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Protein

Nuclear speckle splicing regulatory protein 1

Gene

NSRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that mediates pre-mRNA alternative splicing regulation.1 Publication

GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • developmental process Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • nucleocytoplasmic transport Source: UniProtKB
  • regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126653-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear speckle splicing regulatory protein 1
Alternative name(s):
Coiled-coil domain-containing protein 55
Nuclear speckle-related protein 70
Short name:
NSrp70
Gene namesi
Name:NSRP1
Synonyms:CCDC55, NSRP70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25305. NSRP1.

Subcellular locationi

GO - Cellular componenti

  • intracellular ribonucleoprotein complex Source: UniProtKB
  • nuclear speck Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi536 – 537RD → AA: Inhibits nuclear localization and alternative splicing activity. 1 Publication2

Organism-specific databases

DisGeNETi84081.
OpenTargetsiENSG00000126653.
PharmGKBiPA142672171.

Polymorphism and mutation databases

BioMutaiNSRP1.
DMDMi74733524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404341 – 558Nuclear speckle splicing regulatory protein 1Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei275PhosphothreonineCombined sources1
Modified residuei457PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H0G5.
MaxQBiQ9H0G5.
PaxDbiQ9H0G5.
PeptideAtlasiQ9H0G5.
PRIDEiQ9H0G5.

PTM databases

iPTMnetiQ9H0G5.
PhosphoSitePlusiQ9H0G5.

Expressioni

Tissue specificityi

Expressed in dendritic cells, T-cells, B-cells and natural killer cells. Expressed in secondary lymphoid organs such as spleen and mesenteric, axillary and brachial lymph nodes.1 Publication

Inductioni

Up-regulated in motile T-cells.1 Publication

Gene expression databases

BgeeiENSG00000126653.
CleanExiHS_CCDC55.
ExpressionAtlasiQ9H0G5. baseline and differential.
GenevisibleiQ9H0G5. HS.

Organism-specific databases

HPAiHPA015593.
HPA015603.

Interactioni

Subunit structurei

Interacts (via C-terminus) with SRSF1. Interacts (via C-terminus) with SRSF2.1 Publication

Protein-protein interaction databases

BioGridi123876. 18 interactors.
IntActiQ9H0G5. 10 interactors.
MINTiMINT-2817156.
STRINGi9606.ENSP00000247026.

Structurei

3D structure databases

ProteinModelPortaliQ9H0G5.
SMRiQ9H0G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 170Necessary for alternative splicing activityAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 170Sequence analysisAdd BLAST67
Coiled coili379 – 427Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 37Poly-Asp6
Compositional biasi282 – 359His-richAdd BLAST78

Sequence similaritiesi

Belongs to the NSRP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2117. Eukaryota.
ENOG410Z5A1. LUCA.
GeneTreeiENSGT00730000111127.
HOVERGENiHBG081043.
InParanoidiQ9H0G5.
KOiK13206.
OMAiQQNDQNR.
OrthoDBiEOG091G0KUG.
PhylomeDBiQ9H0G5.
TreeFamiTF319359.

Family and domain databases

InterProiIPR018612. DUF2040.
[Graphical view]
PfamiPF09745. DUF2040. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPGRQYGL ILPKKTQQLH PVLQKPSVFG NDSDDDDETS VSESLQREAA
60 70 80 90 100
KKQAMKQTKL EIQKALAEDA TVYEYDSIYD EMQKKKEENN PKLLLGKDRK
110 120 130 140 150
PKYIHNLLKA VEIRKKEQEK RMEKKIQRER EMEKGEFDDK EAFVTSAYKK
160 170 180 190 200
KLQERAEEEE REKRAAALEA CLDVTKQKDL SGFYRHLLNQ AVGEEEVPKC
210 220 230 240 250
SFREARSGIK EEKSRGFSNE VSSKNRIPQE KCILQTDVKV EENPDADSDF
260 270 280 290 300
DAKSSADDEI EETRVNCRRE KVIETPENDF KHHRSQNHSR SPSEERGHST
310 320 330 340 350
RHHTKGSRTS RGHEKREDQH QQKQSRDQEN HYTDRDYRKE RDSHRHREAS
360 370 380 390 400
HRDSHWKRHE QEDKPRARDQ RERSDRVWKR EKDREKYSQR EQERDRQQND
410 420 430 440 450
QNRPSEKGEK EEKSKAKEEH MKVRKERYEN NDKYRDREKR EVGVQSSERN
460 470 480 490 500
QDRKESSPNS RAKDKFLDQE RSNKMRNMAK DKERNQEKPS NSESSLGAKH
510 520 530 540 550
RLTEEGQEKG KEQERPPEAV SKFAKRNNEE TVMSARDRYL ARQMARVNAK

TYIEKEDD
Length:558
Mass (Da):66,390
Last modified:March 1, 2001 - v1
Checksum:i99B7BDBCFD06F98D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270E → G in CAG38586 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05410486K → T.Corresponds to variant rs11544945dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136806 mRNA. Translation: CAB66740.1.
CR533555 mRNA. Translation: CAG38586.1.
AC104984 Genomic DNA. No translation available.
BC040118 mRNA. Translation: AAH40118.1.
BC105044 mRNA. Translation: AAI05045.1.
BC105046 mRNA. Translation: AAI05047.1.
CCDSiCCDS11255.1.
RefSeqiNP_001248396.1. NM_001261467.1.
NP_115517.1. NM_032141.3.
UniGeneiHs.462663.

Genome annotation databases

EnsembliENST00000247026; ENSP00000247026; ENSG00000126653.
GeneIDi84081.
KEGGihsa:84081.
UCSCiuc002heu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136806 mRNA. Translation: CAB66740.1.
CR533555 mRNA. Translation: CAG38586.1.
AC104984 Genomic DNA. No translation available.
BC040118 mRNA. Translation: AAH40118.1.
BC105044 mRNA. Translation: AAI05045.1.
BC105046 mRNA. Translation: AAI05047.1.
CCDSiCCDS11255.1.
RefSeqiNP_001248396.1. NM_001261467.1.
NP_115517.1. NM_032141.3.
UniGeneiHs.462663.

3D structure databases

ProteinModelPortaliQ9H0G5.
SMRiQ9H0G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123876. 18 interactors.
IntActiQ9H0G5. 10 interactors.
MINTiMINT-2817156.
STRINGi9606.ENSP00000247026.

PTM databases

iPTMnetiQ9H0G5.
PhosphoSitePlusiQ9H0G5.

Polymorphism and mutation databases

BioMutaiNSRP1.
DMDMi74733524.

Proteomic databases

EPDiQ9H0G5.
MaxQBiQ9H0G5.
PaxDbiQ9H0G5.
PeptideAtlasiQ9H0G5.
PRIDEiQ9H0G5.

Protocols and materials databases

DNASUi84081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247026; ENSP00000247026; ENSG00000126653.
GeneIDi84081.
KEGGihsa:84081.
UCSCiuc002heu.5. human.

Organism-specific databases

CTDi84081.
DisGeNETi84081.
GeneCardsiNSRP1.
HGNCiHGNC:25305. NSRP1.
HPAiHPA015593.
HPA015603.
MIMi616173. gene.
neXtProtiNX_Q9H0G5.
OpenTargetsiENSG00000126653.
PharmGKBiPA142672171.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2117. Eukaryota.
ENOG410Z5A1. LUCA.
GeneTreeiENSGT00730000111127.
HOVERGENiHBG081043.
InParanoidiQ9H0G5.
KOiK13206.
OMAiQQNDQNR.
OrthoDBiEOG091G0KUG.
PhylomeDBiQ9H0G5.
TreeFamiTF319359.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126653-MONOMER.

Miscellaneous databases

ChiTaRSiNSRP1. human.
GeneWikiiCCDC55_(gene).
GenomeRNAii84081.
PROiQ9H0G5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126653.
CleanExiHS_CCDC55.
ExpressionAtlasiQ9H0G5. baseline and differential.
GenevisibleiQ9H0G5. HS.

Family and domain databases

InterProiIPR018612. DUF2040.
[Graphical view]
PfamiPF09745. DUF2040. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNSRP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H0G5
Secondary accession number(s): Q6FI71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.