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Q9H0F5

- RNF38_HUMAN

UniProt

Q9H0F5 - RNF38_HUMAN

Protein

E3 ubiquitin-protein ligase RNF38

Gene

RNF38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 4 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri463 – 50442RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. ubiquitin-protein transferase activity Source: FlyBase
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. male gonad development Source: Ensembl
    2. protein ubiquitination Source: FlyBase

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase RNF38 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 38
    Gene namesi
    Name:RNF38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18052. RNF38.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: FlyBase
    2. sperm flagellum Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34438.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515E3 ubiquitin-protein ligase RNF38PRO_0000056078Add
    BLAST

    Proteomic databases

    PaxDbiQ9H0F5.
    PRIDEiQ9H0F5.

    PTM databases

    PhosphoSiteiQ9H0F5.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9H0F5.
    BgeeiQ9H0F5.
    CleanExiHS_RNF38.
    GenevestigatoriQ9H0F5.

    Organism-specific databases

    HPAiHPA015853.

    Interactioni

    Protein-protein interaction databases

    BioGridi127416. 16 interactions.
    IntActiQ9H0F5. 9 interactions.
    MINTiMINT-4720518.
    STRINGi9606.ENSP00000259605.

    Structurei

    Secondary structure

    1
    515
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi449 – 4513
    Beta strandi453 – 4553
    Beta strandi457 – 4593
    Turni464 – 4674
    Beta strandi475 – 4795
    Turni480 – 4823
    Beta strandi483 – 4864
    Helixi489 – 4968
    Turni501 – 5033

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X4JNMR-A445-506[»]
    ProteinModelPortaliQ9H0F5.
    SMRiQ9H0F5. Positions 445-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H0F5.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi57 – 7115Bipartite nuclear localization signal 1Add
    BLAST
    Motifi115 – 13117Bipartite nuclear localization signal 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi239 – 404166Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri463 – 50442RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5540.
    HOGENOMiHOG000231638.
    HOVERGENiHBG059283.
    InParanoidiQ9H0F5.
    OMAiNQHHFSG.
    OrthoDBiEOG74TWZV.
    PhylomeDBiQ9H0F5.
    TreeFamiTF325756.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H0F5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MACKISPGAN SASLPGHPNK VICERVRLQS LFPLLPSDQN TTVQEDAHFK    50
    AFFQSEDSPS PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP 100
    SQHHFSGERC NTPARNRRSP PVRRQRGRRD RLSRHNSISQ DENYHHLPYA 150
    QQQAIEEPRA FHPPNVSPRL LHPAAHPPQQ NAVMVDIHDQ LHQGTVPVSY 200
    TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS VVFSGQHLPV CSVPPPMLQA 250
    CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP GQFVPFQTQQ 300
    SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH 350
    QEVSFGVPYP PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP 400
    AVGPTFSFEL DVEDGEVENY EALLNLAERL GEAKPRGLTK ADIEQLPSYR 450
    FNPNNHQSEQ TLCVVCMCDF ESRQLLRVLP CNHEFHAKCV DKWLKANRTC 500
    PICRADASEV HRDSE 515
    Length:515
    Mass (Da):57,595
    Last modified:December 21, 2004 - v4
    Checksum:iABFE9486CA732AFA
    GO
    Isoform 2 (identifier: Q9H0F5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         5-54: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:465
    Mass (Da):52,106
    Checksum:i18A919182C967BA6
    GO
    Isoform 3 (identifier: Q9H0F5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: Missing.

    Show »
    Length:432
    Mass (Da):48,562
    Checksum:iCCC2D1396DB31D2C
    GO
    Isoform 4 (identifier: Q9H0F5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-44: MACKISPGAN...LPSDQNTTVQ → MQHTCTQQKK...NLAGFQLQSP
         45-120: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:439
    Mass (Da):49,265
    Checksum:i76E2EFFA9FDFA02D
    GO
    Isoform 5 (identifier: Q9H0F5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-183: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:332
    Mass (Da):36,836
    Checksum:i4A2E365DA4A094A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti308 – 3081I → K in CAB66751. (PubMed:11230166)Curated
    Sequence conflicti421 – 4211E → G in BAG52726. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti206 – 2061A → T.1 Publication
    Corresponds to variant rs183475137 [ dbSNP | Ensembl ].
    VAR_055400

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 183183Missing in isoform 5. 1 PublicationVSP_053845Add
    BLAST
    Alternative sequencei1 – 8383Missing in isoform 3. 1 PublicationVSP_037337Add
    BLAST
    Alternative sequencei1 – 4444MACKI…NTTVQ → MQHTCTQQKKVTYKHIARFS PRNRLCQADAVFNNNLAGFQ LQSP in isoform 4. 1 PublicationVSP_053846Add
    BLAST
    Alternative sequencei5 – 5450Missing in isoform 2. 1 PublicationVSP_012243Add
    BLAST
    Alternative sequencei45 – 12076Missing in isoform 4. 1 PublicationVSP_053847Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394047 mRNA. Translation: AAM73697.1.
    AL136817 mRNA. Translation: CAB66751.3.
    AK024996 mRNA. Translation: BAB15050.1.
    AK093480 mRNA. Translation: BAG52726.1.
    AL161792, AL354935 Genomic DNA. Translation: CAO03553.1.
    AL354935, AL161792 Genomic DNA. Translation: CAO03540.1.
    AL354935, AL161792 Genomic DNA. Translation: CAO03541.1.
    AL161792, AL354935 Genomic DNA. Translation: CAO03554.1.
    CH471071 Genomic DNA. Translation: EAW58305.1.
    BC033786 mRNA. Translation: AAH33786.2.
    CCDSiCCDS6603.1. [Q9H0F5-1]
    CCDS6604.1. [Q9H0F5-2]
    RefSeqiNP_073618.3. NM_022781.4. [Q9H0F5-1]
    NP_919309.1. NM_194328.2. [Q9H0F5-3]
    NP_919310.1. NM_194329.2. [Q9H0F5-2]
    NP_919311.1. NM_194330.2. [Q9H0F5-3]
    NP_919313.1. NM_194332.2. [Q9H0F5-3]
    XP_005251423.1. XM_005251366.1. [Q9H0F5-3]
    XP_005251424.1. XM_005251367.1. [Q9H0F5-3]
    XP_005251425.1. XM_005251368.1. [Q9H0F5-3]
    XP_006716784.1. XM_006716721.1. [Q9H0F5-3]
    UniGeneiHs.333503.

    Genome annotation databases

    EnsembliENST00000259605; ENSP00000259605; ENSG00000137075. [Q9H0F5-1]
    ENST00000350199; ENSP00000343947; ENSG00000137075. [Q9H0F5-3]
    ENST00000353739; ENSP00000335239; ENSG00000137075. [Q9H0F5-2]
    ENST00000357058; ENSP00000349566; ENSG00000137075. [Q9H0F5-3]
    ENST00000377877; ENSP00000367109; ENSG00000137075. [Q9H0F5-4]
    ENST00000377885; ENSP00000367117; ENSG00000137075. [Q9H0F5-3]
    GeneIDi152006.
    KEGGihsa:152006.
    UCSCiuc003zzh.3. human. [Q9H0F5-1]
    uc003zzi.3. human. [Q9H0F5-2]

    Polymorphism databases

    DMDMi56749664.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394047 mRNA. Translation: AAM73697.1 .
    AL136817 mRNA. Translation: CAB66751.3 .
    AK024996 mRNA. Translation: BAB15050.1 .
    AK093480 mRNA. Translation: BAG52726.1 .
    AL161792 , AL354935 Genomic DNA. Translation: CAO03553.1 .
    AL354935 , AL161792 Genomic DNA. Translation: CAO03540.1 .
    AL354935 , AL161792 Genomic DNA. Translation: CAO03541.1 .
    AL161792 , AL354935 Genomic DNA. Translation: CAO03554.1 .
    CH471071 Genomic DNA. Translation: EAW58305.1 .
    BC033786 mRNA. Translation: AAH33786.2 .
    CCDSi CCDS6603.1. [Q9H0F5-1 ]
    CCDS6604.1. [Q9H0F5-2 ]
    RefSeqi NP_073618.3. NM_022781.4. [Q9H0F5-1 ]
    NP_919309.1. NM_194328.2. [Q9H0F5-3 ]
    NP_919310.1. NM_194329.2. [Q9H0F5-2 ]
    NP_919311.1. NM_194330.2. [Q9H0F5-3 ]
    NP_919313.1. NM_194332.2. [Q9H0F5-3 ]
    XP_005251423.1. XM_005251366.1. [Q9H0F5-3 ]
    XP_005251424.1. XM_005251367.1. [Q9H0F5-3 ]
    XP_005251425.1. XM_005251368.1. [Q9H0F5-3 ]
    XP_006716784.1. XM_006716721.1. [Q9H0F5-3 ]
    UniGenei Hs.333503.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X4J NMR - A 445-506 [» ]
    ProteinModelPortali Q9H0F5.
    SMRi Q9H0F5. Positions 445-507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127416. 16 interactions.
    IntActi Q9H0F5. 9 interactions.
    MINTi MINT-4720518.
    STRINGi 9606.ENSP00000259605.

    PTM databases

    PhosphoSitei Q9H0F5.

    Polymorphism databases

    DMDMi 56749664.

    Proteomic databases

    PaxDbi Q9H0F5.
    PRIDEi Q9H0F5.

    Protocols and materials databases

    DNASUi 152006.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259605 ; ENSP00000259605 ; ENSG00000137075 . [Q9H0F5-1 ]
    ENST00000350199 ; ENSP00000343947 ; ENSG00000137075 . [Q9H0F5-3 ]
    ENST00000353739 ; ENSP00000335239 ; ENSG00000137075 . [Q9H0F5-2 ]
    ENST00000357058 ; ENSP00000349566 ; ENSG00000137075 . [Q9H0F5-3 ]
    ENST00000377877 ; ENSP00000367109 ; ENSG00000137075 . [Q9H0F5-4 ]
    ENST00000377885 ; ENSP00000367117 ; ENSG00000137075 . [Q9H0F5-3 ]
    GeneIDi 152006.
    KEGGi hsa:152006.
    UCSCi uc003zzh.3. human. [Q9H0F5-1 ]
    uc003zzi.3. human. [Q9H0F5-2 ]

    Organism-specific databases

    CTDi 152006.
    GeneCardsi GC09M036336.
    HGNCi HGNC:18052. RNF38.
    HPAi HPA015853.
    MIMi 612488. gene.
    neXtProti NX_Q9H0F5.
    PharmGKBi PA34438.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5540.
    HOGENOMi HOG000231638.
    HOVERGENi HBG059283.
    InParanoidi Q9H0F5.
    OMAi NQHHFSG.
    OrthoDBi EOG74TWZV.
    PhylomeDBi Q9H0F5.
    TreeFami TF325756.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi RNF38. human.
    EvolutionaryTracei Q9H0F5.
    GeneWikii RNF38.
    GenomeRNAii 152006.
    NextBioi 35466719.
    PROi Q9H0F5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H0F5.
    Bgeei Q9H0F5.
    CleanExi HS_RNF38.
    Genevestigatori Q9H0F5.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain."
      Eisenberg I., Hochner H., Levi T., Yelin R., Kahan T., Mitrani-Rosenbaum S.
      Biochem. Biophys. Res. Commun. 294:1169-1176(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANT THR-206.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
      Tissue: Colon and Testis.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    7. "RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53."
      Sheren J.E., Kassenbrock C.K.
      Biochem. Biophys. Res. Commun. 440:473-478(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, NUCLEAR LOCALIZATION SIGNAL, SUBCELLULAR LOCATION.
    8. "Solution structure of RING finger in RING finger protein 38."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 445-506.

    Entry informationi

    Entry nameiRNF38_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0F5
    Secondary accession number(s): A6PVP9
    , B1AM81, B1AM82, B3KSG4, E7EVL3, Q7LB33, Q8N0Y0, Q9H748
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 109 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

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