SignaLink; Q9H0I2; -. DR BioGRID-ORCS; 84080; 29 hits in 1155 CRISPR screens. DR ChiTaRS; ENKD1; human. DR GeneWiki; C16orf48; -. DR GenomeRNAi; 84080; -. DR Pharos; Q9H0I2; Tdark. DR PRO; PR:Q9H0I2; -. DR Proteomes; UP000005640; Chromosome 16. DR RNAct; Q9H0I2; Protein. DR Bgee; ENSG00000124074; Expressed in body of pancreas and 157 other cell types or tissues. DR ExpressionAtlas; Q9H0I2; baseline and differential. DR GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl. DR GO; GO:0005814; C:centriole; IDA:UniProtKB. DR GO; GO:0005813; C:centrosome; IDA:UniProtKB. DR GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB. DR GO; GO:0097546; C:ciliary base; IEA:Ensembl. DR GO; GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB. DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:LIFEdb. DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. DR GO; GO:0043014; F:alpha-tubulin binding; IDA:UniProtKB. DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB. DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IMP:UniProtKB. DR GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB. DR GO; GO:1905515; P:non-motile cilium assembly; IMP:UniProtKB. DR InterPro; IPR027012; Enkurin_dom. DR PANTHER; PTHR21490:SF2; ENKURIN DOMAIN-CONTAINING PROTEIN 1; 1. DR PANTHER; PTHR21490; UNCHARACTERIZED; 1. DR Pfam; PF13864; Enkurin; 1. DR PROSITE; PS51665; ENKURIN; 1. DR Genevisible; Q9H0I2; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cell projection; Cilium biogenesis/degradation; KW Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome. FT CHAIN 1..346 FT /note="Enkurin domain-containing protein 1" FT /id="PRO_0000265931" FT DOMAIN 251..343 FT /note="Enkurin" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01000" FT REGION 1..35 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 91..171 FT /note="Required for binding to microtubules" FT /evidence="ECO:0000269|PubMed:35197565" FT REGION 114..137 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 167..197 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 260..280 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 176..192 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 91 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 136 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT VAR_SEQ 1..118 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:12975309" FT /id="VSP_021904" FT VAR_SEQ 119..149 FT /note="ERSREQGQPRPLKALWRSPKYDKVESRVKAQ -> MDAKVRRAKMARVLQLE FT PQTSACLLSLLCPA (in isoform 2)" FT /evidence="ECO:0000303|PubMed:12975309" FT /id="VSP_021905" SQ SEQUENCE 346 AA; 38759 MW; EDB07D64A0BB23FF CRC64; MCEGPSRISG PIPPDPTLCP DNYRRPTSAQ GRLEGNALKL DLLTSDRALD TTAPRGPCIG PGAGEILERG QRGVGDVLLQ LEGISLGPGA SLKRKDPKDH EKENLRRIRE IQKRFREQER SREQGQPRPL KALWRSPKYD KVESRVKAQL QEPGPASGTE SAHFLRAHSR CGPGLPPPHV SSPQPTPPGP EAKEPGLGVD FIRHNARAAK RAPRRHSCSL QVLAQVLEQQ RQAQEHYNAT QKGHVPHYLL ERRDLWRREA EARKQSQPDP AMPPGHTRMP ENQRLETLTK LLQSQSQLLR ELVLLPAGAD SLRAQSHRAE LDRKLVQVEE AIKIFSRPKV FVKMDD //