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Protein

Zinc finger protein 541

Gene

ZNF541

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri838 – 860C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1289 – 1311C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 541
Gene namesi
Name:ZNF541
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000118156.12
HGNCiHGNC:25294 ZNF541
neXtProtiNX_Q9H0D2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118156
PharmGKBiPA134941115

Polymorphism and mutation databases

DMDMi221222508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971361 – 1346Zinc finger protein 541Add BLAST1346

Proteomic databases

PaxDbiQ9H0D2
PeptideAtlasiQ9H0D2
PRIDEiQ9H0D2

PTM databases

iPTMnetiQ9H0D2
PhosphoSitePlusiQ9H0D2

Expressioni

Gene expression databases

BgeeiENSG00000118156
CleanExiHS_ZNF541
ExpressionAtlasiQ9H0D2 baseline and differential
GenevisibleiQ9H0D2 HS

Organism-specific databases

HPAiHPA058541

Interactioni

Subunit structurei

Interacts with DNTTIP1 (PubMed:21573134). Identified in a complex with KCDT19, HDAC1 and HSPA2 (By similarity). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ9H0D2
IntActiQ9H0D2, 3 interactors
STRINGi9606.ENSP00000313258

Structurei

3D structure databases

ProteinModelPortaliQ9H0D2
SMRiQ9H0D2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1053 – 1145ELM2PROSITE-ProRule annotationAdd BLAST93
Domaini1160 – 1211SANTPROSITE-ProRule annotationAdd BLAST52

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri838 – 860C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1289 – 1311C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG4167 Eukaryota
ENOG4110BKZ LUCA
GeneTreeiENSGT00530000063277
HOGENOMiHOG000155802
HOVERGENiHBG108770
InParanoidiQ9H0D2
TreeFamiTF106431

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q9H0D2-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQYSLGDEG ALPSEMHLPS FSESQGLNCS DTLNRDLGPN TRGFLYAGLS
60 70 80 90 100
GLDPDPSLPT PDMSSEVLED NLDTLSLYSG KDSDSVKLLE EYADSESQAS
110 120 130 140 150
LQDLGLGVLK AKEADEGGRA TSGSARKGKR QHSSPQNPLL DCSLCGKVFS
160 170 180 190 200
SASSLSKHYL THSQERKHVC KICSKAFKRQ DHLTGHMLTH QKTKPFVCIE
210 220 230 240 250
QGCSKSYCDY RSLRRHYEVH HGLCILKEAP PEEEACGDSP HAHESAGQPP
260 270 280 290 300
PSSLRSLVPP EARSPGSLLP HRDLLRRIVS SIVHQKTPSP GPAPAGASDS
310 320 330 340 350
EGRNTACPCP ASSGSSSCTP AGPHAAPAAL DTELPEEPCL PQKEPATDVF
360 370 380 390 400
TAPNSRAAEN GAPDPPEPEP DTALLQARST AECWPEGGSV PACLPLFRGQ
410 420 430 440 450
TVPASSQPSS HSFQWLRNLP GCPKSKGNNV FVVHKPSAVP SREGSESGPG
460 470 480 490 500
PSSGSPSEES PPGPGGGLED ALPFPAALLR VPAEAPSDPR SASGEDDPCA
510 520 530 540 550
PKKVKVDCDS FLCQNPGEPG LQEAQKAGGL PADASPLFRQ LFLKSQEPLV
560 570 580 590 600
SHEQMQVFQM ITKSQRIFSH AQVAAVSSQL PAPEGKPAAL RPLQGPWPQQ
610 620 630 640 650
PPPLAPAVDS LHAGPGNPEA EGSPARRRKT TPGVPREASP GSTRRDAKGG
660 670 680 690 700
LKVAAVPTPL AAPSLDPSRN PDISSLAKQL RSSKGTLDLE DIFPSTGQRQ
710 720 730 740 750
TQLGGEEPPG ASLPGKQAPA ENGAASRITK GEKGPACSRG GGYRLLGNPR
760 770 780 790 800
APRFSGFRKE KAKMDMCCAA SPSQVAMASF SSAGPPADPS KSKLTIFSRI
810 820 830 840 850
QGGNIYRLPH PVKEENVAGR GNQQNGSPTD WTKPRSTFVC KNCSQMFYTE
860 870 880 890 900
KGLSSHMCFH SDQWPSPRGK QEPQVFGTEF CKPLRQVLRP EGDRHSPPGT
910 920 930 940 950
KKPLDPTAAA PLVVPQSIPV VPVTRHIGSM AMGQEKDGEE RDSKESSQQR
960 970 980 990 1000
KRKKRPPPST AGEPGPAGCH QSRLRSPMFL VDCLLKGLFQ CSPYTPPPML
1010 1020 1030 1040 1050
SPIREGSGVY FNTLCSTSTQ ASPDQLISSM LDQVDGSFGI CVVKDDTKIS
1060 1070 1080 1090 1100
IEPHINIGSR FQAEIPELQE RSLAGTDEHV ASLVWKPWGD MMISSETQDR
1110 1120 1130 1140 1150
VTELCNVACS SVMPGGGTNL ELALHCLHEA QGNVQVALET LLLRGPHKPR
1160 1170 1180 1190 1200
THLLADYRYT GSDVWTPIEK RLFKKAFYAH KKDFYLIHKM IQTKTVAQCV
1210 1220 1230 1240 1250
EYYYIWKKMI KFDCGRAPGL EKRVKREPEE VERTEEKVPC SPRERPSHHP
1260 1270 1280 1290 1300
TPKLKTKSYR RESILSSSPN AGSKRTPELL GSAESQGIFP CRECERVFDK
1310 1320 1330 1340
IKSRNAHMKR HRLQDHVEPI IRVKWPVKPF QLKEEELGAD IGPLQW
Note: No experimental confirmation available. Based on EST data and partial nucleotide sequence.
Length:1,346
Mass (Da):145,587
Last modified:September 3, 2014 - v3
Checksum:iC9FEB46072EED963
GO
Isoform 2 (identifier: Q9H0D2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     932-1189: Missing.

Note: No experimental confirmation available.
Show »
Length:1,088
Mass (Da):116,894
Checksum:iD85DFC8CC72661D5
GO

Sequence cautioni

The sequence AAI01051 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01052 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01053 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB66780 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD38720 differs from that shown. Reason: Frameshift at position 473.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti473P → A in CAD38720 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054220486P → S. Corresponds to variant dbSNP:rs3810320Ensembl.1
Natural variantiVAR_035717712S → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_054221791K → E. Corresponds to variant dbSNP:rs34984302Ensembl.1
Natural variantiVAR_054222795T → S. Corresponds to variant dbSNP:rs3826835Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016024932 – 1189Missing in isoform 2. 1 PublicationAdd BLAST258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010331 Genomic DNA No translation available.
AC016589 Genomic DNA No translation available.
AC073548 Genomic DNA No translation available.
AL136846 mRNA Translation: CAB66780.1 Different initiation.
AL833862 mRNA Translation: CAD38720.2 Frameshift.
BC101050 mRNA Translation: AAI01051.1 Different initiation.
BC101051 mRNA Translation: AAI01052.1 Different initiation.
BC101052 mRNA Translation: AAI01053.1 Different initiation.
BC101053 mRNA Translation: AAI01054.1 Different initiation.
CCDSiCCDS46133.2 [Q9H0D2-3]
RefSeqiNP_001264004.1, NM_001277075.1 [Q9H0D2-3]
XP_005259368.1, XM_005259311.4 [Q9H0D2-3]
UniGeneiHs.14161

Genome annotation databases

EnsembliENST00000391901; ENSP00000375770; ENSG00000118156 [Q9H0D2-3]
GeneIDi84215
KEGGihsa:84215
UCSCiuc002phg.5 human [Q9H0D2-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN541_HUMAN
AccessioniPrimary (citable) accession number: Q9H0D2
Secondary accession number(s): Q8NDK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: September 3, 2014
Last modified: May 23, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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