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Protein

Integrator complex subunit 2

Gene

INTS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

GO - Biological processi

  • snRNA processing Source: HGNC
  • snRNA transcription from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 2
Short name:
Int2
Gene namesi
Name:INTS2
Synonyms:KIAA1287
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29241. INTS2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei428 – 44417HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • integrator complex Source: HGNC
  • intracellular Source: LIFEdb
  • membrane Source: UniProtKB
  • nuclear membrane Source: UniProtKB-SubCell
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671605.

Polymorphism and mutation databases

BioMutaiINTS2.
DMDMi296434542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12041204Integrator complex subunit 2PRO_0000236099Add
BLAST

Proteomic databases

EPDiQ9H0H0.
MaxQBiQ9H0H0.
PaxDbiQ9H0H0.
PeptideAtlasiQ9H0H0.
PRIDEiQ9H0H0.

PTM databases

iPTMnetiQ9H0H0.
PhosphoSiteiQ9H0H0.

Expressioni

Gene expression databases

BgeeiENSG00000108506.
CleanExiHS_INTS2.
ExpressionAtlasiQ9H0H0. baseline and differential.
GenevisibleiQ9H0H0. HS.

Organism-specific databases

HPAiHPA049524.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

Protein-protein interaction databases

BioGridi121572. 38 interactions.
DIPiDIP-48477N.
IntActiQ9H0H0. 2 interactions.
MINTiMINT-4712719.
STRINGi9606.ENSP00000414237.

Structurei

3D structure databases

ProteinModelPortaliQ9H0H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Integrator subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH4R. Eukaryota.
ENOG410XYV2. LUCA.
GeneTreeiENSGT00390000011888.
HOGENOMiHOG000047505.
HOVERGENiHBG059904.
InParanoidiQ9H0H0.
KOiK13139.
OMAiLCMLIAC.
OrthoDBiEOG091G025T.
PhylomeDBiQ9H0H0.
TreeFamiTF324737.

Family and domain databases

InterProiIPR026236. Int2_metazoa.
IPR029321. INTS2.
[Graphical view]
PfamiPF14750. INTS2. 1 hit.
[Graphical view]
PRINTSiPR02105. INTSUBUNIT2.

Sequencei

Sequence statusi: Complete.

Q9H0H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDQQTVIMT ECTSLQFVSP FAFEAMQKVD VVCLASLSDP ELRLLLPCLV
60 70 80 90 100
RMALCAPADQ SQSWAQDKKL ILRLLSGVEA VNSIVALLSV DFHALEQDAS
110 120 130 140 150
KEQQLRHKLG GGSGESILVS QLQHGLTLEF EHSDSPRRLR LVLSELLAIM
160 170 180 190 200
NKVSESNGEF FFKSSELFES PVYLEEAADV LCILQAELPS LLPIVDVAEA
210 220 230 240 250
LLHVRNGAWF LCLLVANVPD SFNEVCRGLI KNGERQDEES LGGRRRTDAL
260 270 280 290 300
RFLCKMNPSQ ALKVRGMVVE ECHLPGLGVA LTLDHTKNEA CEDGVSDLVC
310 320 330 340 350
FVSGLLLGTN AKVRTWFGTF IRNGQQRKRE TSSSVLWQMR RQLLLELMGI
360 370 380 390 400
LPTVRSTRIV EEADVDMEPN VSVYSGLKEE HVVKASALLR LYCALMGIAG
410 420 430 440 450
LKPTEEEAEQ LLQLMTSRPP ATPAGVRFVS LSFCMLLAFS TLVSTPEQEQ
460 470 480 490 500
LMVVWLSWMI KEEAYFESTS GVSASFGEML LLVAMYFHSN QLSAIIDLVC
510 520 530 540 550
STLGMKIVIK PSSLSRMKTI FTQEIFTEQV VTAHAVRVPV TSNLSANITG
560 570 580 590 600
FLPIHCIYQL LRSRSFTKHK VSIKDWIYRQ LCETSTPLHP QLLPLIDVYI
610 620 630 640 650
NSILTPASKS NPEATNQPVT EQEILNIFQG VIGGDNIRLN QRFSITAQLL
660 670 680 690 700
VLYYILSYEE ALLANTKTLA AMQRKPKSYS SSLMDQIPIK FLIRQAQGLQ
710 720 730 740 750
QELGGLHSAL LRLLATNYPH LCIVDDWICE EEITGTDALL RRMLLTNNAK
760 770 780 790 800
NHSPKQLQEA FSAVPVNNTQ VMQIIEHLTL LSASELIPYA EVLTSNMSQL
810 820 830 840 850
LNSGVPRRIL QTVNKLWMVL NTVMPRRLWV MTVNALQPSI KFVRQQKYTQ
860 870 880 890 900
NDLMIDPLIV LRCDQRVHRC PPLMDITLHM LNGYLLASKA YLSAHLKETE
910 920 930 940 950
QDRPSQNNTI GLVGQTDAPE VTREELKNAL LAAQDSAAVQ ILLEICLPTE
960 970 980 990 1000
EEKANGVNPD SLLRNVQSVI TTSAPNKGME EGEDNLLCNL REVQCLICCL
1010 1020 1030 1040 1050
LHQMYIADPN IAKLVHFQGY PCELLPLTVA GIPSMHICLD FIPELIAQPE
1060 1070 1080 1090 1100
LEKQIFAIQL LSHLCIQYAL PKSLSVARLA VNVMGTLLTV LTQAKRYAFF
1110 1120 1130 1140 1150
MPTLPSLVSF CRAFPPLYED IMSLLIQIGQ VCASDVATQT RDIDPIITRL
1160 1170 1180 1190 1200
QQIKEKPSGW SQICKDSSYK NGSRDTGSMD PDVQLCHCIE RTVIEIINMS

VSGI
Length:1,204
Mass (Da):134,323
Last modified:May 18, 2010 - v2
Checksum:iE4E160F25E1ACB4B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → GWRVDL in BAA86601 (PubMed:10574462).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti768 – 7681N → H.4 Publications
Corresponds to variant rs606072 [ dbSNP | Ensembl ].
VAR_049628

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033113 mRNA. Translation: BAA86601.1.
AL136800 mRNA. Translation: CAB66734.1.
CR533582 mRNA. Translation: CAG38656.1.
AC060798 Genomic DNA. No translation available.
BK005721 mRNA. Translation: DAA05721.1.
CCDSiCCDS45750.1.
RefSeqiNP_065799.1. NM_020748.2.
UniGeneiHs.279646.

Genome annotation databases

EnsembliENST00000444766; ENSP00000414237; ENSG00000108506.
ENST00000617492; ENSP00000482710; ENSG00000108506.
GeneIDi57508.
KEGGihsa:57508.
UCSCiuc002izn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033113 mRNA. Translation: BAA86601.1.
AL136800 mRNA. Translation: CAB66734.1.
CR533582 mRNA. Translation: CAG38656.1.
AC060798 Genomic DNA. No translation available.
BK005721 mRNA. Translation: DAA05721.1.
CCDSiCCDS45750.1.
RefSeqiNP_065799.1. NM_020748.2.
UniGeneiHs.279646.

3D structure databases

ProteinModelPortaliQ9H0H0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121572. 38 interactions.
DIPiDIP-48477N.
IntActiQ9H0H0. 2 interactions.
MINTiMINT-4712719.
STRINGi9606.ENSP00000414237.

PTM databases

iPTMnetiQ9H0H0.
PhosphoSiteiQ9H0H0.

Polymorphism and mutation databases

BioMutaiINTS2.
DMDMi296434542.

Proteomic databases

EPDiQ9H0H0.
MaxQBiQ9H0H0.
PaxDbiQ9H0H0.
PeptideAtlasiQ9H0H0.
PRIDEiQ9H0H0.

Protocols and materials databases

DNASUi57508.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000444766; ENSP00000414237; ENSG00000108506.
ENST00000617492; ENSP00000482710; ENSG00000108506.
GeneIDi57508.
KEGGihsa:57508.
UCSCiuc002izn.4. human.

Organism-specific databases

CTDi57508.
GeneCardsiINTS2.
HGNCiHGNC:29241. INTS2.
HPAiHPA049524.
MIMi611346. gene.
neXtProtiNX_Q9H0H0.
PharmGKBiPA142671605.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH4R. Eukaryota.
ENOG410XYV2. LUCA.
GeneTreeiENSGT00390000011888.
HOGENOMiHOG000047505.
HOVERGENiHBG059904.
InParanoidiQ9H0H0.
KOiK13139.
OMAiLCMLIAC.
OrthoDBiEOG091G025T.
PhylomeDBiQ9H0H0.
TreeFamiTF324737.

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

GenomeRNAii57508.
PROiQ9H0H0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108506.
CleanExiHS_INTS2.
ExpressionAtlasiQ9H0H0. baseline and differential.
GenevisibleiQ9H0H0. HS.

Family and domain databases

InterProiIPR026236. Int2_metazoa.
IPR029321. INTS2.
[Graphical view]
PfamiPF14750. INTS2. 1 hit.
[Graphical view]
PRINTSiPR02105. INTSUBUNIT2.
ProtoNetiSearch...

Entry informationi

Entry nameiINT2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0H0
Secondary accession number(s): Q9ULD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have shorter N-terminus.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.