Q9H0F5 (RNF38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger protein 38

Gene names

Name:

RNF38

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Widely expressed with highest levels in testis. Ref.1
Sequence similarities	Contains 1 RING-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H0F5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H0F5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     5-54: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H0F5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 515

515

RING finger protein 38

PRO_0000056078

Regions

Zinc finger

463 – 504

42

RING-type

Compositional bias

239 – 404

166

Pro-rich

Natural variations

Alternative sequence

1 – 83

83

Missing in isoform 3.

VSP_037337

Alternative sequence

5 – 54

50

Missing in isoform 2.

VSP_012243

Natural variant

206

1

A → T. Ref.1

VAR_055400

Experimental info

Sequence conflict

308

1

I → K in CAB66751. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

515

Helix Strand Turn

Details...

Beta strand

449 – 451

3

Beta strand

453 – 455

3

Beta strand

457 – 459

3

Turn

464 – 467

4

Beta strand

475 – 479

5

Turn

480 – 482

3

Beta strand

483 – 486

4

Helix

489 – 496

8

Turn

501 – 503

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 4. Checksum: ABFE9486CA732AFA	FASTA	515	57,595
	10 20 30 40 50 60 MACKISPGAN SASLPGHPNK VICERVRLQS LFPLLPSDQN TTVQEDAHFK AFFQSEDSPS 70 80 90 100 110 120 PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP SQHHFSGERC NTPARNRRSP 130 140 150 160 170 180 PVRRQRGRRD RLSRHNSISQ DENYHHLPYA QQQAIEEPRA FHPPNVSPRL LHPAAHPPQQ 190 200 210 220 230 240 NAVMVDIHDQ LHQGTVPVSY TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS VVFSGQHLPV 250 260 270 280 290 300 CSVPPPMLQA CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP GQFVPFQTQQ 310 320 330 340 350 360 SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH QEVSFGVPYP 370 380 390 400 410 420 PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP AVGPTFSFEL DVEDGEVENY 430 440 450 460 470 480 EALLNLAERL GEAKPRGLTK ADIEQLPSYR FNPNNHQSEQ TLCVVCMCDF ESRQLLRVLP 490 500 510 CNHEFHAKCV DKWLKANRTC PICRADASEV HRDSE
	Isoform 2 [UniParc]. Checksum: 18A919182C967BA6	FASTA	465	52,106
	10 20 30 40 50 60 MACKSEDSPS PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP SQHHFSGERC 70 80 90 100 110 120 NTPARNRRSP PVRRQRGRRD RLSRHNSISQ DENYHHLPYA QQQAIEEPRA FHPPNVSPRL 130 140 150 160 170 180 LHPAAHPPQQ NAVMVDIHDQ LHQGTVPVSY TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS 190 200 210 220 230 240 VVFSGQHLPV CSVPPPMLQA CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP 250 260 270 280 290 300 GQFVPFQTQQ SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH 310 320 330 340 350 360 QEVSFGVPYP PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP AVGPTFSFEL 370 380 390 400 410 420 DVEDGEVENY EALLNLAERL GEAKPRGLTK ADIEQLPSYR FNPNNHQSEQ TLCVVCMCDF 430 440 450 460 ESRQLLRVLP CNHEFHAKCV DKWLKANRTC PICRADASEV HRDSE
	Isoform 3 [UniParc]. Checksum: CCC2D1396DB31D2C	FASTA	432	48,562
	10 20 30 40 50 60 MRPWEMTSNR QPPSVRPSQH HFSGERCNTP ARNRRSPPVR RQRGRRDRLS RHNSISQDEN 70 80 90 100 110 120 YHHLPYAQQQ AIEEPRAFHP PNVSPRLLHP AAHPPQQNAV MVDIHDQLHQ GTVPVSYTVT 130 140 150 160 170 180 TVAPHGIPLC TGQHIPACST QQVPGCSVVF SGQHLPVCSV PPPMLQACSV QHLPVPYAAF 190 200 210 220 230 240 PPLISSDPFL IHPPHLSPHH PPHLPPPGQF VPFQTQQSRS PLQRIENEVE LLGEHLPVGG 250 260 270 280 290 300 FTYPPSAHPP TLPPSAPLQF LTHDPLHQEV SFGVPYPPFM PRRLTGRSRY RSQQPIPPPP 310 320 330 340 350 360 YHPSLLPYVL SMLPVPPAVG PTFSFELDVE DGEVENYEAL LNLAERLGEA KPRGLTKADI 370 380 390 400 410 420 EQLPSYRFNP NNHQSEQTLC VVCMCDFESR QLLRVLPCNH EFHAKCVDKW LKANRTCPIC 430 RADASEVHRD SE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain." Eisenberg I., Hochner H., Levi T., Yelin R., Kahan T., Mitrani-Rosenbaum S. Biochem. Biophys. Res. Commun. 294:1169-1176(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANT THR-206.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[6]	"Solution structure of RING finger in RING finger protein 38." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 445-506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF394047 mRNA. Translation: AAM73697.1.
AL136817 mRNA. Translation: CAB66751.3.
AL161792, AL354935 Genomic DNA. Translation: CAO03553.1.
AL354935, AL161792 Genomic DNA. Translation: CAO03540.1.
AL354935, AL161792 Genomic DNA. Translation: CAO03541.1.
AL161792, AL354935 Genomic DNA. Translation: CAO03554.1.
CH471071 Genomic DNA. Translation: EAW58305.1.
BC033786 mRNA. Translation: AAH33786.2.

IPI

IPI00167875.
IPI00375419.
IPI00478430.

RefSeq

NP_073618.3. NM_022781.4.
NP_919309.1. NM_194328.2.
NP_919310.1. NM_194329.2.
NP_919311.1. NM_194330.2.
NP_919313.1. NM_194332.2.

UniGene

Hs.333503.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X4J	NMR	-	A	445-506	[»]

ProteinModelPortal

Q9H0F5.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9H0F5. 8 interactions.

STRING

9606.ENSP00000259605.

PTM databases

PhosphoSite

Q9H0F5.

Polymorphism databases

DMDM

56749664.

Proteomic databases

PaxDb

Q9H0F5.

PRIDE

Q9H0F5.

Protocols and materials databases

DNASU

152006.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000259605; ENSP00000259605; ENSG00000137075.
ENST00000350199; ENSP00000343947; ENSG00000137075.
ENST00000353739; ENSP00000335239; ENSG00000137075.
ENST00000357058; ENSP00000349566; ENSG00000137075.
ENST00000377885; ENSP00000367117; ENSG00000137075.

GeneID

152006.

KEGG

hsa:152006.

UCSC

uc003zzh.3. human.
uc003zzi.3. human.

Organism-specific databases

CTD

152006.

GeneCards

GC09M036336.

HGNC

HGNC:18052. RNF38.

HPA

HPA015853.

MIM

612488. gene.

neXtProt

NX_Q9H0F5.

PharmGKB

PA34438.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5540.

HOGENOM

HOG000231638.

HOVERGEN

HBG059283.

InParanoid

Q9H0F5.

OMA

FLLHPPH.

OrthoDB

EOG4TB4B7.

PhylomeDB

Q9H0F5.

Gene expression databases

ArrayExpress

Q9H0F5.

Bgee

Q9H0F5.

CleanEx

HS_RNF38.

Genevestigator

Q9H0F5.

GermOnline

ENSG00000137075. Homo sapiens.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF13639. zf-RING_2. 1 hit.
[Graphical view]

SMART

SM00184. RING. 1 hit.
[Graphical view]

PROSITE

PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RNF38. human.

EvolutionaryTrace

Q9H0F5.

GenomeRNAi

152006.

NextBio

86839.

SOURCE

Search...

Entry information

Entry name

RNF38_HUMAN

Accession

Primary (citable) accession number: Q9H0F5
Secondary accession number(s): A6PVP9 , B1AM82, Q7LB33, Q8N0Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 95 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.