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Protein

Zinc finger protein 541

Gene

ZNF541

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 22025C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri838 – 86023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1289 – 131123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 541
Gene namesi
Name:ZNF541
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25294. ZNF541.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941115.

Polymorphism and mutation databases

DMDMi221222508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13461346Zinc finger protein 541PRO_0000197136Add
BLAST

Proteomic databases

PaxDbiQ9H0D2.
PeptideAtlasiQ9H0D2.
PRIDEiQ9H0D2.

PTM databases

iPTMnetiQ9H0D2.
PhosphoSiteiQ9H0D2.

Expressioni

Gene expression databases

BgeeiENSG00000118156.
CleanExiHS_ZNF541.
ExpressionAtlasiQ9H0D2. baseline and differential.
GenevisibleiQ9H0D2. HS.

Organism-specific databases

HPAiHPA054379.
HPA058541.

Interactioni

Subunit structurei

Interacts with DNTTIP1 (PubMed:21573134). Identified in a complex with KCDT19, HDAC1 and HSPA2 (By similarity). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9H0D2. 1 interaction.
STRINGi9606.ENSP00000313258.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1053 – 114593ELM2PROSITE-ProRule annotationAdd
BLAST
Domaini1160 – 121152SANTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 SANT domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 22025C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri838 – 86023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1289 – 131123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
KOG4167. Eukaryota.
ENOG4110BKZ. LUCA.
GeneTreeiENSGT00530000063277.
HOGENOMiHOG000155802.
HOVERGENiHBG108770.
InParanoidiQ9H0D2.
TreeFamiTF106431.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q9H0D2-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQYSLGDEG ALPSEMHLPS FSESQGLNCS DTLNRDLGPN TRGFLYAGLS
60 70 80 90 100
GLDPDPSLPT PDMSSEVLED NLDTLSLYSG KDSDSVKLLE EYADSESQAS
110 120 130 140 150
LQDLGLGVLK AKEADEGGRA TSGSARKGKR QHSSPQNPLL DCSLCGKVFS
160 170 180 190 200
SASSLSKHYL THSQERKHVC KICSKAFKRQ DHLTGHMLTH QKTKPFVCIE
210 220 230 240 250
QGCSKSYCDY RSLRRHYEVH HGLCILKEAP PEEEACGDSP HAHESAGQPP
260 270 280 290 300
PSSLRSLVPP EARSPGSLLP HRDLLRRIVS SIVHQKTPSP GPAPAGASDS
310 320 330 340 350
EGRNTACPCP ASSGSSSCTP AGPHAAPAAL DTELPEEPCL PQKEPATDVF
360 370 380 390 400
TAPNSRAAEN GAPDPPEPEP DTALLQARST AECWPEGGSV PACLPLFRGQ
410 420 430 440 450
TVPASSQPSS HSFQWLRNLP GCPKSKGNNV FVVHKPSAVP SREGSESGPG
460 470 480 490 500
PSSGSPSEES PPGPGGGLED ALPFPAALLR VPAEAPSDPR SASGEDDPCA
510 520 530 540 550
PKKVKVDCDS FLCQNPGEPG LQEAQKAGGL PADASPLFRQ LFLKSQEPLV
560 570 580 590 600
SHEQMQVFQM ITKSQRIFSH AQVAAVSSQL PAPEGKPAAL RPLQGPWPQQ
610 620 630 640 650
PPPLAPAVDS LHAGPGNPEA EGSPARRRKT TPGVPREASP GSTRRDAKGG
660 670 680 690 700
LKVAAVPTPL AAPSLDPSRN PDISSLAKQL RSSKGTLDLE DIFPSTGQRQ
710 720 730 740 750
TQLGGEEPPG ASLPGKQAPA ENGAASRITK GEKGPACSRG GGYRLLGNPR
760 770 780 790 800
APRFSGFRKE KAKMDMCCAA SPSQVAMASF SSAGPPADPS KSKLTIFSRI
810 820 830 840 850
QGGNIYRLPH PVKEENVAGR GNQQNGSPTD WTKPRSTFVC KNCSQMFYTE
860 870 880 890 900
KGLSSHMCFH SDQWPSPRGK QEPQVFGTEF CKPLRQVLRP EGDRHSPPGT
910 920 930 940 950
KKPLDPTAAA PLVVPQSIPV VPVTRHIGSM AMGQEKDGEE RDSKESSQQR
960 970 980 990 1000
KRKKRPPPST AGEPGPAGCH QSRLRSPMFL VDCLLKGLFQ CSPYTPPPML
1010 1020 1030 1040 1050
SPIREGSGVY FNTLCSTSTQ ASPDQLISSM LDQVDGSFGI CVVKDDTKIS
1060 1070 1080 1090 1100
IEPHINIGSR FQAEIPELQE RSLAGTDEHV ASLVWKPWGD MMISSETQDR
1110 1120 1130 1140 1150
VTELCNVACS SVMPGGGTNL ELALHCLHEA QGNVQVALET LLLRGPHKPR
1160 1170 1180 1190 1200
THLLADYRYT GSDVWTPIEK RLFKKAFYAH KKDFYLIHKM IQTKTVAQCV
1210 1220 1230 1240 1250
EYYYIWKKMI KFDCGRAPGL EKRVKREPEE VERTEEKVPC SPRERPSHHP
1260 1270 1280 1290 1300
TPKLKTKSYR RESILSSSPN AGSKRTPELL GSAESQGIFP CRECERVFDK
1310 1320 1330 1340
IKSRNAHMKR HRLQDHVEPI IRVKWPVKPF QLKEEELGAD IGPLQW
Note: No experimental confirmation available. Based on EST data and partial nucleotide sequence.
Length:1,346
Mass (Da):145,587
Last modified:September 3, 2014 - v3
Checksum:iC9FEB46072EED963
GO
Isoform 2 (identifier: Q9H0D2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     932-1189: Missing.

Note: No experimental confirmation available.
Show »
Length:1,088
Mass (Da):116,894
Checksum:iD85DFC8CC72661D5
GO

Sequence cautioni

The sequence AAI01051 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01052 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01053 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB66780 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD38720 differs from that shown. Reason: Frameshift at position 473. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4731P → A in CAD38720 (PubMed:11230166).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti486 – 4861P → S.
Corresponds to variant rs3810320 [ dbSNP | Ensembl ].
VAR_054220
Natural varianti712 – 7121S → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_035717
Natural varianti791 – 7911K → E.
Corresponds to variant rs34984302 [ dbSNP | Ensembl ].
VAR_054221
Natural varianti795 – 7951T → S.
Corresponds to variant rs3826835 [ dbSNP | Ensembl ].
VAR_054222

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei932 – 1189258Missing in isoform 2. 1 PublicationVSP_016024Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010331 Genomic DNA. No translation available.
AC016589 Genomic DNA. No translation available.
AC073548 Genomic DNA. No translation available.
AL136846 mRNA. Translation: CAB66780.1. Different initiation.
AL833862 mRNA. Translation: CAD38720.2. Frameshift.
BC101050 mRNA. Translation: AAI01051.1. Different initiation.
BC101051 mRNA. Translation: AAI01052.1. Different initiation.
BC101052 mRNA. Translation: AAI01053.1. Different initiation.
BC101053 mRNA. Translation: AAI01054.1. Different initiation.
CCDSiCCDS46133.2. [Q9H0D2-3]
RefSeqiNP_001264004.1. NM_001277075.1. [Q9H0D2-3]
XP_005259368.1. XM_005259311.4. [Q9H0D2-3]
UniGeneiHs.14161.

Genome annotation databases

EnsembliENST00000391901; ENSP00000375770; ENSG00000118156. [Q9H0D2-3]
GeneIDi84215.
KEGGihsa:84215.
UCSCiuc002phg.5. human. [Q9H0D2-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010331 Genomic DNA. No translation available.
AC016589 Genomic DNA. No translation available.
AC073548 Genomic DNA. No translation available.
AL136846 mRNA. Translation: CAB66780.1. Different initiation.
AL833862 mRNA. Translation: CAD38720.2. Frameshift.
BC101050 mRNA. Translation: AAI01051.1. Different initiation.
BC101051 mRNA. Translation: AAI01052.1. Different initiation.
BC101052 mRNA. Translation: AAI01053.1. Different initiation.
BC101053 mRNA. Translation: AAI01054.1. Different initiation.
CCDSiCCDS46133.2. [Q9H0D2-3]
RefSeqiNP_001264004.1. NM_001277075.1. [Q9H0D2-3]
XP_005259368.1. XM_005259311.4. [Q9H0D2-3]
UniGeneiHs.14161.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H0D2. 1 interaction.
STRINGi9606.ENSP00000313258.

PTM databases

iPTMnetiQ9H0D2.
PhosphoSiteiQ9H0D2.

Polymorphism and mutation databases

DMDMi221222508.

Proteomic databases

PaxDbiQ9H0D2.
PeptideAtlasiQ9H0D2.
PRIDEiQ9H0D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391901; ENSP00000375770; ENSG00000118156. [Q9H0D2-3]
GeneIDi84215.
KEGGihsa:84215.
UCSCiuc002phg.5. human. [Q9H0D2-3]

Organism-specific databases

CTDi84215.
GeneCardsiZNF541.
HGNCiHGNC:25294. ZNF541.
HPAiHPA054379.
HPA058541.
neXtProtiNX_Q9H0D2.
PharmGKBiPA134941115.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
KOG4167. Eukaryota.
ENOG4110BKZ. LUCA.
GeneTreeiENSGT00530000063277.
HOGENOMiHOG000155802.
HOVERGENiHBG108770.
InParanoidiQ9H0D2.
TreeFamiTF106431.

Miscellaneous databases

GenomeRNAii84215.
PROiQ9H0D2.

Gene expression databases

BgeeiENSG00000118156.
CleanExiHS_ZNF541.
ExpressionAtlasiQ9H0D2. baseline and differential.
GenevisibleiQ9H0D2. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN541_HUMAN
AccessioniPrimary (citable) accession number: Q9H0D2
Secondary accession number(s): Q8NDK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: September 3, 2014
Last modified: September 7, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.